AnatomyDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Asialoglycoprotein ReceptorAsialoglycoproteinsOrosomucoidFetuinsReceptors, Cell SurfaceReceptors, ImmunologicLiverAcetylgalactosamineTechnetium Tc 99m Aggregated AlbuminTechnetium Tc 99m PentetateGalactoseEndocytosisGalactose OxidaseTosyllysine Chloromethyl KetoneMolecular Sequence DataLectinsAmino Acid SequenceHepatoblastomaReceptors, VirusTosylphenylalanyl Chloromethyl KetonePrimaquineGalactosidesLigandsCoated Pits, Cell-MembraneLiver NeoplasmsPolylysineKineticsCarcinoma, HepatocellularCell LineSubstrate Specificityalpha-FetoproteinsSensitivity and SpecificityCell MembraneHepatocytesNeuraminidaseProtein BindingLysosomesVirus AttachmentHemagglutinin Glycoproteins, Influenza VirusBase SequenceBinding SitesTransfectionGolgi ApparatusGlycoproteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsLeucine ZippersLymphoma, Large B-Cell, DiffuseBasic-Leucine Zipper Transcription FactorsTranscription FactorsLymphoma, B-CellHelix-Loop-Helix Motifs
HepaticSubunit of the asialoglycoprotein receptorTransmembraneLigandBindASGPRENDOCYTOSISLigandsHepatocytesGalNAcAsgr1AntibodyRecognizesSiRNALiverAntibodiesResiduesEstrogen receptorGeneGlycoproteinsProteinBiological fluidsComplexesPeptideVesiclesFattyInfectionInduceCellularMeSHCellFormSurfaceInteractionStructuresMajorCellsHumanEnablesExamplesClassSignalShareExpressionDual
Hepatic3
  • To clarify this issue, we used an indirect immunoelectron microscopic method to determine the distribution of the receptor on the surfaces of hepatic cells accessible to the circulation. (nih.gov)
  • The asialoglycoprotein receptor may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. (antibodypedia.com)
  • Dual roles for hepatic lectin receptors in the clearance of chilled platelets. (harvard.edu)
Subunit of the asialoglycoprotein receptor2
Transmembrane3
  • This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. (antibodypedia.com)
  • Hormones, or other extracellular signals, are able to induce changes within the cell by binding to cell surface receptors also known as transmembrane receptors. (wikipedia.org)
  • G-protein-coupled membrane receptors (GPCR) are a major class of transmembrane receptors. (wikipedia.org)
Ligand5
  • After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. (joplink.net)
  • Receptors can have various different structures depending on the function of the hormone and the structure of its ligand. (wikipedia.org)
  • When a ligand binds to a GPCR the receptor changes conformation, which makes the intracellular loops between the different membrane domains of the receptor interact with G proteins. (wikipedia.org)
  • Among the range of proteins shown to co-localize to WPB is angiopoietin-2 (Angpt-2), a ligand of the receptor tyrosine kinase Tie-2. (imperial.ac.uk)
  • In this FcαRI model the residues forming the IgA binding site identified by mutagenesis form a single face near the N-terminus of the receptor, distinct from other leukocyte Fc receptors where ligand binding is in the second domain. (aai.org)
Bind10
  • We conclude that it is unlikely that circulating desialylated cells bind to the asialoglycoprotein receptor in the liver unless a breach in the continuity of sinusoidal lining cells exists. (nih.gov)
  • Hormone receptor proteins bind to a hormone as a result of an accumulation of weak interactions. (wikipedia.org)
  • Upon binding, the receptor often undergoes a conformational change and may bind further, signaling ligands to activate a signaling pathway. (wikipedia.org)
  • Nuclear receptors often bind directly to DNA by targeting specific DNA sequences in order to express or repress transcription of nearby genes. (wikipedia.org)
  • They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. (harvard.edu)
  • GalNAc-siRNA conjugates specifically bind to the asialoglycoprotein receptor (ASGPR) on the surface of hepatocytes and trigger fast endocytosis of the siRNA. (mandyhuser.com)
  • These receptors failed to bind IgA, but were detected by the mAb MY43, which blocks IgA binding to FcαRI, indicating that its epitope does not coincide with these IgA binding residues. (aai.org)
  • Furthermore, use of delivery systems allows surface modification of the nanoparticles (NPs) and incorporation of targeting ligands that bind specifically to receptors on target cells to induce receptor-mediated endocytosis and improve cellular uptake. (jims.org.il)
  • Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. (wakehealth.edu)
  • Neuropilins are 140-kDa vertebrate cell surface receptors that bind neuronal guidance molecules during neural development and axonal outgrowth, and modulate VEGF-mediated angiogenesis. (bvsalud.org)
ASGPR4
  • A more directed approach to the delivery of therapeutic oligonucleotides specifically to the liver has been to target the asialoglycoprotein receptor (ASGPR) using a suitable glycoconjugate. (genelink.com)
  • Indeed, ASGPR is the ideal target for delivery of therapeutic oligonucleotides to the liver since it combines tissue specificity, high expression levels and rapid internalization and turnover. (genelink.com)
  • The specificity to only target hepatocytes is achieved by conjugation of the siRNA to GalNAc (N-acetylgalactosamine) [1], which recognizes the asialoglycoprotein receptor (ASGPR) that is highly expressed on the surface of hepatocytes. (pace-cme.org)
  • Anti-asialoglycoprotein receptor antibodies (anti-ASGPR) occur more often in patients with AIH-1 and may serve as a marker of inflammatory activity. (medscape.com)
ENDOCYTOSIS1
Ligands4
  • Hormone receptors are a wide family of proteins made up of receptors for thyroid and steroid hormones, retinoids and Vitamin D, and a variety of other receptors for various ligands, such as fatty acids and prostaglandins. (wikipedia.org)
  • Intracellular receptors are activated by hydrophobic ligands that pass through the cellular membrane. (wikipedia.org)
  • This study defines the molecular basis of the FcαRI (CD89):IgA interaction, which is distinct from that of the other leukocyte Fc receptors and their Ig ligands. (aai.org)
  • The receptors contain cryptic ligands that are exposed upon the selective proteolysis of specific N-terminal cleavage sites. (uchicago.edu)
Hepatocytes3
  • In contrast, the receptor was associated with hepatocytes, where it was present diffusely on the sinusoidal plasma membranes and concentrated within coated pits. (nih.gov)
  • A new splice variant of the major subunit of human asialoglycoprotein receptor encodes a secreted form in hepatocytes. (unige.ch)
  • The delivery systems based on the uptake of siRNA via interaction of conjugated N-acetylgalactosamine (GalNAc) with its receptor has tremendously accelerated the siRNA drug development for the treatment of diseases associated with any gene expression in hepatocytes. (mandyhuser.com)
GalNAc1
  • In addition, the 3'end of the passenger strand is conjugated to GalNAc, yielding specificity. (pace-cme.org)
Asgr11
Antibody6
  • Antiviral activities of antibodies may either be dependent only on interactions between the antibody and cognate antigen, as in binding and neutralization of an infectious virion, or instead may require interactions between antibody-antigen immune complexes and immunoproteins or Fc receptor expressing immune effector cells. (frontiersin.org)
  • These Fc receptor-dependent antibody functions provide a direct link between the innate and adaptive immune systems by combining the potent antiviral activity of innate effector cells with the diversity and specificity of the adaptive humoral response. (frontiersin.org)
  • The Fc receptor-dependent function of antibody-dependent cellular phagocytosis (ADCP) provides mechanisms for clearance of virus and virus-infected cells, as well as for stimulation of downstream adaptive immune responses by facilitating antigen presentation, or by stimulating the secretion of inflammatory mediators. (frontiersin.org)
  • Fc receptor-dependent antibody functions are important components of the immune response that provide mechanisms for clearance of infected host cells, immune complexes, or opsonized pathogens. (frontiersin.org)
  • Fc receptor-dependent antibody functions are also involved in activation of downstream adaptive immune responses by facilitating antigen presentation or by stimulating the secretion of inflammatory mediators ( 12 , 13 ). (frontiersin.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adrenomedullin Receptor (AMR) in Tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
Recognizes1
SiRNA1
  • Taking into consideration of sequence conservation, homology, immunogenicity and potential off-target etc., this software performs a comprehensive sequence analysis against more than 50 parameters for inter-species sequence comparison and homology assessment to rapidly select high-quality siRNA sequences with desired specificity and potential activity. (mandyhuser.com)
Liver4
  • Cellular distribution of the asialoglycoprotein receptor in rat liver. (nih.gov)
  • It has been postulated that the selective accumulation of circulating desialylated cells in the mammalian liver results from the binding of desialylated glycoproteins on surfaces of the cells to asialoglycoprotein receptors in the liver. (nih.gov)
  • Since circulating cells in the liver are in contact predominantly with sinusoidal lining cells (Kupffer cells and endothelial cells), this postulate requires the presence of asialoglycoprotein receptors on the luminal surface of the sinusoidal lining cells. (nih.gov)
  • Rat liver asialoglycoprotein receptor lacks a cleavable NH2-terminal signal sequence. (joplink.net)
Antibodies2
  • In this review, we discuss the properties of Fc receptors, antibodies, and effector cells that influence ADCP. (frontiersin.org)
  • We propose that additional investigation into the role of ADCP in protective viral responses, the specific virus epitopes targeted by ADCP antibodies, and the types of phagocytes and Fc receptors involved in ADCP at sites of virus infection will provide insight into strategies to successfully leverage this important immune response for improved antiviral immunity through rational vaccine design. (frontiersin.org)
Residues2
  • The role of the essential residues (Y35 and R82) was confirmed by analysis of mutant receptors expressed on the surface of mammalian cells. (aai.org)
  • Key structural features of killer Ig-like receptors are appropriately reproduced in the model, including the structural conservation of the interdomain linker and hydrophobic core (residues V17, V97, and W183). (aai.org)
Estrogen receptor1
Gene1
  • Small interfering RNAs (siRNAs) are emerging as attractive therapeutics since it has the potential to reversibly silence any gene with high efficiency and specificity [9, 10] . (jims.org.il)
Glycoproteins1
Protein3
  • The asialoglycoprotein receptor is a hetero-oligomeric protein composed of major and minor subunits, which are encoded by different genes. (antibodypedia.com)
  • The receptor has an unusual composition in that it shares some structural similarities with G-PROTEIN-COUPLED RECEPTORS and functions as an ubiquitin protein ligase when internalized. (uams.edu)
  • Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles. (rush.edu)
Biological fluids1
  • Description: A sandwich ELISA kit for detection of Adrenomedullin Receptor from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
Complexes1
  • They may also interact synergistically with plexins and with VEGF RECEPTORS to form receptor complexes with distinct affinities and specificities. (bvsalud.org)
Peptide1
  • Receptors for peptide hormones tend to be cell surface receptors built into the plasma membrane of cells and are thus referred to as trans membrane receptors. (wikipedia.org)
Vesicles1
Fatty1
  • Fatty acylation of the rat and human asialoglycoprotein receptors. (unige.ch)
Infection1
  • Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. (unige.ch)
Induce1
  • The hormone receptor interacts with different molecules to induce a variety of changes, such as an increase or decrease of nutrient sources, growth, and other metabolic functions. (wikipedia.org)
Cellular2
  • Because of these highly specific and high affinity interactions between hormones and their receptors, very low concentrations of hormone can produce significant cellular response. (wikipedia.org)
  • Second messengers may also be sent to interact with intracellular receptors in order to enter the complex signal transport system that eventually changes cellular function. (wikipedia.org)
MeSH1
  • Asialoglycoproteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Cell6
  • The receptor then returns to the cell membrane surface. (joplink.net)
  • Intracellular and nuclear receptors are a direct way for the cell to respond to internal changes and signals. (wikipedia.org)
  • Nuclear receptors are a special class of intracellular receptor that specifically aid the needs of the cell to express certain genes. (wikipedia.org)
  • This interaction allows the hormone receptor to produce second messengers within the cell to aid response. (wikipedia.org)
  • The largest family of cell surface receptors involved in SIGNAL TRANSDUCTION. (rush.edu)
  • This report reviews the physiological roles of chemokines and their receptors in the context of hematopoietic cell regulation, with particular focus on the involvement of stromal cell derived factor (SDF)-l/pre-B cell growth stimulating factor (PBSF) and its receptor CXCR4. (go.jp)
Form2
  • The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells. (unige.ch)
  • Neuropilins are receptors for secreted CLASS 3 SEMAPHORINS as well as for vascular endothelial growth factors, and may form hetero- or homodimers. (bvsalud.org)
Surface1
  • Because of the relatively large size of enzymes and receptors, the large amount of surface area provides the basis for these weak interactions to occur. (wikipedia.org)
Interaction1
  • This taken together with major differences in kinetics and affinity for IgA:FcαRI interaction that were observed depending on whether FcαRI was immobilized or in solution suggest a mode of interaction unique among the leukocyte receptors. (aai.org)
Structures1
  • A homology model of the ectodomains of FcαRI was generated based on the structures of killer Ig-like receptors, which share 30-34% identity with FcαRI. (aai.org)
Major1
  • This graph shows the total number of publications written about "Asialoglycoproteins" by people in Harvard Catalyst Profiles by year, and whether "Asialoglycoproteins" was a major or minor topic of these publication. (harvard.edu)
Cells3
  • Whether the receptor is present on these cells, however, remains controversial. (nih.gov)
  • The plasma membranes of Kupffer cells, endothelial cells, and fat-storing cells were devoid of the asialoglycoprotein receptor. (nih.gov)
  • Upon hormone binding, the receptor can initiate multiple signaling pathways, which ultimately leads to changes in the behavior of the target cells. (wikipedia.org)
Human2
Enables2
  • The presence of hormone or multiple hormones enables a response in the receptor, which begins a cascade of signaling. (wikipedia.org)
  • Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. (harvard.edu)
Examples1
  • The most notable examples are the THROMBIN RECEPTORS. (uchicago.edu)
Class1
  • A class of receptors that are activated by the action of PROTEINASES. (uchicago.edu)
Signal3
  • If a signaling pathway ends with the increase in production of a nutrient, that nutrient is then a signal back to the receptor that acts as a competitive inhibitor to prevent further production. (wikipedia.org)
  • An internal signal sequence: the asialoglycoprotein receptor membrane anchor. (unige.ch)
  • Neuropilin binding specificity is determined by CUB and coagulation-factor-like domains in the extracellular portion of the molecule, while a MAM domain is essential for SIGNAL TRANSDUCTION. (bvsalud.org)
Share1
  • Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. (lookformedical.com)
Expression1
  • The factors that govern this specificity of UGT expression remain largely unknown. (aspetjournals.org)
Dual1