Receptor potent inhibitory activity. Medical search. Frequent questions

It also acts as antagonist to TRPM8 and TRPV1 receptor, but agonist of TRPA1. (wikipedia.org)
Ivermectin exerts its antiparasitic action by acting as a potent agonist at gamma-aminobutyric acid (GABA) receptors and potentiating the inhibitory signals sent to motor neurons, thus paralyzing the parasite. (medscape.com)
In vitro metabolism studies were conducted to determine the human cytochrome P450 enzyme(s) involved in the biotransformation of 7-(1,1-dimethylethyl)-6-(2-ethyl-2 H -1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3 b ]pyridazine (TPA023), a selective agonist of human γ-aminobutyric acid A receptor α2 and α3 subunits. (aspetjournals.org)
It is an analog of GABA, but it is not a receptor agonist. (ncats.io)
Muscimol is a potent, selective agonist for the GABAA receptors, and displays sedative-hypnotic, depressant and hallucinogenic psychoactivity. (amanitaresearch.com)
Muscimol is a potent GABAA agonist, activating the receptor for the brain's principal inhibitory neurotransmitter, GABA. (amanitaresearch.com)
A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. (amanitaresearch.com)
ATPM [(-)-3-amino-thiazolo[5,4- b ]- N -cyclopropylmethylmorphinan hydrochloride] was found to have mixed κ- and μ-opioid activity and identified to act as a full κ-agonist and a partial μ-agonist by in vitro binding assays. (aspetjournals.org)
In addition to its agonist profile on the μ-receptor, ATPM also acted as a μ-antagonist, as measured by its inhibition of morphine-induced antinociception. (aspetjournals.org)
Tramadol is a unique analgesic medication, available in variety of formulations, with both monoaminergic reuptake inhibitory and opioid receptor agonist activity increasingly prescribed worldwide as an alternative for high-affinity opioid medication in the treatment of acute and chronic pain. (medscape.com)
Tramadol's simultaneous opioid agonist action and serotonin (5-HT) and norepinephrine reuptake inhibitory effects result in a unique side effect profile and important drug interactions that must be considered. (medscape.com)

Hypertensive patients were divided into three groups according to the type of drug(s) being taken: a calcium antagonist group, an angiotensin II receptor blocker group, and a combination therapy group of calcium antagonists and angiotensin II receptor blockers. (scirp.org)
In conclusion, skin blood flow can be a useful tool to evaluate sympathetic activity and combination therapy with calcium antagonists and angiotensin II receptor blockers were the most useful therapy for suppressing the hemodynamic response to mental stress. (scirp.org)
1] CGRP receptors: a headache to study, but will antagonists prove therapeutic in migraine? (axonmedchem.com)
In contrast to their potent cholinesterase inhibitory activity, all of the pyridophen analogues were less potent antagonists of the muscarinic receptor than aprophen. (inrae.fr)

Our data suggested that celastrol is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. (spandidos-publications.com)
However, vigabatrin is not a potent inhibitor of GABA-T with a Ki of 10 mM. (ncats.io)
Combination of Pin1 inhibitor with ralaniten promoted cell cycle arrest and had improved antitumor activity against CRPC xenografts in vivo compared to individual monotherapies. (bcgsc.ca)
Tivozanib, an investigational new drug, is a highly potent and selective inhibitor of VEGF receptors 1, 2 and 3, exhibiting picomolar inhibitory activity against all three receptors. (aveooncology.com)
it is a potent inhibitor of the 274 mutation in a single PCR. (cdc.gov)
Ritonavir is a potent inhibitor of CYP3A4- and CYP2D6- mediated drug metabolism. (who.int)

The GABA model postulates decreased inhibitory receptor sensitivity, with a resultant excitatory effect. (medscape.com)
In contrast, delta-opioid receptor (DOR) agonists disinhibited ACC pyramidal neuron responses to MThal inputs by suppressing local feed-forward GABA signaling from parvalbumin-positive interneurons. (elifesciences.org)
Vigabatrin increases brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by irreversibly inhibiting enzymes that catabolize GABA (gamma-aminobutyric acid transaminase, GABA-T). Duration of action is determined by rate of GABA-T re-synthesis. (ncats.io)
Muscimol binds to the same site on the GABAA receptor complex as GABA itself, as opposed to other GABAergic drugs such as barbiturates and benzodiazepines which bind to separate regulatory sites. (amanitaresearch.com)
The two receptors GABA-α and GABA-ρ are ion channels that are permeable to chloride ions which reduces neuronal excitability. (amanitaresearch.com)
Gamma-Aminobutyric acid, or γ-aminobutyric acid or GABA, is the chief inhibitory neurotransmitter in the developmentally mature mammalian central nervous system. (amanitaresearch.com)
Neurons that produce GABA as their output are called GABAergic neurons, and have chiefly inhibitory action at receptors in the adult vertebrate. (amanitaresearch.com)
The β-cells secrete GABA along with insulin and the GABA binds to GABA receptors on the neighboring islet α-cells and inhibits them from secreting glucagon (which would counteract insulin's effects). (amanitaresearch.com)
Immune cells express receptors for GABA and administration of GABA can suppress inflammatory immune responses and promote "regulatory" immune responses, such that GABA administration has been shown to inhibit autoimmune diseases in several animal models. (amanitaresearch.com)
I think it's not an issue with gaba per say but an issue with limited receptors due to the benzos. (amanitaresearch.com)
Clarified Euterpe oleracea (EO) juice showed anticonvulsant properties similar to diazepam in an in vivo model with pentylenetetrazol, a GABA A receptor blocker. (hindawi.com)
The results demonstrate, for the first time, that EO can improve GABAergic neurotransmission via interactions with GABA A receptor and modulation of GABA uptake. (hindawi.com)
Considering that PTZ blocks the chloride channel coupled to the GABA A receptor complex, the present study aimed to analyze the possible modulation of GABAergic homeostasis within synaptic clefts in vitro . (hindawi.com)

Pin1 inhibition improves the efficacy of ralaniten compounds that bind to the N-terminal domain of androgen receptor. (bcgsc.ca)
One mechanism underlying CRPC and resistance to hormonal therapies is the expression of constitutively active splice variant(s) of androgen receptor (AR-Vs) that lack its C-terminus ligand-binding domain. (bcgsc.ca)
Ralaniten Sensitizes Enzalutamide-Resistant Prostate Cancer to Ionizing Radiation in Prostate Cancer Cells that Express Androgen Receptor Splice Variants. (bcgsc.ca)
Blocking androgen receptor (AR) transcriptional activity by androgen deprivation therapy (ADT) improves the response to radiotherapy for intermediate and high risk prostate cancer. (bcgsc.ca)
These four pomegranate compounds inhibited DHT-stimulated androgen receptor nuclear accumulation and the expression of the androgen receptor-dependent genes prostate specific antigen and steroid 5α-reductase type 1 at concentrations ≥10 μM. (nih.gov)

These inhibitory effects may be associated with its dual‑receptor inhibition on P2Y12 and TP receptors. (spandidos-publications.com)
The inhibition of Pin1 expression or its activity selectively reduced the transcriptional activities of full-length AR and AR-V7. (bcgsc.ca)
RESULTS: Ellagic acid showed high DPPH radical scavenging and lipid peroxidation inhibition activities. (nutrimedical.com)
Due to its potency and specificity, AVEO believes tivozanib may enable optimal inhibition of the VEGF pathway, while minimizing side effects associated with off-target activity. (aveooncology.com)

We identified four receptor binding domain-targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 23 variants, including the B.1.1.7, B.1.351, P.1, B.1.429, B.1.526, and B.1.617 VOCs. (nih.gov)
85%) in the presence of CYP3A-selective inhibitory antibodies and chemical inhibitors, indicating that members of the CYP3A subfamily play an important role in TPA023 metabolism. (aspetjournals.org)
To provide insight into effective neutralization, we determined cryo-EM structures and evaluated receptor-binding domain (RBD) antibodies for their ability to bind and neutralize B.1.1.529. (cdc.gov)
Significant inhibitory activity was retained by select monoclonal antibodies including A19-58.1, B1-182.1, COV2-2196, S2E12, A19-46.1, S309 and LY-CoV1404, which accommodated these changes and neutralized B.1.1.529. (cdc.gov)
Because some antibodies inhibit or neutralize the activity of BoNT, the choice of antibody with which to extract the toxin is critical. (cdc.gov)
In this work, we evaluated a panel of 16 anti-BoNT/A monoclonal antibodies (mAbs) for their ability to inhibit the in vitro activity of BoNT/A1, /A2, and /A3 complex as well as the recombinant LC of A1. (cdc.gov)
Studies sug- terized by flow cytometry using anti between the immune response and the gest that HCV inhibits receptor genes in CD3, CD56 and CD16 monoclonal virus replication rate [5] and play a cru- the activation of NK cells [20], and the antibodies. (who.int)

and the vasoactive intestinal peptide receptors (VIPR1, VIPR2). (axonmedchem.com)

The activity of these compounds to inhibit K+, histamine (H), actylcholine (ACh), nicotine (Nic) and serotonin (5-HT) induced contractions was determined using superfused GPI segments. (erowid.org)
In our previous study, several compounds extracted from this herb, including luteolin‑4'‑O‑β‑D‑glucopyranoside (LGP), were revealed to exert inhibitory effects on adenosine diphosphate (ADP)‑induced platelet aggregation. (spandidos-publications.com)
1966) characterised ATP and ADP as the most potent inhibitory purine compounds in the gut and observed that the effects of ATP mimic more closely the inhibitory response of the taenia to non-adrenergic nerve-stimulation than to adrenergic nerve stimulation (Burnstock et al. (uni-frankfurt.de)
An additive inhibitory effect on proliferation of enzalutamide-resistant cells was achieved with a combination of ralaniten compounds with ionizing radiation. (bcgsc.ca)
Therefore, a new series of compounds named pyridophens were designed and synthesized to achieve binary prodrugs to preferentially inhibit AChE over BChE, while still retaining the muscarinic receptor antagonism of aprophen. (inrae.fr)
In this study, we investigated the growth inhibitory, antiandrogenic, and pro-apoptotic effects of 13 pure compounds found in the pomegranate in androgen-dependent LNCaP human prostate cancer cells. (nih.gov)
Inhibitory concentration (IC50) for both the hit compounds 6d and 8a was observed in micromolar range, 1.20 µM and 1.66 µM, respectively. (thesciencein.org)
Synthesis of new cyclitol compounds that influence the activity of phosphatidylinositol 4-kinase isoform, PI4K230. (embl.de)

Methods NSCLC cell lines with different epidermal growth factor receptor (EGFR) statuses and in vivo orthotopic bioluminescent xenograft model were employed to determine antitumor activity of API. (figshare.com)
Amplification of the human epidermal growth factor receptor 2 ( HER2 ) gene and overexpression of the HER2 protein is found in 15%-20% of patients with gastric and gastroesophageal junction cancer. (wjgnet.com)

Voacangine exhibits AChE inhibitory activity. (wikipedia.org)
As a group, the carbaphens retained the muscarinic receptor antagonist properties of aprophen but also preferentially inhibited butyrylcholinesterase (BChE) in contrast to acetylcholinesterase (AChE). (inrae.fr)

The mechanism of the antidepressant action of venlafaxine in humans is believed to be associated with its potentiation of neurotransmitter activity in the CNS. (drugs.com)

To answer this question, we first investigated the ability of ellagic acid to influence the activity of the estrogen receptor subtypes ERalpha and ERbeta in HeLa cells. (nutrimedical.com)
Among the mAbs, there were significant differences in extraction efficiency, ability to extract BoNT/A subtypes, and inhibitory effect on BoNT catalytic activity. (cdc.gov)

Particularly, compound 2, bearing a double bond in the tether, ameliorated the biological profile of compound 1 in invitro studies, increasing cholinesterases inhibitory potencies and selective antagonism toward excitotoxic-related GluN1/2B NMDAR over beneficial GluN1/2A NMDAR. (bvsalud.org)

Biochemical data consistently demonstrated that αC-IN inhibitors are more effective in inhibiting dimeric RAF activity compared to αC-OUT inhibitors 11 , 12 . (nature.com)
Preclinical studies have shown that venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak inhibitors of dopamine reuptake. (drugs.com)

There are three receptors of the gamma-aminobutyric acid. (amanitaresearch.com)

In this study, Aryl hydrocarbon receptor (AhR) expression was associated with lymph node and distant metastasis in patients with gastric cancer and was correlated with clinicolpathological pattern. (oncotarget.com)

Hypertension, which has been proposed as a biomarker of clinical effect among agents targeting the VEGF receptor tyrosine kinases in RCC, was the most commonly reported treatment-related adverse effect, and was observed in 50% of treated patients. (aveooncology.com)

MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC 50 of 79 nM. (medchemexpress.com)
MPX-004 inhibits NMDA receptor-mediated currents in Xenopus oocytes expressing human GluN1 + GluN2A with an IC 50 of 198 nM. (medchemexpress.com)
At 10 μM, MPX-004 only weakly (up to 8%) inhibits currents in oocytes expressing GluN2B, C, or D receptors or in control oocytes [1] . (medchemexpress.com)

Venlafaxine and ODV do not possess monoamine oxidase (MAO) inhibitory activity. (drugs.com)

The FLEX-NK TM tetravalent, multifunctional antibody CYT-303 directed against NKp46 and GPC3 demonstrated in vitro and in vivo activity against HCC tumor targets. (biospace.com)
The combination of the FLEX-NK TM and iNK platforms demonstrated greater in vitro and in vivo anti-tumor activity in HCC models than iNK cells alone, with a favorable in vitro cytokine release and immune cell subset safety profile. (biospace.com)
In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
Recently, the potent anticonvulsant properties of açaí ( Euterpe oleracea Martius, family Arecaceae) were demonstrated in an in vivo pentylenetetrazol (PTZ) mouse model [ 2 ]. (hindawi.com)
LC accounts for the specific toxicity, it requires the heavy chain to of infants or immunocompromised individuals, inhalation of the produce this toxic activity in vivo. (cdc.gov)

Fibroblast growth factor receptor 3 (FGFR3) is an attractive therapeutic target for the treatment of bladder cancer. (rcsb.org)
With the ability of the mAbs to demonstrate therapeutic antitumor activity in those patients with relatively advanced malignancies, the term tumor specific was introduced. (jcancer.org)
Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)

MAO-B: IC50 = 3.25 ± 0.20 µM), moderate inhibitory effects on self-mediated amyloid-ß (Aß) aggregation and antioxidant activity. (bvsalud.org)

As the brain develops into adulthood, GABA's role changes from excitatory to inhibitory. (amanitaresearch.com)

Tarragon (Artemisia d.) essential oil has anticonvulsant activity, confirming its traditional use in Iranian folkloric medicine. (greenmedinfo.com)

This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
This network is the main organizational feature that allows the immune system to keep its dynamic equilibrium (homeostasis) through activating and inhibitory signals and, at the same time, to adapt the response to environmental cues. (frontiersin.org)
Although some ANAs can have immune activity, the manifestation of ANAs appears to be widespread in humans. (columbiagypsy.net)

The serotonergic model suggests an exaggerated or inefficient postsynaptic receptor response to synaptic serotonin, potentially in the signal transduction cascade. (medscape.com)
Some studies report subsensitivity of serotonin 1A (5HT1A) receptors. (medscape.com)
It was also found that LGP exhibited marked inhibitory effects on the activation of αIIbβ3 integrin, the secretion of serotonin from granules, and the synthesis of thromboxane A2. (spandidos-publications.com)

2-ATs, 2-AIs, M and CLON dose-dependently inhibited contractions produced by low frequency stimulation through alpha-adrenergic, opioid or unknown receptor mediated mechanisms. (erowid.org)
drugs that can produce parallel blocking of potentiating effects on the responses of both exogenous transmitter and nerve stimulation Tachyphylaxis to ATP produced in the rabbit ileum resulted in a consistent depression of responses to non-adrenergic inhibitory nerve stimulation, whereas responses to adrenergic nerve stimulation remained unaffected (Burnstock et al. (uni-frankfurt.de)
Using higher concentrations of the compound, relaxant responses of GPTC to ATP as well as to non-adrenergic inhibitory nerve stimulation were abolished (Burnstock et al. (uni-frankfurt.de)
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
0-50 min) causes a concentration-dependent reduction in NMDA receptor-mediated fEPSPs in region CA1 in response to Schaffer collateral stimulation in hippocampal slices prepared from brains of 3- to 4-week old rats [1] . (medchemexpress.com)

Mu-opioid receptor (MOR) agonists potently inhibited MThal inputs without affecting ACC inputs to individual striatal medium spiny neurons (MSNs). (elifesciences.org)
It was further found that the antinociceptive effects of ATPM were mediated by κ- and μ-, but not δ-opioid, receptors. (aspetjournals.org)
It is a prodrug that is metabolized by cytochrome P450 (CYP) enzymes CYP2D6 and CYP3A4 to its more potent opioid analgesic metabolites, particularly the O -demethylation product M1. (medscape.com)

Venlafaxine and ODV have no significant affinity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. (drugs.com)
A series of "binary prodrugs" called carbaphens,(1) carbamylated derivatives on one or both of the aromatic rings of the muscarinic receptor antagonist aprophen [(N,N-diethylamino)ethyl 2,2-diphenylpropionate], were synthesized to develop binary prophylactic agents against organophosphorus intoxication. (inrae.fr)

A discussion relating other biological actions of 2-ATs or 2-AIs (e.g. alpha-adrenergic mediated antinociception) to the observed inhibitory neuroeffector responses is provided. (erowid.org)
The catecholamine model postulates increased sensitivity to or improper processing of adrenergic CNS discharges, with potential hypersensitivity of presynaptic alpha-2 receptors. (medscape.com)

MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. (medchemexpress.com)

MPX-004 (50 μM) has no effect on AMPA receptor-mediated synaptic currents of pyramidal neurons in slices from mouse visual cortex- currents [1] . (medchemexpress.com)

However, the inhibitory effects of 2-ATs. (erowid.org)
Its precise mechanism of action is not understood, but it has been shown to induce immobilization of microfilariae by using hyperpolarization effects to decrease muscle activity. (medscape.com)
The aim of this study was to clarify the response of sympathetic activity to antihypertensive drugs using a mental stress test in hypertensive patients and to determine the effects of antihypertensive drugs on the sympathetic activitymediated hemodynamic response to mental stress. (scirp.org)
Pharmacologic activity at these receptors is hypothesized to be associated with the various anticholinergic, sedative, and cardiovascular effects seen with other psychotropic drugs. (drugs.com)
Data from a radiolabeled ligand‑binding assay indicated that LGP exhibited apparent competing effects on thromboxane receptor (TP) and P2Y12 receptors. (spandidos-publications.com)
Combination therapies using ralaniten with ionizing radiation were evaluated for effects on proliferation, colony formation, cell cycle, DNA damage, and Western blot analyses in human prostate cancer cells that express both full-length AR and AR-Vs. Ralaniten and a potent next-generation analog (EPI-7170) decreased expression of DNA repair genes whereas enzalutamide had no effect. (bcgsc.ca)
ATPM was demonstrated to yield more potent antinociceptive effects than (-)U50,488H ( trans -3,4-dichloro- N -methyl- N -[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide). (aspetjournals.org)

Monoclonals developed from these tumor antigens are in the initial phases of investigation with regard to their specificity and antitumor activity. (jcancer.org)

Docking simulation reveals that it has inhibitory effect on VEGF2 kinase and reduces angiogenesis. (wikipedia.org)
Apigenin (API), a flavonoid with a potent Akt-inhibitory effect, shows oncostatic activities in various cancers. (figshare.com)
MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. (medchemexpress.com)
U50,488H (2 mg/kg s.c.) also produced similar inhibitory effect. (aspetjournals.org)

An extract of tarragon (Artermisia d.) increases insulin sensitivity and enhances insulin receptor signaling in an animal model of insulin resistance. (greenmedinfo.com)
Here we investigate whether blocking the transcriptional activities of full-length AR and AR-Vs with ralaniten leads to enhanced sensitivity to radiotherapy. (bcgsc.ca)

Like ibogaine, its a potent HERG blocker in vitro. (wikipedia.org)

At low concentrations (10(-7) to 10(-9) M), this compound displayed a small but significant estrogenic activity via ERalpha, whereas it was a complete estrogen antagonist via ERbeta. (nutrimedical.com)

Genome-wide association studies (GWAS) identified strong associations between severe disease and several chemokine receptors and molecules from the type I interferon pathway. (bvsalud.org)
Extensive in silico studies conducted indicate plasmepsin IX as a possible target for inhibitory activity of the reported molecules. (thesciencein.org)

GABAA receptors are widely distributed in the brain, and so when muscimol is administered, it alters neuronal activity in multiple regions including the cerebral cortex, hippocampus, and cerebellum. (amanitaresearch.com)

In addition, elevated levels of residual t -butyl hydroxylase and N -deethylase activities were observed in the presence of both CYP3A5-rich and CYP3A5-deficient preparations when the substrate concentration increased from 4 to 40 μM. (aspetjournals.org)

The FLEX-NK TM multifunctional engager antibody CYT-338 directed against NKp46 and CD38 demonstrated in vitro activity against multiple myeloma tumor targets. (biospace.com)

Activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX) were measured in ellagic acid-treated V79-4 cells. (nutrimedical.com)

This is because several of the contaminants in technical grade methoxychlor are directly estrogenic (Kupfer and Bulger 1987b), whereas pure methoxychlor is proestrogenic and requires metabolic activation before exhibiting estrogenic activity (Bulger et al. (cdc.gov)

References are publications that support the biological activity of the product. (tocris.com)
It is important to recognize that because of the biological activity of these contaminants, dose-response relationships obtained using technical grade methoxychlor may not be directly applicable to pure methoxychlor. (cdc.gov)

Cytovia's GPC3-directed NK-engager in combination with iPSC-derived NK cells demonstrated impressive anti-tumor activity in mice that merits clinical development," added Dr. Michael Friedman , a member of Cytovia's Board of Directors. (biospace.com)
iNK cells expressed a favorable combination of multiple activation and few inhibitory receptors that corresponded to more potent cytolytic activity against HCC targets. (biospace.com)
Antagonizes the inhibitory affect of [Pyr 1 ]-Apelin-13 on forskolin-induced cAMP accumulation in CHO-K1-APJ cells. (tocris.com)
Electroporation of primary T cells with Alt-R RNP complex targeted to alpha chain of the T-cell receptor routinely results in over 80% knockout of surface TCR complex, without detectable toxicity ( Figure ). (genengnews.com)
Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. (medchemexpress.com)
Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. (nutrimedical.com)
SOD, CAT and GPX activities were significantly increased in ellagic acid-treated V79-4 cells. (nutrimedical.com)
CONCLUSION: Ellagic acid exhibited both antioxidant activity in V79-4 cells and apoptosis-inducing activity in HOS cells through the up-regulation of Bax and activation of caspase-3. (nutrimedical.com)
In addition to potent and selective BTK enzyme and cellular activity, rilzabrutinib inhibited activation and inflammatory activities of B cells and innate cells such as macrophages, basophils, mast cells, and neutrophils, without cell death (in human and rodent assay systems). (aai.org)
In conclusion, punicic acid, the main constituent of pomegranate seed (70-80%), exhibited potent growth inhibitory activities in androgen-dependent LNCaP cells, which appear to be mediated by both antiandrogenic and pro-apoptotic mechanisms. (nih.gov)
of various populations of NKR+ T cells whole blood were withdrawn from Natural killer (NK) cells are potent have been reported to be impaired in each participant on ethylenediamine- antiviral cells which eliminate the vi- chronic hepatitis C patients [16,21]. (who.int)
2005). Notch1 and syndecan-1 potent human embryonic stem (ES) cells. (lu.se)

Furthermore, HIF-1α is also stabilized by reactive oxygen species (ROS), which block PHD activities ( 8 ). (spandidos-publications.com)

Do most proteins show cross-species activity? (medchemexpress.com)
Other proteins may have a lower specific activity when used in the opposite species. (medchemexpress.com)
The heavy chain is responsible for both receptor some species of the genus Clostridium, in particular, Clostridium binding via its C-terminal (CT) binding domain [4,5] (HC) and botulinum, C. butyricum, C. baratii, and C. argentinense. (cdc.gov)

Individuals that suffered from severe COVID-19 show reduced frequencies of T cell, mucosal-associated invariant T cell (MAIT) and dendritic cell (DC) subsets and altered chemokine receptor expression on several subsets, such as reduced levels of CCR1 and CCR2 on monocyte subsets. (bvsalud.org)

unlike most autoantibodies, which are inhibitory, this autoantibody is stimulatory, thus causing continuous synthesis and secretion of excess T4 and T3. (msdmanuals.com)

Anatomy14

Organisms56

Diseases1

Chemicals and Drugs121

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes32

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

Information Science4

Health Care1

Agonist11

Antagonists4

Inhibitor6

GABA13

Androgen receptor5

Inhibition4

Antibodies7

Peptide Receptors1

Compounds8

Epidermal growth f2

AChE2

Neurotransmitter1

Subtypes2

Antagonism1

Inhibitors2

Gamma-amin1

Gastric1

Tyrosine kinases1

Inhibits3

Monoamine1

Vivo5

Therapeutic3

IC501

Excitatory1

Anticonvulsant1

Immune3

Serotonin3

Stimulation5

Opioid3

Muscarinic2

Adrenergic2

Pharmacological1

Synaptic1

Effects7

Antitumor activity1

Effect4

Sensitivity2

Blocker1

Significant1

Molecules2

Neuronal1

Concentration1

Antibody1

Enzymes1

Estrogenic activity1

Biological2

Cells12

Reactive1

Species3

Expression1

Synthesis1