Substrate SpecificitySignal TransductionReceptors, Death DomainKineticsMolecular Sequence DataCaspase 8Amino Acid SequenceApoptosisCells, CulturedPhosphorylationReceptor, Epidermal Growth FactorProtein BindingBinding SitesReceptors, LDLCatalysisCaspasesFas-Associated Death Domain ProteinCell LineEnzyme ActivationRecombinant ProteinsMutationModels, MolecularLipoproteins, LDLCaspase 9Antigens, CD95Cell Line, TumorBase SequenceRNA, MessengerHydrolysisEscherichia coliEnzyme InhibitorsProtein Structure, TertiaryCASP8 and FADD-Like Apoptosis Regulating ProteinCatalytic DomainMembrane ProteinsReceptors, Aryl HydrocarbonFas Ligand ProteinModels, BiologicalTransfectionDose-Response Relationship, DrugBH3 Interacting Domain Death Agonist ProteinHydrogen-Ion ConcentrationCarrier ProteinsMice, KnockoutMitochondriaReceptors, Tumor Necrosis FactorCrystallography, X-RayMice, Inbred C57BLFibroblastsTumor Cells, CulturedProtein ConformationCyclohexanonesCaspase InhibitorsElectrophoresis, Polyacrylamide GelTime FactorsCaspase 3LiverBlotting, WesternGene Expression RegulationSequence Homology, Amino AcidMutagenesis, Site-DirectedReceptors, Cell SurfaceBinding, CompetitiveReverse Transcriptase Polymerase Chain ReactionHydroxycholesterolsReceptor Cross-TalkDrosophila ProteinsTNF-Related Apoptosis-Inducing LigandIntracellular Signaling Peptides and ProteinsDown-RegulationStructure-Activity RelationshipAntineoplastic AgentsToll-Like ReceptorsInsect ProteinsRecombinant Fusion ProteinsProteinsMembrane GlycoproteinsOxidation-ReductionLigandsBenzoflavonesPhosphoproteinsReceptor, TIE-2Receptors, LipoproteinRats, Sprague-DawleyProto-Oncogene ProteinsAdaptor Proteins, Signal TransducingQuinazolinesProto-Oncogene Proteins c-bcl-2Epidermal Growth FactorCell SurvivalBacterial ProteinsDNA PrimersReceptor, IGF Type 1Hydrocarbons, FluorinatedGene Expression ProfilingProtein-Serine-Threonine KinasesMacrophagesCell DivisionCloning, MolecularAdenosine Triphosphate