Receptor of escherichia coli. Medical search. Frequent questions

With electron microscopy and western blot analysis, we found that IbeA protein was secreted from E. coli bodies into the extracellular environment upon contact with host cells, i.e., brain microvascular endothelial cells (BMECs) which is the primary component of BBB. (microbialcell.com)
In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes. (wikipedia.org)
Colicins are protein antibiotics produced by strains of Escherichia coli to kill non-producing strains of the same organims presumably as a method of competitive inhibition. (nottingham.ac.uk)
Structural evidence that colicin A protein binds to a novel binding site of TolA protein in Escherichia coli periplasm Journal of Biological Chemistry. (nottingham.ac.uk)
The minor coat protein P3 attaches to the receptor at the tip of the F pilus of the host Escherichia coli . (bionity.com)
However, deletion of a phage protein (p3) prevents full escape from the host E. coli , and phage that are 10-20X the normal length with several copies of the phage genome can be seen shedding from the E. coli host. (bionity.com)
Filamentous phage use a bacterial structure known as the F pilus to infect E. coli , with the M13 p3 tip contacting the TolA protein on the bacterial pilus. (bionity.com)
A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli. (umm.de)
Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry. (umm.de)
Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)

Shiga toxin (Stx) is the main virulence factor of Shiga toxin-producing Escherichia coli (STEC), and ruminants are the main reservoir of STEC. (frontiersin.org)
Delayed lactose utilization among Shiga toxin-producing Escherichia coli of serogroup O121. (cdc.gov)

Uropathogenic Escherichia coli strain CFT073 disrupts NLRP3 inflammasome activation. (umm.de)

Followed by deductive genomics towards potential drug targets using E. coli strain CUI-B1, strain O25b: H4-ST131, Proteus mirabilis strain HI4320, Klebsiella pneumoniae strain 1721, and Staphylococcus saprophyticus strain ATCC 15305 uropathogenic strains. (bvsalud.org)
PacBio Genome Sequences of Escherichia coli Serotype O157:H7, Diffusely Adherent E. coli , and Salmonella enterica Strains, All Carrying Plasmids with an mcr-1 Resistance Gene. (cdc.gov)

In Escherichia coli , ribosomes must interact with translocons on the membrane for the proper integration of newly synthesized membrane proteins, cotranslationally. (rupress.org)
Recently, it has been recognized that membrane-bound ribosomes are crucial for biogenesis of integral membrane proteins in E. coli , thus renewing interest in ribosome targeting to and association with the membrane in this organism. (rupress.org)
Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
The Toll-like receptor (TLR) family in mammals comprises a set of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain, and in the IL-1 receptor motif in the cytoplasmic domain. (novusbio.com)
These form the rounded tip of the phage and are the first proteins to interact with the E. coli host during infection. (bionity.com)
In separate work, my team identified a set of secreted proteins overexpressed in the tumor microenvironment, and developed antibodies to block their cognate receptors for therapeutic gain. (gene.com)
Comparative genome analysis revealed that genes related to the survival of E. coli, P. mirabilis, K. pneumoniae, and S. saprophyticus, such as genes of metal-requiring proteins, defense-associated genes, and genes associated with general physiology, were found to be highly conserved in the genomes including strain CUI-B1. (bvsalud.org)

Both E. coli O157:H7 and non-O157:H7 serotypes can cause human disease and among non-O157 infections, up to 70% of human infections are attributed to six non-O157 STEC serogroups (O26, O45, O103, O111, O121, and O145) ( Bosilevac and Koohmaraie, 2012 ). (frontiersin.org)

Inhibition of LPS-induced neutrophil ROS production by various adenosine receptor agonists. (avma.org)
Concentration of cAMP in equine neutrophils induced by 5 adenosine A 2A receptor agonists (A) and effects of ZM241385 and MRS1706 on ATL313-induced accumulation of cAMP (B). Each point represents the mean ± SEM of 3 replicates. (avma.org)
Our contributions to elucidating the mechanisms of apoptosis led to clinical investigation of a novel class of molecules called Pro-Apoptotic Receptor Agonists, and aided in the advancement of apoptosis-promoting cancer medicines such as venclexta. (gene.com)
Serum thyroxine levels are generally low in patients with non-alcoholic hepatitis and are improved following the application of thyroxine receptor agonists ( 1 ). (spandidos-publications.com)

Further characterization of these bacterial virulence factor in the context of pathogen-host interaction is necessary to elucidate the molecular mechanism of E. coli meningitis (ECM), which is helpful to design novel strategies for therapeutic interventions. (microbialcell.com)
Identification of the major human sialoglycoprotein from red cells, glycophorin AM, as the receptor for Escherichia coli IH 11165 and characterization of the receptor site. (bdbiosciences.com)
Longitudinal surveillance and comparative characterization of Escherichia albertii in wild raccoons in the United States. (cdc.gov)

LN-T cells derived from donor trained vs. sedentary PLP-immunized mice were analyzed in vitro for proliferation assays and cytokine and chemokine receptor genes expression. (pulsus.com)

Here we present the crystallographic structures of the natural siderophore-antibiotic conjugate albomycin and the siderophore phenylferricrocin, in complex with the active outer membrane transporter FhuA from Escherichia coli. (rcsb.org)
Earlier Postdoctoral positions involved investigating the translocation of toxins produced by E. coli , through the Gram negative outer membrane with a view to use these molecules as novel antibiotics. (ncl.ac.uk)

This plasmid is inserted into the yeast cell Saccharomyces cerevisieae genome where it produces the receptors. (diwou.com)
In the 1990's, the Human Genome Project inspired my team to discover several novel members of the TNF cytokine superfamily, most notably, Apo2L/TRAIL and its "death" and "decoy" receptors. (gene.com)
The current study aimed to sequence the genome of uropathogenic Escherichia coli strain CUI-B1 resourced from a woman having uncomplicated cystitis and pyelonephritis. (bvsalud.org)

this particular model contains the C-terminal domain of CdiA (CdiA-CT) from Escherichia coli, Klebsiella pneumoniae and other bacteria. (nih.gov)
These results may provide the foundation for the optimal target for future discovery of drugs for E. coli-, P. mirabilis-, K. pneumoniae-, and S. saprophyticus-based infections and could be investigated further to employ in personalized drug development. (bvsalud.org)
bacterial causes include Staphylococcus aureus , S. epidermis , Streptococcus pyogenes , S. pneumoniae , Escherichia coli , and Clostridium septicum . (msdmanuals.com)

Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, thereby promoting inflammation. (frontiersin.org)
They represent the first line of defense against pathogens in the lower airspace and recognize microbial ligands via pattern recognition receptors ( 4 , 5 ). (frontiersin.org)
The biosensor makes use of a yeast organism that is genetically engineered with the sequences needed to express estrogen and LH receptors and the attached color-producing ligands. (diwou.com)

The HAP systems works as follows: the HPK (e.g. in Escherichia coli , CheA interacting with transmembrane receptors) is trans-autophosphorylated on a His residue. (igem.org)

The primary mechanism is stimulating antibodies for the TSH receptor. (msdmanuals.com)
Other antibodies block the TSH receptor, and the balance between stimulating and blocking determines the severity of Graves disease. (msdmanuals.com)

The regulation of the neuraminidase gene nanA was examined in Pseudomonas and as cloned and expressed in Escherichia coli. (jci.org)
Sequence comparison between wild-type hfsH from Caulobacter crescentus [37] and our optimized gene for Escherichia coli . (igem.org)
Sequence comparison between wild-type hfsG from Caulobacter crescentus [37] and our optimized gene for Escherichia coli . (igem.org)

Rapid detection of cefotaxime-resistant Escherichia coli by LC-MS.Burrer A, Findeisen P, Jäger E, Ghebremedhin B, Grundt A, Ahmad-Nejad P, Miethke T, Neumaier M. Int J Med Microbiol. (umm.de)

In a recent paper (Nat Commun 9:2296), we identify Caspr1 as a host receptor for E. coli virulence factor IbeA to pave the way the penetration of bacteria through the BBB. (microbialcell.com)
In the past decades, microbiologists identified several virulence factors in E. coli K1 strain that were involved in bacterial meningitis. (microbialcell.com)

Colicin import into E. coli cells: A model system for insights into import mechanisms of bacteriocins. (nottingham.ac.uk)

However, the mechanism of transient receptor potential melastatin 2 regulating bacterial killing remains unknown. (asahq.org)
CD4 receptor diversity represents an ancient protection mechanism against primate lentiviruses. (cdc.gov)

In addition, the presence of EVs reduced inflammatory responses in Pam 3 CSK 4 -treated endothelial cells and HEK Dual reporter cells, demonstrating that TLR2-EVs can act as decoy receptors. (frontiersin.org)

Bacterial IbeA interacts with endothelial Caspr1 to trigger intracellular focal adhesion kinase activation, leading to E. coli internalization into the brain endothelial cells. (microbialcell.com)

A quarter of the E. coli proteome is extracytoplasmic, targeted to a final destination by short, canonical N-terminal sequences that for the most part direct them either to the general secretory or Tat pathway machines. (nottingham.ac.uk)
These sequences are cloned into the bacterium Escherichia coli using USER technology, where they are amplified and then assembled into a single plasmid. (diwou.com)

B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)

E. coli with K1 capsule is the primary bacteria that cause neonatal bacterial meningitis. (microbialcell.com)
Upon binding to a receptor on the surface of target bacteria, the CDI toxin is delivered via the C-terminal. (nih.gov)
E-coli bacteria counts and dissemination were similar in trained and sedentary mice. (pulsus.com)
High intensity training possesses superior modulatory effects on autoimmunity in EAE, while also inhibiting T cell responses to ovalbumin, but sustains immune defenses against E-coli bacteria. (pulsus.com)

T cell-dependent immune responses of trained- vs. sedentary mice to the nonautoantigen ovalbumin and susceptibility to Escherichia coli - induced acute peritonitis were examined. (pulsus.com)

E . coli serotypes were O117:H7 (case 1, 8-day-old boy) and O156:H7 (case 2, 4-day-old boy). (cdc.gov)

Transient receptor potential melastatin 2 is a Ca 2+ -permeable cation channel abundantly expressed in macrophages. (asahq.org)
The impact of increasing intracellular Ca 2+ concentration on bacterial clearance in macrophages (n = 3) and on survival rate of Trpm2 −/− mice infected with E. coli (n = 21) was investigated. (asahq.org)
Receptor binding studies on guinea-pig pulmonary macrophages, rabbit neutrophils, and human neutrophils utilizing tritium labeled fMLP were undertaken to investigate the possibility they could be used to develop a competitive binding assay. (cdc.gov)

Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)

In another recent study , published in Advanced Healthcare Materials , researchers engineered Escherichia coli to recruit radioactive molecules to tumor sites, thereby avoiding effects associated with traditional radiotherapy. (aacr.org)

Clagett-Dame, M & Repa, JJ 1997, ' Generating and characterizing retinoid receptors from Escherichia coli and insect cell expression systems ', Methods in Enzymology , vol. 282, pp. 13-24. (elsevierpure.com)
In hyperosmolar conditions neuraminidase expression was increased by 50% (P less than 0.0004), an effect which was OmpR dependent in E. coli. (jci.org)

Trpm2 −/− mice were intraperitoneally injected with Escherichia coli . (asahq.org)
Importantly, endothelial knockout of Caspr1 in mice significantly reduced E. coli crossing through the BBB. (microbialcell.com)
In mice, the modified E. coli selectively colonized solid tumors and attracted a therapeutic radioisotope that had been delivered systemically. (aacr.org)

Deformylases were isolated from Escherichia-coli in an attempt to develop a competitive binding assay for detecting fMLP. (cdc.gov)
The receptor binding patterns indicated the presence of at least three fMLP receptors that would interfere with measuring fMLP in a competitive assay. (cdc.gov)

Caspr1 is a host receptor for meningitis-causing Escherichia coli. (microbialcell.com)
Escherichia coli ( E. coli ) penetration of the blood-brain barrier (BBB) is the key step essential for the development of meningitis. (microbialcell.com)
The results showed that Caspr1(203-355) peptides effectively attenuated E. coli penetration into the brain during meningitis, indicating that Caspr1(203-355) peptides could be used to neutralize the virulent IbeA to prevent meningitis. (microbialcell.com)
These findings demonstrate that E. coli hijack Caspr1 as a host receptor for penetration of BBB and invasion of hippocampal neurons, resulting in progression of meningitis. (microbialcell.com)

Infection with filamentous phages is not lethal, however the infection causes turbid plaques in E. coli . (bionity.com)

In contrast, TLR2 was upregulated in a GC receptor-dependent manner, as shown by Western blot and qPCR. (frontiersin.org)

We further found that E. coli can directly invade into hippocampal neurons causing apoptosis which required the interaction between bacterial IbeA and neuronal Caspr1. (microbialcell.com)
Overactivation of NMDA receptors is believed to induce neuronal death by increasing phospholipid hydrolysis and subsequent degradation. (jneurosci.org)

Our results with E. coli , in conjunction with recent observations made with the yeast Saccharomyces cerevisiae , raise the possibility that the SRP receptor-mediated formation of intracellular membrane networks is governed by evolutionarily conserved principles. (rupress.org)

As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. (nature.com)

Toll-like receptors (TLRs) are the major pattern recognition receptors of the innate immune system that sense a wide range of "danger" signals or pathogen-associated molecular patterns (PAMPs) ( 6 - 8 ). (frontiersin.org)

This is because AR, unlike any other nuclear receptor, prefers its own N-terminal FXXLF motif to the canonical LXXLL motifs of coactivators. (rcsb.org)

Through biochemical and crystallographic studies, we identify that steroid receptor coactivator-3 (SRC3) (also named as amplified in breast cancer-1 or AIB1) interacts strongly with AR via synergistic binding of its first and third LXXLL motifs. (rcsb.org)

DR=EC 50 with the addition of various concentrations of receptor antagonist)/EC 50 without the addition of a receptor antagonist. (avma.org)
They evaluate the changes in concentrations by comparing the number of bound receptors over the past 1s with the number during the past 3s. (igem.org)

0.01) and aggravated bacterial burden during E. coli sepsis. (asahq.org)
IbeA was first identified as a critical determinant of E. coli K1 to facilitate bacterial penetration through the blood-brain barrier (BBB). (microbialcell.com)
The typical bacterial scenario seemed to be a two-component sHsps system of two homologous sHsps, such as the Escherichia coli sHsps IbpA and IbpB. (cipsm.de)

Crystal structure and mutational analysis of the Escherichia coli putrescine receptor. (expasy.org)

This effect correlated with increased adherence of PAO1 to epithelial cells after exposure to PAO1 neuraminidase and was consistent with in vitro studies demonstrating Pseudomonas adherence to asialoganglioside receptors. (jci.org)

In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. (ptglab.com)

Previous in vivo studies indicated that unlike the E. coli signal recognition particle (SRP), the SRP receptor FtsY is required for membrane targeting of ribosomes. (rupress.org)

These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)

The complement system exerts many of its effects through complement receptors (CRs). (medscape.com)

Metabolic labeling experiments in whole cells showed that NMDA receptor overactivation does not modify the activity of phosphocholine or phosphoethanolamine cytidylyltransferases but strongly inhibits choline-ethanolamine phosphotransferase activity. (jneurosci.org)

My postdoc studies on neurotransmitter receptors led to papers in Science, Nature and Cell, and earned the 1988 Boeringer Ingelheim Award. (gene.com)

whether a distinct receptor for C4a is present is unclear (see Table 1). (medscape.com)

Anatomy8

Organisms24

Diseases7

Chemicals and Drugs111

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes82

Disciplines and Occupations2

Technology, Industry, Agriculture1

Information Science4

Health Care5

Protein10

Shiga2

Inflammasome activation1

Strains2

Proteins7

O157:H71

Agonists4

Characterization3

Genes1

Outer membrane2

Genome3

Pneumoniae3

Ligands3

Transmembrane1

Antibodies2

Gene3

Microbiol1

Virulence2

Colicin1

Mechanism2

Decoy1

Internalization1

Sequences2

Interleukin1

Endothelial cells1

Bacteria4

Acute1

Serotypes1

Macrophages3

Deficiency2

Molecules1

Expression2

Mice3

Assay2

Meningitis4

Infection1

TLR21

Neuronal2

Intracellular1

Regulation1

Immune1

Motif1

Biochemical1

Concentrations2

Bacterial3

Crystal1

Vitro1

Transcription1

Unlike1

Results1

System1

Metabolic1

Cell1

Unclear1