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  • modulate
  • Mechanical, cellular, and molecular factors interact to modulate circulating endothelial cell progenitors. (nih.gov)
  • predominantly
  • On the other hand, the selective destruction of cholinergic afferents to the visual cortex caused a dramatic, but not complete, reduction of the cortical NGFRs, which suggests that these receptors are located on cholinergic terminals predominantly. (jneurosci.org)
  • phosphorylation
  • Activation of the FGF and NGF receptors results in tyrosine phosphorylation of the docking proteins Shc and FRS2 ( 19 ). (asm.org)
  • For example, members of the insulin receptor substrate (IRS) family of docking proteins have an N-terminal PH domain followed by a PTB domain and a large C-terminal sequence containing numerous tyrosine phosphorylation sites ( 40 ). (asm.org)
  • ovaries
  • Corresponding for the immunohistochemical results, immunoreactivities of NGF and its two receptors were greater in the ovaries of the breeding season then decreased to a relatively low level in the nonbreeding season. (ebscohost.com)
  • Treatment of 2-d-old rat ovaries in organ culture with NGF increased FSH receptor (FSHR) mRNA within 8 h of exposure. (biomedsearch.com)
  • activation
  • Dal Toso R, De Bernardi MA, Brooker G, Costa E, Mocchetti I (1988) Beta adrenergic and prostaglandin receptor activation increases nerve growth factor mRNA content in C6-2B rat astrocytoma cells. (springer.com)
  • However, both the FGF and NGF receptors lack the consensus p YXN binding site for the SH2 domain of Grb2 and therefore utilize docking proteins to indirectly recruit the Grb2-Sos complex, a step essential for activation of the Ras/MAPK kinase signaling cascade. (asm.org)
  • In an in vivo model of mouse trigeminal pain, anti-NGF pretreatment suppressed responses evoked by P2X 3 receptor activation. (jneurosci.org)
  • bind
  • Here we show that the PTB domains of both the α and β isoforms of FRS2 bind directly to the FGF or NGF receptors. (asm.org)
  • mediators
  • In TLR-activated monocytes, NGF reduces inflammatory cytokine production (IL-1β, TNF-α, IL-6, and IL-8) while inducing the release of anti-inflammatory mediators (IL-10 and IL-1 receptor antagonist). (jimmunol.org)
  • suggests
  • This experiment suggests that FGFR1 may regulate signaling via NGF receptors by sequestering a common key element which both receptors utilize for transmitting their signals. (asm.org)