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  • Molecular
  • Figure 1 Diversity in the antigen-combining site of the B cell receptor repertoire (and thus also in the corresponding secreted antibody repertoire) is mediated by three principal molecular mechanisms, illustrated in the three panels, left, middle, and right. (aksumuniversity.org)
  • allosteric site
  • Taken together, these data are consistent with the hypothesis that THRX-160209 binds in a multivalent manner to the M 2 receptor, simultaneously occupying the orthosteric site and a spatially distinct allosteric site. (aspetjournals.org)
  • antibody
  • Extra functional variety in secreted antibodies can be conferred by variations between isotypes after course switching, because the Fc area of immunoglobulins determines the valency from the antibody combining sites and many functions such as complement fixation, and interaction with various Fc receptors or the polyimmunoglubilin receptor. (aksumuniversity.org)
  • parasympathetic
  • The M 2 muscarinic receptors are located in the heart, where they act to slow the heart rate down to normal sinus rhythm after positive stimulatory actions of the parasympathetic nervous system, by slowing the speed of depolarization . (ipfs.io)
  • inositol
  • These oscillations were observed in intact myocytes after removal of external Ca 2+ , in permeabilized cells after abolition of the membrane potential and in the presence of heparin (an inhibitor of inositol 1,4,5-trisphosphate receptors) but were inhibited by ryanodine, indicating that they are dependent on Ca 2+ release from intracellular stores through ryanodine receptors. (biologists.org)
  • assay
  • A peptide, corresponding to amino acid sequences of the second extracellular loops of the M2 receptor, was synthesized as antigen to test for the presence of autoantibodies, using an enzyme-linked immunosorbent assay. (spotidoc.com)