We aimed to expand our knowledge about the variable susceptibility of inbred strains to this model and test for genetic variants associated with this trait. (bvsalud.org)
There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
Laboratory5
The authors state, "Stock A Strain k AKR mouse originally inbred in the laboratory of Dr. C. P. Rhoads by K. B. Rhoads at the Rockefeller Institute. (wikipedia.org)
The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
An experimental assessment of in silico haplotype association mapping in laboratory mice. (jax.org)
Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)
Glomerular1
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)
Gene6
A mouse model with complete deletion of the Akt1 gene manifests growth retardation and increased spontaneous apoptosis in tissues such as testes and thymus. (wikipedia.org)
Gene expression of ANT2 is reduced in lung tissue from COPD patients and in a mouse smoking model, and overexpression of ANT1 and ANT2 resulted in enhanced oxidative respiration and ATP flux. (bvsalud.org)
These gene loci are deleted in mice having the a (e.g. (bdbiosciences.com)
Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
Homozygous inactivation of this gene causes embryonic lethality and extensive developmental defects in inbred strains. (jax.org)
MeSH1
Mice, Inbred DBA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
C57BL4
C57BL/6 lymph node cells were incubated simultaneously with FITC Mouse Anti-Mouse Vβ 5.1, 5.2 T-Cell Receptor (Cat. (bdbiosciences.com)
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
Spontaneous3
The "Ak" in Akt refers to the AKR mouse strain that develops spontaneous thymic lymphomas. (wikipedia.org)
Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively. (aspetjournals.org)
Functional3
Human nasal polyp microenvironments maintained in a viable and functional state as xenografts in NOD-scid IL2rgamma(null) mice. (jax.org)
It expresses multiple functional molecules, including transporters and receptors, and serves to control the traffic of a variety of molecules in and out of the CNS. (aspetjournals.org)
Loci3
To that end, we sought to measure differential susceptibility to cigarette smoke-induced emphysema in the mouse, identify genetic loci associated with this quantitative trait, and find homologous human genes associated with COPD. (bvsalud.org)
Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
Susceptibility3
There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
Haplotype1
The MR9-4 monoclonal antibody specifically recognizes the Vβ 5.1 and Vβ 5.2 T-cell Receptors of strains having the b haplotype (e.g. (bdbiosciences.com)
Embryonic1
The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
Neurons3
Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. (ouhsc.edu)
We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
Variation1
The titers and duration of vaccine-specific IgG subclass responses were different among mouse strains, indicating that genetic factors contribute to this variation. (bvsalud.org)
Genetics3
Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)
Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
The future of mouse genetics in osteoporosis research. (jax.org)
BALB2
Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
Systemic2
Systemic PD149163, a neurotensin receptor 1 agonist, decreases methamphetamine self-administration in DBA/2J mice without causing excessive sedation. (ouhsc.edu)
A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice. (jax.org)
IgG14
IgG1, IgG2b, and IgG3 titers against diphtheria toxoid (DT), pertussis toxin (PT), filamentous hemagglutinin (FHA), and pertactin (Prn) were measured in mice from 28 different inbred and wild-derived strains vaccinated with an aluminum hydroxide-adjuvanted DTaP vaccine. (bvsalud.org)
The ratio of IgG1 and IgG3 titers identified Th1 and Th2-prone mouse strains. (bvsalud.org)
TLR4-deficient C3H/HeJ mice had an enhanced IgG1 response compared with C3H/HeOuJ mice with intact TLR4. (bvsalud.org)
This work demonstrates that the genetic background contributes significantly to the magnitude and longevity of vaccine-induced IgG1, IgG2b, and IgG3 titers in mice. (bvsalud.org)
Induce1
Hyp13 does not activate pregnan-X-receptor (PXR) and thereby loses the potential to induce drug-drug interactions. (afpm.org.my)
Specific2
In contrast, mice which do not have Akt2, but have normal Akt1, have mild growth deficiency and display a diabetic phenotype (insulin resistance), again consistent with the idea that Akt2 is more specific for the insulin receptor signaling pathway. (wikipedia.org)
Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
Cell2
Dr. Mak was recognized for his seminal work to clone the T cell receptor. (cancerresearch.org)
Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. (ouhsc.edu)
Model3
Chronic cigarette smoke exposure in the mouse is a commonly used animal model of COPD. (bvsalud.org)
An ENU-induced mutation in mouse glycyl-tRNA synthetase (GARS) causes peripheral sensory and motor phenotypes creating a model of Charcot-Marie-Tooth type 2D peripheral neuropathy. (jax.org)
A mouse model of antiepileptic drug treatment was prepared by consecutive 5-week administration of phenytoin (PHT). (aspetjournals.org)
Glucose2
In a mouse which is null for Akt1 but normal for Akt2, glucose homeostasis is unperturbed, but the animals are smaller, consistent with a role for Akt1 in growth. (wikipedia.org)
Neuroendocrine inhibition of glucose production and resistance to cancer in dwarf mice. (jax.org)
Brain2
Quantitative targeted absolute proteomic analysis of 31 membrane proteins showed that P-glycoprotein (P-gp/mdr1a) protein expression levels were significantly increased in brain capillaries of PTZ (129%), EL (143%), and PHT mice (192%) compared with controls. (aspetjournals.org)
In all mice, reconstructed K p brain values agreed well with the observed values within a 1.21-fold range. (aspetjournals.org)
Susceptible1
Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. (jefferson.edu)
Lung1
A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)
Identify1
Here we identify the transient receptor potential canonical 6 channel (TRPC6) as a druggable target to control anxious and depressive behavior and as a requirement for hyperforin antidepressant action. (afpm.org.my)
Genetic1
Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
Area1
Antagonism of Neurotensin Receptors in the Ventral Tegmental Area Decreases Methamphetamine Self-Administration and Methamphetamine Seeking in Mice. (ouhsc.edu)
Shows2
This graph shows the total number of publications written about "Mice, Inbred DBA" by people in this website by year, and whether "Mice, Inbred DBA" was a major or minor topic of these publications. (ouhsc.edu)
We synthesized the hyperforin analog Hyp13, which shows similar binding to TRPC6 and recapitulates TRPC6-dependent anxiolytic and antidepressant effects in mice . (afpm.org.my)
Models2
Foreword for special issue: mouse models for hearing research. (jax.org)