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  • aryl hydrocar
  • Recent studies have implicated the aryl hydrocarbon receptor (AHR) as a transcription factor that plays a critical role in multiple aspects of hematopoiesis. (bu.edu)
  • The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors. (wikipedia.org)
  • erythroid
  • The presence of N -methyl- d -aspartate receptor (NMDAR) was previously shown in rat red blood cells (RBCs) and in a UT-7/Epo human myeloid cell line differentiating into erythroid lineage. (physiology.org)
  • Functional receptor is required for survival of erythroid precursors. (physiology.org)
  • expression
  • These data suggest that the AHR plays a significant role in megakaryocyte specification by modulating the expression of multiple lineage specific gene targets, including MPL, the thrombopoietin receptor. (bu.edu)
  • The concomitant expression of all three subunits is required to allow the effective expression of GPIb-IX on the platelet cell surface and analysis of receptor expression in transfected Chinese hamster ovary (CHO) cells has further supported that the interaction between these subunits also acts to stabilize them. (wikipedia.org)
  • Typically, a lack of a single subunit significantly decreases the surface expression of the entire receptor complex. (wikipedia.org)
  • Additionally, EpoR has been implicated in suppressing expression of death receptors Fas, Trail and TNFa that negatively affect erythropoiesis. (wikipedia.org)
  • Many of the morphological features of megakaryocyte differentiation can be recapitulated in non-hematopoietic cells by the expression of Class VI β-tubulin (β6) and they provide a mechanistic basis for understanding these changes. (wikipedia.org)
  • neurons
  • The sensitivity of G q PCR IP 3 signaling in neurons to voltage itself may represent a fundamental mechanism by which ionotropic signals can shape metabotropic receptor activity in neurons and influence processes such as synaptic plasticity in which the detection of coincident signals is crucial. (jneurosci.org)
  • Bearss JJ, Limke TL, Atchison WD (2001) Methylmercury (MeHg) causes calcium release from smooth endoplasmic reticulum (SER) inositol-1,4,5-triphosphate receptors in rat cerebellar granule neurons. (springer.com)
  • activation
  • IP is classified as a relaxant type of prostenoid receptor based on its ability, upon activation, to relax certain pre-contracted smooth muscle preparations and smooth muscle-containing tissues such as those of pulmonary arteries and veins. (wikipedia.org)
  • Stimulation of receptors coupled to G q/11 -proteins results in activation of phospholipase C (PLC). (jneurosci.org)