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  • subunits
  • The invasive phenotype of the immortalized cells was also reflected by the consistent expression of several metastasis-associated adhesion molecules, including α5 (eight of nine), α6 (five of nine), αV (nine of nine), β1 (nine of nine), and β3 (nine of nine) integrin subunits and the M r 67,000 laminin receptor (seven of nine). (aacrjournals.org)
  • Prior studies have found that loss of laminin subunits from vertebrate Schwann cells causes loss of myelination and neuropathies, results attributed to loss of laminin-receptor signaling. (sdbonline.org)
  • However, whereas invertebrates possess one to two laminin heterotrimers, mammals possess at least 15, which are formed through combinations of 5α, 4β and 3γ subunits (Aumailley, 2005). (sdbonline.org)
  • This regulatory effect of reconstituted basement membrane was reproduced by two of its components, collagen-IV and laminin-1, and it was blocked by antibodies against α2, α6 and β1 integrin subunits. (biologists.org)
  • ligand
  • In our present study, we show that s-LOTUS inhibits the interaction between NgR1 and p75 NTR , NgR1 ligand-induced RhoA activation, growth cone collapse, and neurite outgrowth inhibition and promotes axonal regeneration. (jneurosci.org)
  • The spatial and temporal expression of osteopontin mRNA was determined by in situ hybridization, and that of osteopontin ligand and its integrin receptor α v β 3 was determined by immunohistochemistry. (ahajournals.org)
  • At 5 days osteopontin ligand is at a distance from the peri-infarct astrocytes expressing integrin receptor α v β 3 . (ahajournals.org)
  • The de novo expression and interaction of osteopontin ligand with its receptor integrin α v β 3 suggest a role in wound healing after focal stroke. (ahajournals.org)
  • metastasis
  • Interactions between cancer cells and laminin, a major component of basement membranes, play a critical role at several steps of the complex process of tumor invasion and metastasis. (ac.be)
  • These data argue for a 2-fold effect of CD44v on metastasis formation: CD44v-mediated matrix formation is crucial for the settlement and growth at a secondary site, whereas apoptosis resistance supports the efficacy of metastasis formation. (aacrjournals.org)
  • subunit
  • Glial cells in many organisms secrete laminin, a large heterotrimeric protein consisting of an α, β, and γ subunit. (sdbonline.org)
  • This study demonstrates that loss of the laminin γ subunit (LanB2) in the peripheral glia of Drosophila melanogaster results in the disruption of glial morphology due to disruption of laminin secretion. (sdbonline.org)
  • Baker SE, Hopkinson SB, Fitchmun M, Andreason GL, Frasier F, Plopper G, Quaranta V, Jones JC (1996) Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. (springer.com)
  • tumour cells
  • The 37kDa/67kDa laminin receptor (LRP/LR) is a central receptor mediating interactions between tumour cells and the basement membrane and is thereby a key player in adhesion and invasion, essential processes in metastatic cancer. (jove.com)
  • Our results demonstrate that distinct MMPs are modulated by distinct mechanisms, all depending on specific interactions between tumour cells and host fibroblasts. (ac.be)
  • proliferation
  • The laminar development of the cerebral cortex is dependent on the proliferation of neuronal precursors, scaffolding of radial glia, interactions between glia and neurons, and the presence of external localization cues ( Diaz and Gleeson, 2009 ). (jneurosci.org)
  • Integrin-mediated interactions with the extracellular matrix (ECM) are required for the attachment, cytoskeletal organization, mechanosensing, migration, proliferation, differentiation and survival of cells in the context of a multitude of biological processes including fertilization, implantation and embryonic development, immune response, bone resorption and platelet aggregation. (thno.org)
  • basement membrane
  • The entry of HPV in vitro is initiated by binding to a cell surface receptor in contrast to the in vivo situation where the basement membrane has recently been identified as the primary site of virus binding. (biomedcentral.com)
  • Our results indicate that integrin-mediated response to specific basement membrane components, rather than cell rounding or cell growth arrest induced by reconstituted basement membrane, is critical in the regulation of estrogen receptor α expression and function in mammary epithelial cells. (biologists.org)
  • endogenous
  • Using a newly generated GPR97-specific monoclonal antibody, we confirmed that endogenous GPR97 is a proteolytically processed, dichotomous, N-glycosylated receptor. (frontiersin.org)
  • Here, we use a combination of two- and three-dimensional culture systems to dissect the extracellular signals that control endogenous estrogen receptor α. (biologists.org)
  • matrix metalloproteinases
  • Interactions can be direct or via the recruitment of matrix metalloproteinases by the heparan sulfate chain of CD44v3 ( 21 , 22 ) and can depend on CD44v expression, such as the c-Met activation by CD44v6-bound scatter factor ( 23 ). (aacrjournals.org)
  • heterotrimeric
  • Laminin-332 (laminin-5), a heterotrimeric BM component composed of α3-, β3- and γ2-chains, has recently been identified as a target structure of Smad4 and represents the first example for expression control of an essential BM component by a tumor and invasion suppressor. (biomedcentral.com)
  • mammalian
  • We have identified that laminin-5 undergoes proteolytic processing of two of its three chains, via mammalian Tolloid, a metalloprotease of the astacin family. (stanford.edu)
  • Cell adhesion also depends upon carbohydrate-protein interactions, mediated by mammalian lectins of different families (Sharon N & Lis H 1995 Essays Biochem 30:59-75). (google.com)
  • phosphorylation
  • This effect was mediated by Smo's broadly conserved core, and was specifically activated in response to phosphorylation of the Smo C-terminus by GPCR kinase 2 (Gprk2) . (sdbonline.org)
  • In the inactivated state, this site and the Src recruitment site, located in the activation loop, are blocked by the regulatory domain, preventing autophosphorylation of Y397 and the ensuing Src-mediated phosphorylation of the activation loop ( 15 ). (diabetesjournals.org)
  • Alt A, Ohba M, Li L, Gartsbein M, Belanger A, Denning MF, Kuroki T, Yuspa SH, Tennenbaum T (2001) Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment. (springer.com)
  • coreceptor
  • Here, we show that s-LOTUS inhibits NgR1-mediated signaling by inhibiting the molecular interaction between NgR1 and its coreceptor, p75 neurotrophin receptor (p75 NTR ). (jneurosci.org)
  • Interactions between thymocytes and specialized thymic microenvironmental cells (thymic epithelial cells, macrophages, dendritic cells, and fibroblasts) support and drive T-cell differentiation from bone marrow-derived precursors, by means of a series of interactions including receptor/coreceptor interactions, cytokines, chemokines, and hormones [ 3 - 7 ], as illustrated in Figure 1 . (hindawi.com)
  • processes
  • In the absence of integrin ligation, these processes are abrogated therefore pharmacological inhibition of integrin ligation is of great interest for the therapy of numerous diseases resulting from abberant integrin mediated signaling. (thno.org)
  • family
  • Herein, we report that Smad4 mediates transcriptional regulation through three different mechanisms, namely through Smad4 binding to a functional SBE site exclusively in the LAMA3 promoter, Smad4 binding to AP1 (and Sp1) sites presumably via interaction with AP1 family components and lastly a Smad4 impact on transcription of AP1 factors. (biomedcentral.com)
  • Specific mechanisms of this system (including the amazing family of about 1000 different olfactory receptors) have been also proposed. (frontiersin.org)
  • One pathway proceeds via CD44 interaction with neighboring transmembrane receptor tyrosine kinases, such as the ErbB family ( 21 ). (aacrjournals.org)
  • tissue
  • It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. (genetex.com)
  • Lack of laminin-10 in lama5 -/- mice results in aberrant tissue development. (stanford.edu)