AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
MacrophagesMacrophage Colony-Stimulating FactorColony-Stimulating FactorsGranulocyte-Macrophage Colony-Stimulating FactorMacrophage ActivationColony-Forming Units AssayMacrophages, PeritonealGranulocytesBone Marrow CellsReceptor, Macrophage Colony-Stimulating FactorCells, CulturedInterleukin-3Macrophages, AlveolarHematopoietic Stem CellsGrowth SubstancesHematopoiesisCell DifferentiationMonocytesBone MarrowMice, Inbred C57BLCell DivisionOsteoclastsCytokinesCell LineRecombinant ProteinsCulture MediaMice, Inbred C3HInterleukin-1Interleukin-6Tumor Necrosis Factor-alphaPhagocytosisInterleukinsClone CellsMice, Inbred BALB CRNA, MessengerDrug SynergismSpleenLipopolysaccharidesNeutrophilsGranulocyte Colony-Stimulating FactorBone ResorptionAntigens, CDMacrophage Migration-Inhibitory FactorsFlow CytometryTime FactorsSignal TransductionDendritic CellsMice, KnockoutThioglycolatesPeritoneal CavityMacrophage Inflammatory ProteinsInflammationAntigens, Differentiation, MyelomonocyticAscitic FluidInterferon-gammaColony Count, MicrobialClodronic AcidGene Expression RegulationColony CollapseScavenger Receptors, Class APhagosomesNitric OxidePulmonary AlveoliNitric Oxide Synthase Type IIMacrophage-Activating FactorsLungMolecular Sequence DataApoptosisDisease Models, AnimalMice, Inbred StrainsZymosanLipoproteins, LDLImmunohistochemistryT-LymphocytesMannose-Binding LectinsChemokine CCL2Receptors, Cell SurfaceReverse Transcriptase Polymerase Chain ReactionPhenotypeCell CountAntsNF-kappa BImmunity, InnateReceptors, ScavengerReceptors, ImmunologicAgarCell SurvivalToll-Like Receptor 4AtherosclerosisInflammation MediatorsGene ExpressionInterleukin-10Up-RegulationPhagocytesBase SequenceCell MovementBronchoalveolar Lavage FluidChemokinesChemokine CCL4Lysosomes
MonocytesGranulocyteLigandNeutrophilsDifferentiationMonocyteProto-oncogeneCytokinesCytokine receptorsCSF1RDendritic cellsPulmonary Alveolar PrCellsLineageCD115Signal transductionAntigenSurvivalAlveolarPeptidePDGFProteinGranulocytesInhibitorsNuclearInhibitionEpitopesSubunitsCSF1Alpha subunitActivatorMolecularInducesInnateViralImmuneBFGFPhosphorylationMCSF
Monocytes8
  • The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development. (wikipedia.org)
  • Remaining extracellular domain acts as a soluble GM-CSFRα and have been identified in bone marrow, monocytes and macrophages, placenta and chorio-carcinoma cells. (wikipedia.org)
  • M-CSF R engagement is continuously required for macrophage survival and regulates lineage decisions and maturation of monocytes, macrophages, osteoclasts and DC (3, 4). (rndsystems.com)
  • Macrophage colony stimulating factor (MCSF) regulates monocytes/macrophages. (researchsquare.com)
  • Although tumor cells were first thought to drive the cellular events underpinning tumor angiogenesis and growth, considerable evidence has now emerged for the central role of tumor infiltrating myeloid cells such as monocytes, macrophages, and neutrophils in this phenomenon [ 8 - 12 ]. (hindawi.com)
  • Activation of the vascular innate immune system inducing recruitment of macrophages, monocytes and neutrophils to the alveoli. (racgp.org.au)
  • M-CSF (or CSF-1) is a hematopoietic growth factor that is involved in the proliferation, differentiation, and survival of monocytes, macrophages, and bone marrow progenitor cells. (meddic.jp)
  • [3] M-CSF affects macrophages and monocytes in several ways, including stimulating increased phagocytic and chemotactic activity, and increased tumour cell cytotoxicity. (meddic.jp)
Granulocyte12
Ligand15
  • Extracellular domain contains cytokine receptor domain for binding its cognate ligand with conserved cysteine residues, WSXWS motif and 11 potential N-glycosylation sites for oligosaccharides, which are important for ligand binding and signalling. (wikipedia.org)
  • β chain is crucial for enhancement of binding affinity to the ligand and transduces signal of the activated receptor complex. (wikipedia.org)
  • Formation of high affinity receptor complex includes specific interactions between both subunits and ligand. (wikipedia.org)
  • NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. (m-csf.com)
  • In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. (m-csf.com)
  • Mouse M-CSF receptor cDNA encodes a 977 amino acid (aa) type I membrane protein with a 19 aa signal peptide, a 492 aa extracellular region containing the ligand-binding domain, a 25 aa transmembrane domain and a 441 aa cytoplasmic domain. (rndsystems.com)
  • 99% aa identity with rat and 60-63% aa identity with corresponding sequences in human, canine, feline and bovine M-CSF R. Activators of protein kinase C induce TACE/ADAM17 cleavage of the M-CSF receptor, releasing the functional ligand-binding extracellular domain (5). (rndsystems.com)
  • Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. (thermofisher.com)
  • RANK binds to transmembrane protein nuclear factor-κB receptor activating factor ligand (RANKL) to activate RANK/RANKL, TRAF6/RANKL/MAPKs, TRAF6/ RANKL/NF-κB, Wnt/RANKL/RANKL, and JAK2/STAT3/RANKL. (frontiersin.org)
  • IL-34, a ligand of the MCSF receptor, acts as a "twin" to MCSF, demonstrating overlapping and complimentary actions. (researchsquare.com)
  • All other native NR functional/structural domains (ligand binding domain, hinge region, and various activation domains) are present in these hybrid receptors. (indigobiosciences.com)
  • Consequently, once a bioactive compound associates with the ligand binding domain of the hybrid receptor, only the luciferase reporter gene is induced. (indigobiosciences.com)
  • Ligand-activation of the hybrid receptor will not induce collateral expression of target genes that are otherwise regulated by the native nuclear receptor. (indigobiosciences.com)
  • These data provide the first evidence for ligand-dependent proteasomal degradation of the betac cytoplasmic domain, and they establish a novel mechanism for heterotypic desensitization of shared cytokine receptor signaling. (tamu.edu)
  • Ristocetin is an activator of the von Willebrand factor that interacts with glycoprotein (GP) Ib/IX/V, which generates thromboxane A2 via phospholipase A2 activation, resulting in the release of the soluble CD40 ligand (sCD40L) from human platelets. (bvsalud.org)
Neutrophils2
  • We believe that the proinflammatory cytokine GM-CSF plays an important role in rheumatoid arthritis through the activation, differentiation, and survival of macrophages and neutrophils, and that modulation of macrophage function through targeting the receptor may offer a novel approach to treatment," Gerd Burmester , MD, of Charite-University-Medicine Berlin, explained. (medpagetoday.com)
  • The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
Differentiation10
  • Colonies can be formed by stimulating factors or recombinant GM-CSF and CSFs activity expressed in Units compared to a standard.Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (m-csf.com)
  • Although erythropoietin (EPO) and its receptor (EPOR) are crucial for the proliferation, survival, and terminal differentiation of erythroid progenitors, it remains to be elucidated whether EPOR-unique signaling is required for erythropoiesis. (elsevierpure.com)
  • All together, the results of the present study demonstrated that hGM-CSF can stimulate the proliferation and differentiation of primitive and definitive erythroid cells independently of EPOR signal if they express hGMR, and the activity is comparable to that of EPO in definitive, but not primitive, erythropoiesis. (elsevierpure.com)
  • CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. (thermofisher.com)
  • Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. (thermofisher.com)
  • Runx2 is a critical regulatory factor promoting OB maturation in early differentiation. (frontiersin.org)
  • Its differentiation and function are mainly regulated by macrophage colony-stimulating factor (M- CSF), receptor activator of nuclear factor kappa B(RANK) ( 7 ). (frontiersin.org)
  • M-CSF binds to the M-CSF receptor, which is promote the proliferation and differentiation of OC and the continuous expression of RANK. (frontiersin.org)
  • Multiple signaling pathways stimulate the differentiation and proliferation of OC. (frontiersin.org)
  • While the IL34/MCSF/MCSFR axis is very important for regulating macrophage differentiation, the specific interplay between these cytokines, macrophages and tumour development is unclear. (researchsquare.com)
Monocyte3
  • M-CSF receptor is expressed primarily on cells of the monocyte/macrophage lineage, dendritic cells, stem cells and in the developing placenta (1). (rndsystems.com)
  • Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. (springer.com)
  • [4] The role of M-CSF is not only restricted to the monocyte/macrophage cell lineage. (meddic.jp)
Proto-oncogene2
  • M-CSF receptor, the product of the c - fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. (rndsystems.com)
  • By interacting with its membrane receptor (CSF1R or M-CSF-R encoded by the c-fms proto-oncogene), M-CSF also modulates the proliferation of earlier hematopoietic progenitors and influence numerous physiological processes involved in immunology, metabolism, fertility and pregnancy. (meddic.jp)
Cytokines6
  • These receptors are found on the surface of various cells and are activated by cytokines, which are small proteins involved in cell-to-cell communication. (indigobiosciences.com)
  • When cytokines bind to their respective receptors on the cell surface, they initiate a cascade of events within the cell. (indigobiosciences.com)
  • We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). (duke.edu)
  • Special considerations are given to the causal involvement of novel molecular pathways, including cytokines, growth factors, and intracellular signaling cascades in RA pathophysiology, and the emerging role of targeted therapeutic agents in the management of RA. (jscimedcentral.com)
  • Release of pathogen-associated molecular patterns due to the viral infection and activation of transcription factors such as nuclear factor kappa B, NOD-like receptor protein 3 inflammasome via pattern recognition receptors and ongoing production of cytokines at the entry sites. (racgp.org.au)
  • The receptors for these three cytokines consist of a cytokine-specific alpha (Ralpha) chain and a shared common beta (betac) chain. (tamu.edu)
Cytokine receptors5
  • It is shared with other cytokine receptors IL-3 and IL-5. (wikipedia.org)
  • Extracellular domain contains haematopoietin domains, also known as cytokine receptor modules, which can be found in other cytokine receptors (growth hormone receptor, erythropoietin receptor). (wikipedia.org)
  • Cytokine receptors are integral components of the immune system and play a crucial role in cell signaling. (indigobiosciences.com)
  • By modulating these signaling pathways, cytokine receptors help coordinate immune responses, inflammation, and other physiological processes. (indigobiosciences.com)
  • Dysregulation or malfunctioning of cytokine receptors can lead to immune disorders, autoimmune diseases, and other pathological conditions. (indigobiosciences.com)
CSF1R1
  • CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. (thermofisher.com)
Dendritic cells2
Pulmonary Alveolar Pr1
  • Pulmonary alveolar proteinosis (PAP) is a severe autoimmune disease caused by autoantibodies that neutralize GM-CSF resulting in impaired function of alveolar macrophages. (nih.gov)
Cells29
  • In methylcellulose clonal culture of fetal liver (FL) cells of generated hGMR-expressing EPOR -/- embryos at embryonic day (E) 12.5 of gestation, hGM-CSF stimulated erythroid colony formation under serum-containing and serum-free conditions. (elsevierpure.com)
  • Analysis of globin expression in individual erythrocyte-containing colonies formed from E12.5 FL cells showed that hGM-CSF supports primitive and definitive erythropoiesis even in EPOR -/- embryos. (elsevierpure.com)
  • and induced increase of GATA-1 expression and decrease of erythroid Kruppel-like factor and cMyb expression in the FL cells. (elsevierpure.com)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • THP-1 cells have Fc and C3b receptors and lack surface and cytoplasmic immunoglobulins. (sigmaaldrich.com)
  • THP-1 cells can also restore the response of purified T lymphocytes to Concanavlin A, show increased CO 2 production on phagocytosis and can be differentiated into macrophage-like cells using for example DMSO. (sigmaaldrich.com)
  • These cells expressed central nervous system-homing receptors, exhibited a dysregulated CD25-IL-2 axis, and their proliferative capacity positively correlated with MS severity. (nature.com)
  • Myeloid cells promote tumor growth by stimulating tumor angiogenesis, suppressing tumor immunity, and promoting metastasis to distinct sites. (hindawi.com)
  • Specific growth factors, such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), stimulate the proliferation and migration of naturally quiescent endothelial cells, resulting in the formation of new vessel structures during embryonic development and tumor growth [ 7 ]. (hindawi.com)
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
  • Subsequent studies described a VEGFR2 and AC133 expressing subpopulation of these CD34 positive circulating cells that could form endothelial colonies in vitro [ 14 , 15 ]. (hindawi.com)
  • Factors in seminal plasma elicit a surge of GM-CSF expression in uterine epithelial cells after mating in mice. (edu.au)
  • Cells expressing GM-CSF receptors were identified in sections of uterus on the day after mating using 125I-GM-CSF, and were located predominantly in the endometrial stroma subjacent to the luminal epithelium, co-localising with abundant populations of myeloid leukocytes. (edu.au)
  • Quantifying changes in luciferase expression in the treated reporter cells provides a sensitive surrogate measure of the changes in receptor activity. (indigobiosciences.com)
  • INDIGO's nuclear receptor assays utilize proprietary human and non-human mammalian cells engineered to provide constitutive, high-level expression of the designated receptor. (indigobiosciences.com)
  • INDIGO's other nuclear receptor assays, however, include reporter cells that express hybrid nuclear receptors. (indigobiosciences.com)
  • Chimeric antigen receptor (CAR) T-cell therapy is designed to enhance the body's immune system to effectively kill malignant cells. (ajmc.com)
  • NeuVax works by stimulating the body's own immune system, via cytotoxic T lymphocytes (CTLs), to seek out and destroy micrometastatic cancer cells that may be circulating or deposited in a patient's body after they are deemed clinically disease-free. (her2support.org)
  • There is oligoclonal expansion of lung T cells bearing certain V beta transcripts and the T cell receptor (TCR) is internalised with upregulation of TCR mRNA transcription suggesting recent occupancy by a specific antigen. (bmj.com)
  • COVID-19 is caused by SARS-CoV-2, which primarily targets angiotensin converting enzyme-2 (ACE2) receptors on cells of the respiratory system and induces an immediate immunological cascade of cytokine responses that affect the individual cells and vascular system. (racgp.org.au)
  • The colony stimulating factor 1 ( CSF1 ), also known as macrophage colony-stimulating factor ( M-CSF ), is a secreted cytokine which influences hematopoietic stem cells to differentiate into macrophages or other related cell types. (meddic.jp)
  • Basic fibroblast growth factor (bFGF) stimulates IL-6 release via p38 MAPK in MC3T3-E1 osteoblast-like cells. (bvsalud.org)
  • In the present study, the effects of HSP70 on the bFGF-stimulated release of IL-6 was evaluated using MC3T3-E1 osteoblast-like cells. (bvsalud.org)
  • HSP70 inhibitor VER-155008 significantly increased the bFGF-stimulated release of IL-6 in both MC3T3-E1 osteoblastic cells and normal human osteoblasts. (bvsalud.org)
  • Western blotting demonstrated a significant increase in the bFGF-stimulated phosphorylation of p38 MAPK in VER-155008-treated MC3T3-E1 cells. (bvsalud.org)
  • A significant increase in the bFGF-stimulated phosphorylation of p38 MAPK was also demonstrated in MC3T3-E1 cells treated with YM-08, another HSP70 inhibitor. (bvsalud.org)
  • Resveratrol regulates basic fibroblast growth factor (bFGF)-induced osteoprotegerin synthesis through Akt pathway in osteoblast-like MC3T3-E1 cells. (bvsalud.org)
  • In this study, we investigated resveratrol effects on bFGF-induced macrophage colony-stimulating factor (M-CSF) synthesis in MC3T3-E1 cells. (bvsalud.org)
  • Lavage fluid is characterized by scattered surfactant-engorged macrophages, an increase in T cells, and high levels of surfactant apoprotein-A. (msdmanuals.com)
Lineage2
  • In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. (wikipedia.org)
  • Osteoclast, derived from macrophage-mononuclear lineage, is a special myeloid cell. (frontiersin.org)
CD1151
  • Description: The AFS98 monoclonal antibody reacts with the mouse CD115 molecule, a receptor for macrophage colony stimulating factor (M-CSF) or colony stimulating factor-1 (CSF-1). (thermofisher.com)
Signal transduction3
  • The β chain is involved in signal transduction and formation of high affinity receptor complex together with α chain. (wikipedia.org)
  • M-CSF binding induces receptor homodimerization, resulting in transphosphorylation of specific cytoplasmic tyrosine residues and signal transduction (6). (rndsystems.com)
  • Herein, we demonstrate that agonistic ligation of these receptor subunits rapidly induces proteasomal degradation of the betac, but not the Ralpha, cytoplasmic domain, resulting in termination of signal transduction and yielding a truncated betac isoform ligated to the Ralpha subunit. (tamu.edu)
Antigen1
  • Chimeric antigen receptor (CAR) T-cell therapy is an example of how immunotherapy is revolutionizing the treatment of hematologic malignancies with unprecedented response rates in patients with relapsed/refractory lymphoma, multiple myeloma, and acute lymphoblastic leukemia. (ajmc.com)
Survival2
Alveolar1
  • Binding of SARS-CoV-2 to angiotensin converting enzyme-2 (ACE2) receptor on the surface of alveolar pneumocytes inducing local inflammation. (racgp.org.au)
Peptide2
  • Scholars@Duke publication: Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. (duke.edu)
  • The chemotactic peptide receptor expression was significantly higher in patients treated with ABMT alone or ABMT plus G-CSF. (duke.edu)
PDGF1
  • Endogenous ligands of PDGF receptors are homo- or heterodimeric: PDGFA, PDGFB, VEGFE and PDGFD ( PDGFD , Q9GZP0 ) combine as homo- or heterodimers to activate homo- or heterodimeric PDGF receptors. (guidetoimmunopharmacology.org)
Protein4
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
  • protein tyrosine phosphatase, non-receptor. (wikigenes.org)
  • Further, there are signaling pathways that participate in regulation, such as Wnt channel, mitogen-activated protein kinase (MAPK) channel, bone morphogenetic protein (BMPs) channel, peroxisome proliferator activated-receptors (PPARs) channel, and Notch channel. (frontiersin.org)
  • Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
Granulocytes1
  • Recombinant GM-CSF injected into the uterine lumen of ovariectomised mice was found to elicit a dose-dependant accumulation of macrophages and granulocytes in the endometrium, in a pattern of distribution comparable to that seen in uteri after natural mating. (edu.au)
Inhibitors3
  • A class of potent inhibitors of colony-stimulating factor-1 receptor (CSF-1R or FMS), as exemplified by 8 and 21, was optimized to improve pharmacokinetic and pharmacodynamic properties and potential toxicological liabilities. (rcsb.org)
  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
  • HSP70 inhibitors amplify TGF-ß-stimulated VEGF synthesis in the mouse osteoblastic MC3T3-E1 cell line. (bvsalud.org)
Nuclear2
  • They are cell-based trans-activation assays, and the principal application is in the screening of test samples to quantify any functional activity, either agonist or antagonist, that the compounds may exert against the nuclear receptors. (indigobiosciences.com)
  • Do INDIGO's nuclear receptor assays express the native, full-length receptor? (indigobiosciences.com)
Inhibition1
  • Instead, the luciferase light response is measured which correlates to the activation status of the receptor (either activation or inhibition). (indigobiosciences.com)
Epitopes1
  • We combined the high-throughput of mass cytometry, facilitating the analysis of 57 twin pairs, with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) of eight selected twin pairs to obtain a comprehensive overview of epitopes, transcriptome and T cell receptor (TCR) clonotypes. (nature.com)
Subunits3
  • Furthermore association of the α and β subunits results in receptor activation. (wikipedia.org)
  • Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (m-csf.com)
  • Proteasomal degradation of the betac cytoplasmic domain was also a prerequisite for endocytosis and lysosomal degradation of the ligated receptor subunits. (tamu.edu)
CSF11
  • 2021 ) Conditional genetic deletion of CSF1 receptor in microglia ameliorates the physiopathology of Alzheimer's disease. (neurotree.org)
Alpha subunit1
  • In quantitative RT-PCR studies, expression of the alpha-subunit of the GM-CSF receptor (GM-CSF-R) parallelled GM-CSF expression, being maximal during the 48 h period after mating and declining thereafter. (edu.au)
Activator1
  • bFGF significantly stimulated release and mRNA expression of M-CSF, which was reduced by resveratrol and SRT1720, sirtuin 1 (SIRT1) activator. (bvsalud.org)
Molecular2
  • Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. (cusabio.com)
  • Evidence suggest that a patient's genetic predisposition together with environmental factors, such as exposure to pathogens that exhibit molecular mimicry, disturb immune tolerance ( 4 ). (frontiersin.org)
Induces1
  • Release of tissue factor, Von Willebrand factor, that in turn induces hypercoagulation and prothrombotic state. (racgp.org.au)
Innate1
  • Vitamin D receptors are expressed on the principal cell populations involved in the innate and adaptive immune responses. (springer.com)
Viral1
  • Endothelial activation and endotheliitis due to direct viral activity and also via downregulated receptors (ACE2 and other receptors). (racgp.org.au)
Immune2
  • Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. (nature.com)
  • Unveil insights into cellular signaling and immune system function with Cytokine Receptor Assay Kits from INDIGO Biosciences. (indigobiosciences.com)
BFGF3
  • Furthermore, VER-155008 significantly enhanced the mRNA expression levels of IL-6 stimulated by bFGF. (bvsalud.org)
  • Finally, the specific p38 MAPK inhibitor SB203580 markedly suppressed the enhancing effects of VER-155008 on bFGF-stimulated release of IL-6. (bvsalud.org)
  • Taken together, these results indicated that HSP70 inhibitor amplified bFGF-stimulated release of IL-6 through p38 MAPK activation in the osteoblastic MC3T3-E1 cell line. (bvsalud.org)
Phosphorylation1
MCSF2