Receptor like kinase. Medical search. Frequent questions

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. (wikipedia.org)
The first RTKs to be discovered were the EGF and NGF receptors in the 1960s, but the classification of receptor tyrosine kinases was not developed until the 1970s. (wikipedia.org)
In particular, drugs targeting receptor tyrosine kinases (RTKs) have been successful. (europa.eu)
Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
This family of RTKs has been highly implicated in the formation and progression of various cancers via aberrant overexpression, kinase activation, and mutation [1] , [2] . (plos.org)
While the classical membrane-bound functions of HER family RTKs have been extensively studied, accumulating data suggest that these receptors can be found in the cell's nucleus where they can function as co-transcriptional activators [4] , [5] . (plos.org)
Receptor tyrosine kinases (RTKs) play fundamental tasks in varied cell functions including proliferation differentiation survival migration and rate of metabolism (16). (exposed-skin-care.net)
The class 1A phosphoinositide 3-kinase (PI3K) beta (PI3Kβ) is functionally unique in the ability to integrate signals derived from receptor tyrosine kinases (RTKs), heterotrimeric guanine nucleotide-binding protein (G-protein)-coupled receptors (GPCRs), and Rho-family GTPases. (elifesciences.org)
AXL receptor tyrosine kinase belongs to the TAM subfamily of receptor tyrosine kinases (RTKs) and overexpression has been detected in various cancers. (justia.com)
The ALK gene provides instructions for making a protein called ALK receptor tyrosine kinase, which is part of a family of proteins called receptor tyrosine kinases (RTKs). (medlineplus.gov)
The development elements activate adjacent arteries resulting in angiogenesis.5,6 Pursuing angiogenesis, the tumor can develop at an elevated price.7 For angiogenesis that occurs, the pro-angiogenic development factors need to bind to users of the proteins kinase family defined as receptor tyrosine kinases (RTKs). (thetechnoant.info)
Pursuing binding, the RTKs dimerize and go through autophosphorylation, initiating some downstream events resulting in proliferation migration and cell success.8 The growth factor VEGF activates angiogenesis by binding to a family group of VEGF receptors, Rabbit Polyclonal to ATP5I including VEGFR-2 (KDR), VEGFR-1 (Flt-1), and VEGFR-3 (Flt-4). (thetechnoant.info)

Exploration of the SAR around a series of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines led to the discovery of novel pyrrolopyridine inhibitors of the IGF-1R tyrosine kinase. (rcsb.org)
About 70% of the patients with EGFR mutations respond to EGFR tyrosine kinase inhibitors (TKIs) including gefitinib and erlotinib, whereas only 10% of those without the mutations do so. (nih.gov)
In isolated strips of rat aorta, the MAPK/Erk kinase inhibitor U0126 (50 μM), Src inhibitor PP1 (0.5 μM), PKC inhibitors calphostin C (1 μM) and chelerythrine (10 μM), and the PI-3-K inhibitor LY294002 (1-20 μM) reduced 5-HT-induced contraction. (aspetjournals.org)
In patients whose lung adenocarcinomas harbor epidermal growth factor receptor (EGFR) tyrosine kinase domain mutations, acquired resistance to the tyrosine kinase inhibitors (TKI) gefitinib (Iressa) and erlotinib (Tarceva) has been associated with a second-site EGFR mutation, which leads to substitution of methionine for threonine at position 790 (T790M). (aacrjournals.org)
Personalized Radiation Oncology: Epidermal Growth Factor Receptor and Other Receptor Tyrosine Kinase Inhibitors. (ox.ac.uk)
With the purpose of developing multitargeted receptor tyrosine kinase inhibitors that display potent inhibition against PDGFRand VEGFR-2 we designed and synthesized eleven and VEGFR-2. (thetechnoant.info)

Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. (duke.edu)
Functionally active targeting domain of the beta-adrenergic receptor kinase: an inhibitor of G beta gamma-mediated stimulation of type II adenylyl cyclase. (duke.edu)
The EGF receptor tyrosine kinase inhibitor AG1478 (0.25-1 μM) was without effect. (aspetjournals.org)
Inhibitor of apoptosis (IAP) proteins cIAP1, cIAP2, and XIAP (X-linked IAP) regulate apoptosis and cytokine receptor signalling, but their overlapping functions make it difficult to distinguish their individual roles. (ozgene.com)

The proposed mechanisms of such rapid receptor desensitization include receptor phosphorylation by either cAMP-dependent protein kinase or the specific beta-adrenergic receptor kinase (BARK), leading to functional uncoupling from adenylyl cyclase and sequestration of the receptors away from the cell surface. (jci.org)

Scientific Background TrkA is a member of the neurotrophic tyrosine kinase receptor family. (biosensis.com)

Of the 90 unique tyrosine kinase genes identified in the human genome, 58 encode receptor tyrosine kinase proteins. (wikipedia.org)
Receptor tyrosine kinases are part of the larger family of protein tyrosine kinases, encompassing the receptor tyrosine kinase proteins which contain a transmembrane domain, as well as the non-receptor tyrosine kinases which do not possess transmembrane domains. (wikipedia.org)
The phosphorylation of specific tyrosine residues within the activated receptor creates binding sites for Src homology 2 (SH2) domain- and phosphotyrosine binding (PTB) domain-containing proteins. (wikipedia.org)
Phosphorylation and activation of these two proteins on receptor binding lead to the initiation of signal transduction pathways. (wikipedia.org)
Other proteins that interact with the activated receptor act as adaptor proteins and have no intrinsic enzymatic activity of their own. (wikipedia.org)
These adaptor proteins link RTK activation to downstream signal transduction pathways, such as the MAP kinase signalling cascade. (wikipedia.org)
Oomycetes possess a family of novel proteins called GPCR-PIPKs (GKs) that are composed of a seven-transmembrane spanning (7-TM) domain fused to a phosphatidylinositol phosphate kinase (PIPK) domain. (wur.nl)
Ectodomain dropping has emerged as an important posttranslational mechanism to regulate the functions of various integral membrane-bound proteins including adhesion molecules cytokines growth factors and their receptors (57 60 Both. (exposed-skin-care.net)
Previous experiments have not been able to elucidate whether interactions with membrane-tethered proteins primarily control PI3Kβ localization versus directly modulate lipid kinase activity. (elifesciences.org)
To decipher how amplification of PI(3,4,5)P 3 arises from the relay of signals between cell surface receptors, lipids, and peripheral membrane proteins, we must understand how membrane localization and activity of PI3Ks is regulated by different signaling inputs. (elifesciences.org)
In addition to plexins, various other proteins have been implicated either as receptors for semaphorins or as components of the semaphorin receptor complex ( Pasterkamp and Kolodkin, 2003 ). (rupress.org)
The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. (justia.com)
The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. (justia.com)
We have identified a novel G protein-coupled receptor kinase-interacting protein, GIT1, that is a GTPase-activating protein (GAP) for the ADP ribosylation factor (ARF) family of small GTP-binding proteins. (duke.edu)
These results suggest an essential role for ARF proteins in regulating beta2-adrenergic receptor endocytosis. (duke.edu)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)

Mutations in receptor tyrosine kinases lead to activation of a series of signalling cascades which have numerous effects on protein expression. (wikipedia.org)
Oncogenic mutations of ALK kinase in neuroblastoma. (nature.com)
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. (nature.com)
Epidermal growth factor receptor (EGFR) gene mutations are frequent in lung cancer arising in patients of Asian ethnicity, female sex, nonsmokers, and adenocarcinoma histology. (nih.gov)
Tumor cells from patients with acquired resistance were examined for secondary EGFR kinase domain mutations by molecular analyses. (aacrjournals.org)
Strong genetic data link the Tyrosine kinase receptor B (TrkB) and its own main endogenous ligand brain-derived neurotrophic factor (BDNF) towards the regulation of energy homeostasis, with loss-of-function mutations in either gene causing severe obesity in both humans and mice. (biobender.com)
Mutations in the ALK gene change single protein building blocks (amino acids) in ALK receptor tyrosine kinase. (medlineplus.gov)

The ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. (wikipedia.org)
G protein-coupled receptors can activate Erk MAPK pathways through a variety of mechanisms, including stimulation of Src, phosphoinositide-3 kinase (PI-3-K), protein kinase C (PKC), or the epidermal growth factor (EGF) receptor tyrosine kinase. (aspetjournals.org)
Among them, the most data are available for the epidermal growth factor receptor (EGFR) that plays a major role for prognosis of patients after radiotherapy, but seems also to be involved in mechanisms of radioresistance, specifically in repopulation of tumour cells between radiotherapy fractions. (ox.ac.uk)

Exposure of beta-adrenergic receptors (BAR) to agonists often leads to a rapid loss of receptor responsiveness. (jci.org)
Furthermore, our data indicate that in addition to its suggested role as a rapid modulator of adrenergic receptor function at synapse, rapid BARK-mediated receptor regulation may have functional relevance in other tissues in response to high circulating or local levels of agonists. (jci.org)
The beta-adrenergic receptor kinase is an enzyme, possibly analogous to rhodopsin kinase, that multiply phosphorylates the beta-adrenergic receptor only when it is occupied by stimulatory agonists. (duke.edu)
Protein kinase Cdependent potentiation of intracellular calcium influx by σ1 receptor agonists in rat hippocampal neurons. (anavex.com)
These agents compete with beta-adrenergic agonists for available beta-receptor sites. (medscape.com)

An example of a vital signal transduction pathway involves the tyrosine kinase receptor, c-met, which is required for the survival and proliferation of migrating myoblasts during myogenesis. (wikipedia.org)
As RTK receptors phosphorylate multiple tyrosine residues, they can activate multiple signal transduction pathways. (wikipedia.org)
We have previously shown that excretory-secretory product-62 (ES-62), a homologue of phosphorylcholine-containing molecules that are secreted by human parasites and which is active in rodent models of filarial infection, is able to polyclonally activate certain protein tyrosine kinase and mitogen-activating protein kinase signal transduction elements in B lymphocytes. (eurekamag.com)
Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. (medlineplus.gov)

Direct evidence that Gi-coupled receptor stimulation of mitogen-activated protein kinase is mediated by G beta gamma activation of p21ras. (duke.edu)

Zhou L, Guo X, Chen M, Fu S, Zhou J, Ren G, Yang Z and Fan W: [Retracted] Inhibition of δ‑opioid receptors induces brain glioma cell apoptosis through the mitochondrial and protein kinase C pathways. (spandidos-publications.com)
Protein kinase C regulates tonic GABAA receptor-mediated inhibition in the hippocampus and thalamus. (ucl.ac.uk)
Tonic inhibition mediated by extrasynaptic GABAA receptors (GABAA Rs) is an important regulator of neuronal excitability. (ucl.ac.uk)
however, less attention has been focused on the plasticity of tonic inhibition and whether this can also be modulated by receptor phosphorylation. (ucl.ac.uk)
Using bath application of low GABA concentrations to mimic activation by ambient neurotransmitter, we demonstrated a similar inhibition of receptor function following PKC activation at physiological temperature. (ucl.ac.uk)
This effect was mediated by an action on cholesterol metabolism in lipid rafts and was prevented by tyrosine kinase inhibition. (jneurosci.org)
The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)

The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. (nih.gov)

In separate rats, we measured the effects of salvA on activation of extracellular signal regulated kinase (ERK), cyclic adenosine monophosphate (cAMP) response element binding protein, and c-Fos within the NAc. (erowid.org)
5-Hydroxytryptamine (5-HT) activates the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinases (MAPKs) in the vasculature, resulting in contraction. (aspetjournals.org)

Overexpression of GIT1 leads to reduced beta2-adrenergic receptor signaling and increased receptor phosphorylation, which result from reduced receptor internalization and resensitization. (duke.edu)
This phenomenon, known as gene amplification, results in overexpression of ALK receptor tyrosine kinase. (medlineplus.gov)

Dimerization leads to a rapid activation of the protein's cytoplasmic kinase domains, the first substrate for these domains being the receptor itself. (wikipedia.org)
This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)
G protein-coupled receptor activation leads to the membrane recruitment and activation of G protein-coupled receptor kinases, which phosphorylate receptors and lead to their inactivation. (duke.edu)
Stimulation of Gi-coupled receptors leads to the activation of mitogen-activated protein kinases (MAP kinases). (duke.edu)
Using single molecule Total Internal Reflection Fluorescence (TIRF) Microscopy, we determined the mechanism controlling membrane localization of PI3Kβ, prioritization of signaling inputs, and lipid kinase activation. (elifesciences.org)
A sensitive microtiter well-based assay for the measurement of insulin activation of insulin receptor kinase in intact human circulating mononuclear cells has been developed and characterized. (diabetesjournals.org)
and 3 ) the finding that kinase activation in NIDDM is reduced in a tissue that, according to the literature, contains only the A isoform of the insulin receptor, suggests that mechanisms other than a different abundance of the A and B insulin receptor isoforms must exist that contribute to the decreased kinase activity in NIDDM. (diabetesjournals.org)
Our data indicate that ErbB-2 is an important component of the plexin-B receptor system and that ErbB-2-mediated phosphorylation of plexin-B1 is critically involved in Sema4D-induced RhoA activation, which underlies cellular phenomena downstream of plexin-B1, including axonal growth cone collapse. (rupress.org)
IAPs limit activation of RIP kinases by TNF receptor 1 during development. (ozgene.com)
Moreover, they provide a mechanism for integration of receptor activation and endocytosis through regulation of ARF protein activation by GRK-mediated recruitment of the GIT1 ARF GAP to the plasma membrane. (duke.edu)
Constitutive activation of ALK receptor tyrosine kinase may increase the proliferation of immature nerve cells, leading to neuroblastoma. (medlineplus.gov)
Activation of the D1 dopamine receptor/cAMP/PKA cascade is regulated by the neuronal protein kinase, Cdk5. (cdc.gov)

Fusion of a kinase gene, ALK , to a nucleolar protein gene, NPM , in non-Hodgkin's lymphoma. (nature.com)
ALK , the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). (nature.com)
This gene encodes a receptor tyrosine kinase. (nih.gov)
Homozygous inactivation of this gene leads to impaired cytokine production in response to LPS treatment, and may result in resistance to LPS-induced septic shock and defects in Toll-like receptor and T-cell receptor signaling. (jax.org)
To identify their cognate receptors, the grapevine family of LysM receptor kinases (LysM‐RKs) was annotated and their gene expression profiles were characterized. (uzh.ch)
In mice lacking one copy of the BDNF gene ( BDNF +/− ), CB 1 R (GABA) responses were potentiated and were preserved from the action of haloperidol, a DA D 2 receptor (D 2 R) antagonist able to fully abolish CB 1 R (GABA) function in rewarded animals. (jneurosci.org)

Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
The HER2 receptor does not bind to any known ligands, however, its dimerization arm is innately positioned in an open conformation. (plos.org)

Rapid desensitization of neonatal rat liver beta-adrenergic receptors. (jci.org)
A role for beta-adrenergic receptor kinase. (jci.org)
A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination. (duke.edu)
Chronic human heart failure is characterized by abnormalities in beta-adrenergic receptor (betaAR) signaling, including increased levels of betaAR kinase 1 (betaARK1), which seems critical to the pathogenesis of the disease. (duke.edu)
Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. (duke.edu)
The beta-adrenergic receptor kinase 1 (beta ARK1) is a member of the G protein-coupled receptor kinase (GRK) family that mediates the agonist-dependent phosphorylation and desensitization of G protein-coupled receptors. (duke.edu)
Heart failure is accompanied by severely impaired beta-adrenergic receptor (betaAR) function, which includes loss of betaAR density and functional uncoupling of remaining receptors. (duke.edu)
Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). (duke.edu)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates its membrane-associated receptor substrates, such as the beta-adrenergic receptor, triggering events leading to receptor desensitization. (duke.edu)
This is a nonselective beta-adrenergic receptor blocker. (medscape.com)

Kinase enzymes that specifically phosphorylate tyrosine amino acids are termed tyrosine kinases. (wikipedia.org)
The auxin-regulated receptor CAMEL (Canalization-related Auxin-regulated Malectin-type RLK) together with CANAR (Canalization-related Receptor-like kinase) interact with and phosphorylate PIN auxin transporters. (ugent.be)

The intracellular C terminal region displays the highest level of conservation and comprises catalytic domains responsible for the kinase activity of these receptors, which catalyses receptor autophosphorylation and tyrosine phosphorylation of RTK substrates. (wikipedia.org)
The activated receptor as a result then becomes autophosphorylated on multiple specific intracellular tyrosine residues. (wikipedia.org)
We also showed that PAF could stimulate intracellular cAMP accumulation in lymphocytes, suggesting that PAFR-coupling with adenylyl cyclase may be important also for endogenously expressed receptors. (open.ac.uk)

Upon immobilization sAxl advertised cell migration and induced the phosphorylation of Axl and phosphatidylinositol 3-kinase. (exposed-skin-care.net)
Dexamethasone may inhibit placental growth by blocking glucocorticoid receptors via phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin and reactive oxygen species/AMP-activated protein kinase signalling pathways in human placental JEG-3 cells. (bvsalud.org)
Treatment of JEG-3 cells with GRα siRNA , LY294002, XO/HX or rapamycin inhibited phosphorylation of phosphatidylinositol 3-kinase (PI3K), Akt, glycogen synthase kinase 3 and mammalian target of rapamycin (mTOR) and induced the phosphorylation of AMP-activated protein kinase (AMPK) and tuberous sclerosis complex 2. (bvsalud.org)

Results from these analyses demonstrated that the C-terminal domain of HER3 (CTD, amino acids distal to the tyrosine kinase domain) contained potent transactivation potential. (plos.org)

beta2-Adrenergic receptor regulation by GIT1, a G protein-coupled receptor kinase-associated ADP ribosylation factor GTPase-activating protein. (duke.edu)

Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
We showed that receptor pathways mediated by Gs-coupling were regulated through a strictly phosphorylation-dependent process, while Gq-mediated signalling could be modulated in a phosphorylation-independent way. (open.ac.uk)

The death of cIap2(-/-)cIap1(-/-) double mutants was rescued to birth by deletion of tumour necrosis factor (TNF) receptor 1, but not TNFR2 genes. (ozgene.com)

As a result, the kinase and the downstream signaling pathway are constantly turned on (constitutively activated). (medlineplus.gov)
Repetitive CP exposure increased striatal PKA-dependent phosphorylation of the D1 dopamine receptor downstream effector Ser845 of the GluR1 subunit of the AMPA receptor. (cdc.gov)

Angiotensin AT1 Receptor Phosphorylation and Desensitization in a Hepatic Cell Line. (aspetjournals.org)

To address this gap in our understanding of PI3Kβ regulation, we established an assay to directly visualize and decipher how three binding interactions regulate PI3Kβ when presented to the kinase in a biologically relevant configuration on supported lipid bilayers. (elifesciences.org)
Although pY peptides strongly localize PI3Kβ to membranes, they only modestly stimulate lipid kinase activity. (elifesciences.org)

In approximately 80% of patients, auto-antibodies to the muscle nicotinic acetylcholine receptor (AChR) are present. (nih.gov)
Here we show that 70% of AChR-Ab-seronegative MG patients, but not AChR-Ab-seropositive MG patients, have serum auto-antibodies against the muscle-specific receptor tyrosine kinase, MuSK. (nih.gov)
Specifically, the present invention relates to anti-AXL tyrosine kinase receptor antibodies and their uses thereof. (justia.com)

Phylogenetic analysis clearly distinguished three V. vinifera LysM‐RKs (VvLYKs) located in the same clade as the Arabidopsis CHITIN ELICITOR RECEPTOR KINASE1 (AtCERK1), which mediates chitin‐induced immune responses. (uzh.ch)

Through diverse means, extracellular ligand binding will typically cause or stabilize receptor dimerization. (wikipedia.org)
Fig. 4: ALKAL2-mediated receptor dimerization. (nature.com)
After dimerization, the kinase is tagged with a marker called a phosphate group (a cluster of oxygen and phosphorus atoms) in a process called phosphorylation. (medlineplus.gov)

In this sense, am olfactory receptor is a protein-molecule that recognizes and responds to endogenous-chemical signals, chemokinesor cytokines e.g. an acetylcholine-receptor recognizes and responds to its endogenous-ligand, acetylcholine. (gentaur.com)

Such therapy functions through mediating alterations in antigen or receptor function, modulating the immune system or delivering a specific drug that is conjugated to an antibody that targets a specific antigen. (justia.com)
In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof that competes with the antigen binding protein as defined herein for binding to AXL receptor tyrosine kinase. (justia.com)

Here, we addressed the functional interplay between BDNF and cannabinoid CB 1 receptors (CB 1 Rs) in the striatum, a brain area in which both BDNF and CB 1 s play a role in the emotional consequences of stress and of rewarding experiences. (jneurosci.org)
The effect of BDNF was restricted to CB 1 Rs controlling GABA-mediated IPSCs (CB 1 R (GABA) ), whereas CB 1 Rs modulating glutamate transmission and GABA B receptors were not affected. (jneurosci.org)
The action of BDNF on CB 1 R (GABA) function was tyrosine kinase dependent and was complete even after receptor sensitization with cocaine or environmental manipulations activating the dopamine (DA)-dependent reward system. (jneurosci.org)

In vivo, tumour cells are simultaneously exposed to signals initiated by a variety of oncogenes, cytokine receptors and adhesion molecules, and it is the integrated signals that determine the cellular phenotype. (europa.eu)
The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. (gentaur.com)
When such chemical-signals couple or bind to a receptor, they cause some form of cellular/tissue-response, e.g. a change in the electrical-activity of a cell. (gentaur.com)
Little is known about how the kinase activity-deficient RYKs transduce Wnt signals. (biologists.com)
Fibroblast growth factor receptor 1 contains three extracellular IMMUNOGLOBULIN C2-SET DOMAINS and is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM. (bvsalud.org)

Mononuclear cells from 100-150 ml blood were incubated with various insulin concentrations to activate the receptor kinase. (diabetesjournals.org)

This local action of FGFs (Fibroblast Growth Factors) with their RTK receptors is classified as paracrine signalling. (wikipedia.org)

P90 ribosomal S6 kinases: A bona fide target for novel targeted anticancer therapies? (lu.se)

Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. (duke.edu)
Mutated or overexpressed ALK receptor tyrosine kinase no longer requires stimulation from outside the cell to be phosphorylated. (medlineplus.gov)
It may be used to treat excessive beta-receptor stimulation in patients with inoperable metastatic pheochromocytoma. (medscape.com)

moreover, ligand binding to the extracellular domain induces formation of receptor dimers. (wikipedia.org)
This mechanism is underpinned by an unusual architecture of the receptor-ligand complex. (nature.com)
Repeated exposure to drugs of abuse and stress increase dynorphin, a kappa opioid receptor (KOR) ligand, in the nucleus accumbens (NAc). (erowid.org)

Role of mitogen-activated protein kinases in endothelin ETB receptor up-regulation after organ culture of rat mesenteric artery. (lu.se)
These cellular effects of GIT1 require its intact ARF GAP activity and do not reflect regulation of GRK kinase activity. (duke.edu)

In addition, one of the direct targets of miR-31 was found to be receptor tyrosine kinase MET, and upregulation of MET caused the chemoresistance to PTX. (nature.com)
Receptor kinase module targets PIN-de. (ugent.be)

Anatomy13

Organisms10

Chemicals and Drugs172

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes42

Information Science3

RTKs13

Inhibitors6

Inhibitor4

CAMP-depend1

Neurotrophic Tyrosine1

Proteins16

Mutations7

Epidermal3

Agonists5

Signal transduction4

Mitogen-activa1

Inhibition7

Transmembrane1

Extracellular signal2

Overexpression2

Activation12

Gene6

Ligands2

Beta-adrenergic10

Phosphorylate2

Intracellular3

Phosphatidylinositol 3-kina3

Amino acids1

Beta2-Adrenergic receptor1

Pathways2

Genes1

Downstream2

Phosphorylation and desensitization1

PI3K2

Antibodies3

Mediates1

Dimerization3

Acetylcholine receptor1

Antigen2

BDNF3

Signals5

Activate1

Fibroblast Growth1

Ribosomal1

Stimulation3

Ligand3

Regulation2

Targets2