Receptor isoforms mediate. Medical search. Frequent questions

TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. (origene.com)
TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. (cancerindex.org)
Increases in ligand secretion need to be coupled to efficient signal transduction dependent on receptor availability and optimal function, regulated by different molecular modules. (nature.com)
CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. (exbio.cz)
This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. (immunoway.com)
Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not. (immunoway.com)

Two alternatively spliced transcript variants that encode different isoforms have been described. (wikipedia.org)
Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. (nih.gov)
Two transcript variants encoding different isoforms have been found for this gene. (antibodies-online.com)
Alternatively spliced transcript variants encoding different isoforms have been described for this gene. (antikoerper-online.de)
Alternatively spliced transcript variants encoding either the same or different isoforms have been identified for this gene. (genetex.com)
Two transcript variants encoding different isoforms have been found for CDf. (thermofisher.com)
Humans ubiquitously express three genes (HRAS, KRAS, and NRAS) that encode four different isoforms of Ras, an integral p21 GTPase acting as an effector of cell surface receptors and regulating cell survival, proliferation, and differentiation. (jhu.edu)
CD44 is a broadly distributed cell surface glycoprotein expressed in different isoforms in various tissues and cell lines. (rupress.org)

This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. (origene.com)
This review will focus on innovative drug development for the treatment of relapsed or refractory MCL, including therapies aimed at disrupting the B-cell receptor signaling pathway, regulators of apoptosis, and immunomodulators. (cancernetwork.com)
Our results further suggest that GPER expression and FOXO3a localization could be utilized as prognostic markers in breast cancer therapy and that GPER antagonists could promote apoptosis in GPER-positive breast cancers, particularly in combination with chemotherapeutic and ER-targeted drugs, by antagonizing estrogen-mediated FOXO3a inactivation. (biomedcentral.com)
SM-induced cell death in M1 MÏ s was mediated by apoptosis as well as necroptosis, activated both extrinsic and intrinsic pathways of apoptosis, and was attributed to the IFN-Î³-mediated differentiation. (bvsalud.org)

Receptor assembly and intracellular trafficking of ionotropic glutamate receptors are regulated by RNA editing and alternative splicing. (wikipedia.org)
Functionally, integrins are cell surface receptors that interact with the extracellular matrix and mediate intracellular signals that affect cellular shape, mobility, and progression through the cell cycle in response to the extracellular matrix. (thermofisher.com)
I was the first to identify a pathological role for pancreatic acinar cell Ca2+ release from the intracellular Ca2+ channel the ryanodine receptor (RyR). (stanford.edu)

Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. (origene.com)
Several alternatively spliced transcript variants encoding three distinct isoforms have been reported. (cancerindex.org)
Six alternatively spliced transcript variants encoding three distinct isoforms have been reported. (creativebiomart.net)

[ 12 , 13 ] It is anticipated that ET A -selective antagonists will be more effective vasodilators in treating PAH than dual endothelin receptor antagonists. (medscape.com)
Although these effects are blocked by antagonists of the receptor (TP) for the cyclooxygenase product thromboxane A(2), it has been speculated that the iPs may activate a receptor related to, but distinct from, the TP. (unicatt.it)
This receptor subtype is believed to mediate the anorectic action of SEROTONIN, while selective antagonists of the 5-HT2C receptor appear to induce ANXIETY. (reference.md)

This gene encodes one of the many ionotropic glutamate receptor (GluR) subunits that function as a ligand-gated ion channel. (wikipedia.org)
This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. (nih.gov)
This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. (nih.gov)
This gene encodes the integrin beta 4 subunit, a receptor for the laminins. (thermofisher.com)
This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares significant homology with members of the glucagon/secretin receptor family. (nih.gov)

Alternative splicing results in multiple transcript variants that encode different protein isoforms. (nih.gov)

These actions are mediated by insulin pathway activation and can be blocked by phosphatidylinositol 3-kinase (PI(3) Kinase) inhibitor wortmannin. (nih.gov)
AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 thereby activating mTORC1 pathway. (rcsb.org)
The Ras/RAF/MAP2K/MAPK pathway is mainly involved in mediating cell growth, survival and cellular differentiation of insulin. (rcsb.org)
11-13] More specifically, evidence that MCL pathogenesis is antigen-dependent[14] and that these tumors exhibit constitutive B-cell receptor (BCR) activation[15] posits the BCR signaling pathway as a rational prospect for drug development. (cancernetwork.com)
Recently, we have shown that a second pathway for activation of ERK by Gs-coupled GPCRs exists: the family B receptor PAC1 causes ERK activation and ERK-dependent neuritogenesis in neuroendocrine cells (see Emery, et al. (nih.gov)
We selected most pathways IL5RA participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Hematopoietic cell lineage, which may be useful for your reference. (creativebiomart.net)
Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). (nih.gov)
Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). (nih.gov)
The replication and activator of known role existing mediates teamed at Mitochondrial tissues through cells that are dysplasia and pathway, Glycosyltransferases to transfer circulating cis-cisternae and human processing( indexed in Matallanas et al, 2011). (familie-vos.de)
The progesterone receptor isoform B (PGR-B) mediates suppression of uterine contractibility via the Oxtr-Plcl2-Trpc3 pathway, according to NIEHS researchers and their collaborators. (nih.gov)

FREM1 (Fras-related extracellular matrix 1) and its splice variant TILRR (Toll-like interleukin-1 receptor regulator) have been identified as integral components of innate immune systems. (nih.gov)

Of the multiple proteins that transiently interact with AMPARs and that determine their trafficking, synaptic targeting and recycling in neurons, some special attention must be given to transmembrane proteins that form integral part of the functional receptor. (frontiersin.org)
The cellular actions of estrogen are mediated by the nuclear estrogen receptors ERα and ERβ as well as the 7-transmembrane spanning G protein-coupled estrogen receptor (GPER). (biomedcentral.com)
G Protein-Coupled Receptors (GPCRs) comprise a large protein family of seven transmembrane domain receptors that are linked to a number of diseases. (nih.gov)
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. (thermofisher.com)
CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. (exbio.cz)

This amino acid activates primarily ionotropic glutamate receptors (iGluRs): NMDA, AMPA, and Kainate receptors. (frontiersin.org)

DHR78 , which encodes another candidate ecdysteroid receptor, is also not required. (biologists.com)

This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. (nih.gov)

Activation of ET A leads to vasoconstriction and vascular smooth-muscle cell proliferation, while ET B receptor activation leads to the clearance of endothelin and a compensatory vasodilatory response. (medscape.com)
16. Ulipristal Acetate Inhibits Progesterone Receptor Isoform A-Mediated Human breast cancer Proliferation and BCl2-L1 Expression. (nih.gov)
Estrogen (17β-estradiol) promotes the survival and proliferation of breast cancer cells and its receptors represent important therapeutic targets. (biomedcentral.com)

ApoE mediates cholesterol metabolism by binding various receptors. (nih.gov)
Therefore, AdipoR1 and R2 serve as the predominant receptors for adiponectin in vivo and play important roles in the regulation of glucose and lipid metabolism, inflammation and oxidative stress in vivo . (nature.com)
The belonging state: The outlined domain of cleaving s in their strand other plasma: A metabolism associated in ROCK-mediated frequency of the specificities for the subunits of Master of Arts in Nursing at Massey University. (familie-vos.de)

Sitaxsentan (Thelin, Encysive Pharmaeuticals) is an orally active, organic nonpeptide that binds competitively to the human ET A receptor. (medscape.com)
This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. (antikoerper-online.de)
When present in a hybrid receptor with IGF1R, binds IGF1. (rcsb.org)
VEGF binds to and activates a receptor tyrosine kinase, VEGFR, through transphosphorylation. (tocris.com)
The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. (prospecbio.com)

Ablation of the gene for RARγ ( Rarg ) rescues Cyp26a1 -null mutant animals from caudal regression and embryonic lethality, thus demonstrating that CYP26A1 suppresses the RA-mediated downregulation of WNT3A and FGF8 signaling pathways by eliminating ectopic RA in gastrulating tail bud mesoderm. (biologists.com)
A new gene, stumps , has been identified that participates in the signaling pathways of both FGF receptors. (sdbonline.org)
Here we show that adenovirus-mediated expression of AdipoR1 and R2 in the liver of Lepr −/− mice increased AMP-activated protein kinase (AMPK) activation and peroxisome proliferator-activated receptor (PPAR)-α signaling pathways, respectively. (nature.com)
Figure 2: Adenovirus-mediated expression of AdipoR1 in the liver of Lepr −/− mice results in activation of AMP kinase pathways. (nature.com)
Figure 3: Adenovirus-mediated expression of Adipor2 in the liver of Lepr −/− mice results in activation of PPAR-α pathways. (nature.com)

Thyroid hormone receptors are nuclear receptors that act as ligand-regulated transcription factors and control a critical point at which the hormonal signal is converted into a cellular response. (nih.gov)
Evidence indicates that deiodinases cooperate closely with thyroid hormone receptors to exert powerful control over tissue responses. (nih.gov)
Our studies include investigation of thyroid hormone receptors in sensory development, including in the auditory and visual systems. (nih.gov)
Moreover, this receptor contributes to the death or survival of cone photoreceptors, suggesting a key role for thyroid hormone throughout the life history of these specialized light-sensitive neurons. (nih.gov)
Mutations in human thyroid hormone receptor genes are associated with syndromes of resistance to thyroid hormone. (nih.gov)
Transcriptional control of cone photoreceptor diversity by a thyroid hormone receptor. (nih.gov)
This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human Thyroid Hormone Receptor Alpha (TRa). (indigobiosciences.com)
Thyroid hormone receptor alpha (TR-alpha) (erythroblastic leukemia viral (v-erb-a) oncogene homolog, avian), also known as NR1A1, is nuclear receptor protein encoded by the THRA gene. (indigobiosciences.com)
It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. (indigobiosciences.com)
Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. (indigobiosciences.com)
The Human TRα Reporter Assay Systems utilize proprietary human cells engineered to provide constitutive, high-level expression of Human Thyroid Hormone Receptor Alpha (NR1A1), a ligand-dependent transcription factor commonly referred to as TRα. (indigobiosciences.com)
Inasmuch as local cerebral glucose utilization is closely related to local synaptic activity, we also examined which thyroid hormone receptor is involved in the expression of synaptotagmin-related gene 1 (Srg1), a TH-positively regulated gene involved in the formation and function of synapses [Thompson, C. C. (1996) J. Neurosci. (nih.gov)
www.pnas.org/cgi/doi/10.1073/pnas.171319498 The action of the thyroid hormone, L-triiodothyronine (T3), is mediated by thyroid hormone receptors (TRs), which are ligand-dependent transcription factors (12, 13). (nih.gov)

However, spontaneous channel activity has been reported in recombinant α4β1 receptors as well as β1 or β3 homomeric receptors, although these isoforms are insensitive to activation by GABA. (aspetjournals.org)
Here we compared activity of purified recombinant idInlB isoforms characteristic for L. monocytogenes phylogenetic lineage I and II. (nih.gov)
Solid-phase microplate binding and competition assay was used to quantify interactions with gCq1-R. Isogenic recombinant L. monocytogenes strains were used to elucidate the input of idInlB isoforms in HEp-2 cell invasion. (nih.gov)

In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. (antibodies-online.com)
The antibody MEM-56 reacts with an extracellular epitope of CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform). (exbio.cz)
CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. (exbio.cz)

These receptors mediate excitatory neurotransmission and are critical for normal synaptic function. (wikipedia.org)
Amongst iGluRs, the AMPA receptors (AMPARs) are essential as they mediate 90% of the fast excitatory neurotransmission in the central nervous system (CNS). (frontiersin.org)

Calmodulin contributes to the regulation of both ER-mediated transcriptional activation and ER degradation. (nih.gov)
This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. (cancerindex.org)
The protein functions as a scaffolding/adaptor protein in concert with TNF receptor-associated factor 6 to mediate activation of NF-kB in response to upstream signals. (genetex.com)
Additionally, estrogen-and G-1-mediated stimulation of MCF7 cells results in a decrease in caspase activation under proapoptotic conditions. (biomedcentral.com)
However, estrogen also mediates rapid cellular signaling events, such as kinase activation (e.g. (biomedcentral.com)
This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. (creativebiomart.net)
Activation of AMPK reduced gluconeogenesis, whereas expression of the receptors in both cases increased fatty acid oxidation and lead to an amelioration of diabetes. (nature.com)
CD45 plays a critical role in T and B cell antigen receptor-mediated activation by dephosphorylating substrates including p56Lck, p59Fyn, and other Src family kinases. (biolegend.com)
download The Post Utopian Imagination: American Culture in 3 genes the activation of from( 50) with receptor to window, written by the Small cell transfer vitamin. (familie-vos.de)

We also investigate other nuclear receptors in mammalian development, including retinoid-related orphan receptors. (nih.gov)
Phylogenetically defined substitutions were described in the L. monocytogenes virulence factor InlB, which mediates active invasion into mammalian cells via interactions with surface receptors c-Met and gC1q-R. InlB internalin domain (idInlB) is central to interactions with c-Met. (nih.gov)
mammalian surface receptors. (nih.gov)

In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. (rndsystems.com)

While CD44H has been shown to mediate cell adhesion, direct demonstration that CD44H expression promotes cell motility has been lacking. (rupress.org)

These functions are mediated by CIKS, an adaptor protein that is recruited to the receptor after IL-17 stimulation. (unina.it)
online information:ZAP70 mutation db,PTM:Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. (immunoway.com)
urinary recruitment USP7 genes( LCFAs) can look conserved for expression cases and field stimulation localization and be clathrin-coated such ions neuronal as affinity, calcium cell, the developing vitro, internalization activity records and the ATP-dependent receptor. (familie-vos.de)

Furthermore, Corosolic acid inhibits the enzymatic activities of several diabetes-related non-receptor protein tyrosine phosphatases (PTPs) in vitro, such as PTP1B, T-cell-PTP, src homology phosphatase-1 and src homology phosphatase-2. (nih.gov)
Receptor tyrosine kinase which mediates the pleiotropic actions of insulin. (rcsb.org)

1995 . Expression of prolactin and prolactin receptor in human breast carcinoma. (nih.gov)
Evaluation of LDL receptor and Scavenger Receptor, Class B, Type 1 in the malignant and benign breast tumors: The correlation with the expression of miR-199a-5p, miR-199b-5p and miR-455-5p. (antibodies-online.com)
In the present study, the expression of estrogen receptor (ER)α and ERβ isoforms in ER-positive (MCF7, T-47D and ZR-75-1) and ER-negative (MDA-MB-231, SK-BR-3, MDA-MB-453 and HCC1954) breast cancer cell lines was investigated. (spandidos-publications.com)
When bound to estrogens as homodimers, the transcription of target genes is activated ( 8 , 9 ), while as heterodimers, ERβ exhibits an inhibitory action on ERα-mediated gene expression and, in many instances, opposes the actions of ERα ( 7 , 9 ). (spandidos-publications.com)
Low expression of transferrin receptor 2 predict poor prognosis in gastric cancer patients. (nih.gov)
Overexpression of LRRFIP1 isoform 3 blocks the IL-17 induced gene expression, via down-regulation of NF-κB and AP-1. (unina.it)
There is a switch from Broad complex Z2 to Z1 zinc-finger isoform expression at the furrow which requires Z2 expression and responds to Hedgehog signals. (biologists.com)
Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. (thermofisher.com)
Figure 1: Adenovirus-mediated expression of Adipor1 or Adipor2 in the liver of Lepr −/− mice improves insulin resistance and ameliorates diabetes. (nature.com)
These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. (exbio.cz)
Cosenza-Nashat MA, Kim MO, Zhao ML, Suh HS, Lee SC: CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis. (exbio.cz)
These results show that the same receptor, TRa'1, is involved in the regulation by TH of both glucose utilization and Srg1 expression. (nih.gov)
Recently, TR83 and TRAB3 isoforms have been identified but have limited expression in the brain (14). (nih.gov)

The specific GluR subunit encoded by this gene is of the kainate receptor subtype. (wikipedia.org)
A new γ-aminobutyric acid (GABA) A receptor (GABAR) subunit class, ε, has recently been cloned and shown to form functional channels when coexpressed with both α and β subunits. (aspetjournals.org)
AMPARs mediate the vast majority of fast excitatory synaptic transmission in the brain and their biophysical and trafficking properties depend on their subunit composition and on several posttranscriptional and posttranslational modifications. (frontiersin.org)
GPER-mediated inactivation of FOXO3a is effected by the p110α catalytic subunit of PI3Kinase as a result of transactivation of the EGFR. (biomedcentral.com)
Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. (creativebiomart.net)
The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. (creativebiomart.net)
The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). (creativebiomart.net)
CD104 is a 202 kDa subunit that associates with integrin alpha 6 (CD49f), thereby forming the laminin receptor. (thermofisher.com)

The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. (nih.gov)

[ 11 ] It is currently undergoing Phase III trials, and unlike bosentan, it has a high affinity for the ET A receptor. (medscape.com)
PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. (rcsb.org)

In addition to the aforementioned ER isoforms, several ER variants have been identified for both receptors. (spandidos-publications.com)

Several factors, including coactivators, corepressors and integrator proteins are important in ER-mediated transcription. (nih.gov)
The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. (nih.gov)
The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. (nih.gov)

γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the vertebrate brain, and fast inhibitory postsynaptic potentials are mediated by GABA A receptors (GABARs). (aspetjournals.org)

The study of nuclear receptors, which act as ligand-regulated transcription factors, should reveal how networks of transcriptional responses mediate specific biological processes. (nih.gov)
The classic steroid hormone estrogen mediates its biological effects in cells through the estrogen receptor (ER), a member of the nuclear receptor family. (nih.gov)
This receptor mediates diverse biological actions of adenylate cyclase activating polypeptide 1 and is positively coupled to adenylate cyclase. (nih.gov)

Additionally, in the brain AMPARs associate with auxiliary subunits, which modify the properties of the receptors. (frontiersin.org)

A serotonin receptor subtype found primarily in the CENTRAL NERVOUS SYSTEM and the CHOROID PLEXUS. (reference.md)
Several isoforms of this receptor subtype exist, due to adenine deaminase editing of the receptor mRNA. (reference.md)
To ascertain which subtype of thyroid hor- mone (TH) receptors, TRa1 or TRB, is involved in the regulation of glucose utilization during brain development, we used the 2-[*4C]deoxyglucose method in mice with a mutation in either their TRa or TRB gene. (nih.gov)

VEGFR-2 mediates the majority of cellular responses to VEGF, in particular its mitogenic and angiogenic effects. (tocris.com)
VEGFR-2 mediates the majority of cellular responses to VEGF. (nih.gov)
It has been concluded that stumps may contribute to the specificity of developmental responses elicited by FGF receptor signaling (Michelson, 1998, and Vincent, 1998). (sdbonline.org)
It is proposed that this receptor mediates inflammatory responses. (nih.gov)

OSCAR is a receptor for surfactant protein D that activates TNF-α release from human CCR2+ inflammatory monocytes. (nih.gov)
Human apolipoprotein E (apoE) exists in three isoforms: apoE2, apoE3 and apoE4. (nih.gov)
Two of these sites, FP3 (bases −7738 to −7715) and FP4 (bases −7698 to −7682), overlapped binding motifs for the orphan human pregnane X receptor (hPXR). (aspetjournals.org)
One of two recently characterized human isoforms, CD44H, is a cell surface receptor for hyaluronate, suggesting a role in the regulation of cell-cell and cell-substrate interactions as well as of cell migration. (rupress.org)
In this work we show that a human melanoma cell line, stably transfected with CD44H, displays enhanced motility on hyaluronate-coated surfaces while transfectants expressing an isoform that does not bind hyaluronate, CD44E, fail to do so. (rupress.org)
Atomic force microscopy-mediated mechanobiological profiling of complex human tissues. (nih.gov)
Combined AAV-mediated gene replacement therapy improves auditory function in a mouse model of human DFNB42 deafness. (nih.gov)

This confirms that each receptor is the product of independent genes. (spandidos-publications.com)
Drosophila possesses two FGF receptors that are encoded by the heartless and breathless genes. (sdbonline.org)
Three ligand- activated nuclear TR isoforms have been identified, TRel, TRBI1, and TR£2, which are produced by alternative splicing of the primary transcripts of the TRe and TRB genes, respectively. (nih.gov)

Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta. (rndsystems.com)
The two receptor subtypes are expressed equally in brain, where their distinct functions are less obvious than in the periphery. (nih.gov)

19. Spontaneous lung and lymph node metastasis in transgenic breast cancer is independent of the urokinase receptor upa R. (nih.gov)
To explore the in vivo role of progesterone signaling and progesterone receptor (PGR) isoforms in childbirth, the team employed transgenic mice with an overexpression of PGR-A or PGR-B in their myometrial smooth muscle. (nih.gov)

The biophysical properties and the effects of allosteric modulators were similar for spontaneous and evoked GABAR currents, suggesting that a single GABAR isoform was responsible for both currents. (aspetjournals.org)

Recent investigations demonstrated that the thromboxane (TX) A 2 receptor (TP) antagonist NTP42 attenuates experimental PAH across key hemodynamic parameters in the lungs and heart. (frontiersin.org)

GABARs belong to the superfamily of ligand-gated ion channels that includes the glycine, nicotinic cholinergic (nAChR), and 5-hydroxytryptamine receptors. (aspetjournals.org)
The protein encoded by this gene is a member of the TNF-receptor superfamily. (origene.com)

Ras1 is a key signal transducer acting downstream of all (receptor tyryosine kinases) Rtks, including Htl. (sdbonline.org)

[ 10 ] Therefore, in theory, an ideal endothelin antagonist would selectively antagonize the ET A receptor without ET B blockade. (medscape.com)

Secondly, CPT1C enhanced whole-cell currents of GluA1 homomeric and GluA1/GluA2 heteromeric receptors. (frontiersin.org)

Mutations in KRAS account for the majority of all RAS-mediated cancers, and are amongst the most frequently observed in epithelial carcinomas. (jhu.edu)
Nearly all observed Ras isoform mutations are found at codons 12, 13 and 61, and affect both splice variants of KRAS, K-Ras4A and K-Ras4B. (jhu.edu)

These receptors, which are co-expressed in a number of tissues, form functional homodimers or heterodimers. (spandidos-publications.com)
While DNA-binding nuclear receptors have been characterized for many steroid hormones, our understanding of how steroid hormone signaling directs tissues to differentiate remains rudimentary. (biologists.com)

In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). (rcsb.org)
In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin. (rcsb.org)
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. (nature.com)

The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). (antibodies-online.com)
The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. (antikoerper-online.de)
The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. (indigobiosciences.com)

Clues to differential signaling in the brain may be obtained from an expanded knowledge of how these two receptors signal in neurons. (nih.gov)

Editing results in a change in amino acid in the second membrane domain of the receptor. (wikipedia.org)
Editing of the Q/R site is thought to reduce the permeability of the channel to Ca2+ RNA editing of the Q/R site can effect inhibition of the channel by membrane fatty acids such as arachidonic acid and docosahexaenoic acid For Kainate receptors with only edited isoforms, these are strongly inhibited by these fatty acids. (wikipedia.org)
The anionic STAT5-mediated download The Post Utopian Imagination: American Culture in membrane SLC35 extend application result channels( NSTs), loaded on Golgi and well-described cysteines, which can see the development of transfer lacks in deacetylation for the acid transport repeats( source. (familie-vos.de)

Glutamate receptor, ionotropic, kainate 1, also known as GRIK1, is a protein that in humans is encoded by the GRIK1 gene. (wikipedia.org)

Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. (nih.gov)
Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. (curehunter.com)

Integrins are known to participate in cell adhesion as well as cell-surface mediated signaling. (thermofisher.com)
In the 15R-HETE accessibility, a cell linking stalk is receptor for E2 conditions. (familie-vos.de)

Anatomy20

Organisms7

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes36

Disciplines and Occupations1

Information Science3

Signal Transduction6

Different isoforms8

Apoptosis4

Intracellular3

Alternatively spliced transcript variants3

Antagonists3

Gene encodes5

Transcript variants that encode different1

Pathway10

Interleukin-1 recept1

Transmembrane5

Ionotropic glutamate receptors1

Encodes1

Selectivity1

Proliferation3

Metabolism3

Binds5

Pathways5

Thyroid hormone13

Recombinant3

Glycoprotein3

Excitatory neurotransmission2

Activation9

Mammalian3

Endothelial cells1

Shown to mediate1

Stimulation3

Tyrosine2

Expression13

Subunit8

Extracellular1

High affinity2

Variants have been identified1

Proteins3

Inhibitory1

Biological3

Subunits1

Subtype3

Responses4

Human7

Genes3

Distinct2

Transgenic2

Biophysical properties1

Thromboxane1

Superfamily2

Kinases1

Antagonist1

Homomeric1

Mutations2

Tissues2

Insulin3

Protein encoded by this gene3

Neurons1

Membrane3

Kainate1

Lipoprotein2

Cell2