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CalcimycinIonophoresLasalocidMonensinIonomycinCalciumNigericinTetradecanoylphorbol AcetateEthersCalcium IonophoresEgtazic AcidArachidonic AcidsFuransLeukotriene B4ValinomycinSRS-AArachidonic AcidAcrosomeKineticsPotassiumCells, CulturedArachidonate 5-LipoxygenaseHistamine ReleaseAnti-Bacterial AgentsSodiumNeutrophilsDiglyceridesProtein Kinase CN-Formylmethionine Leucyl-PhenylalanineArachidonate LipoxygenasesMagnesiumBlood PlateletsPlatelet Activating FactorPhospholipases A2Phospholipases ATrifluoperazineBiological TransportHydrogen-Ion ConcentrationVeratridineLeukotriene A4LanthanumSpermatozoaAminoquinolinesDose-Response Relationship, DrugAdenosine TriphosphateAcrosome ReactionLeukotrienesCytosolCell LineCell MembraneHydroxyeicosatetraenoic AcidsIon-Selective ElectrodesChelating AgentsZymosanThrombinEnzyme ActivationMast CellsPhosphatidylinositolsCyclic AMPCarbonyl Cyanide m-Chlorophenyl HydrazoneCytoplasmic GranulesMembrane PotentialsStimulation, ChemicalThapsigarginClioquinolChlortetracyclineGramicidinBucladesinePhospholipidsPhorbolsCarbonyl Cyanide p-TrifluoromethoxyphenylhydrazoneCell Membrane PermeabilityCarbacholSperm CapacitationPyransExocytosisPhorbol EstersRabbitsBiological Transport, ActiveRats, Inbred StrainsTime FactorsProstaglandins EPhospholipasesCattleCoccidiostatsEndothelium, VascularLipoxygenasep-Methoxy-N-methylphenethylamineEicosanoic AcidsTerpenesCarboxylic AcidsCations, DivalentBradykinin4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-aminePlatelet AggregationIndomethacinSuperoxidesLipoxygenase InhibitorsErythrocytesGlycerides
GABAGlucagon-like pepBenzodiazepineZinc ionophoreCalciumACE2Ghrelin receptorLaminin receptorInsulinNMDAValinomycinInhibitorsGABAAComplexSelectiveLigandsInducesMembraneBlockadeProteinMechanismSelectivityProteolyticExpressionBindingGenePropertiesActivationIncreasesHumanFunctionShowPresentTreatmentAlpha
GABA6
  • We also provide evidence that ethanol does not enhance [ 3 H]diazepam directly at the benzodiazepine binding site, but, rather, indirectly via the picrotoxinin-sensitive site of the benzodiazepine-GABA receptor-ionophore complex. (aspetjournals.org)
  • The resulting imbalance between the excitatory and inhibitory neurotransmission in the cerebral cortex is reflected by an increased duration of sleep when the animals receive a GABA receptor agonist. (jneurosci.org)
  • Anticonvulsant steroids and the GABA/benzodiazepine receptor-chloride ionophore complex. (nih.gov)
  • Other pesticides, the type-II pyrethroids and several organochlorines interact with the GABA receptor/ionophore complex. (cdc.gov)
  • Receptor-binding studies in vitro indicate that felbamate has weak inhibitory effects on GABA-receptor binding, benzodiazepine receptor binding, and is devoid of activity at the MK-801 receptor binding site of the NMDA receptor-ionophore complex. (pediatriconcall.com)
  • Interactions of pentamethylenetetrazole and tetrazole analogues with the picrotoxinin site of the benzodiazepine-GABA receptor-ionophore complex. (bvsalud.org)
Glucagon-like pep1
  • Vallöf D, Maccioni P, Colombo G, Mandrapa M, Jörnulf JW, Egecioglu E, Engel JA , Jerlhag E. The glucagon-like peptide 1 receptor agonist liraglutide attenuates the reinforcing properties of alcohol in rodents. (neurotree.org)
Benzodiazepine1
  • Alterations in the brain GABAA/benzodiazepine receptor-chloride ionophore complex in a genetic model of paroxysmal dystonia: a quantitative autoradiographic analysis. (yale.edu)
Zinc ionophore1
Calcium11
  • We developed a calcium signaling-based assay, using cultured human embryonic kidney cells (HEK), that evaluates simultaneously, the activation/desensitization or blockade of the proteinase-activated receptors, PAR 1 and PAR 2 . (aspetjournals.org)
  • We sought to extend the receptor-desensitization paradigm for use with a cultured cell system, in which an intracellular calcium signal rather than a contractile response might be used as an index of receptor activation. (aspetjournals.org)
  • To study the structural basis of pathological remodelling and altered calcium channel functional states in the heart, we sought to re-purpose high-affinity ligands of the cardiac calcium channel, the ryanodine receptor (RyR2), into super-resolution imaging probes. (whiterose.ac.uk)
  • In this study, we demonstrate that the cross-linking of cell surface high-affinity IgE-R on mast cells derived from mouse bone marrow cultured for 3 wk in the presence of WEHI-3-conditioned media acts as a highly sensitive physiologic stimulus for this attachment and that receptor activation is also induced by calcium ionophore A23187. (aai.org)
  • Adherence was inhibited by antibodies to laminin and laminin receptor and was calcium ion and temperature dependent. (aai.org)
  • Treatment of cells with dibutyryl cAMP, which activates protein kinase A, inhibited both adherence and histamine release induced by Ag or calcium ionophore. (aai.org)
  • Treatment of cells with staurosporin, which inhibits protein kinase C, also inhibited adherence and histamine release induced by calcium ionophore, but was not significantly active against either adherence or histamine release induced by Ag. (aai.org)
  • We have found that, although chronic TNF attenuates TCRζ expression and TCR-proximal signalling, IL-2 expression is suppressed regardless of whether cells are stimulated via the TCR, or with phorbol ester and calcium ionophore to activate the MAPK and NFAT pathways directly. (biomedcentral.com)
  • In a similar manner, oxygen-depletion prevented neuronal killing by the calcium ionophore, ionomycin. (umn.edu)
  • treatment of resting human B cells with phorbol ester, calcium ionophore and forskolin results in modest increases in cell surface levels of CD25. (gla.ac.uk)
  • However, initiation of a strong calcium signal by an ionophore only results the generation of EV devoid of any antibacterial or pro-inflammatory effect. (figshare.com)
ACE21
  • Indirect evidence also indicates that Zn2+ may decrease the activity of angiotensin‑converting enzyme 2 (ACE2), known to be the receptor for SARS‑CoV‑2. (spandidos-publications.com)
Ghrelin receptor2
  • Engel JA , Nylander I, Jerlhag E. A ghrelin receptor (GHS-R1A) antagonist attenuates the rewarding properties of morphine and increases opioid peptide levels in reward areas in mice. (neurotree.org)
  • Suchankova P, Engel JA , Jerlhag E. Sub-chronic Ghrelin Receptor Blockade Attenuates Alcohol- and Amphetamine-Induced Locomotor Stimulation in Mice. (neurotree.org)
Laminin receptor1
  • The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Insulin2
  • Manganese Acts upon Insulin/IGF Receptors to Phosphorylate AKT and Increase Glucose Uptake in Huntington's Disease Cells. (purdue.edu)
  • Protein kinase receptors (e.g. insulin). (surrey.ac.uk)
NMDA2
  • However, felbamate does interact as an antagonist at the strychnine-insensitive glycine recognition site of the NMDA receptor-ionophore complex. (pediatriconcall.com)
  • Toxicities caused by activation of NMDA, AMPA, or kainate receptors were each ameliorated by oxygen depletion. (umn.edu)
Valinomycin1
  • ensuring from the addition of sakacin A. The ionophore valinomycin was used at the end of these experiments (arrow 6) to completely dissipate ΔΨ (McAuliffe et al. (cdk-receptor.com)
Inhibitors1
GABAA2
  • Neuroactive steroid actions at the GABAA receptor. (nih.gov)
  • A putative receptor for neurosteroids on the GABAA receptor complex: the pharmacological properties and therapeutic potential of epalons. (nih.gov)
Complex3
  • Regional differences in neuroactive steroid modulation of the gamma-aminobutyric acidA receptor-chloride ionophore complex (GBRC), as measured by t-butylbicyclophosphoro[35S]thionate ([35S] TBPS) binding and 36Cl- uptake, were demonstrated in rat spinal cord versus frontal cortex. (aspetjournals.org)
  • Substances that do not act as agonists or antagonists but do affect the GAMMA-AMINOBUTYRIC ACID receptor-ionophore complex. (wakehealth.edu)
  • CD25 is the alpha chain of the multi- component interleukin-2 receptor complex and is a requirement for formation of high affinity interleukin-2 receptors. (gla.ac.uk)
Selective3
  • Solid-contact ion-selective electrodes with carbazole-derived ionophores were prepared. (abo.fi)
  • Identification of a selective manganese ionophore that enables nonlethal quantification of cellular manganese. (purdue.edu)
  • We show that selective stimulation of Mac-1 integrin (complement receptor 3) by specific ligands initiates the generation of EVs which are able to impair bacterial growth and to induce the secretion of the pro-inflammatory cytokine IL-8 (aEV). (figshare.com)
Ligands1
  • Furthermore, we reasoned that, provided receptor cross-desensitization did not occur, it would be advantageous to assess PAR-targeted ligands in a cell that expressed both receptors. (aspetjournals.org)
Induces1
  • Neonatal exposure to a Type-I pyrethroid (bioallethrin) induces dose-response changes in brain muscarinic receptors and behaviour in neonatal and adult mice. (cdc.gov)
Membrane4
  • Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
  • The potentiometric response characteristics (slope, detection limit, selectivity, and pH sensitivity) of sensors prepared with different membrane compositions (ionophore, ionophore concentration, anion exchanger concentration, and plasticizer) were evaluated. (abo.fi)
  • Overview of plasma membrane and soluble receptors. (surrey.ac.uk)
  • Influenza Hemagglutinin-Mediated Membrane Fusion: Influence of Receptor Binding on the Lag Phase Preceding Fusion. (biomedcentral.com)
Blockade1
  • Engel JA , Jerlhag E, Svensson L, Smith RG, Egecioglu E. Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates the NMDAR antagonist, phencyclidine-induced impairments in prepulse inhibition. (neurotree.org)
Protein3
  • Among these protein which show upregulation are a variety of channels and receptors. (asra.com)
  • G-protein coupled receptors (e.g. glucagon receptor). (surrey.ac.uk)
  • T-cell receptor (TCR)-induced IL-2 expression is suppressed at the level of mRNA and protein following chronic culture of T cells with tumour necrosis factor (TNF) at picomolar concentrations, an effect that is reversible upon removal of TNF. (biomedcentral.com)
Mechanism1
  • However, the mechanism of transient receptor potential melastatin 2 regulating bacterial killing remains unknown. (asahq.org)
Selectivity3
  • With both receptors present in the same cell, the selectivity or nonselectivity of a variety of compounds that would affect PAR 1 and/or PAR 2 could be efficiently evaluated in a single experiment. (aspetjournals.org)
  • The results show that for the macrocyclic ionophores, a larger cavity provided better selectivity. (abo.fi)
  • The selectivity, detection limit, and linear range were improved by choosing a suitable plasticizer and by reducing the ionophore and anion exchanger concentrations. (abo.fi)
Proteolytic1
  • An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)
Expression1
  • How does tumour necrosis factor uncouple T-cell receptor-induced IL-2 gene expression in murine T cells? (biomedcentral.com)
Binding1
Gene1
  • Suchankova P, Nilsson S, von der Pahlen B, Santtila P, Sandnabba K, Johansson A, Jern P , Engel JA , Jerlhag E. Genetic variation of the growth hormone secretagogue receptor gene is associated with alcohol use disorders identification test scores and smoking. (neurotree.org)
Properties2
  • Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
  • General properties of nuclear receptors. (surrey.ac.uk)
Activation2
  • Furthermore, we used this assay to develop a PAR 1 receptor-activating probe [Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH 2 (Cit-NH 2 )], which displays a high degree of specificity for PAR 1 over PAR 2 , and we used the assay to quantitate the ability of trypsin to disarm the activation of PAR 1 by thrombin. (aspetjournals.org)
  • The psychophysics of this state clearly emphasize that the pain is evoked by the activation of low threshold mechano-receptors (Aß afferents). (asra.com)
Increases1
  • In the absence of oxygen, glutamate evoked normal increases in [Ca 2+ ](i), indicating that glutamate receptors functioned normally. (umn.edu)
Human3
  • In contrast, thrombin receptor-activating peptides derived from the human PAR 1 receptor sequence (e.g. (aspetjournals.org)
  • The chemokine receptor CXCR4 is widely expressed in human cancers and regulates cell invasion, proliferation and survival. (cnr.it)
  • To give insight into the function of the mutant CXCR4 receptor, human A431, epidermoid carcinoma cells, were stably transfected with both mutant and wild type CXCR4. (cnr.it)
Function1
  • Peroxisome Proliferator Activated Receptors (PPAR's): Structure and function. (surrey.ac.uk)
Show1
  • Gamma-aminobutyric acidA receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. (aspetjournals.org)
Present2
  • The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
  • The extra accumulation of 22Na+ into dark-adapted retinas can be removed if the retinas are washed in darkness with low-Ca2+ Ringer's solutions, or if the ionophore gramicidin D is present in the perfusate. (escholarship.org)
Treatment1
  • This was prevented by treatment of the permeabilised cells with the ionophore FCCP, revealing a striated staining pattern in confocal imaging which had weak colocalisation with RyR2 clusters. (whiterose.ac.uk)
Alpha1
  • Clark JM, Annenkov AE, Panesar M, Isomäki P, Chernajovsky Y, Cope AP: T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha. (biomedcentral.com)