• Moreover in recent years these antigen receptor proteins have attracted attention in the field of cancer immunotherapy to elevate the patient's immune response against tumor cells with few side-effects [10 11 In cellular immunotherapy T cells recognizing tumor-associated antigens can be administrated back to patients after ex vivo culture and processing for immune response enhancement. (researchatlanta.org)
  • Statistical comparison of all inhibitory and activating killer cell immunoglobulin receptors (KIRs) between controls, survivors, and persons who died of Ebola virus disease in Guinea, 2015-2017. (cdc.gov)
  • Killer immunoglobulin-like receptors (KIRs) are involved in the regulation of natural killer cell cytotoxicity. (amsterdamumc.org)
  • HLA-C is a ligand of killer cell immunoglobulin receptors (KIRs) and is an essential regulator of natural killer cell activity, which is associated with endometriosis progression. (tmu.edu.tw)
  • Polymeric immunoglobulin receptor (pIgR) is a transmembrane protein that in humans is encoded by the PIGR gene. (wikipedia.org)
  • Interaction of IL-1 and TNF-α with their receptors ultimately lead to transcriptional activation of PIGR gene due to nuclear translocation of NF-kB. (wikipedia.org)
  • The gene has been cloned independently as ILT6 [ immunoglobulin-like transcript 6 ], LIR4 [ leukocyte immunoglobulin-like receptor 4 ], HM43 . (copewithcytokines.org)
  • You can now search immunoglobulin (Ig) nucleotide sequences against the Constant region (C) gene database (Figure 1) to determine the Ig isotypes including subtypes (IgM, IgG, IgA1, etc. (nih.gov)
  • Characterization of the receptor for the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), encoded by the gene TNFRSF13B ( tumor necrosis factor receptor superfamily member 13B), suggests that people with the C104, A181E, and ins204A variants may be at risk for IgAD that progresses to CVID. (medscape.com)
  • This gene encodes a receptor tyrosine kinase. (nih.gov)
  • IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. (jax.org)
  • The functional IL-36 receptor is a heterodimer containing interleukin-1 receptor-like 2 ( IL1RL2 ) as the ligand binding moeity and the IL-1 receptor accessory protein ( IL1RAP ). (guidetoimmunopharmacology.org)
  • Postendocytotic sorting of the ligand for the polymeric immunoglobulin receptor in Madin-Darby canine kidney cells. (silverchair.com)
  • Cells infected with herpes simplex virus type 1 (HSV-1) express a cell surface receptor able to bind to the Fc region of immunoglobulin G (IgG). (lu.se)
  • Configuration of immunoglobulin and T cell receptor beta and gamma genes in acute myeloid leukaemia: pitfalls in the analysis of 40 cases. (bmj.com)
  • Upstream and downstream sequences of immunoglobulin genes may affect the expression of such genes. (lu.se)
  • We have now established a new data pre-processing procedure to eliminate artifacts caused by a 5'-RACE library generation process, reanalyzed a previously studied data set defining human immunoglobulin heavy chain genes, and identified novel upstream regions, as well as previously identified upstream regions that may have been identified in error. (lu.se)
  • pIgR has a strong specificity to polymeric immunoglobulins and is not responsive to monomeric immunoglobulin. (wikipedia.org)
  • The process of transporting polymeric immunoglobulins from the basolateral to apical side, known as transcytosis, is composed of several distinct steps. (wikipedia.org)
  • The polymeric immunoglobulin receptor (pIg-R) is responsible for the receptor-mediated transcytosis of polymeric immunoglobulins (IgA and IgM) across various epithelia. (silverchair.com)
  • NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
  • NKp46 consists of two Ig-like domains assembled to leukocyte immunoglobulin-like (LIR) and killer inhibitory receptors (KIR). (thermofisher.com)
  • It is an Fc receptor which facilitates the transcytosis of the soluble polymeric isoforms of immunoglobulin A and immunoglobulin M (pIg) and immune complexes. (wikipedia.org)
  • Keith Mostov and colleagues found that secretory component was a proteolytic fragment of a transmembrane precursor, the pIgR, which led them to propose the currently accepted model Polymeric immunoglobulin receptor is responsible for transcytosis of soluble dimeric IgA, pentameric IgM, and immune complexes from the basolateral to the apical mucosal epithelial cell surface. (wikipedia.org)
  • Transcytosis is initiated by either the binding of dimeric IgA to the receptor or the phosphorylation of Ser-664 residue of the receptor. (wikipedia.org)
  • The neonatal Fc receptor (FcRn) mediates the transcytosis of maternal immunoglobulin G (IgG) across fetal and/or neonatal tissues for the acquisition of passive immunity. (rcsb.org)
  • dblp: IMGT/LIGM-DB, the IMGT ® comprehensive database of immunoglobulin and T cell receptor nucleotide sequences. (dagstuhl.de)
  • The extracellular portion of the protein contains 6 domains: 5 evolutionary conserved immunoglobulin-like domains, and 1 non-homologous domain, which is involved in proteolytic cleavage of pIg-pIgR complex from the apical side of the IECs. (wikipedia.org)
  • 2. Bulut Y, Faure E, Thomas L, Equils O, Arditi M. (2001) Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. (guidetopharmacology.org)
  • These data indicate that the HSV Fc receptor requires both the C gamma 2 and C gamma 3 domains for interaction with the IgG molecule analogous to the known interaction of protein A of Staphylococcus aureus, the Fc binding proteins of Group A, C and G streptococci, and certain human rheumatoid factors. (lu.se)
  • The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. (nih.gov)
  • History Immunoglobulin (IG or antibody) as well as the T-cell receptor TH-302 (TR) are pivotal protein in the disease fighting capability of higher microorganisms. (researchatlanta.org)
  • MybiosourceProduct Short Name: [G-Protein Coupled Receptor 126 (GPR126)]Product Name Synonyme: [G-Protein Coupled Receptor. (biocheminfo.org)
  • Polymeric immunoglobulin receptor (pIgR) is essential for the proper functioning of the mucosal immune system. (sandiego.edu)
  • Anti-TLR-IgA are chimeric monoclonal antibodies specific for Toll-like receptor. (invivogen.com)
  • IgA-deficient patients with immunoglobulin E (IgE)-class anti-IgA antibodies are at risk for anaphylaxis if they receive blood or intravenous immunoglobulin, but this situation is extremely rare. (medscape.com)
  • We've released a new version (1.16.0) of IgBLAST , the popular NCBI package for classifying and analyzing immunoglobulin (IG) and T cell receptor (TCR) variable domain sequences. (nih.gov)
  • However, these sequences are rarely studied or characterized in most studies of immunoglobulin repertoires. (lu.se)
  • Inference from large, rearranged immunoglobulin transcriptome data sets offers an opportunity to define the upstream regions (5'-untranslated regions and leader sequences). (lu.se)
  • Within the V regions, hypervariable regions determine the specificity of the immunoglobulin (Ig). (msdmanuals.com)
  • The analysis of the human high affinity IgE receptor Fc epsilon Ri alpha from multiple crystal forms. (expasy.org)
  • Selective immunoglobulin A deficiency (SIgAD) is a primary immunodeficiency disease and is the most common of the primary antibody deficiencies. (medscape.com)
  • Available residual clinical serum specimens were collected from prior SARS-CoV-2 infection, serum antibody levels (anti-spike fully vaccinated hospitalized control patients at all sites and tested immunoglobulin G [IgG] and anti-receptor binding domain at CDC. (cdc.gov)
  • For instance trastuzumab (trade name Herceptin) a humanized antibody that targets the human epidermal growth factor receptor. (researchatlanta.org)
  • The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface. (genebiosystems.com)
  • Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
  • However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
  • On days 8 and 16 of life the morphometry, intestinal architecture, and cytokine release, mesenteric lymph nodes cell composition, plasma immunoglobulin concentrations, fecal microbiota composition, cecal short-chain fatty acids content, and the urinary metabolic profile were assessed. (frontiersin.org)
  • NKp46 (CD335, NCR1, ) is a cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. (thermofisher.com)
  • Intravenous immunoglobulin (IVIg) is used to prevent infection before BMT and, in selected patients, after BMT, if B-cell function remains poor. (medscape.com)
  • The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
  • Large animal confinement farm ing exposures produce a wide spectrum of upper and lower respiratory tract diseases due to the complex diversity of organic dust, particulates, microbial cell wall components, and gases and resultant activation of various innate immune receptor signaling pathways. (cdc.gov)
  • The B-cell receptor consists of an Ig molecule anchored to the cell's surface. (msdmanuals.com)
  • The composition of the receptor is complex, including 6 immunoglobulin-like domains, a transmembrane region, and an intracellular domain. (wikipedia.org)
  • The quite long intracellular domain of the receptor, along with the transmembrane region, is responsible for the transduction of highly conserved signals. (wikipedia.org)
  • Cleavage occurs at the junction of the transmembrane region of the receptor and domain 5. (wikipedia.org)
  • Predicted to enable transmembrane signaling receptor activity. (nih.gov)
  • Individuals with such an unusual profile should receive only low IgA intravenous immunoglobulin preparations. (medscape.com)
  • Background Discussion between immunoglobulin-like receptor glycoprotein VI (GPVI) and collagen plays a central role in platelet activation and sequent firm adhesion. (ap26113.com)
  • Contains 3 Immunoglobulin-like C2-type domains. (lu.se)
  • The MHC class I-related receptor, FcRn, is involved in binding and transporting immunoglobulin G (IgG) within and across cells. (nih.gov)
  • 2014). Human NK cells: From surface receptors to the therapy of leukemias and solid tumors. (springer.com)
  • It is metabolized so one iodine atom is removed to produce T3 - about 10 times as active as T4 in binding to a receptor that exerts the action as receptor to the thyroid hormone. (cdc.gov)
  • Adaptive Immune Receptor Repertoire (AIRR) format is more consistent with AIRR specs including changing undefined type (NON, N/A) to empty string, not appending "reversed" to sequence identifier when the query is in reversed orientation, and using standard locus names such as IGH, TRB instead of traditional VH, VB etc. (nih.gov)
  • Toll-like receptors (TLR) and nucleotide oligomerization domain (NOD)-like innate immune pathways respond to these exposures. (cdc.gov)
  • These observations suggest that there is another receptor for the myelin-associated proteins. (jneurosci.org)
  • T3 binds to the nuclear receptor (TR) and combines with another receptor (RXR) then combines with a receptor element on DNA. (cdc.gov)
  • 3. Garlanda C, Di Liberto D, Vecchi A, La Manna MP, Buracchi C, Caccamo N, Salerno A, Dieli F, Mantovani A. (2007) Damping excessive inflammation and tissue damage in Mycobacterium tuberculosis infection by Toll IL-1 receptor 8/single Ig IL-1-related receptor, a negative regulator of IL-1/TLR signaling. (guidetopharmacology.org)
  • and positive regulation of immunoglobulin production in mucosal tissue. (nih.gov)
  • Immunoglobulin-like family of IL-1 receptors: Interleukin-36 receptor. (guidetoimmunopharmacology.org)
  • This study aimed to elucidate the relationship between local and systemic inflammation in smoking-induced COPD by assessing levels of soluble (s) tumor necrosis factor (TNF) receptors, TNF-alpha, and interleukin-8 (IL-8) in induced sputum and in plasma. (nih.gov)
  • Based on a wealth of validating preclinical studies, we contend that the favorable metabolic effects of mineralocorticoid receptor antagonists, such as spironolactone, support their inclusion in novel immunosuppressive strategies to inhibit new onset type II diabetic symptoms in post-transplantation patient populations. (medscimonit.com)
  • There is lower prevalence of immunoglobulin (Ig) E-mediated asthma and atopy in farm ers and their children, but organic dust worsens existing asthma. (cdc.gov)
  • When comparing sTNF receptors in sputum and plasma, no direct correlations were found despite elevation of circulating sTNF-R75 levels in patients with COPD. (nih.gov)
  • Ils ont été répartis en deux groupes : 12 patients souffrant d'une thrombocytopénie à médiation immunitaire (groupe 1) et 12 patients atteints d'une thrombocytopénie à médiation non immunitaire (groupe 2). (who.int)
  • They have been selected for there ability to efficiently neutralize Toll-like receptor activation. (invivogen.com)
  • Activation by these agonists is opposed by the IL-36 receptor antagonist (IL-36RA) cytokine. (guidetoimmunopharmacology.org)
  • 2004) Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. (guidetopharmacology.org)