Receptor identification nuclear localization signals. Medical search. Frequent questions

Both receptors belong to the TAM (TYRO3, AXL and MER - MER proto-oncogene, tyrosine kinase) receptor tyrosine kinase family, which emerged as new potential targets in many oncological diseases, from leukaemia to solid tumours ( Graham et al, 2014 ). (nature.com)
Brand TM, Iida M, Luthar N, Wleklinski MJ, Starr MM, Wheeler DL (2013) Mapping C-Terminal Transactivation Domains of the Nuclear HER Family Receptor Tyrosine Kinase HER3. (plos.org)
This process leads to the activation of each receptors' tyrosine kinase and the subsequent phosphorylation of tyrosine residues located on their C-terminal tails. (plos.org)
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. (caslab.com)
PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
it is a membrane receptor with a tyrosine kinase component. (medscape.com)

Subcellular localization critically influences protein function, and cells control protein localization to regulate biological processes. (elifesciences.org)
Protein function is critically determined by subcellular localization, as organelles offer different chemical environments and interaction partners. (elifesciences.org)
In order to regulate protein activity, many biological processes involve changes in protein subcellular localization. (elifesciences.org)
Interestingly, analysis of MIER1α subcellular localization in breast samples revealed a stepwise shift from the nucleus to the cytoplasm during progression to invasive carcinoma. (mun.ca)
Results In this study, we demonstrate that treatment of MCF7 breast carcinoma cells with either insulin or insulin-like growth factor affects the subcellular localization of MIER1α. (mun.ca)
By employing proteomic and cell-based approaches, we have determined that each FAM83 member has unique interacting partners and subcellular localization profile, suggesting specific cellular roles. (dundee.ac.uk)
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. (cipsm.de)

Membrane-bound HER receptors activate numerous tumor promoting signaling cascades via this mechanism, including the PI3K/AKT, Ras/Raf/Mek/Erk, PLCγ/PKC, and signal transducer and activator of transcription (STAT) pathways [1] , [2] . (plos.org)
We also molecularly defined the development of Sertoli, Leydig and peritubular myoid cells during the perinatal period, allowing us to identify candidate signaling pathways acting between somatic and germ cells in a stage-specific manner during the perinatal period. (biologists.com)
The apoptosis was transduced by multiple signaling pathways mediated by FasL and TNFR2 and mainly activated the mitochondrial control of apoptosis via Bid and Bim, which was rescued by silencing Bid or/and Bim . (biomedcentral.com)
CD8+ NKG2D+ T cells promote the inflammation of hair follicles through interferon-γ (IFN-γ) and interleukin-15 (IL-15) signaling pathways, which consequently activate Janus kinase (JAK)/signal transducer and activator of transcription (STAT) molecular pathways. (drugbank.com)
DYRK1B inhibits the Sonic Hedgehog and WNT pathways, increasing the expression of master adipogenic transcription factors CCAAT/enhancer binding protein (C/EBP-alpha) and peroxisome proliferator-activated receptor gamma (PPAR-gamma) [ 2 ]. (biomedcentral.com)
Transforming Growth Factor β (TGFβ), Bone Morphogenetic Protein (BMP) and Wnt signalling pathways. (dundee.ac.uk)

However, BF + GCV only induced apoptosis via Fas/FasL signal pathway accompanied with increased P53 expression. (biomedcentral.com)
Building on the identification of OTUB1 as a player in the TGFβ pathway (Herhaus et al, 2013) , we want to establish the molecular basis through which OTUB1 is recruited to the active phospho-SMAD2/3 complex. (dundee.ac.uk)
This pathway can be potentiated by R-spondins, a family of proteins that bind RNF43/ZNRF3 E3 ubiquitin ligases and LGR4/5 receptors to prevent Frizzled degradation. (xenbase.org)
Discussion at the Vancouver meeting spanned several areas of research, including signaling pathway activation of EMT and the transcription factors and gene targets involved. (rupress.org)
Downregulation of Herg1 suppresses osteosarcoma proliferation and invasion by targeting Hippo signaling pathway]. (cancerindex.org)

Fig. 1: Cellular sources, target cells, signalling and downstream effects of IL-12. (nature.com)
Also acts downstream of some G-protein coupled receptors. (caslab.com)
Moreover, KPNA2 mediated the nuclear translocation of CREB3L1, thus allowing it to activate downstream ECM signaling. (biomedcentral.com)
From this, we have identified a handful of novel kinases that appear to either inhibit or activate TGFβ and BMP signalling, downstream of SMAD phosphorylation. (dundee.ac.uk)

Rev-Erb alpha (Rev-Erbɑ), also known as nuclear receptor subfamily 1 group D member 1 (NR1D1), is one of two Rev-Erb proteins in the nuclear receptor (NR) family of intracellular transcription factors. (wikipedia.org)
These three domains are a common feature of nuclear receptor proteins. (wikipedia.org)
The Rev-Erb proteins are unique from other nuclear receptors in that they do not have a helix in the C-terminal that is necessary for coactivator recruitment and activation by nuclear receptors via their LBD. (wikipedia.org)
Subsequently, by using independent RNAi/ dominant negative forms, it was shown that Ecdysone Receptor (EcR) is essential for male fertility due to its requirement in the normal development of accessory glands in Drosophila: EcR depleted glands fail to make seminal proteins and have dying cells. (sdbonline.org)
RGS proteins are GTPase-activating proteins for certain Gα subunits, accelerating the shutoff mechanism of G protein signaling, and also may interact with receptors and effectors to modulate G protein signaling. (elsevierpure.com)
Confocal microscopy and subcellular fractionation of COS-7 cells expressing RGS12 proteins with three different N termini (brain (B), peripheral (P), and trans-spliced (TS)) and a shared short (S) C-terminal domain demonstrated exclusive nuclear localization of these proteins and an influence of the N-terminal region on the pattern of intranuclear distribution. (elsevierpure.com)
Both native RGS12TS-S in HEK-293T cells and ectopically expressed RGS12TS-S localized to discrete nuclear foci (dots), a characteristic of various tumor suppressor proteins. (elsevierpure.com)
We initially used maps statically to generate a database with localization and absolute copy number information for over 8700 proteins from HeLa cells, approaching comprehensive coverage. (elifesciences.org)
Availability of complete genome sequences from soybean and common bean allowed us to perform a genome-wide identification and analysis of the Toll interleukin-1 receptor-like nucleotide-binding site leucine-rich repeat (TNL) proteins. (sdstate.edu)
Biological Function Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. (qedbio.com)
Most of the Hsp90-regulated proteins are involved in cell signaling and include the kinases, v-Src, Wee1, c-Raf, transcriptional regulators such as p53 and steroid receptors, and the polymerases of hepatitis B virus and telomerase. (qedbio.com)
Nuclear proteins are actively and posttranslationally transported across the nuclear envelope. (unibas.ch)
Receptor-binding is mediated by nuclear localization signals that have been identified in many nuclear proteins. (unibas.ch)
INTRODUCTION: Proteins that undergo receptor-mediated endocytosis are subject to lysosomal degradation, requiring radioiodination methods that minimize loss of radioactivity from tumor cells after this process occurs. (duke.edu)
Reversible phosphorylation of nuclear proteins is required for both DNA replication and entry into mitosis. (duke.edu)
Due to their positive charge, polyamines can interact with nucleic acids and proteins and regulate specific ion channels, thereby exerting wide-ranging effects on transcription, translation, RNA and protein stability and cell signaling (10). (ubatubasat.com)

One of the genes encoded a protein that was highly similar to chicken thyroid hormone receptor, and the other, which they termed ear-1, would later be described as Rev-Erbɑ. (wikipedia.org)
As such, NR1D1 is functionally related to other nuclear receptor genes, such as peroxisome proliferator activated receptor delta (PPARD) and retinoic acid receptor alpha (RARA). (wikipedia.org)
Predictive identification of exonic splicing enhancers in human genes. (xenbase.org)
Ecdysone-regulated genes are bound by a heterodimer of Ecdysone receptor (EcR) and Ultraspiracle . (sdbonline.org)
Hidden Markov model (HMM) profiling of all protein sequences resulted in the identification of 117 and 77 regular TNL genes in soybean and common bean, respectively. (sdstate.edu)
We identified three undifferentiated SG subsets at postnatal day 7, each of which expresses distinct genes, including transcription factor and signaling genes. (biologists.com)
There is no longer a need for signals to activate these genes. (cancerquest.org)
Many of these genes are responsible for providing the positive signals that lead to cell division. (cancerquest.org)
The identification of carriers of pathogenic variants in genes such as DYRK1B could be useful for establishing early diagnostic strategies and medical interventions in a reasonable number of affected individuals even before symptoms or complications appear. (biomedcentral.com)

Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. (caslab.com)
In vitro , ritlecitinib inhibits cytokine-induced STAT phosphorylation mediated by JAK3-dependent receptors and the signaling of immune receptors dependent on TEC kinase family members. (drugbank.com)
Rspo2 inhibits TCF3 phosphorylation to antagonize Wnt signaling during vertebrate anteroposterior axis specification. (xenbase.org)
These observations suggest that Rspo2 is a context-specific regulator of TCF3 phosphorylation and Wnt signaling. (xenbase.org)

In the cytoplasm, plays a pivotal role in Signal Transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily including the receptors for growth hormone (GHR) , prolactin (PRLR) , leptin (LEPR) , erythropoietin (EPOR) , granulocyte-macrophage colony-stimulating factor (CSF2) , thrombopoietin (THPO) and multiple interleukins. (caslab.com)
The pharmacology and classification of the nuclear receptor superfamily: thyroid hormone receptors. (guidetopharmacology.org)

Also involved in promoting the localization of EPOR to the plasma membrane. (caslab.com)

The NR1D1 (nuclear receptor subfamily 1 group D member 1) gene, located on chromosome 17, encodes the protein REV-ERBɑ in humans. (wikipedia.org)

Nuclear localized HER family receptor tyrosine kinases (RTKs) have been observed in primary tumor specimens and cancer cell lines for nearly two decades. (plos.org)
These results demonstrate that CREB3L1 maintains the CAF - like property of ATC cells by activating the ECM signaling, which remodels the tumor stromal microenvironment and drives the malignancy of ATC. (biomedcentral.com)
Gastric gastrointestinal stromal tumor (GIST) en face. (medscape.com)

The ErbB/HER family of receptor tyrosine kinases (RTKs) consists of four family members: the epidermal growth factor receptor (EGFR/ErbB1), HER2 (ErbB2/Neu), HER3 (ErbB3), and HER4 (ErbB4). (plos.org)
HER2/neu (also called ERB B2 ) is the gene that encodes the human epidermal growth factor receptor type 2. (cancerquest.org)

According to the bimodal switch model, steroid hormone receptors recruit corepressors in the absence of hormone and coactivators in its presence. (sdbonline.org)

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor. (xenbase.org)
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. (nih.gov)

Phosphorylated tyrosine residues recruit various intracellular adaptor and effector molecules that result in the propagation of growth promoting signal transduction cascades [1] , [2] . (plos.org)
MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

First, an RNAi screen was carried out involving 19 hormone receptors, individually and specifically, in a male reproductive tissue (accessory gland) for their requirement in Drosophila male fertility. (sdbonline.org)
Bernal J. (2007) Thyroid hormone receptors in brain development and function. (guidetopharmacology.org)
2009) Nongenomic activation of phosphatidylinositol 3-kinase signaling by thyroid hormone receptors. (guidetopharmacology.org)

This study examined the roles of hormone-dependent transcription factors (Nuclear Receptors), in accessory gland development, function and male fertility of a genetically tractable insect model, Drosophila melanogaster. (sdbonline.org)

Liu YY, Brent GA. (2010) Thyroid hormone crosstalk with nuclear receptor signaling in metabolic regulation. (guidetopharmacology.org)

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. (nature.com)
It has been suggested that the dual activity of ritlecitinib toward JAK3 and the TEC kinase family block cytokine signaling as well as the cytolytic activity of T cells, both implicated in the pathogenesis of alopecia areata. (drugbank.com)

Similar to the gene in rats, they found that human Rev-Erbɑ was transcribed from the strand opposite human thyroid hormone receptor alpha (THRA, c-erbAα). (wikipedia.org)
It is transcribed from the opposite strand of the human thyroid hormone receptor alpha (THRA, c-erbAα) so that NR1D1 and THRA cDNA are complementary on 269 bases. (wikipedia.org)
Grover GJ, Mellström K, Malm J. (2007) Therapeutic potential for thyroid hormone receptor-beta selective agonists for treating obesity, hyperlipidemia and diabetes. (guidetopharmacology.org)

Genome-wide association studies have linked the overexpression of UL16-binding protein 3 (ULBP3), a protein that binds to natural killer cell receptors, to the pathogenesis of alopecia areata. (drugbank.com)

In eukaryotic cells the genetic material is surrounded by a membrane system called the nuclear envelope (NE). (brookes.ac.uk)
The Nuclear Envelope is a hallmark of eukaryotic cells. (brookes.ac.uk)

Localization: Cytoplasm. (qedbio.com)
These receptors, which include Toll-like receptors, are portion of an internal sponsor defense Paroxetine HCl realizing nucleic acids aberrantly present in the cytoplasm from illness or cell stress. (columbiagypsy.net)
The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. (nih.gov)

2011) Minireview: cracking the metabolic code for thyroid hormone signaling. (guidetopharmacology.org)
The identification of novel metabolic targets of mTORC1 hyperactivity may improve our general understanding of TSC biology and its inherent variability. (ubatubasat.com)

Background MIER1α is a transcriptional regulator that interacts with estrogen receptor α and inhibits estrogen-stimulated growth of breast carcinoma cells. (mun.ca)

Instead, Rev-Erbα interacts via its LBD with Nuclear Receptor Co-Repressor (NCoR) and another closely related co-repressor Silencing Mediator of Retinoid and Thyroid Receptors (SMRT), although the interaction with NCoR is stronger due to its structural compatibility. (wikipedia.org)
Once activated by a ligand, the receptor acts as a transcription factor either as a monomer, homodimer or heterodimer with members of the retinoid X receptor family. (guidetopharmacology.org)

In addition to its role in BMP signalling, our findings indicate that PAWS1 controls transcription, cell proliferation and migration and regulates embryogenesis. (dundee.ac.uk)

The TAM receptor and ligand expression was evaluated in LMS cell lines and 358 sarcoma samples by either gene expression or immunohistochemistry. (nature.com)
Subnuclear localization of RGS12TS-S into nuclear dots was cell cycle-dependent. (elsevierpure.com)
Classically, HER family members function from the cell surface, where binding to cognate ligands can induce receptor homo- or hetero-dimerization with other HER family receptors [3] . (plos.org)
Conclusions Our data demonstrate that insulin and IGF-1 can contribute to loss of nuclear MIER1α in the MCF7 breast carcinoma cell line. (mun.ca)
Single - cell RNA-sequencing analysis revealed that CREB3L1 expression gradually increased during the neoplastic progression of a thyroid follicular epithelial cell to an ATC cell, accompanied by the activation of the extracellular matrix (ECM) signaling. (biomedcentral.com)
2010) Mini-review: Cell surface receptor for thyroid hormone and nongenomic regulation of ion fluxes in excitable cells. (guidetopharmacology.org)
Also covered in detail was the basic cell biology of EMT and its role in cancer and fibrosis, as well as the identification of new markers to facilitate the observation of EMT in vivo. (rupress.org)
Wnt/β-catenin signaling acts cell-autonomously to promote cardiomyocyte regeneration in the zebrafish heart. (uni-ulm.de)
Spindle cell GISTs are characterized by nuclear palisading or prominent perinuclear vacuolization pattern. (medscape.com)

The NR1D1 promoter itself contains a REV-ERB response element (RevRE), which allows for regulation of gene expression both through autoregulation and regulation by retinoic acid receptor-related orphan receptor alpha (RORɑ), another nuclear receptor transcription factor. (wikipedia.org)
A cardiomelic developmental field has also been postulated to relate the genetic heterogeneity of HOS (and other similar syndromes) to a cascade of molecules, including the brachyury, sonic hedgehog, bone morphogenetic protein, retinoic acid receptor, and transforming growth factor beta families. (medscape.com)

Notably, the separate overexpression of EcR-B1 or a transforming growth factor- β receptor Baboon , whose activation can upregulate the EcR-B1 expression, in MB neurons rescued the miR-34 -induced gamma axon pruning phenotype. (sdbonline.org)

This transport is a highly selective process that can be divided into two steps, receptor-binding followed by translocation through the nuclear envelope. (unibas.ch)

ANA production can precede symptoms and indications of disease by 5 or more years, with more complete serological evaluation demonstrating increasing creation of antibodies to nuclear antigens such as for example DNA, Sm, RNP, Ro, and La.4 This stage of disease could be known as preautoimmunity because symptomatology isn't manifest. (columbiagypsy.net)

This study identifies a non-canonical EcR-corepressor complex with the potential for a direct regulation of ATP-dependent nucleosome remodelling by a nuclear hormone receptor. (sdbonline.org)
Next, we identified full-length nuclear HER3 association and regulation of a 122 bp region of the cyclin D1 promoter. (plos.org)

Upon their secretion by antigen-presenting cells, they exert both pro-inflammatory and anti-inflammatory receptor-mediated effects. (nature.com)

NIpredict is a method to predict nuclear import activity based on characterization of NLS-import receptor interaction using molecular interaction energy components (MIECs). (mybiosoftware.com)

Computational identification of post-translational modification-based nuclear import regulations by characterizing nuclear localization signal-import receptor interaction. (mybiosoftware.com)
The role of SUN3 in the ER is reinforced by the identification of a protein interaction between SUN3 and the ER membrane-bound transcription factor maMYB. (brookes.ac.uk)

Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. (nih.gov)
Having established PAWS1 as the first non-SMAD substrate of type I BMP receptor (Vogt et al, 2014) , we want to explore whether there are other non-SMAD targets of type I TGFβ and BMP receptors. (dundee.ac.uk)

However, the regions of each receptor that confer transcriptional potential remain poorly defined. (plos.org)
To understand how the B 1 and B 2 regions influenced the transcriptional functions of nuclear HER3, we performed cyclin D1 promoter-luciferase assays in which HER3 deleted of the B 1 and B 2 regions was severely hindered in regulating this promoter. (plos.org)
While the classical membrane-bound functions of HER family RTKs have been extensively studied, accumulating data suggest that these receptors can be found in the cell's nucleus where they can function as co-transcriptional activators [4] , [5] . (plos.org)

Efficient generation of embryonic stem cells from single blastomeres of cryopreserved mouse embryos in the presence of signalling modulators. (axonmedchem.com)

Translocation is energy-dependent and occurs through the nuclear pore complex. (unibas.ch)

We want to pursue functional tests on these kinases to establish how they regulate TGFβ and BMP signalling and whether these can target pathologies associated with TGFβ and BMP. (dundee.ac.uk)

My research focuses on the nuclear envelope in plants. (brookes.ac.uk)
Previous higher plant studies have associated them with functions at the nuclear envelope and the endoplasmic reticulum (ER). (brookes.ac.uk)
This Frontiers Research Topic aims to highlight recent advances made to examine the role of the nuclear envelope (NE) as the "key border" in plants. (brookes.ac.uk)

inhibitors and assessing the efficacy of in TGFβ/BMP signalling. (dundee.ac.uk)

Journal Article] Compositionally distinct nuclear pore complexes of functionally distinct dimorphic nuclei in ciliate Tetrahymena. (nii.ac.jp)

Pramfalk C, Pedrelli M, Parini P. (2011) Role of thyroid receptor β in lipid metabolism. (guidetopharmacology.org)

Apoptotic signaling is initiated either through extrinsic or intrinsic stimulation, resulting in the activation of caspases [ 12 ]. (biomedcentral.com)

Previously, we demonstrated that MIER1α is nuclear in MCF7 cells yet it does not contain a nuclear localization signal. (mun.ca)
Both factors reduce the percentage of cells with nuclear MIER1α from 81 and 89 to 41 and 56 %, respectively. (mun.ca)
In normal cells, both internal and external signals control the activity of the oncogenes. (cancerquest.org)
What this means for cells is that they divide continuously even in the absence of any signals telling them to divide. (cancerquest.org)
This receptor is found in moderate levels on some normal cells and as the gene's name implies, it is involved in cellular responses to growth factors. (cancerquest.org)

Unbiased identification of Angiogenin as an endogenous antimicrobial peptide with activity against virulent Mycobacterium tuberculosis. (uni-ulm.de)

Anatomy26

Organisms20

Chemicals and Drugs99

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes65

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science3

Tyrosine kinase6

Subcellular localization7

Pathways6

Pathway5

Downstream4

Proteins16

Genes9

Phosphorylation4

Superfamily2

Plasma membrane1

Subfamily 1 group1

Tumor3

Epidermal growth f2

Steroid hormone r1

Importin-alpha subunit2

Transduction2

Hormone receptors3

Examined the roles1

Crosstalk1

Cytokine2

Thyroid hormone3

Binds1

Eukaryotic cells2

Cytoplasm3

Metabolic2

Estrogen receptor1

Retinoid2

Proliferation1

Cell9

Retinoic2

Overexpression1

Selective1

Antibodies1

Regulation2

Inflammatory1

Characterization1

Interaction2

Substrate2

Transcriptional3

Embryos1

Pore complex1

Regulate1

Envelope3

Inhibitors1

Functionally1

Lipid1

Activation1

Cells5

Activity1