• Despite lower co-stimulatory molecule expression, ProGP-4-generated Class II+/CD11c+ cells stimulated proliferation of allogeneic T cells and an antigen-specific T cell hybridoma as efficiently as bone marrow derived dendritic cells from untreated mice. (medscimonit.com)
  • Adoptive cell therapy (ACT) with chimeric antigen receptor T (CAR-T) cells can restore the activity of exhausted T cell through reprogramming and is widely used in the treatment of relapsed/refractory (r/r) hematological malignancies. (hindawi.com)
  • The most active T cell endogenous inhibitory pathway is the immunoglobulin superfamily such as CD28/cytotoxic T lymphocyte antigen-4 (CTLA-4): B7-1/B7-2 receptor/ligand grouping, which plays a central role in coordinating immune responses [ 7 , 8 ]. (hindawi.com)
  • The G-CSF receptors belong to a family of cytokine receptors known as the hematopoietin receptor family. (wikipedia.org)
  • Granulocyte colony-stimulating factor (G-CSF) is a hematopoietic growth factor that is widely used to treat neutropenia. (elsevierpure.com)
  • Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. (rndsystems.com)
  • Because G-CSF receptor (G-CSFR)-deficient mice do not have the expected neutrophilia after administration of human interleukin- 8 (IL-8), we examined the effect of the loss of G-CSFR on IL-8-stimulated PMN function. (elsevierpure.com)
  • RESULTS: Administration of this dual receptor agonist to mice resulted in dose-dependent increases in the numbers of total white blood cells and Class II+/CD11c+ cells in spleen and peripheral blood. (medscimonit.com)
  • However, from the beginning of puberty after thymus degeneration, human cytomegalovirus (HCMV) persists due to the chronic activation of cytomegalovirus in humans causing repeated activation of T cells, which is considered the driving factor of human immune aging [ 9 ]. (hindawi.com)
  • The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. (wikipedia.org)
  • GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. (wikipedia.org)
  • Impact of beta and gamma variants on ligand-binding properties of gamma-aminobutyric acid type A receptors. (aspetjournals.org)
  • A carboxyl-terminally truncated mutant and nonglycosylated A2a adenosine receptors retain ligand binding. (aspetjournals.org)
  • These data provide the first evidence for ligand-dependent proteasomal degradation of the betac cytoplasmic domain, and they establish a novel mechanism for heterotypic desensitization of shared cytokine receptor signaling. (tamu.edu)
  • Binding of G-CSF to its receptor induces dimerization or oligomerization of the receptor activating cytoplasmic tyrosine kinases. (rndsystems.com)
  • COVID-19 is caused by SARS-CoV-2, which primarily targets angiotensin converting enzyme-2 (ACE2) receptors on cells of the respiratory system and induces an immediate immunological cascade of cytokine responses that affect the individual cells and vascular system. (racgp.org.au)
  • Release of tissue factor, Von Willebrand factor, that in turn induces hypercoagulation and prothrombotic state. (racgp.org.au)
  • Herein, we demonstrate that agonistic ligation of these receptor subunits rapidly induces proteasomal degradation of the betac, but not the Ralpha, cytoplasmic domain, resulting in termination of signal transduction and yielding a truncated betac isoform ligated to the Ralpha subunit. (tamu.edu)
  • Restoration aims to reverse the degeneration of thymus by the combination of bioengineered thymus organoids and growth-promoting factors or cytokines such as IL-21, which may restore and stabilize the thymus environment. (hindawi.com)
  • We studied the changes in actin state and chemotactic peptide receptor expression in granulocytes from patients receiving different cytokines following high dose chemotherapy and autologous bone marrow transplantation (ABMT). (duke.edu)
  • Release of pathogen-associated molecular patterns due to the viral infection and activation of transcription factors such as nuclear factor kappa B, NOD-like receptor protein 3 inflammasome via pattern recognition receptors and ongoing production of cytokines at the entry sites. (racgp.org.au)
  • The receptors for these three cytokines consist of a cytokine-specific alpha (Ralpha) chain and a shared common beta (betac) chain. (tamu.edu)
  • The defective chemotactic response to IL-8 does not appear to be due to impaired chemoattractant receptor function, as the number of IL-8 receptors and chemoattractant-induced calcium influx, actin polymerization, and release of gelatinase B were comparable to those of wild- type PMNs. (elsevierpure.com)
  • Therefore, the present study aimed to evaluate the influence of HMB on the chemotactic activity (MIGRATEST® kit), phagocytic activity (PHAGOTEST® kit) and oxidative burst (BURSTTEST® kit) of monocytes and granulocytes in the peripheral blood of calves by flow cytometry. (researchsquare.com)
  • Results An analysis of granulocyte and monocyte chemotactic activity and phagocytic activity revealed significantly higher levels of phagocytic activity in calves administered HMB than in the control group, expressed in terms of the percentage of phagocytising cells and mean fluorescence intensity (MFI). (researchsquare.com)
  • Scholars@Duke publication: Changes in actin state and chemotactic peptide receptor expression in granulocytes during cytokine administration after autologous bone marrow transplantation. (duke.edu)
  • Although the basal level of F-actin was high following ABMT, granulocytes from all patients showed an additional increase in F-actin content after stimulation with either the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) or phorbol myristate acetate (PMA). (duke.edu)
  • The chemotactic peptide receptor expression was significantly higher in patients treated with ABMT alone or ABMT plus G-CSF. (duke.edu)
  • Characterization of dendritic cells generated in vivo by an E. coli derived chimeric dual receptor agonist. (medscimonit.com)
  • BACKGROUND: Progenipoietin-4 (ProGP-4) is an E. coli derived chimeric growth factor that activates the human Flt3 and G-CSF receptors. (medscimonit.com)
  • E. coli derived chimeric receptor agonists such as ProGP-4 may enable further investigations of immunotherapeutic approaches to the treatment of diseases such as cancer and autoimmunity. (medscimonit.com)
  • Over 500 products have been investigated for neuroprotective effects including those from the categories of free radical scavengers, anti-excitotoxic agents, apoptosis (programmed cell death) inhibitors, anti-inflammatory agents, neurotrophic factors, metal ion chelators, ion channel modulators, and gene therapy. (researchandmarkets.com)
  • Mutations of the thrombopoietin receptor gene ( MPL ) or the calreticulin ( CALR ) gene also may be the cause of primary myelofibrosis. (msdmanuals.com)
  • In methylcellulose clonal culture of fetal liver (FL) cells of generated hGMR-expressing EPOR -/- embryos at embryonic day (E) 12.5 of gestation, hGM-CSF stimulated erythroid colony formation under serum-containing and serum-free conditions. (elsevierpure.com)
  • Analysis of globin expression in individual erythrocyte-containing colonies formed from E12.5 FL cells showed that hGM-CSF supports primitive and definitive erythropoiesis even in EPOR -/- embryos. (elsevierpure.com)
  • and induced increase of GATA-1 expression and decrease of erythroid Kruppel-like factor and cMyb expression in the FL cells. (elsevierpure.com)
  • The inhibitory effect of PAP-BALF occurred only when TF-1 cells were cultured with GM-CSF but not when cultured with IL-3, suggesting that PAP-BALF contains a factor that specifically interferes with GM-CSF function. (wiley.com)
  • These cells expressed central nervous system-homing receptors, exhibited a dysregulated CD25-IL-2 axis, and their proliferative capacity positively correlated with MS severity. (nature.com)
  • The D2S and D2L dopamine receptor isoforms are differentially regulated in Chinese hamster ovary cells. (aspetjournals.org)
  • These primary myelofibrosis progeny cells stimulate bone marrow fibroblasts (which are not part of the neoplastic transformation) to secrete excessive collagen. (msdmanuals.com)
  • Mutations in the intracellular part of this receptor are also associated with certain types of leukemia. (wikipedia.org)
  • Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits. (aspetjournals.org)
  • Expression of mRNAs encoding subunits of the N-methyl-D-aspartate receptor in cultured cortical neurons. (aspetjournals.org)
  • Proteasomal degradation of the betac cytoplasmic domain was also a prerequisite for endocytosis and lysosomal degradation of the ligated receptor subunits. (tamu.edu)
  • Here we investigated the peripheral immune signatures of 61 monozygotic twin pairs discordant for MS to dissect the influence of genetic predisposition and environmental factors. (nature.com)
  • Cell activation by G-CSF is mediated by a type I membrane protein belonging to the cytokine receptor superfamily. (rndsystems.com)
  • Endothelial activation and endotheliitis due to direct viral activity and also via downregulated receptors (ACE2 and other receptors). (racgp.org.au)
  • These observations suggest that the granulocytes generated following ABMT and cytokine administration may have different functional potential depending on the cytokine administered. (duke.edu)
  • Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. (cusabio.com)
  • Further studies to evaluate these potential differences are essential to devise optimal therapeutic protocols for maximizing the granulocyte protective function in this clinical setting. (duke.edu)
  • FYLNETRA is a leukocyte growth factor indicated to decrease the incidence of infection, as manifested by febrile neutropenia, in patients with non-myeloid malignancies receiving myelosuppressive anti-cancer drugs associated with a clinically significant incidence of febrile neutropenia. (nih.gov)
  • On the other hand, in E8.0 yolk sac erythropoiesis, both substances had a similar effect on erythroid colony formation, but hGM-CSF induced an increase of β-major globin expression, while EPO did not. (elsevierpure.com)
  • These data suggest that IPAP is caused by expression of binding factor(s) which inhibit GM-CSF function in the lung. (wiley.com)
  • Proteasomal regulation of betac signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization. (tamu.edu)
  • Risk Factors and Clinical Outcomes of COVID-19 Infection in Multiple Sclerosis Patients: A Retrospective St. (medscimonit.com)
  • In addition to stimulating polymorphonuclear neutrophil (PMN) production, G-CSF may have significant effects on PMN function. (elsevierpure.com)
  • vasogenic factors, thrombin formation, erythrocyte lysis and hemoglobin (Hb) toxicity [ 5 ] have been proved to be related to brain edema growth [ 6 ]. (karger.com)
  • G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). (wikipedia.org)
  • Conclusion HMB stimulates non-specific cell-mediated immunity, which is a very important consideration in newborn calves that are exposed to adverse environmental factors in the first weeks of their life. (researchsquare.com)
  • We combined the high-throughput of mass cytometry, facilitating the analysis of 57 twin pairs, with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) of eight selected twin pairs to obtain a comprehensive overview of epitopes, transcriptome and T cell receptor (TCR) clonotypes. (nature.com)
  • 5-Hydroxytryptamine type 2A receptors regulate cyclic AMP accumulation in a neuronal cell line by protein kinase C-dependent and calcium/calmodulin-dependent mechanisms. (aspetjournals.org)
  • The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)