• The c-erb-B-2 gene is conserved in vertebrates and it has been suggested that the neu gene, detected in a series of rat neuro/glioblastomas, is, in fact, the rat c-erb-B-2 gene. (nih.gov)
  • Amplification of the c-erb-B-2 gene in a salivary adenocarcinoma and a gastric cancer cell line MKN-7 suggests that its over-expression is sometimes involved in the neoplastic process. (nih.gov)
  • Its sequence shows that the c-erb-B-2 gene encodes a possible receptor protein and allows an analysis of the similarity of the protein to the EGF receptor and the neu product. (nih.gov)
  • A wide variety of human tumors contain an amplified or overexpressed erbB-2 gene, which encodes a growth factor receptor-like protein. (apexbt.com)
  • When erbB-2 complementary DNA was expressed in NIH/3T3 cells under the control of the SV40 promoter, the gene lacked transforming activity despite expression of detectable levels of the erbB-2 protein. (apexbt.com)
  • The high levels of the erbB-2 product associated with malignant transformation of NIH/3T3 cells were observed in human mammary tumor cells that overexpressed this gene 3 . (apexbt.com)
  • More specifically, we investigated the prognostic value of four Notch receptors in breast cancer patients through "the Kaplan-Meier plotter" (KM plotter) database, in which updated gene expression data and survival information are from a total of 3554 breast cancer patients. (springer.com)
  • In non-small cell lung cancer (NSCLC) HER-2 gene amplification and 3+ staining by immunohistochemistry are present in only 2% to 5% of the tumors. (aacrjournals.org)
  • Therefore, relatively few patients with lung cancer are likely to benefit from treatment with trastuzumab, the humanized monoclonal antibody that is effective in the 20% of patients with breast cancer and HER-2 gene amplification and/or 3+ staining by immunohistochemistry. (aacrjournals.org)
  • Pertuzumab can have antitumor activity in patients with HER-2 present on the tumor without gene amplification or 3+ staining by immunohistochemistry. (aacrjournals.org)
  • Amplifiction of the Her-2/ neu gene is accompanied by overexpression of its cell surface receptor product, c‐erbB2 protein. (hindawi.com)
  • In conclusion, we observed marked intratumoural heterogeneity of c‐erbB2 protein overexpression and Her‐2/neu gene copy number in the majority of the primary BCA analyzed. (hindawi.com)
  • Postnatal disruption of NRG-1/ErbB signaling by gene targeting in mice leads to dilated cardiomyopathy. (ahajournals.org)
  • Subsequent sequencing of a primary tumor from this patient and of a metastatic lesion revealed several drivers - an amplification of the FGFR2 locus (encoding fibroblast growth factor receptor 2) that was found exclusively in the primary, and a deletion in the gene TGFBR2 (encoding TGF-beta receptor type-2) found exclusively in the metastasis. (biomedcentral.com)
  • This chromosomal region carries several loci implicated in human proliferation disorders, including the tuberous sclerosis 2 gene ( TSC2 ), polycystic kidney disease 1 gene ( PKD1 ), and the CREB binding protein ( CBP ) locus (Yin and Rozakis-Adcock, 2001). (atlasgeneticsoncology.org)
  • The 5' flanking region contains several consensus binding sites for transcription factors that regulate gene expression during tissue and organ development, such as myeloid zinc finger ( MZF1 ), Ikaros 2 and homeodomain proteins, as well as factors implicated in cell growth and survival responses, including AP-1 , PEA3 , E2F and NF-kB . (atlasgeneticsoncology.org)
  • Aggressive brain tumors were intracranially established in nude rats by using human U87 glioma genetically marked with a firefly luciferase reporter gene (U87-luc), and the rats were stereotactically treated with 2 intracranial injections of deimmunized EGFATFKDEL via convection-enhanced delivery (CED). (thejns.org)
  • Danazol decreases transcription of estrogen receptor gene in human monocytes. (nii.ac.jp)
  • 2 , 9 In breast tissues, the epithelial mucin produced by the MUC1 gene is secreted in human milk and it is present in the apical cell membrane of normal epithelium. (bmj.com)
  • The protein is produced by a cancer-causing gene called c-erbB-2 and it probably functions as a receptor molecule for a growth factor. (newscientist.com)
  • PRs are expressed in two forms, the progesterone receptor A (PRA) and progesterone receptor B (PRB) isoforms derived from splice variants from a single gene. (frontiersin.org)
  • Established tumors in BALB/c transgenic mice expressing a constitutively active ErbB-2/neuT were treated with anti-DR5 mAb and/or anti-ErbB-2 mAb and monitored for tumor progression. (pnas.org)
  • Combined therapy with anti-DR5 and anti-ErbB-2 mAbs further significantly suppressed the growth of advanced spontaneous tumors in ErbB-2/neuT transgenic mice, even when treatment was delayed until tumors were palpable. (pnas.org)
  • By the endpoint (first tumor ∼1.5cm 3 ), the average number of palpable tumors per mouse were 1.15 and 2 for control and DMBA groups, respectively. (aacrjournals.org)
  • an addition to chromosome 4 and trisomy 5 in the control mouse, trisomy 2, trisomy 3 and a deletion to chromosome 4 were detected from tumors of the DMBA mice, suggesting that DMBA induced chromosomal instability contributed to tumor promotion in this model. (aacrjournals.org)
  • Comparative analysis of h tid and HER-2 expression in breast and non breast tumors . (biomedcentral.com)
  • One of the molecular ligands of the cytosolic hTid-L and hTid-I forms is the ErbB-2 receptor variably over expressed in diverse solid tumors. (biomedcentral.com)
  • We evaluated h tid and HER-2 expression by quantitative real time PCR in tumors of different TNMG status and by immunohistochemistry in a cohort of breast tumors of the Luminal A, B, HER-2 and triple negative subtype. (biomedcentral.com)
  • In contrast h tid expression is significantly lower in tumors of the Luminal B (20%) and HER-2 (18%) subtype over expressing the receptor and in the triple negative (40%) more aggressive malignancies. (biomedcentral.com)
  • Thus, in the context of the functional link between the h tid encoded proteins and ErbB-2 in the present study we addressed the question whether in human sporadic breast tumors the in vivo expression profiles of the two tumor genes provide support for h tid function as a negative regulator of ErbB-2 activity. (biomedcentral.com)
  • There have been extensive efforts to develop agents effective against the HER family of tyrosine kinase receptors for the treatment of human solid tumors. (aacrjournals.org)
  • PURPOSE: Hormone receptor-positive (HR+) tumors have heterogeneous biology and present a challenge for determining optimal treatment. (bireme.br)
  • ErbB-1 and ErbB-2 are found in many human cancers and their excessive signaling may be critical factors in the development and malignancy of these tumors. (wikipathways.org)
  • Figure 2: LIF promotes proliferation and anchorage-independent growth of breast cancer cells and promotes the growth of xenograft breast tumors. (amazonaws.com)
  • A total of 116 specimens with early breast cancer, defined as tumors of ≤2 cm in size and clinically negative axilla, were studied immunohistochemically for ER, PgR, and c-erbB-2 expression. (ebscohost.com)
  • However, if triple-positive and triple-negative cases were excluded from the original sample, the remaining c-erbB-2 positive cases were connected with poor prognosis, relative to the remaining c-erbB-2 negative tumors. (ebscohost.com)
  • c-erbB-2 oncogene has a complex biological role in early breast carcinomas for its expression characterizes subgroups of patients with both favorable (triple-positive phenotype) and unfavorable prognosis (c-erb-B2 positive cases after excluding triple-positive and triple-negative tumors)â€"a phenomenon presumably due to activation of different biological pathways. (ebscohost.com)
  • Breast tumors with overexpression of the receptor tyrosine kinase erbB-2/neu/HER-2 occur in ∼25% to 30% of human breast cancers and are associated with increased metastasis, increased resistance to chemotherapy, and poor clinical outcome ( 1 ). (aacrjournals.org)
  • Overexpression of HER-2/neu in transgenic mice leads to spontaneous development of mammary tumors and metastasis to the lung ( 2 ). (aacrjournals.org)
  • Coexpression of HER-2 and COX-2 was observed in breast cancer cells ( 8 ), human breast cancers ( 10 , 11 ), and in mammary tumors from MMTVneu202 transgenic mice ( 12 , 13 ). (aacrjournals.org)
  • In human breast tumors, COX-2 localized to breast cancer cells rather than the surrounding stroma and was associated with metastases and poor survival ( 14 ). (aacrjournals.org)
  • The most direct evidence for the link between COX-2 and tumorigenesis was shown in a study showing that overexpression of COX-2 in the mammary gland induces mammary tumors in transgenic mice ( 16 ). (aacrjournals.org)
  • Clinical implication of human progesterone receptor forms A and B ingynecologic malignant tumors. (nii.ac.jp)
  • Our studies in a cohort of human breast tumors identified PR and AP-1 nuclear interaction as a marker of good prognosis and better OS in patients treated with tamoxifen (Tam), an anti-estrogen receptor therapy. (sigmaaldrich.com)
  • Various therapeutics targeting these receptors have been approved for the treatment of several cancers. (nih.gov)
  • HER-2 is amplified in a subset of human breast cancers, and women with amplified HER-2 have a shorter survival than women without amplification ( 9 ). (aacrjournals.org)
  • There is considerable preclinical evidence to indicate that COX-2 has an important role in many cancers including breast. (aacrjournals.org)
  • Expression of aberrant estrogen receptor mRNA in endometrial cancers in comparison with normal endometrium. (nii.ac.jp)
  • Publications] Fujimoto J,et al: 'Expression of Aberrant Estrogen Receptor mRNA in Endometrial Cancers in Comparison with Normal Endometria' Horm.Res.42. (nii.ac.jp)
  • Around 20 to 30 percent of breast cancers have mutations leading to high expression and activation of ErbB-1 and ErbB-2, which are associated with an increased risk that the cancer will recur after treatment. (drugs.com)
  • Previous studies have shown that lapatinib treatment to block these receptors improves outcomes for women with advanced (metastatic) "ErbB-2-overexpressing" breast cancers. (drugs.com)
  • This target has been validated because trastuzumab has shown single-agent antitumor activity against breast cancer with evidence of abundant HER-2, and the addition of trastuzumab to combination chemotherapy can prolong survival for patients with advanced breast cancer ( 10 , 11 ). (aacrjournals.org)
  • Inhibition of IGF1R activity enhances response to trastuzumab in HER-2-positive breast cancer cells. (springer.com)
  • Figure 2: Combination of neratinib and trastuzumab has an additive effect and prevents re-activation of pHER3 and pAkt. (amazonaws.com)
  • Evaluation of the Insulin-like Growth Factor Receptor Pathway in Patients with Advanced Breast Cancer Treated with Trastuzumab. (bioportfolio.com)
  • Eighteen genes regulating metabolism of fatty acids, lipid second messengers and gangliosides were 2-9 fold upregulated in melanomas of GDS-1375. (cancerindex.org)
  • Immunohistochemistry is the first-line modality with recourse to FISH only in scores of 2. (ganfyd.org)
  • The expressions of C-erbB-2, CXCR4 and ER-α were measured by immunohistochemistry (IHC) on full tissue sections and on tissue microarrays (TMAs). (biomedsearch.com)
  • Insufficient ErbB signaling in humans is associated with the development of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's Disease. (wikipathways.org)
  • Analysis of the selected phage EGF variants revealed clones with high binding affinity to ErbB-2/ErbB-3 while maintaining high affinity to ErbB-1. (cnrs.fr)
  • These studies indicate that Herceptin applied to cells expressing only c-erbB-YFP induces receptor internalisation into a compartment apparently just under the surface of the plasma cell membrane, supporting the observations of Austin and colleagues [ 2 ] who explored this by electron microscopy. (biomedcentral.com)
  • [2] GnRH, in turn, induces the secretion of the gonadotropins , follicle-stimulating hormone (FSH) and luteinizing hormone (LH), from the pituitary gland . (wikipedia.org)
  • We demonstrated that at the cyclin D1 promoter and through coordinated rapid and transcriptional effects, progestin induces the assembly of a transcriptional complex among AP-1, Stat3, PR, and ErbB-2 which functions as an enhanceosome to drive breast cancer growth. (sigmaaldrich.com)
  • Enhancing β-cell proliferation is a major goal for type 1 and type 2 diabetes research. (diabetesjournals.org)
  • In contrast to previously characterized chimeras of EGF with NRG-1 or TGF-alpha, these variants did not only show high binding affinity for ErbB-2/ErbB-3 heterodimers but also for ErbB-3 alone. (cnrs.fr)
  • Laboratory of Receptor Biology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021. (asm.org)
  • The physiology of the cardiac NRG-1/ErbB system has implications for the treatment of both cancer and heart failure. (ahajournals.org)
  • 2 Graduate Institute for Cancer Biology and Center for Molecular Medicine, China Medical University, Taichung 404, Taiwan. (sciencemag.org)
  • Tissue microarrays from 273 invasive cancer from women residing in Chile were examined for nuclear ErbB-2 (NuclErbB-2) and membrane. (ebscohost.com)
  • Estrogen receptor (ER) mRNA was overexpressed in uterine endometrial cancer than normal endometrium, and it had some point mutations in DNA binding domain (Horm.Res. (nii.ac.jp)
  • It's one thing to think about the ErbB-2's enzymology, how its regulation goes awry, and how its constituitive activity sets in motion the spread of the cancer. (scienceblogs.com)
  • A similar rash occurs in patients treated with other drugs that block the ErbB-1 receptor, such as erlotinib (Tarceva) -- a new drug used to treat advanced lung or pancreatic cancer. (drugs.com)
  • 2 Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany. (sciencemag.org)