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  • tumor
  • The high levels of the erbB-2 product associated with malignant transformation of NIH/3T3 cells were observed in human mammary tumor cells that overexpressed this gene 3 . (apexbt.com)
  • chromosome
  • Her-2 immunohistochemical expression in oral squamous cell carcinomas is associated with polysomy of chromosome 17, not Her-2 amplification. (biomedsearch.com)
  • In some OSCC Her-2 immunohistochemical expression may be associated with chromosome 17 polysomy and not Her-2 amplification. (biomedsearch.com)
  • Staining
  • Intensity also follows the breast scoring system with the rule of thumb that score 3 staining is visible at ~5x, score 2 visible at 10-20x and 1+ visible requiring 40x magnification. (ganfyd.org)
  • activator
  • Unexpectedly, Wip1 allows steroid hormone-receptor-positive cells but not alveolar progenitors to activate STAT5 (signal transducer and activator of transcription 5) in the virgin state. (nih.gov)
  • Pathological
  • In addition, the change expressions of C-erbB-2 and CXCR4 in specimens tended to be correlated with pathological change to neo-adjuvant chemotherapy on full tissue sections and on TMAs in a Pearson chi-square analysis. (biomedsearch.com)
  • potent
  • A further five- to tenfold increase in its expression under influence of the long terminal repeat of Moloney murine leukemia virus was associated with activation of erbB-2 as a potent oncogene. (apexbt.com)
  • erbB-2 is a Potent Oncogene When Overexpressed in NIH/3T3 Cells. (apexbt.com)
  • breast cancer
  • Decreased expression of C-erbB-2 and CXCR4 in breast cancer after primary chemotherapy. (biomedsearch.com)
  • Women (n = 74) with clinical stage II or III breast cancer were enrolled in this open-label, multicenter study to receive six 2-weekly courses of gemcitabine 1000 mg/m2 plus docetaxel 75 mg/m2 on days 1 and 15, and vinorelbine 25 mg/m2 plus epirubicin 100 mg/m2 on days 29 and 43. (nih.gov)