• We would like to thank all members of the Cell Growth Regulation Lab for the helpful discussion and technical assistance. (springer.com)
  • Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. (springer.com)
  • Proteins belonging to the Cbl family are multidomain scaffolds that participate in numerous processes, assembling signaling complexes and mediating attachment of ubiquitin to receptor and non-receptor tyrosine kinases.We characterized a novel role for Cbl and Cbl-b in ligand-dependent internalization of growth factor receptors. (dissertations.se)
  • Contact-inhibited cells expressing this internalization-defective receptor exhibited a normal mitogenic response at significantly lower ligand concentrations than did cells expressing wild-type receptors. (sciencemag.org)
  • Moasser MM, Basso A, Averbuch SD, Rosen N: The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells. (hmdb.ca)
  • Chen WS, Lazar CS, Poenie M, Tsien RY, Gill GN and Rosenfeld MG (1987) Requirement for intrinsic protein tyrosine kinase in the immediate and late actions of the EGF receptor. (springer.com)
  • These secreted polypeptides all bind to the 170-kDa cell-surface EGF receptor, activating its intrinsic kinase activity. (pnas.org)
  • In India approximately 94% of oral malignancies are those of oral squamous cell carcinomas (OSCC) whose etiology is multifactorial with various intrinsic and extrinsic factors [ 2 ]. (hindawi.com)
  • Amphiregulin only partially competes with EGF for binding EGF receptor, and amphiregulin does not induce anchorage-independent growth of normal rat kidney cells (NRK) in the presence of TGF-beta. (pnas.org)
  • A transformed phenotype and anchorage-independent growth were observed at ligand concentrations that failed to elicit these responses in cells expressing wild-type receptors. (sciencemag.org)
  • The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. (uniprot.org)