Loading...
  • ErbB
  • The ErbB family members are cell surface receptors that are expressed in most tissues throughout the body and form both homo- and heterodimers to generate signals. (springer.com)
  • The gene symbol, ErbB, is derived from the name of a viral oncogene to which these receptors are homologous: erythroblastic leukemia viral oncogene. (wikipedia.org)
  • In ErbB-3 receptor mutant mice, they have less severe defects in the heart and thus are able to survive longer throughout embryogenesis. (wikipedia.org)
  • ErbB-1 and ErbB-2 are found in many human cancers, and their excessive signaling may be critical factors in the development and malignancy of these tumors. (wikipedia.org)
  • All four ErbB receptor family members are nearly same in the structure having single-chain of modular glycoproteins. (wikipedia.org)
  • The intracellular/cytoplasmic region of the ErbB receptor consists mainly of three subdomains: A juxtamembrane with approximately 40 residues, a kinase domain containing approximately 260 residues and a C-terminal domain of 220-350 amino acid residues that become activated via phosphorylation of its tyrosine residues that mediates interactions of other ErbB proteins and downstream signaling molecules. (wikipedia.org)
  • The figure below shows the tridimensional structure of the ErbB family proteins, using the pdb files 1NQL (ErbB-1), 1S78 (ErbB-2), 1M6B (ErbB-3) and 2AHX (ErbB-4): The four members of the ErbB protein family are capable of forming homodimers, heterodimers, and possibly higher-order oligomers upon activation by a subset of potential growth factor ligands. (wikipedia.org)
  • There are 11 growth factors that activate ErbB receptors. (wikipedia.org)
  • 1984
  • Berridge MJ, Heslop JP, Irvine RF and Brown KD (1984) Inositol trisphosphate formation and calcium mobilization in Swiss 3T3 cells in response to platelet-derived growth factor. (springer.com)
  • interact
  • These findings suggest that amphiregulin may interact with a separate receptor in certain cell types. (pnas.org)
  • intrinsic
  • In India approximately 94% of oral malignancies are those of oral squamous cell carcinomas (OSCC) whose etiology is multifactorial with various intrinsic and extrinsic factors [ 2 ]. (hindawi.com)
  • oligomerization
  • Significant intermolecular contacts involving the carboxyl-terminal tail are discussed with respect to receptor oligomerization. (nih.gov)
  • Signaling
  • His subsequent research in the laboratory and clinic pioneered the universally adopted concept of anti-receptor therapy that targets key cell signaling pathways as a new form of cancer treatment. (wikipedia.org)
  • These specialised membrane microdomains compartmentalise cellular processes by serving as organising centers for the assembly of signaling molecules, influencing membrane fluidity and membrane protein trafficking, and regulating neurotransmission and receptor trafficking. (wikipedia.org)
  • reduces
  • It was reported, that menadione topical lotion reduces epidermal growth factor receptor inhibitor-related side effects by the prevention of skin toxicities that result from inhibition of protein kinases by drugs such as erlotinib (Tarceva) and cetuximab (Erbitux), however, the paper was later retracted. (wikipedia.org)
  • epithelial
  • Amphiregulin also appears to abrogate the stimulatory effect of TGF-alpha on the growth of several aggressive epithelial carcinomas that overexpress EGF receptor. (pnas.org)
  • amphiregulin
  • Amphiregulin only partially competes with EGF for binding EGF receptor, and amphiregulin does not induce anchorage-independent growth of normal rat kidney cells (NRK) in the presence of TGF-beta. (pnas.org)
  • saliva
  • Risk factors include conditions that result in less saliva such as: diabetes mellitus, Sjogren's syndrome and some medications. (wikipedia.org)
  • amino
  • Several of these factors have been purified to homogeneity and their primary amino acid sequence has been determined completely or in part. (springer.com)
  • cells
  • however, it explains the next step in the process of the radial growth, when individual cells start to acquire invasive potential. (thetanningguru.com)
  • In adults, telomerase is highly expressed only in cells that need to divide regularly especially in male sperm cells[citation needed] but also in epidermal cells, in activated T cell and B cell lymphocytes, as well as in certain adult stem cells, but in the great majority of cases somatic cells do not express telomerase. (wikipedia.org)
  • include
  • Factors that increase the risk of prostate cancer include: older age, a family history of the disease, and race. (wikipedia.org)
  • Other factors that may be involved include a diet high in processed meat, red meat, or milk products or low in certain vegetables. (wikipedia.org)
  • Risk factors for glaucoma include increased pressure in the eye, a family history of the condition, migraines, high blood pressure, and obesity. (wikipedia.org)
  • important
  • Below are some of the other important functions and biological roles AP-1 transcription factors have been shown to be involved in. (wikipedia.org)
  • Of the several causes for glaucoma, ocular hypertension (increased pressure within the eye) is the most important risk factor in most glaucomas, but in some populations, only 50% of people with primary open-angle glaucoma actually have elevated ocular pressure. (wikipedia.org)
  • levels
  • Activation of PPARδ in the macrophage leads to lipid accumulation, with an increase in mRNA levels of the scavenger receptors SR-A and CD36. (biomedcentral.com)