LeukotrienesSignaling moleculesProtein-coupledStudying the role of eicosanoidsCannabinoid receptorsGPCRsMediatorsArachidonic acidPathwayPurinergicPPARBindAntagonistMetabolitesStimulationLeukotriene receptorVascularCytochromeAffinityFindingsCholinergicMetabotropicToll-like recSynthaseFatty acidsIntegral membranBLT1FPR2PathwaysActivationCharacterizationExertFunctionalAntibodiesGeneScopolamineInducesInflammatoryMucosaSpeciesMechanismImmunityBrainExpressionCell
Leukotrienes11
- GPR99 is also the receptor for alpha-ketoglutarate, binding and responding to this ligand much more weakly than to any of the three cited leukotrienes. (wikipedia.org)
- The arachidonic acid, released by phospholipase A2, is an important substrate for the production of a group of lipid mediators known as leukotrienes, which induce proinflammatory signaling through the activation of specific BLT and CysLT receptors. (hindawi.com)
- The term "eicosanoids" includes prostaglandins (PGs), tromboxanes (TX), leukotrienes (LTs), and hydroxyl-eicosatetraenoic acid made by polyunsaturated 20-carbon fatty acids (PUFA), including the most abundant and biological precursor AA [ 21 ]. (hindawi.com)
- Class 2 lipid mediators are eicosanoids, such as prostaglandins and leukotrienes, that are produced from arachidonic acid via cyclooxygenase (COX) and lipoxygenase (LOX) pathways. (rndsystems.com)
- Our laboratory is focused on identifying the known and discovering new fatty acids and eicosanoid metabolites (prostaglandins and leukotrienes) in these cells and using LC/MS to follow their production upon cell stimulation and determining lipid metabolite fluxes at the cellular level. (virginia.edu)
- Both prostaglandins and leukotrienes are major eicosanoids. (proprofs.com)
- Eicosanoids include prostaglandins (the most important), prostacyclins, leukotrienes, and thromboxanes, which are responsible for many of the beneficial effects of the good fats. (wellnessadvantage.com)
- Among the eicosanoid receptors are receptors for the prostaglandins , thromboxanes, and leukotrienes. (wellnessadvantage.com)
- In organic chemistry, Leukotrienes are a subclass of organic compounds in the eicosanoids subclass of the fatty acyl class [FA class] within the lipids superclass , consisting of eicosanoids containing a hydroxyl group attached to the aliphatic chain of an arachidonic acid. (wellnessadvantage.com)
- In lipid science, Leukotrienes [FA0302] are a family of biologically active organic compounds in the lipid science , Eicosanoids subclass in the fatty acyl class [FA class] of the lipids superclass . (wellnessadvantage.com)
- She concluded that NO had a beneficial role in the peripheral lung and that nitric oxide (NO) may interact with eicosanoids, especially leukotrienes. (lu.se)
Signaling molecules4
- Most of the eicosanoid receptors are integral membrane protein G protein-coupled receptors (GPCRs) that bind and respond to eicosanoid signaling molecules. (wikipedia.org)
- Eicosanoids, oxidized fatty acids that serve as cell-signaling molecules, have been broadly implicated in tumorigenesis. (nih.gov)
- Eicosanoids are signaling molecules derived from polyunsaturated fatty acids and play important roles in inflammation, immune response, and various physiological processes. (proprofs.com)
- In our body, Eicosanoids are a family of signaling molecules (hormone-like substances) derived from the oxidation of twenty-carbon Essential Fatty Acids, (EFAs). (wellnessadvantage.com)
Protein-coupled7
- This gene encodes MC 3 , a G-protein coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. (wikidoc.org)
- Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
- Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
- LTs exert their biological effects by activating specific receptors belonging to the superfamily of G protein-coupled receptors (GPCRs) [ 22 - 24 ]. (hindawi.com)
- This group of G protein-coupled receptors share lipid mediators as ligands. (rndsystems.com)
- In contrast, the mAChRs are not ion channels, but belong instead to the superfamily of G-protein-coupled receptors that activate other ionic channels via a second messenger cascade. (wikidoc.org)
- The receptor is a G-protein coupled receptor , which activates the G protein G s . [2] . (wikidoc.org)
Studying the role of eicosanoids1
- In particular we are studying the role of eicosanoids in normal pregnancy and preeclampsia, the contribution of a purinergic receptor to the release of the cytokine interleukin-1beta in pregnancy as well as investigation of the inflammasome in coordinating inflammatory pathways coupled to cytokine release. (nottingham.ac.uk)
Cannabinoid receptors8
- R&D Systems offers antibodies for the receptors listed below, as well as agonists for the cannabinoid receptors. (rndsystems.com)
- In a story very similar to the discovery of opiate receptors in the brain, cannabinoid receptors have been discovered along with their endogenous cannabinoids, representing the largest neurotransmitter system in the brain and immune system. (greenmedinfo.com)
- It seemed likely that something similar was happening with THC and the cannabinoid receptors in the brain and the immune system. (greenmedinfo.com)
- The presence of cannabinoid receptors in invertebrates has been controversial, due to conflicting evidence. (researchgate.net)
- we therefore tested for cannabinoid receptors in seven representative species, using tritiated ligand binding assays with [3H]CP55,940 displaced by the CB1-selective antagonist SR141716A. (researchgate.net)
- Our discovery of cannabinoid receptors in some nematodes, onychophorans, and crustaceans does not contradict the Ecdysozoa hypothesis, but gives it no support. (researchgate.net)
- We hypothesize that cannabinoid receptors evolved in the last common ancestor of bilaterians, with secondary loss occurring in insects and other clades. (researchgate.net)
- No cannabinoid receptors are expressed in sponges, which probably diverged before the origin of the eumetazoan ancestor. (researchgate.net)
GPCRs1
- The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
Mediators2
- Lipid mediators are bioactive lipids, such as lysophospholipids (and their derivatives) and arachidonic acid-derived eicosanoids. (rndsystems.com)
- The development of inflammatory bowel diseases (IBD) and colon cancer (CC) has been shown to involve the up-regulation of inflammatory mediators and the machinery producing them such as the eicosanoids. (lu.se)
Arachidonic acid2
- Accordingly, the eicosanoid-receptor interaction is typically limited to a local interaction: cells, upon stimulation, metabolize arachidonic acid to an eicosanoid which then binds cognate receptors on either its parent cell (acting as an Autocrine signalling molecule) or on nearby cells (acting as a Paracrine signalling molecule) to trigger functional responses within a restricted tissue area, e.g. an inflammatory response to an invading pathogen. (wikipedia.org)
- The eicosanoids derived from Arachidonic Acid, may be potentially harmful if excessive amounts build up in the body. (wellnessadvantage.com)
Pathway6
- Regardless of the etiology, a deficiency of cyclooxygenase (COX), a key regulatory enzyme in the synthetic pathway of eicosanoid production, results in beneficial and detrimental physiologic conditions relative to imbalances of the eicosanoids. (medscape.com)
- Their regulation may be carried out either through direct binding to DNA as peroxisome proliferator-activated receptors or via modulation in an indirect manner of signaling pathway molecules (e.g., protein kinase C) and other transcription factors (nuclear factor kappa B and sterol regulatory element binding protein). (springer.com)
- Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2. (oncotarget.com)
- However, in 82As2 cells, LIF production was significantly increased by stimulation with TLR5, which was suppressed by an inhibitor of interleukin-1 receptor-associated kinase-1/4, which are important factors in the TLR5 signaling pathway. (oncotarget.com)
- This is an important pathway for the generation of eicosanoids with vasoactive and renal effects. (ucsf.edu)
- Eicosanoids are a major pathway by which the EFAs act in the body. (wellnessadvantage.com)
Purinergic2
- The purinergic P2X 7 receptor: regulation of uterine function in labour and preterm labour. (nottingham.ac.uk)
- Application of lipidomic analysis to characterize cellular lipid signaling of Toll-like and purinergic receptors and their "synergy" in stimulated macrophages including analysis of eicosanoid fluxes and effects of supplementation with omega-3 fatty acids as models for inflammation and infection. (selectbiosciences.com)
PPAR8
- An example of a non-GPCR receptor that binds many eicosanoids is the PPAR-γ nuclear receptor. (wikipedia.org)
- Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
- Pioglitazone is a potent agonist for peroxisome proliferator-activated receptor-gamma (PPARγ). (globalrph.com)
- PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. (globalrph.com)
- Activation of PPARγ nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. (globalrph.com)
- Activation of PPARγ nuclear receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. (globalrph.com)
- At NCI, I worked on the cloning and characterization of liver carboxylesterases and was involved in the early studies leading to the development of a knockout mouse for the nuclear receptor PPARα. (ucsf.edu)
- The role of the PPAR nuclear receptors in regulating the vascular effects of these eicosanoids is also being studied. (ucsf.edu)
Bind5
- In the 1970s, Morphine was isolated from the poppy and found to bind to opiate receptors in the brain. (greenmedinfo.com)
- This allows them to bind to intracellular receptors and directly affect gene expression. (proprofs.com)
- Instead, they bind to receptors on the cell surface, triggering a cascade of events that ultimately leads to the activation of a second messenger inside the cell. (proprofs.com)
- Drugs such as the neuromuscular blocking agents bind reversibly to the nicotinic receptors in the neuromuscular junction and are used routinely in anaesthesia. (wikidoc.org)
- In our body's cells, Eicosanoid Receptors are cell surface receptor proteins that bind eicosanoids with high affinity and trigger intracellular changes influencing the behavior of cells. (wellnessadvantage.com)
Antagonist1
- Histamine1-receptor antagonist. (medscape.com)
Metabolites1
- the receptor for 12-Hydroxyheptadecatrienoic acid, leukotriene B4, and certain other eicosanoids and polyunsaturated fatty acid metabolites (see BLT2). (wikipedia.org)
Stimulation2
- We are determining the lipid changes upon cell stimulation by various agonists such as TLR receptor agonists. (virginia.edu)
- We observed that direct stimulation with LT D4, induced intestinal epithelial cell migration, through activation of the CysLT1 receptor, phosphotidylinositol-3 kinase, Vav2 and Rac localisation to membrane ruffles. (lu.se)
Leukotriene receptor1
- For these, reasons both leukotriene synthesis inhibitors and leukotriene receptor antagonists have been suggested for inducing beneficial effects at different stages of the atherosclerosis process and may represent a new therapeutic target in the treatment of atherosclerotic vessel diseases, in particular in acute coronary syndrome. (hindawi.com)
Vascular2
- SIP receptors are regulators of developmental vascular integrity, anaphylaxis and leukocyte egress from lymphoid organs. (rndsystems.com)
- Mechanisms underlying non-prostanoid eicosanoid modulation of vascular function in normal and pre-eclamptic pregnancies. (nottingham.ac.uk)
Cytochrome2
- Changes in dietary fatty acids, specifically the polyunsaturated fatty acids of the ω-3 and ω-6 families and some derived eicosanoids from lipoxygenases, cyclooxygenases, and cytochrome P-450, seem to control the activity of transcription factor families involved in cancer cell proliferation or cell death. (springer.com)
- Mechanisms underlying the modulatory actions of cytochrome P450-derived eicosanoids in human myometrium. (nottingham.ac.uk)
Affinity1
- BLT2 is a pharmacologically distinct receptor, which is ubiquitously expressed and displays low affinity for LTB4 and also binds other eicosanoids [ 26 , 27 ]. (hindawi.com)
Findings2
- The new findings on eicosanoid actions in insect immunity have emerged from a very broad range of research at the genetic, cellular and organismal levels, all taking place at the international level. (usda.gov)
- Based on findings in neurological diseases ( 20-23 ) and pharmacological interactions ( 24-27 ), it appears that a malfunction of 5-hydroxytryptamine (HT)2 receptors may have a major role in the pathogenesis of bruxism. (spandidos-publications.com)
Cholinergic1
- The muscarine cholinergic receptor activates a G protein when bound to ex.c. ach. (wikidoc.org)
Metabotropic1
- muscarinic acetylcholine receptors ( mAChR , also known as " metabotropic " acetylcholine receptors) are particularly responsive to muscarine . (wikidoc.org)
Toll-like rec1
- 85As2 cells displayed more genetic changes compared to MKN45cl85 cells, which were related to Toll-like receptor (TLR) 4/5 signaling. (oncotarget.com)
Synthase1
- We interrogated RNA sequencing datasets for eicosanoid synthase or receptor expression. (nih.gov)
Fatty acids1
- In lipid science , Eicosanoids are a subclass of organic compounds in the fatty acyl class [FA class] of the lipids superclass generally derived from unsaturated C20 fatty acids or skeletally related compounds, that have hormone-like effects ( autacoid effects , mediated by specialized eicosanoid receptors ). (wellnessadvantage.com)
Integral membran1
- An acetylcholine receptor (abbreviated AChR ) is an integral membrane protein that responds to the binding of the neurotransmitter acetylcholine . (wikidoc.org)
BLT12
- BLT1 is the primary receptor for leukotriene B4. (wikipedia.org)
- Two receptors for LTB 4 have been molecularly identified: BLT1 and BLT2. (hindawi.com)
FPR21
- SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils. (frontiersin.org)
Pathways1
- Next, the EFA is oxygenated via a couple od different pathways, further modified, yielding the eicosanoids. (wellnessadvantage.com)
Activation1
- Activation of this receptor is associated with pro-allergic responses in cells, tissues, and animal models. (wikipedia.org)
Characterization1
- Characterization of a functional thrombin receptor. (jci.org)
Exert1
- Eicosanoids exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. (wellnessadvantage.com)
Functional1
- Electrophysiological measurements were used to determine the functional consequence of the seven missense δ subunit variants in receptor combinations of α1β3δ and α4β2δ GABAA receptors. (aau.dk)
Antibodies1
- In myasthenia gravis , the receptor is targeted by antibodies , leading to muscle weakness. (wikidoc.org)
Gene2
- Melanocortin receptor 3 is a protein that in humans is encoded by the MC3R gene . (wikidoc.org)
- It also denotes the human gene encoding the receptor. (wikidoc.org)
Scopolamine1
- Muscarinic acetylcholine receptors can be blocked by the drugs atropine and scopolamine . (wikidoc.org)
Induces3
- Histoplasma capsulatum cell wall {beta}-glucan induces lipid body formation through CD18, TLR2, and dectin-1 receptors: correlation with leukotriene B4 generation and role in HIV-1 infection. (microbiologyresearch.org)
- They compete with histamine for histamine receptor type 1 (H1) receptor sites in the blood vessels, GI tract, and respiratory tract, which, in turn, inhibits physiologic effects that histamine normally induces at the H1 receptor sites. (medscape.com)
- Induces also bronchial relaxation and increases heart rate and contractility by stimulating beta-adrenergic receptors. (medscape.com)
Inflammatory1
- 4 For example, eicosanoids have been identified to play a role in cancerous cells' neoplastic transformations and blocking eicosanoid receptors can impede the inflammatory response of tumour cells. (sanbio.nl)
Mucosa1
- Pseudoephedrine stimulates vasoconstriction by directly activating alpha-adrenergic receptors of the respiratory mucosa. (medscape.com)
Species1
- Our analyses identify key changes in eicosanoid species during pancreatic tumorigenesis and the cell types that contribute to their synthesis. (nih.gov)
Mechanism2
- We hypothesize that increase in tonic GABA-evoked current levels mediated by δ-containing extrasynaptic GABAA receptors lead to abnormal neurotransmission, which represent a novel mechanism for severe neurodevelopmental disorders. (aau.dk)
- It can be explained if, in man, signals associated with individual cone receptors do not depend linearly on light intensity, but instead are scaled by a fast sensitivity-regulating or light-adaptation mechanism. (umn.edu)
Immunity1
- We briefly review the relatively scant knowledge on insect PG receptors and note PGs also act in gut immunity and in humoral immunity. (usda.gov)
Brain1
- Receptors for LPA are involved in brain development, embryo implantation, and hair growth. (rndsystems.com)
Expression2
- Our cancer studies have expanded to include oesophageal cancer with emphasis on oestrogen receptor expression and function in this malignancy. (nottingham.ac.uk)
- an enzyme involved in the production of various eicosanoids) expression, by activating integrin collagen receptors. (lu.se)
Cell3
- Here, we aimed to identify eicosanoids associated with pancreatic tumorigenesis and the cell types responsible for their synthesis. (nih.gov)
- Eicosanoids signal a wide range of cellular immune reactions to infections, invasions and wounding, including nodulation, cell spreading, hemocyte migration and releasing prophenoloxidase from oenocytoids, a class of lepidopteran hemocytes. (usda.gov)
- When a hormone is present in excessive levels, the number of target-cell receptors may decrease. (proprofs.com)