Receptor cd46 receptor antigens cd46. Medical search. Frequent questions

Our cell cultures were strongly positive for CD46, CD47, CD56 and CD63 and were also strongly positive for some markers never described before in mesothelioma cell lines, including CD55, CD90 and CD99. (biomedcentral.com)
Antigens, CD47" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
This graph shows the total number of publications written about "Antigens, CD47" by people in this website by year, and whether "Antigens, CD47" was a major or minor topic of these publications. (rush.edu)
Below are the most recent publications written about "Antigens, CD47" by people in Profiles. (rush.edu)

To identify this receptor we selected a monoclonal antibody (MAb) directed to the surface of B95a cells which inhibits MV binding and contamination and identified the acknowledged molecule as SLAM (CD150). (careersfromscience.org)
The majority of our de novo radiotracer development focuses on small molecule organic chemistry, and our antibody radiotracer development programs involves new bioconjugation chemistry, and defining and exploiting the biological mechanisms that underwrite the aberrant expression of cell surface receptors in cancer. (ucsf.edu)
The virus CD46 molecule is the cellular receptor. (bestessaywriters.com)

Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
Interestingly, NPSC and iPS expressed mRNA of complement regulatory proteins (CRP) such as membrane cofactor protein (CD46), decay accelerating factor (DAF or CD55), and protectin (CD59), but CD59 mRNA expression was negligible in iPS. (johnshopkins.edu)
The team has developed two prostate cancer vaccines, which activate the immune system against two prostate cancer associated proteins - the androgen receptor (AR), and prostatic acid phosphatase (PAP). (pcf.org)
Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)

The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)

The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)

Although anti-SLAM and/or anti-CD46 antibodies stop virus binding they don't hinder the contact-mediated proliferation inhibition. (careersfromscience.org)
The T-cells and antibodies will then recognize, attack, and continually "remember" how to identify tumor cells based on the tumor-specific antigens in the vaccine. (ucsf.edu)

On the other hand, the proliferation of oncolytic viruses into target cells and subsequent recognition of viral elements by pattern recognition receptors (PRRs) such as toll-like receptors can positively affect the development of the innate and adaptive immune responses against tumor cells (Fig. 1 ) [ 6 ]. (biomedcentral.com)

To study how humoral tolerance is normally maintained to organ-specific membrane antigens, transgenic mice were generated selectively expressing membrane-bound hen egg lysozyme (mHEL) on the thyroid epithelium. (silverchair.com)

The LG.3A10 antibody reacts with CD27, a 45 - 55 kDa member of the tumor necrosis factor receptor superfamily. (stemcell.com)
CD27 is found on peripheral T cells, memory B cells, and NK cells and in mice has been found on most thymocytes, except CD46-CD8- precursors. (stemcell.com)

Results: Our immortalized SC line (iPS) proliferated stably and had a phenotype similar to NPSC, as indicated by the immunoexpression of follicle stimulating hormone receptor (FSHR), and mRNA expression of androgen receptor (AR), and Wilms' tumor antigen (WT1). (johnshopkins.edu)

Graves' Disease results from the production of autoantibodies against receptors for thyroid stimulating hormone (TSH) on thyroid epithelial cells, and represents the prototype for numerous autoimmune diseases caused by autoantibodies that bind to organ-specific cell membrane antigens. (silverchair.com)
Factor I, with cofactors including membrane cofactor protein (CD46), inactivates C3b and C4b. (msdmanuals.com)
Her study in Immunology concentrates on Complement, Inflammation, Complement receptor, Classical complement pathway and Complement membrane attack complex. (research.com)

Granzyme B is induced in CD8 + T lymphocytes with ConA/ IL-2 and CD4 + T lymphocytes with anti CD3/CD28 or CD3/CD46. (biolegend.com)

The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. (wikidoc.org)

The human CD46 antigen is known to be the functional cellular receptor for Measles virus. (wikipedia.org)
Measles trojan (MV) interacts with cellular receptors on the top of peripheral bloodstream lymphocytes (PBL) which mediate trojan binding and uptake. (careersfromscience.org)
The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
The H protein targets the cellular receptors of the CD46 and CD150. (bestessaywriters.com)

This imaging technique is an improvement over initial efforts to engineer a Measles virus to carry the soluble marker human carcinoembryonic antigen (CEA). (wikipedia.org)
During and weeks after acute measles delayed-type hypersensitivity skin test responses to recall antigens are suppressed and there is an increased susceptibility to opportunistic infections which aggravates the course of the disease. (careersfromscience.org)
Wild-type MV strains WTFb and Wü5679 (same as TC5679 in reference 35) were isolated from patients with acute measles (Erlangen Germany 1990 and Würzburg Germany 1996 respectively [35]) and propagated on BJAB cells since these cells in contrast to B95a cells do not IDH-C227 contain EBV and express CD46 and SLAM and therefore do not exert a selective pressure for one of the receptors. (careersfromscience.org)
Thus, we have described a molecular link between CD46 and autophagy, which is engaged upon measles virus infection. (cfatg.org)

Recently we have shown the dual function of an autophagic receptor which, in addition to target pathogens towards the autophagic machinery, also regulates the maturation of autophagosome to efficiently degrade the substrates. (cfatg.org)
Antigen presentation by molecules of the major histocompatibility complex (MHC) is an essential step to initiate an adaptive immune response to efficiently fight pathogens. (cfatg.org)
Since numerous antigens which are presented by MHC molecules traffic via the lysosomes, autophagy is an important reservoir for the production of antigenic peptides derived from the degradation of intracellular pathogens. (cfatg.org)
We seek to understand the molecular connections between autophagy and antigen presentation and to measure their impact on the diversity of the presentation, especially in the context of self antigens (those of the cell), and non-self antigens (those from pathogens). (cfatg.org)
8 , 11 - 14 Numerous stimuli can drive the activation of the complement system, including apoptotic debris, pathogens, and antibody-antigen complexes, in addition to ischemia-reperfusion injuries associated with organ transplantation. (jrheum.org)

Patients will be evaluated for safety, clinical responses, immune system responses against the vaccine antigens (PAP and AR), as well as immune system changes that correlate with clinical responses. (pcf.org)

extended and triggered with SIINFEKL peptide antigen pulsed tumor cells as focuses on. (grandlacs-med-journal.com)
In bursting, the tumor cell releases molecules called tumor antigens, which allows the immune system to recognize and target remaining tumor cells. (ucsf.edu)

Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)

Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor. (biolegend.com)
Our results indicate that an Arg279Glu substitution is sufficient to convert the Ad11p receptor-interaction phenotype to that of Ad7p and abolish sB2AR and CD46 interaction. (grandlacs-med-journal.com)

For example, production of autoantibodies that bind to and stimulate the thyroid-stimulating hormone (TSH) receptor cause the thyrotoxicosis of Graves' Disease, and anti-thyroid peroxidase antibody in Graves' and Hashimoto's thyroiditis is thought to inhibit thyroid function and promote complement deposition and thyroid destruction ( 2 ). (silverchair.com)

The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
Her Innate immune system research focuses on Classical complement pathway and how it connects with T cell, Complement receptor and Acquired immune system. (research.com)
The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (wikidoc.org)

Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)

SELPLG codes for PSGL-1, the high affinity counter-receptor for P-selectin on myeloid cells and stimulated T lymphocytes. (wikidoc.org)

Virus-based immunostimulatory cytokine and chemokine expression can recruit and activate T cells, antigen-presenting cells (APCs), and natural killer (NK) cells, and subsequently, improve the therapeutic activity of OVs. (biomedcentral.com)

Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Recently we found that direct contact of the MV glycoproteins hemagglutinin (H) and fusion protein (F) with the cell surface of lymphocytes or lymphoid cell lines induces a dominant negative signal in the contacted cells leading to this proliferative inhibition (33 44 It is likely that this unfavorable signal is usually transduced by a receptor present on the surface of lymphoid cells. (careersfromscience.org)

Binds to VLA1 (Very Late Antigen-1) and α4β1 integrins. (goconqr.com)

The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors. (uams.edu)

These CD3/CD46-stimulated IL-10-producing CD4 + cells proliferate strongly, suppress activation of bystander T cells and acquire a memory phenotype. (nature.com)

Figure 3: Characteristics of CD3/CD46-activated, sorted CD3 + CD4 + CD45RA + CD45RO + T cells. (nature.com)
Figure 4: Suppressive and proliferative properties of CD3/CD46-activated CD4 + T cells. (nature.com)
One aspect of the viral immunosuppression is the proliferation inhibition in response to mitogens T-cell receptor cross-linking or recall antigens of IDH-C227 peripheral blood mononuclear cells (PBMC) isolated from patients (ex vivo) and in vitro. (careersfromscience.org)
The role of an intact endothelial barrier in sequestering organ-specific antigens from circulating preimmune B cells is discussed. (silverchair.com)
Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
Because of their high numbers, red blood cells express an average of 90% of the CR1 receptors despite their having a lower number of antigenic sites per cell. (medscape.com)
Among healthy individuals, the number of CR1 receptors on the red blood cells varies widely, yet the phenotypic expression, regulated by 2 codominant alleles, is stable. (medscape.com)
Searching for more direct proof to implicate thymic myoid and/or epithelial cells in the response, we now have looked for symptoms of go with attack in it and for appearance from the complement-regulatory protein CD46, Compact disc55, and Compact disc59. (kentlandsinitiative.org)
This stress condition can also lead to the attraction of immune cells, notably antigen presenting cells (APCs) (i.e. immature dendritic cells), natural killer cells (NK cells), and cytotoxic T-cells to the site of infection [ 5 , 6 ]. (biomedcentral.com)
In this manner, the reduced detection of self MHC-I molecules by NK cell-inhibitory receptors coupled with an increase in activating signals by recognition of stress-induced surface ligands promote the cytolytic activity of NK cells. (biomedcentral.com)
Cancer antigen discovery is enabled by RNA-sequencing of highly purified malignant and non-malignant cells. (cardiff.ac.uk)
Moreover, HSV engineered in gH of a scFv targeting the cancer-specific HER2 receptor, scFv-HER2-gH chimera, can enter, replicate and kill cancer cells efficiently [ 14 ]. (biomedcentral.com)

Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)

A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)

CD46 (3 16 23 It has been exhibited that MV can efficiently be isolated from patients using B-cell lines such as B95a (19) which lack a complete CD46 (15 28 indicating the presence of another receptor. (careersfromscience.org)
These results provide evidence that tolerance is not actively acquired to organ-specific antigens in the preimmune B cell repertoire, underscoring the importance of maintaining tolerance to such antigens by other mechanisms. (silverchair.com)
[ 2 ] T cell-derived complement C3a and CD46 activation is required for Th1 induction. (medscape.com)
The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
CR1 and CR2 have been shown to influence the immune environment in a B-cell receptor-independent manner. (medscape.com)
This result is comparable to Cytochalasin H another non-coxsackie-adenovirus receptor binding Ad (Ad37p), where substitution of one amino acid abolishes virus-cell connection. (grandlacs-med-journal.com)
As a part of the same scientific study, she usually deals with the Cell biology, concentrating on Decay-accelerating factor and frequently concerns with Complement receptor 1. (research.com)

Note the image below, as well as the article Pediatric Complement Receptor Deficiency may be helpful. (medscape.com)

Four distinct complement receptors, CR1, CR2, CR3, and CR4, have been described for the surface-bound complement fraction C3 and its cleavage fragments. (medscape.com)

In 1993, the team of Prof. Chantal Rabourdin-Combe (1952-2011) identified the first human receptor for this virus, CD46. (cfatg.org)
The human interferon-gamma receptor. (wikidoc.org)

Evaluation of CD46 re-targeted adenoviral vectors for clinical ovarian cancer intraperitoneal therapy. (cardiff.ac.uk)

In conjunction with earlier results, our findings Cytochalasin H also strongly suggest that sB2AR is equivalent to CD46. (grandlacs-med-journal.com)

Identification of folate receptor α (FRα) binding oligopeptides and their evaluation for targeted virotherapy applications. (cardiff.ac.uk)

The info suggest that proliferation inhibition induced by MV get in touch with is in addition to the existence or absence of the virus-binding receptors SLAM and CD46. (careersfromscience.org)

Anatomy33

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CD474

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