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  • neuronal
  • The study of endogenous cannabinoid CB1 receptor proteins in neuronal tissues and cells relies on the availability of highly specific antibodies. (nih.gov)
  • The cannabinoid CB1 receptor is expressed in different neuronal subpopulations, and is engaged in fine-tuning excitatory and inhibitory neurotransmission. (jneurosci.org)
  • These data reveal that CB1 receptor in dorsal telencephalic glutamatergic neurons plays a sufficient role to control neuronal functions that are in large part hippocampus-dependent, while it is insufficient for proper amygdala functions, suggesting an unexpectedly complex circuit regulation by endocannabinoid signaling in the amygdala. (jneurosci.org)
  • The underlying cellular mechanisms have been intensively investigated, but the causal relationships between CB1 receptor signaling and neuronal circuit functions have been only partially addressed. (jneurosci.org)
  • To elucidate the behavioral effects of CB1R deficiency in this specific neuronal subpopulation, we subjected D1-CB1 −/− mice to a battery of behavioral tests which included exploration-based tests, depressive-like behavioral tests, social behavior, and fear-related memory paradigms. (frontiersin.org)
  • However, the anatomical organization of the neuronal substrates that express 2-AG/CB1 signaling system-related molecules associated with selective Ca(2+)-binding proteins (CaBPs) is still unknown. (sigmaaldrich.com)
  • The identification of anatomically related-neuronal substrates that expressed 2-AG/CB1 signaling system and selective CaBPs should be considered when analyzing the cannabinoid signaling associated with hippocampal functions. (sigmaaldrich.com)
  • In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. (deepdyve.com)
  • mRNA
  • Both mRNA for CB1 and the corresponding protein are expressed in the human prostate gland at a level comparable with the receptor expressed in cerebellum. (420magazine.com)
  • We investigated CB1 receptor expression within specific corticostriatal circuits by mapping CB1 mRNA levels in striatal sectors defined by their cortical inputs in rats. (frontiersin.org)
  • In so far as CB1 mRNA levels reflect receptor function, our findings suggest differential CB1 signaling between different developmental stages and between sensorimotor and associative/limbic circuits. (frontiersin.org)
  • Cannabinoid CB1 receptor mRNA was detected using reverse transcription-polymerase chain reaction (RT-PCR) in endothelial cells from human aorta and hepatic artery and in the ECV304 cell line derived from human umbilical vein endothelial cells. (biochemj.org)
  • In addition, in adipose tissue of CB 1 -receptor knockout mice, SR141716 had no effect on Acrp30 mRNA expression, demonstrating a CB 1 receptor mediating effect. (aspetjournals.org)
  • Furthermore, RT-PCR analysis revealed that rat adipose tissue and 3T3 F442A adipocytes expressed CB 1 receptor mRNA. (aspetjournals.org)
  • Relative quantification of this expression revealed an up-regulation (3- to 4-fold) of CB 1 receptor mRNA expression in adipose tissue of obese (fa/fa) rats and in differentiated 3T3 F442A adipocytes compared with lean rats and undifferentiated adipocytes, respectively. (aspetjournals.org)
  • Over a decade ago, the CB1 receptor mRNA has been shown to be present in the human ovary (Galiegue et al. (docme.ru)
  • Rimonabant
  • Other cannabinoid antagonists such as rimonabant have been marketed for this application, but have subsequently been withdrawn from sale because of centrally mediated side effects such as depression and nausea. (wikipedia.org)
  • It has potent anorectic effects in animals, and was researched for the treatment of obesity, although CB1 antagonists as a class have now fallen out of favour as potential anorectics following the problems seen with rimonabant, and so ibipinabant is now only used for laboratory research, especially structure-activity relationship studies into novel CB1 antagonists. (wikipedia.org)
  • Abstract
  • THE ANATOMICAL RECORD 293:1425-1432 (2010) Temporal and Spatial Distribution of the Cannabinoid Receptors (CB1, CB2) and Fatty Acid Amide Hydroxylase in the Rat Ovary P. BAGAVANDOSS* AND S. GRIMSHAW Department of Biological Sciences, Kent State University at Stark, North Canton, Ohio ABSTRACT Although the effects of D9-tetrahydrocannabinol (THC) on ovarian physiology have been known for many decades, its mechanism of action in the rat ovary remains poorly understood. (docme.ru)
  • antagonists or inverse agonists
  • It may also be developed as an anorectic drug to assist with weight loss, however there are already several CB1 antagonists or inverse agonists on the market or under development for this application, so surinabant is at present mainly being developed as an anti-smoking drug, with possible application in the treatment of other addictive disorders such as alcoholism. (wikipedia.org)
  • CB1Rs
  • This behavioral effect was associated with preserved activity of CB1Rs regulating GABA transmission in the striatum, whereas these receptors were dramatically down-regulated by stress in control animals. (aspetjournals.org)
  • behavior
  • However, weak- to moderate anxiety-like phenotypes were evident when D1-CB1 −/− mice were tested for social behavior. (frontiersin.org)
  • The role of the dopaminergic (DAergic) neurotransmitter system in the processing of emotional behavior is well established and supported by several preclinical and clinical data showing that DA, acting on D1- or D2-like receptors, is one of the most important neuromodulators of fear and anxiety ( LeDoux, 2000 ). (frontiersin.org)
  • Density of expression varies based on species and correlates with the efficacy that cannabinoids will have in modulating specific aspects of behavior related to the site of expression. (wikipedia.org)
  • suggests
  • Previous work suggests that the extreme carboxy-terminus of the receptor regulates this internalization - likely through the phosphorylation of serines and threonines clustered within this region. (nih.gov)
  • Compounds
  • Compounds SC4a , SN15b , SC33 and FG45a were found to decrease the SRE response induced by CB1 agonist CP55,940 (33 nM). (nih.gov)