Receptor biological function of genes. Medical search. Frequent questions

This gene encodes a secreted protein that has low sequence similarity to the dickkopf-3 protein. (nih.gov)

It shows no homology to other mammalian proteins but strikingly shares 30% sequence identity and 69% similarity with the ERG2 gene product of yeast, which is a C8-C7 sterol isomerase in the ergosterol biosynthetic pathway. (wikipedia.org)
The receptor interacts with proteins called endothelins to regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division (proliferation). (medlineplus.gov)
Endothelin 3 (produced from the EDN3 gene) is one of the proteins that interacts with endothelin receptor type B. During early development before birth (embryonic development), endothelin 3 and endothelin receptor type B together play an important role in neural crest cells. (medlineplus.gov)
Protein-protein interaction (PPI) networks and modules were constructed to identify hub genes with the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Cytoscape. (researchsquare.com)
2021). Similarly, cell senescence due to aging has been widely associated with the impairment of mitochondrial as well as proteosome and lysosome functions responsible for the accumulation of aberrant or misfolded proteins often observed in different neurodegenerative disorders (Sikora et al. (researchgate.net)
Regulation of gene transcription is controlled in part by nuclear receptors that function coordinately with coregulator proteins. (aspetjournals.org)
Plant intracellular nucleotide binding and leucine-rich repeat proteins (NB-LRR, NLRs) function as immune receptors to detect microbial pathogens directly or indirectly. (ubc.ca)
In chapter 2, by using CRISPR/Cas9 gene editing, genetic analysis and biochemical assays, I identified the differential pairings of typical NLR receptor SOC3 with atypical NLR proteins CHS1 or TN2 to guard the homeostasis of the E3 ligase SAUL1. (ubc.ca)
She focuses on the genes and proteins that are important in inhibiting cell death following chemotherapy, such as the BCL2 family of proteins and cell surface "death" receptors. (ladydavis.ca)
Global mapping of CARM1 substrates revealed that CARM1 methylates a large cohort of proteins with diverse biological functions, including regulation of intracellular estrogen receptor signaling, chromatin organization, chromatin remodeling and others. (nih.gov)
Exemplified by MED12, hypermethylation of these proteins by CARM1 served as a molecular beacon for recruiting coactivator protein, tudor domain-containing 3 (TDRD3), to ensure the full activation of estrogen/ERa target genes. (nih.gov)
As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. (embl.de)
To direct signals to specific target genes, Ets proteins interact with (other) transcription factors that promote the binding of Ets proteins to composite Ras-responsive elements. (embl.de)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
Defects in genes and proteins important for B cell maturation block the maturation on certain stage and cause primary immunodeficiencies ( IDbase ). (lu.se)
Bioinformatic analysis of the proteomes revealed shared Gene Ontology (GO) terms and signaling pathways within the clusters of co-expressed proteins (Tables 1-3 and S4. (lu.se)

AXL, a tyrosine kinase receptor, is commonly overexpressed in several solid tumours and numerous hematopoietic malignancies including acute myeloid leukaemia, acute lymphocytic leukaemia, chronic myeloid leukaemia, chronic lymphocytic leukaemia and multiple myeloma. (cancerindex.org)
PAX6 is expressed in pancreatic cancer and actively participates in cancer progression through the activation of the MET tyrosine kinase receptor gene. (bu.edu)
FGFR 3 encodes a transmembrane tyrosine kinase receptor involved in signaling via interaction with the family of fibroblast growth factors. (aacrjournals.org)

By integrating two datasets (GSE77459 and GSE92681) in the GEO database using the sva and limma packages of R, differentially expressed genes (DEGs) of pulpitis were identified. (researchsquare.com)
In recent years, bioinformatics analysis and the microarray technology have been used to identify transcriptomic alterations and differentially expressed genes (DEGs), as well as their physiological functions, in many diseases. (hindawi.com)
Differential expression analysis was performed on the genes expressed between THCA and paraneoplastic tissues in TCGA, and Wayne analysis was performed on the ERGs obtained from the Gene Set Enrichment Analysis MsigDB and differentially expressed genes (DEGs). (biomedcentral.com)
Univariate Cox and least absolute shrinkage and selection operator (LASSO) analyses were used to identify the set of estrogen-related differentially expressed genes (ERDEGs) associated with progression-free intervals (PFI) and to establish a prediction model. (biomedcentral.com)
Correlation analysis was used to identify estrogen-related differentially expressed genes (ERDEGs). (biomedcentral.com)

GO analysis revealed that the DEGs were enriched in biological processes related to inflammation, and the enriched pathways in the KEGG pathway analysis were cytokine-cytokine receptor interaction, chemokine signalling pathway and NF-κB signalling pathway. (researchsquare.com)

Variants (also known as mutations) in the EDNRB gene have been found to cause Hirschsprung disease, a disorder that causes severe constipation or blockage of the intestine. (medlineplus.gov)
Wildin RS, Antush MJ, Bennett RL, Schoof JM, Scott CR: Heterogeneous AVPR2 gene mutations in congenital nephrogenic diabetes insipidus. (hmdb.ca)
DNA sequence analyses and reporter gene assays were performed in order to identify candidate gene mutations. (bmj.com)
Phylogenetic analysis of the VP2 gene showed that amino acid and nucleotide mutations promoted the evolution of FPV and CPV lineages. (bvsalud.org)
One study included in the review found that mutations in TLR3 and IRF7 and genes in related pathways were more common in patients with severe COVID-19, compared to patients with mild or asymptomatic COVID-19. (cdc.gov)
Mutations in toll-like receptor 7 ( TLR7 ), which are responsible for X-linked recessive toll-like receptor 7 deficiency (XR TLR7 deficiency), were also associated with severe COVID-19 . (cdc.gov)

The wide scope and effect of ligand binding on σ1 receptors has led some to believe that σ1 receptors are intracellular signal transduction amplifiers. (wikipedia.org)
The putative mechanism for cannabinoid biological action involves binding to cannabinoid receptor types 1 and 2 (CB1 and CB2) to negatively regulate adenylate cyclase and inhibit intracellular signaling via the cAMP cascade. (aspetjournals.org)
Currently our major efforts are on identification of cell surface receptors that recognize products of microbial pathogens and on elucidation of intracellular signaling pathways responsible for transmitting information from the cell surface to the nucleus. (scripps.edu)
While focused on specific problems of biomedical importance, our research also impacts general areas of cell biology that include the understanding of how GPI-anchored cell surface receptors function and how intracellular kinase cascades are regulated and how such kinase cascades modulate cell function. (scripps.edu)

The opioid classification was eventually dropped however resulting from it not possessing the canonical opioid G-protein coupled receptor structure and the receptor was later referred to as simply the σ1 receptor. (wikipedia.org)
The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. (nih.gov)
G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. (nih.gov)
The structural basis of G-protein-coupled receptor function and dysfunction in human diseases. (nih.gov)
False positive non-synonymous polymorphisms of G-protein coupled receptor genes. (nih.gov)
G-protein-coupled receptor signaling and neural tube closure defects. (nih.gov)
Barlow A, de Graaff E, Pachnis V. Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. (medlineplus.gov)
Transcriptome analyses revealed that Caco-2 BBE cells respond to stimulation with IL-8 supporting the hypothesis that IL-8 induces G protein-coupled receptor signalling. (biomedcentral.com)
IL-8 can signal through two receptors, CXCR1 and CXCR2 both of which are members of the G-protein-coupled receptor (GPCR) family [ 2 ]. (biomedcentral.com)

Significant changes shared by the fly species belong to the expression of genes involved in processes such as oxidation-reduction process, iron-ion binding, and voltage-gated potassium-channel activity. (nature.com)
PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. (caslab.com)
The results published in the journal Nature could have vast therapeutic implications in cardiovascular pathologies where there are mitochondrial and metabolic dysfunctions, as well as diseases related to alterations in maturational processes after birth», explains Mercedes Ricote , head of the Nuclear Receptor Signaling Group of the CNIC and research leader. (ub.edu)
Oxygen-substituted PAHs (OPAHs) are formed during combustion processes and via phototoxidation and biological degradation of parent (unsubstituted) PAHs. (oregonstate.edu)
While protein arginine methyltransferases (PRMTs) and PRMT-catalyzed protein methylation have been well-known to be involved in a myriad of biological processes, their roles in carcinogenesis, particularly in estrogen receptor alpha (ERa)-positive breast cancers, remain incompletely understood. (nih.gov)
Fibroblast growth factor (FGF) signaling controls a vast array of biological processes including cell differentiation and migration, wound healing and malignancy. (biologists.com)
Click "Gene Ontology Details" to view all GO information and evidence for this locus as well as biological processes it shares with other genes. (yeastgenome.org)
We would like to know if different genetic profiles can influence the biological processes and thereby increase or decrease sensitivity to pollutants and endocrine disrupters. (lu.se)

Treatment of RAW 264.7 with delta 9-THC inhibited forskolin-stimulated cAMP production in a dose-related manner, verifying the expression of functional cannabinoid receptors by this cell line. (aspetjournals.org)

Then, the DEGs were analysed to identify biological pathways of dental pulp inflammation with Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis and Gene Set Enrichment Analysis (GSEA). (researchsquare.com)
We downloaded the GSE75010 and GSE10588 datasets from the GEO database and performed weighted gene coexpression network analysis (WGCNA) as well as Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. (hindawi.com)
GO Annotations consist of four mandatory components: a gene product, a term from one of the three Gene Ontology (GO) controlled vocabularies ( Molecular Function , Biological Process , and Cellular Component ), a reference, and an evidence code. (yeastgenome.org)

Some, for example, pointed to genes that expressed themselves in brain cells, or that involved immune function, a previously established connection. (discovermagazine.com)
Some studies have found that vitamin D and omega-3 fish oil may be able to regulate genes involved in inflammation and innate immune responses. (medicalnewstoday.com)
In this study, we used bioinformatics analysis to identify hub genes, establish a logistic model, and study immune cell infiltration to clarify the physiopathogenesis of PE. (hindawi.com)
KEGG and GO analyses further indicated the involvement of these genes in bioprocesses, such as gonadotropin secretion, immune cell infiltration, and the SMAD and MAPK pathways. (hindawi.com)
This study identified 10 hub genes in PE and used 6 of them to establish a logistic model and also analyzed immune cell infiltration. (hindawi.com)
For specific methodology, please visit please visit the protocols section or chapter on ELISA in the Immune Function Handbook, both of which are posted on our web site, www.bdbiosciences.com. (bdbiosciences.com)
delta 9-Tetrahydrocannabinol (delta 9-THC) a prototypic compound belonging to the family of agents known as cannabinoids, produces a wide variety of biological effects, including inhibition of immune function. (aspetjournals.org)
Ulevitch, R. J. Toll-like receptors in the induction of the innate immune response. (scripps.edu)
Primary immunodeficiency (PI)-often used interchangeably with inborn error of immunity (IEI) -refers to a set of rare, single-gene disorders that affect the functioning of the immune system. (cdc.gov)
immune destruction of insulin-pro- vestigate the relationship of VDR gene ducing beta cells by T-cell infiltration polymorphism to the risk of type 1 DM DNA isolation and PCR experiments of the pancreatic islets [1]. (who.int)

The reasons for these effects are not well understood, even though σ1 receptors have been linked circumstantially to a wide variety of signal transduction pathways. (wikipedia.org)
By integrating different datasets from the Gene Expression Omnibus (GEO) database, we analysed a merged expression matrix of pulpitis, aiming to identify biological pathways and diagnostic biomarkers of pulpitis. (researchsquare.com)
Diverse signal recognition receptors and signal transduction pathways were defined which regulate cellular functions, metabolism and development. (mdpi.com)
The discovery of these molecular pathways and knowledge on how they function will reveal new targets for future melanoma therapies. (bu.edu)
ADR1s and NRG1s function in two distinct parallel pathways contributing to TNL-specific immunity. (ubc.ca)
Although only a small proportion of patients are ill due to rare, single gene disorders, studying them may improve understanding of underlying biological pathways, eventually leading to new therapies that are relevant across the disease spectrum. (cdc.gov)

The sigma-1 receptor (σ1R), one of two sigma receptor subtypes, is a chaperone protein at the endoplasmic reticulum (ER) that modulates calcium signaling through the IP3 receptor. (wikipedia.org)
The 5-HT receptor family includes at least 7 classes (5-HT 1−7 receptor) and 15 subtypes with different functional and transduction properties. (frontiersin.org)
North WG, Fay MJ, Longo KA, Du J: Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. (hmdb.ca)

In the search for a biological pacemaker, various approaches were explored, including beta(2)-adrenergic receptor overexpression, down regulation of the inward rectifier current, and overexpression of the pacemaker current. (nih.gov)
Taken together, our study uncovered a "hypermethylation" strategy utilized by CARM1 in gene transcriptional regulation, and suggested that CARM1 can server as a therapeutic target for breast cancer treatment. (nih.gov)

Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
Alternative splicing results in multiple transcript variants of this gene. (cancerindex.org)
Although Hirschsprung disease is a feature of another condition called Waardenburg syndrome type IV (described below), EDNRB gene variants can also cause Hirschsprung disease in people without Waardenburg syndrome. (medlineplus.gov)
People with a variant in one of the two copies of the EDNRB gene tend to develop Hirschsprung disease, while people with variants in both copies of the gene usually develop Waardenburg syndrome type IV. (medlineplus.gov)
Most of these variants change single DNA building blocks (nucleotides) in the gene. (medlineplus.gov)
Variants in the EDNRB gene have been identified in people with Waardenburg syndrome type IV (also known as Waardenburg-Hirschsprung disease or Waardenburg-Shah syndrome). (medlineplus.gov)
Variants in the EDNRB gene disrupt the normal function of endothelin receptor type B or lead to the production of an abnormally small, nonfunctional version of the protein. (medlineplus.gov)
The good news from the study was that many of the variants associated with the disorder made biological sense. (discovermagazine.com)
If you line up these [variants] and determine the likely function of the genes, do they tell the same story? (discovermagazine.com)
The polymorphic variants of the IGF genes may serve as a susceptibility factor for pancreatic cancer. (aacrjournals.org)
In order to investigate the origin of CPV-2 variants in cats, we amplified full-length VP2 genes from seven fecal samples of dogs infected with CPV-2, which were further classified as CPV-2c. (bvsalud.org)

This research is focused on investigating how products of microbial pathogens activate cells to express new genes. (scripps.edu)

This research utilizes molecular, cellular and structural biological approaches. (scripps.edu)

A total of 470 DEGs comprising 394 upregulated and 76 downregulated genes were found in pulpitis tissue. (researchsquare.com)

Western Blot: TR alpha/NR1A1/Thyroid Hormone Receptor alpha Antibody [NBP2-22523] - Analysis of 25 ug of mouse thyroid (lane 1), NIH-3T3 (lane 2) and A431 (lane 3) cell lysates onto an SDS polyacrylamide gel. (novusbio.com)

An endogenous ligand for the σ1 receptor has yet to be conclusively identified, but tryptaminergic trace amines and neuroactive steroids have been found to activate the receptor. (wikipedia.org)
Ligand-Specific Transcriptional Mechanisms Underlie Aryl Hydrocarbon Receptor-Mediated Developmental Toxicity of Oxygenated PAHs. (oregonstate.edu)
TGF-β signaling is initiated when the ligand binds to type II serine/threonine kinase receptor (TGFBR2), which then phosphorylates and activates type I serine/threonine kinase receptor (TGFBR1) [ 13 ]. (degruyter.com)
In vertebrates, FGF signaling is complex, with over 100 predicted FGF ligand-receptor combinations. (biologists.com)

In the present review, the phenotypes of Met gene‑modified mice are summarized. (spandidos-publications.com)
Phenotype annotations for a gene are curated single mutant phenotypes that require an observable (e.g., "cell shape"), a qualifier (e.g., "abnormal"), a mutant type (e.g., null), strain background, and a reference. (yeastgenome.org)

The online search tool for the retrieval of interacting genes and Cytoscape software were used to identify hub genes, which were then used to establish a logistic model. (hindawi.com)

Autophagy is a broad homeostatic, metabolic, cytoplasmic quality control, and metabolic process affecting many functions in the cell. (wikipedia.org)
The Clinical Significance of Dickkopf Wnt Signaling Pathway Inhibitor Gene Family in Head and Neck Squamous Cell Carcinoma. (nih.gov)
This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. (cancerindex.org)
The EDNRB gene provides instructions for making a protein called endothelin receptor type B. This protein is located on the surface of cells and functions as a signaling mechanism, transmitting information from outside the cell to inside the cell. (medlineplus.gov)
Because the receptor is necessary for the formation of enteric nerves and melanocytes, these cell types do not form normally during embryonic development. (medlineplus.gov)
RXR is a protein that acts as a nutritional sensor for lipids and vitamin A derivatives, altering gene expression and influencing biological functions as important as immunity, cell differentiation or metabolism. (ub.edu)
Pax3 functions at a nodal point in adult melanocyte stem cell differentiation. (bu.edu)
Interleukin-4 (IL-4) is a potent lymphoid cell growth factor which can stimulate the growth, differentiation and survivability of and regulate the function of various cell types of hematopoietic (including B and T lymphocytes, mast cells, monocytes and macrophages) and non-hematopoietic (e.g., vascular endothelial cells and certain tumor cells) origin. (bdbiosciences.com)
IL-4 exerts its biological activities by binding to specific high affinity receptors expressed by a wide variety of cell types. (bdbiosciences.com)
Hepatocyte growth factor (HGF) is produced by stromal and mesenchymal cells, and it stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine phosphorylation of its cognate receptor, Met. (spandidos-publications.com)
MYC gene re-arrangements are associated with a poor prognosis in diffuse large B cell lymphoma patients treated with R-CHOP chemotherapy. (ladydavis.ca)
In consistent with its critical role in estrogen-induced gene transcriptional activation, CARM1 was found to promote cell proliferation of ERa-positive breast cancer cells in vitro and tumor growth in mice. (nih.gov)
Most Fibroblast growth factors (FGFs) have N-terminal signal peptides and are secreted from cells, allowing binding to and activation of their cell surface receptors (FGFRs). (biologists.com)
In embryos, these functions include mesoderm induction and patterning, cell growth, migration and differentiation. (biologists.com)
and TNFR2, which signals cell proliferation, gene activation and apoptosis mainly in T cells. (biologists.com)
The authors engineered PC60 cells to express both human TNF receptors and then used mutants of human TNF capable of binding either human TNFR1 or human TNFR2 to investigate cell death induction in the T cell hybridoma. (biologists.com)
The HA glycoprotein forms spikes at the surface of virions, mediating attachment to host cell sialoside receptors and subsequent entry by membrane fusion. (cdc.gov)
Further, B cell antigen receptor (BCR) activation induced proteomic changes were studied in anti-IgM stimulated Ramos B cells in a long time series. (lu.se)

Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Clinicopathological and transcriptome data of patients with THCA from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) were cleaned before consensus clustering. (biomedcentral.com)

The mammalian σ1 receptor is an integral membrane protein with 223 amino acids. (wikipedia.org)
The CXCR1 receptor for IL-8 was expressed only on the apical membrane of Caco-2 BBE cells and differentiated epithelial cells in the human small intestine and colon. (biomedcentral.com)

Thyroid Hormone Receptor alpha is encoded by this gene is a nuclear hormone receptor for triiodothyronine. (novusbio.com)
It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. (novusbio.com)
Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. (novusbio.com)
PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. (caslab.com)
NR1I3) is expressed primarily in liver and regulates the expression of genes involved in xenobiotic metabolism as well as hormone, energy, and lipid homeostasis. (aspetjournals.org)
Seibold A, Brabet P, Rosenthal W, Birnbaumer M: Structure and chromosomal localization of the human antidiuretic hormone receptor gene. (hmdb.ca)
My research interests focus on the sex hormone systems in aquatic ecosystem, especially the estrogen receptor system in fish. (lu.se)
I am interested in evolutionary history as well as gene expression dynamic of hormone receptors and how gene activities are influenced by anthropogenic factors (e.g. environmental pollutant and sewage treatment plant effluents) throughout the life cycle. (lu.se)
This causes salmonids to have two or three gene copies of hormone receptors, which in other vertebrates would only be found in a single copy. (lu.se)

c-Src (cellular Src), encoded by Src gene, is a non-receptor tyrosine kinase first isolated as the normal cellular homolog to the potent avian sarcoma viral transforming oncogene v-Src [ 4 ]. (intechopen.com)
Despite those advances, significant questions remain unanswered about the functioning of those viral capsids and their roles in release, transmission, or cellular infection. (bvsalud.org)
All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses. (cdc.gov)
The M2 is a transmembrane protein that forms an ion channel required for the uncoating process that precedes viral gene expression. (cdc.gov)
We show that the protein is required at an early, but post-receptor engagement, stage of the viral lifecycle. (cdc.gov)

A total of 100 and 212 differently expressed genes were identified in the GSE75010 and GSE10588 datasets, respectively, and after overlapping with WGCNA results, 17 genes were identified. (hindawi.com)

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. (caslab.com)

PAX3 and SOX10 activate MET receptor expression in melanoma. (bu.edu)

Additionally, protein-protein interaction network analysis identified 10 hub genes, six ( FLT1 , FLNB , FSTL3 , INHA , TREM1 , and SLCO4A1 ) of which were used to establish a logistic model for PE. (hindawi.com)
Furthermore, results obtained from mammalian two-hybrid experiments assessing various domain configurations of the respective receptors showed that full-length DAX-1 inhibited the CAR-SRC1 interaction by approximately 50%, whereas the same interaction was restored to 90% of control when the DAX-1 transcription silencing domain was deleted. (aspetjournals.org)
Interaction annotations are curated by BioGRID and include physical or genetic interactions observed between at least two genes. (yeastgenome.org)
In addition we will address important areas of modern epidemiology such as the influence of early life factors on adult health and disease, but also the importance of the gene-diet-microbiota interaction for body function and health. (lu.se)

And the 5-HT 1A receptors regulate several transduction mechanisms in the memory formation. (frontiersin.org)

Receptor for retinoic acid. (abcam.com)
The PLZF gene is one of five partners fused to the retinoic acid receptor α in acute promyelocytic leukaemia. (bmj.com)

This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. (nih.gov)

Journal of Biological Chemistry 290:(36)21901-14. (bu.edu)
Journal of Biological Chemistry 284:(40)27524-32. (bu.edu)

Results obtained in primary human hepatocytes further demonstrated DAX-1 inhibition of CAR-mediated CITCO induction of the CYP2B6 target gene. (aspetjournals.org)

Zinc and copper modulate differentially the P2X receptor. (cdc.gov)

The σ1 receptor is a transmembrane protein expressed in many different tissue types. (wikipedia.org)

It may function as an integrator of transcription repression and nuclear receptor signaling. (caslab.com)
Deletion of DAX-1's C-terminal transcription silencing domain restored CAR1 transactivation activity in reporter assays to approximately 90% of control, demonstrating its critical function in mediating the CAR repression activities. (aspetjournals.org)

In particular, the omega-6 γ -linolenic fatty acid (GLA), from breast milk, is responsible for binding to the cellular protein Retinoid X Receptor (RXR). (ub.edu)
The v-ets oncogene was originally discovered as part of a fusion protein expressed by a transforming retrovirus (avian E26), and later shown to be transduced from a cellular gene. (embl.de)

In this report, DAX-1, a nuclear receptor family member with corepressor properties, was identified as a potent CAR regulator. (aspetjournals.org)
Various growth factors, cytokines, and prostaglandins upregulate HGF gene expression, including basic fibroblast growth factor, oncostatin M, hypoxia-inducible factor 1α and nuclear factor-κB (NF-κB) ( 9 ). (spandidos-publications.com)
Attenuation of inducible nitric oxide synthase gene expression by delta 9-tetrahydrocannabinol is mediated through the inhibition of nuclear factor- kappa B/Rel activation. (aspetjournals.org)

In addition, pulmonary expression of interferon alpha and beta and Irf7 specific pattern recognition receptors (PRR) and signaling molecules (Ddx58, Ifih1, Dhx58, ISGF3) were induced, an effect that showed specificity when compared to other inflammatory exposures. (cdc.gov)
The type I IFN signaling pathway includes toll-like receptor 3 ( TLR3 ) and interferon regulator factor 7 ( IRF7 ). (cdc.gov)

A total of 2164 orthologous genes were used. (nature.com)

Much is known about the binding affinity of hundreds of synthetic compounds to the σ1 receptor. (wikipedia.org)

Rats carrying rs198585630 C allele exhibited increased mRNA and protein expression of 5-HT 1A receptor and were more susceptible to 30 mW/cm 2 microwave exposure, showing cognitive deficits and inhibition of brain electrical activity. (frontiersin.org)

d) Identify the liver GDF15 receptor and elucidate its signaling pathway in the liver. (upenn.edu)

In addition to the University of Barcelona and the IBUB, teams from the National Biotechnology Center and Center for Biological Research Margarita Salas Centre (CNB-CSIC, CIB-CSIC), the Complutense University of Madrid (UCM), the Institute of Functional Biology and Genomics/University of Salamanca (IBFG/USAL), the CEMBIO/CEU Sant Pau, the CIBER of Cardiovascular Diseases (CIBERCV) and the Karolinska Institute (Sweden). (ub.edu)
Both Pyr and Ths function in a non-autonomous fashion to support mesoderm spreading during gastrulation, but Pyr exhibits a longer functional range. (biologists.com)

Old age and a variety of cardiovascular disorders may disrupt normal sinus node function. (nih.gov)

CARM1 was found to be predominantly and specifically recruited to ERa-bound active enhancers and essential for the transcriptional activation of cognate estrogen-induced gene transcriptional activation in response to estrogen. (nih.gov)

In addition, the interactions of capsids with host receptors, antibodies, or other biological components are also still incompletely understood. (bvsalud.org)

Electroencephalograms (EEGs), spatial learning and memory, and mRNA and protein expression of 5-HT 1A receptor were evaluated in vivo . (frontiersin.org)
Fay MJ, Du J, Yu X, North WG: Evidence for expression of vasopressin V2 receptor mRNA in human lung. (hmdb.ca)

snc1 harbors a gain-of-function mutation in the TNL SNC1 (Suppressor of npr1, Constitutive 1) and exhibits autoimmune phenotype. (ubc.ca)

σ1 receptors apparently co-localize with IP3 receptors on the endoplasmic reticulum where they may be involved in preventing endoplasmic reticulum stress in neurodegenerative diseases. (wikipedia.org)
There has been much interest in the sigma-1 receptor and its role in age-related neurodegenerative diseases such as Alzheimer's disease. (wikipedia.org)
However, in diseases such as Alzheimer's disease, there appears to be a reduction in sigma-1 receptor expression. (wikipedia.org)

Taking into account specific alpha-helical propensities of Val and Met, this mutation is likely to destabilise the alpha helix of the zinc finger that forms the contact with the DNA duplex, thus affecting the biological function as shown by reporter-gene assays. (bmj.com)

A variety of specific physiological functions have been attributed to the σ1 receptor. (wikipedia.org)

Here, we investigated, in females of both D. melanogaster and D. nigrosparsa , the gene expression between animals uninfected and infected with w Mel, using RNA sequencing to see if the two Drosophila species respond to the infection in the same or different ways. (nature.com)
Drosophila melanogaster presents a simpler model system in which to study FGF signaling, with only three ligands and two FGF receptors (FGFRs) identified. (biologists.com)

In both plants and animals, nucleotide-binding leucine-rich repeat (NLR) receptors play crucial roles in the recognition of pathogen-derived molecules and the activation of defense. (ubc.ca)

The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. (who.int)

Anatomy17

Organisms18

Diseases3

Chemicals and Drugs49

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes97

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture2

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Secreted protein1

Proteins16

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Mutations6

Intracellular4

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Processes8

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Ontology3

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Regulation2

Variants11

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Molecular1

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Identify hub genes1

Cell18

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Membrane2

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Viral5

Datasets1

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Activate1

Interaction4

Regulate several1

Retinoic2

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