Receptor axin protein. Medical search. Frequent questions

Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. (wikipedia.org)
Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). (novusbio.com)
In this study, we found that Wnt3a acts in parallel to induce the caveolin-dependent internalization of low-density-lipoprotein receptor-related protein 6 (LRP6), as well as the phosphorylation of LRP6 and the recruitment of Axin to LRP6 on the cell surface membrane. (elsevierpure.com)
When secreted Wnt protein situation to Frizzled and low-density lipoprotein receptor-related protein (LRPs) at the plasma membrane layer, a sign is definitely transduced to destabilize the -catenin damage complicated. (insulin-receptor.info)

these in turn inhibit the destruction complex responsible for degrading β-catenin, which includes GSK-3 , adenomatous polyposis coli (APC) and axin. (tocris.com)
Wnt and Rho GTPase signaling Rabbit polyclonal to NGFR and their discussion In the canonical Wnt signaling pathway, most -catenin in the cytoplasm can be sequestered in a oligomeric complicated of casein kinase, axin, the adenomatous polyposis coli tumor suppressor proteins (APC) and glycogen synthase kinase 3 (GSK3) [16]. (exposed-skin-care.net)
In canonical Wnt signaling, most -catenin in the cytoplasm can be sequestered within an oligomeric complicated of glycogen synthase kinase 3 (GSK3), casein kinase (CK), axin and adenomatous polyposis coli tumor suppressor proteins (APC). (exposed-skin-care.net)
In the lack of Wnt signaling, cytoplasmic -catenin is definitely destined by damage complicated healthy proteins, including AXIN, adenomatous polyposis coli (APC), and glycogen synthase kinase 3 beta (GSK3M). (insulin-receptor.info)
The degradation of β-catenin is regulated by interaction with a number of proteins including Axin , glycogen synthase kinase 3 (GSK3) and the adenomatous polyposis coli protein (APC). (biomedcentral.com)
The level of free β-catenin is low in normal cells, since the protein is sequestered in a complex, which includes the adenomatous polyposis coli (APC) protein, a serine threonine glycogen kinase (GSK-3β) and conductin or Axin, leading to degradation of β-catenin by proteasome. (biomedcentral.com)
The initial case for the participation of WNT signaling in individual cancers was produced when the hereditary cancers symptoms termed familial adenomatous polyposis (FAP) gene item, adenomatous polyposis coli (APC) 13, 14, was discovered to connect to -catenin 15, 16, and was afterwards shown to enjoy a critical function in managing -catenin proteins stability. (icsv20.org)

In the absence of Wnt ligands, β-catenin is degraded via a destruction complex (DC) consisting of two core tumor suppressors that serve as scaffold proteins (APC and Axin) and two kinases (glycogen synthase kinase-3 β [GSK3β] and casein kinase 1 [CK1]) ( 4 ). (rupress.org)
In the absence of Wnt ligands, a complex containing APC, AXIN and GSK3 phosphorylates β-catenin, marking it as a substrate for ubiquitination by β-TrCP and subsequent proteasomal degradation. (plos.org)
Cytoplasmic -catenin is definitely managed by the degradation complicated made up of adenomatosis polyposis coli (APC), Axin, proteins phosphatase 2A (PP2A), glycogen synthase kinase 3 beta (GSK3) and casein kinase 1 (CK1) [6C9]. (opioid-receptors.com)

Nevertheless, when Wnt ligands bind to cell membrane receptors, signaling through the frizzled receptors inhibits this degradation procedure, thereby raising the degrees of free of charge cytoplasmic -catenin. (exposed-skin-care.net)
When Wnt ligands bind with their cognate cell membrane receptors, indicators are released to inhibit this degradation procedure, leading to -catenin build up and nuclear translocation controlled by Rac1, DKK1 and FRZB, which are antagonists of canonical Wnt signaling. (exposed-skin-care.net)
In the canonical Wnt/β-catenin signaling, a Wnt ligand binds to a cell surface receptor complex consisting of the members of Frizzled family and the transmembrane protein LRP 5 and 6 to prevent phosphorylation and degradation of β-catenin by the GSK3β/APC/Axin destruction complex. (oncotarget.com)
We show that RNF146, tankyrase, and Axin form a protein complex, and that RNF146 mediates ubiquitylation of all three proteins to target them for proteasomal degradation. (omicsdi.org)
Tankyrase auto-PARsylation and PARsylation of Axin is known to lead to proteasome-mediated degradation of these proteins, and we demonstrate that, through ubiquitylation, RNF146 mediates this process to regulate Wnt signaling. (omicsdi.org)
In addition to ligand-regulated degradation of β-catenin, Wnt signaling is antagonized by extracellular factors that inhibit the ability of Wnt ligands to bind to Fzd and initiate signaling, such as the secreted frizzled-related proteins (SFRP1, WNT inhibitory factor (WIF) and dickkopf (DKK) [3] . (plos.org)

LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. (wikipedia.org)
LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. (wikipedia.org)
LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. (wikipedia.org)
Canonical WNT signals are transduced through Frizzled receptor and LRP5/LRP6 coreceptor to downregulate GSK3beta (GSK3B) activity not depending on Ser-9 phosphorylation. (wikipedia.org)
There are promising osteoporosis clinical trials targeting sclerostin, an osteocyte-specific protein which inhibits Wnt signaling by binding to Lrp5. (wikipedia.org)
A glial-derived extracellular ligand, Norrin, acts on a transmembrane receptor, Frizzled4, a coreceptor, Lrp5, and an auxiliary membrane protein, TSPAN12, on the surface of developing endothelial cells to control a transcriptional program that regulates endothelial growth and maturation. (wikipedia.org)
LRP5 mRNA and protein expression are also significantly up-regulated in osteoarthritic cartilage compared to normal cartilage, and LRP5 mRNA expression was further increased by vitamin D. Blocking LRP5 expression using siRNA against LRP5 resulted in a significant decrease in MMP13 mRNA and protein expressions. (wikipedia.org)
Signaling is initiated when the Wnt ligand binds to the Frizzled receptor on the cell membrane and the LDL receptor-associated protein 5/6 (LRP5/6) co-receptor. (frontiersin.org)
Canonical Wnt/β-catenin signaling is initiated by binding of Wnt ligands to Frizzled (Fzd)-LRP5/6 receptor complexes, leading to inactivation of the destruction complex and stabilization of β-catenin. (plos.org)
Canonical WNT signals are transduced through Frizzled family receptors and LRP5/LRP6 coreceptor to the β-catenin signaling cascade. (aacrjournals.org)

The Wnt co-receptor, Lrp6, is required for signaling along the β-catenin arm. (silverchair.com)
Finally, we identify the region of the Lrp6 protein with Wnt/PCP activity to a stretch of 36 amino acids, distinct from regions required for Wnt/β-catenin signaling. (silverchair.com)

Recent cancer genome deep sequencing efforts have revealed an unanticipated high frequency of mutations in G proteins and G-protein-coupled receptors (GPCRs) in most tumour types. (nature.com)
Mutations in β-catenin, axin and APC have been discovered in numerous cancers, and other members of the canonical pathway may also contribute to misregulation of Wnt signaling. (tocris.com)
Loss-of-function mutations in APC or AXIN or activating mutations in the gene encoding β-catenin, CTNNB1 , lead to aberrant activation of Wnt/β-catenin signaling and have been causally linked to tumorigenesis of the colon, liver and skin [1] , [4] . (plos.org)
In this study, we investigated the expression pattern of β-catenin and cyclin D1 using immunohistochemistry and searched for mutations in exon 3 of the β-catenin gene and Axin gene in esophageal squamous cell carcinoma. (biomedcentral.com)
Mutations in β-catenin or axin genes are not responsible for this abnormal localization of β-catenin. (biomedcentral.com)

In each protein, about 85% of its 1600-amino-acid length is extracellular. (wikipedia.org)
The roles of b-catenin are 'classically' defined: as an adhesion protein and as a signaling protein, transducing extracellular signals to the nucleus to modify gene expression. (chemdiv.com)
This highly adhesive nature is attributable to molecules of E-cadherin, a transmembrane protein, on the surface of one epithelial cell binding with the E-cadherin moelcules of another epithelial cell across the extracellular space. (biomedcentral.com)
The first step in the Wnt signal occurs when extracellular Wnt ligand binds Frizzled receptors on the cell surface, leading to the activation of several distinct transduction pathways (see Figure 1 ). (biomedcentral.com)

SUMOylation is a post-translational modification of proteins that has been found to play a major role in the Wnt/β-catenin signaling pathway. (frontiersin.org)
Proteins associated with the Wnt/β-catenin pathway have been identified as SUMOylated substrates, and evidences suggested that the initiation and progression of cancers depended on the function of the SUMOylation ( 23 ). (frontiersin.org)
β-catenin protein is an integral part of the canonical Wnt signaling pathway. (tocris.com)
Within this pathway, Dishevelled interprets and propagates signals from 19 Wnts engaging 10 Frizzled (Fzd) receptors/co-receptors embedded in the plasma membrane (PM). For years, interest in how Dishevelled receives, interprets, and relays this information has been immense. (rupress.org)
The signaling pathway is initiated by the binding of WNT PROTEINS to cell surface WNT RECEPTORS which interact with the AXIN SIGNALING COMPLEX and an array of second messengers that influence the actions of BETA CATENIN. (bvsalud.org)
Local factors, including transcription factors such as SRY-box 9 protein (SOX9), Runt-related transcription factor 2 (RUNX2), and bone morphogenetic proteins (BMPs), along with signaling pathways such as the Wnt pathway, play critical roles in chondrocyte proliferation and differentiation. (pfmjournal.org)
This work presents a simple mathematical model of EMT, specifically the roles played by four key proteins in the Wnt signaling pathway: Dishevelled (Dvl), E-cadherin, β-catenin, and Slug. (biomedcentral.com)
Now, in Journal of Biology [ 1 ], Sergei Sokol and colleagues show that the Dishevelled (Dsh) protein of the Wnt signaling pathway can shuttle in and out of the nucleus (see 'The bottom line' box for a summary of the work and 'Background' for further explanations and definitions). (biomedcentral.com)
The canonical Wnt pathway involves stabilization of the intracellular protein β-catenin . (biomedcentral.com)
Frizzled receptors can also initiate an independent ' non-canonical ' Wnt pathway that diverges to regulate complex developmental events involved in planar cell polarity and convergent extension movements during embryo development, via small GTPases and the JNK kinase. (biomedcentral.com)
Ras-dependent activation of MAP kinase pathway mediated by G-proteinβγ subunits. (gutkindlab.org)
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK (SAPK) signaling pathway. (gutkindlab.org)
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase g. (gutkindlab.org)
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's Sarcoma Associated Herpesvirus G Protein-Coupled Receptor. (gutkindlab.org)
A fuller picture of the WNT signaling pathway surfaced when T-cell aspect/lymphocyte enhancer aspect (TCF/LEF) transcription elements had been defined as WNT nuclear effectors 9, 10 and Frizzleds (FZDs) had been defined as WNT obligate receptors 11, working as well as co-receptors, such as for example low-density lipoprotein-receptor-related proteins (LRPs)/Arrow 12. (icsv20.org)

Post-translational modifications (PTMs) of proteins, including phosphorylation, acetylation, ubiquitination, and SUMOylation, can regulate the function of proteins, determine the active state and subcellular location of proteins, and dynamically interact with other proteins related to carcinogenesis and progression ( 17 - 20 ). (frontiersin.org)
Protein phosphorylation of G-protein-coupled receptors (GPCR) is central to the myriad of functions that these ubiquitous receptors perform in biology. (biomedcentral.com)

The standard model of Wnt signaling specifies that after receipt of a Wnt ligand at the membranous receptor complex, downstream mediators inhibit a cytoplasmic destruction complex, allowing β-catenin to accumulate in the cytosol and nucleus and co-activate Wnt target genes. (silverchair.com)

Both start when Wnt ligand binds the Frizzled receptor at the cell surface, and both include the key mediator Dsh. (biomedcentral.com)

Wnt proteins regulate developmental processes, tissue regeneration and stem cell maintenance. (exeter.ac.uk)
Structure-function analysis of the Dishevelled (Dsh) protein in frog embryos has defined sequences that regulate Dsh nuclear localization, which proves critical for Wnt signaling. (biomedcentral.com)
As BPC-157 and TB-500 regulate axin protein, wound healing is influenced. (direct-sarms.com)

This library represents a selection of drug-like compounds aimed at modulating protein-protein interaction (PPI) of β-catenin with different proteins involved in significant physiological processes. (chemdiv.com)

These alterations may arise from cancer-specific changes in gene copy number, as well as from other genetic, epigenetic and post-translational changes resulting in higher protein expression, thereby enhancing tumour progression and metastasis. (nature.com)
Membrane-spanning proteins often function as receptors involved in recognition and cell adhesion, whereas nuclear proteins frequently play a role in regulating gene expression and transcription. (biomedcentral.com)
This effect is accompanied by epigenetic changes involving histone post-translational modifications at the mineralocorticoid receptor (MR) gene and decreased MR expression in the hippocampus. (nature.com)
This is accompanied by epigenetic changes at the mineralocorticoid receptor (MR) gene and decreased MR expression, that can be mimicked in vivo by pharmacological blockade of MR. These findings highlight the potential adaptive benefit of adverse experiences in early life, and implicate a stress hormone receptor and its epigenetic regulation. (nature.com)
Mutational analyses of the exon3 of the β-catenin gene and Axin gene were performed on tumors with nuclear β-catenin expression. (biomedcentral.com)
Non-canonical WNT signaling can also activate calcium flux and kinase cascades, including protein kinase C (PKC), calcium/calmodulin-dependent protein kinase II (CaMKII) and JUN N-terminal kinase (JNK), leading to the activation of AP1- and NFAT-regulated gene expression 25-27. (icsv20.org)

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling. (omicsdi.org)
The axin protein regulates cell movement. (direct-sarms.com)
Non-canonical WNT signaling can be initiated by WNT conversation with Frizzled receptors, or RYK and ROR receptor tyrosine kinases, and regulates small GTPases (such as RhoA, Rac and Cdc42) in DVL-dependent manner. (icsv20.org)

Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the Dishevelled-dependent (Rho family GTPases and c-jun NH 2 -terminal kinase) or the Ca 2+ -dependent (NLK and nuclear factor of activated T cells) signaling cascades. (aacrjournals.org)
PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
NM23-H1 (also known as NME1) was the first identified metastasis suppressor, which displays a nucleoside diphosphate kinase (NDPK) and histidine protein kinase activity. (biomedcentral.com)
p38 mitogen-activated protein kinase has been implicated in both skeletal muscle atrophy and hypertrophy. (biomedcentral.com)
G protein-coupled receptor kinase 2 (GRK2) was originally identified as the kinase that mediates. (biomedcentral.com)

The most frequently mutated GPCRs include thyroid-stimulating hormone receptor (TSHR), Smoothened (SMO), glutamate metabotropic receptors (GRMs), members of the adhesion family of GPCRs and receptors for bioactive lipid mediators such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) that accumulate in the tumour microenvironment. (nature.com)
Aberrant expression, overexpression or signal reprogramming of GPCRs and G proteins in tumour cells can contribute to cancer development and progression. (nature.com)
G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. (nature.com)
These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment. (nature.com)
While expression patterns of many proteins in human medulloblastoma subgroups have been discerned, the expression pattern of GPCRs in medulloblastoma has not been investigated. (biomedcentral.com)
Illuminating G-Protein-Coupling Selectivity of GPCRs. (gutkindlab.org)

https://doi.org/10.1083/jcb.202205069 ) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane. (rupress.org)

Mechanistically, how tankyrase limits Axin protein accumulation, and how tankyrase levels and activity are regulated for this function, are currently under investigation. (omicsdi.org)

To activate canonical signaling, Wnt ligands bind to a Fzd receptor/co-receptor complex to initiate signaling at the PM. This Wnt/receptor complex recruits Dvl to Fzd where Dvl serves as a binding partner for Axin. (rupress.org)
This function of Axin is counteracted through relocalization of Axin protein to the Wnt receptor complex to allow for ligand-activated Wnt signaling. (omicsdi.org)
Therefore in the nucleus of AML stem/BPCs the β-catenin-TCF4/LEF1 complex increases manifestation of the pro-growth and pro-survival genes including cyclin D1 c-MYC and survivin while reducing Axin 2 levels1 3 15 In AML stem/BPCs Citalopram Hydrobromide multiple mechanisms are known to deregulate WNT signaling. (researchassistantresume.com)

Aspartate β-hydroxylase (ASPH) is a type II transmembrane protein and the member of α-ketoglutarate-dependent dioxygenase family, found to be overexpressed in different cancer types, including PC. (bjbms.org)

The lipid the different parts of WNTs are necessary for effective signaling, including WNT proteins secretion 30, 31. (icsv20.org)

Each protein has a single-pass, 22-amino-acid segment that crosses the cell membrane and a 207-amino-acid segment that is internal to the cell. (wikipedia.org)
Elegant studies have demonstrated Dvl-mediated formation of a membrane proximal "signalosome," which enables critical protein interactions at the PM ( 5 ). (rupress.org)

WNT signals are context-dependently transduced to both pathways based on the expression profile of WNT, SFRP, WIF, DKK, Frizzled receptors, coreceptors, and the activity of intracellular WNT signaling regulators. (aacrjournals.org)

The highly conserved family of Wnt proteins represents important regulators of cell behaviour, tissue development and homeostasis by inducing responses in a concentration-dependent manner. (exeter.ac.uk)
We identified a novel way of spreading Wnt proteins in vertebrates: Wnt molecules are mobilized on specific cell protrusions known as cytonemes. (exeter.ac.uk)
In our research, we use the zebrafish embryo to investigate how intercellular Wnt protein transport is regulated and how signals are subsequently delivered to the target cell in a living vertebrate organism. (exeter.ac.uk)
Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line. (novusbio.com)
Axin recruitment to the PM represents a key step in β-catenin stabilization, which ultimately leads to β-catenin nuclear translocation to act as a coactivator of transcription with T cell factor/lymphoid enhancer-binding factor (TCF/LEF) at Wnt target genes. (rupress.org)
These receptors, which include Toll-like receptors, are portion of an internal sponsor defense Paroxetine HCl realizing nucleic acids aberrantly present in the cytoplasm from illness or cell stress. (columbiagypsy.net)
In this way, axin filaments, which are essential for fibroblast and immune cell migration, are concentrated in the areas where they are most needed. (direct-sarms.com)
Prostaglandin E2 promotes colon cancer cell growth through a novel Gs-axin-β-catenin signaling axis. (gutkindlab.org)
β-catenin is a multifunctional protein involved in two apparently independent processes: cell-cell adhesion and signal transduction. (biomedcentral.com)

RNF146 is a cytoplasmic protein that also prevents tankyrase protein aggregation at a centrosomal location. (omicsdi.org)

By RNAi screening, we identified the RNF146 RING-type ubiquitin E3 ligase as a positive regulator of Wnt signaling that operates with tankyrase to maintain low steady-state levels of Axin proteins. (omicsdi.org)

Noncanonical WNT signals are transduced through Frizzled family receptors and ROR2/RYK coreceptors to the DVL-dependent (Rho family GTPases and JNK) or the Ca 2+ -dependent (NLK and NFAT) signaling cascades. (aacrjournals.org)
Smurf2, a member of the HECT domain E3 ligase family, is well known for its role as a negative regulator of TGF-β signaling by targeting Smads and TGF-β receptor. (molcells.org)
Recent studies on the involvement of the G12 family of heterotrimeric G proteins (Gα12 and Gα13, the products of the GNA12 and GNA13 genes, respectively) in oncogenic pathways have uncovered a link between G12. (biomedcentral.com)
Generally in most mammalian genomes, the WNT family members is normally made up of 19 associates that are seen as a an extremely conserved cysteine-rich secreted glycoproteins, which present the specialized challenges in effective creation, biochemical characterization and structural evaluation of WNT proteins 28, however the structure from the Xenopus WNT8 proteins as destined to Frizzled (FZD) was lately resolved 29. (icsv20.org)

The intracellular protein Dishevelled is common to both canonical and non-canonical signaling pathways, raising the question of how this mysterious protein acts at the signal crossroads. (biomedcentral.com)
The roles of the other proteins in the two pathways, and of the Dsh motifs, are discussed in the text. (biomedcentral.com)
ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)

Telomerase maintains telomeres canonically, but latest reviews possess suggested that the primary proteins mammalian telomerase change transcriptase (TERT) element, together with the chromatin remodeling element BRG1 and -catenin, might also situation to and promote appearance of Wnt focus on genetics. (insulin-receptor.info)

β -catenin has many binding partners that mediate a diverse set of cellular functions, and the protein probably acts as a 'hub' on which many cellular signaling networks impinge. (chemdiv.com)
Here we demonstrate aberrant activation of Wnt/β-catenin signaling in bone sarcoma cells, involving an autocrine Wnt signaling loop with upregulation of specific Wnt ligands and receptors. (oncotarget.com)
AXIN1 and AXIN2 protein levels are regulated by tankyrase-mediated poly(ADP-ribosyl)ation (PARsylation), which destabilizes Axin and promotes signaling. (omicsdi.org)
WNT, fibroblast growth factor (FGF), Notch, Hedgehog, and transforming growth factor β/bone morphogenetic protein signaling network are implicated in the maintenance of tissue homeostasis by regulating self-renewal of normal stem cells as well as proliferation or differentiation of progenitor (transit-amplifying) cells. (aacrjournals.org)
Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis. (gutkindlab.org)

But it is becoming increasingly clear that protein subcellular localization can be extremely dynamic, allowing key proteins to play different roles in different compartments. (biomedcentral.com)
Analysis of Dsh sequence alignments revealed the presence of three conserved domains called DIX , PDZ and DEP [ 5 , 6 ], which are implicated in protein-protein interactions and targeting to subcellular sites. (biomedcentral.com)

Those writers additionally reported protein-protein relationships between hTERT and the chromatin redesigning element BRG1 and between hTERT and -catenin. (insulin-receptor.info)

They are involved in protein-protein interactions. (embl.de)

β-catenin is also required for the HOXA9 and MEIS1-mediated transformation of the hematopoietic stem cells MLL-AF9-mediated transformation of the committed myeloid progenitor cells as well as necessary for the development and growth of MLL fusion protein-transformed leukemia stem cells2-5. (researchassistantresume.com)
Growth hormone receptors on the fibroblast surface are increased by BPC-157, extending the life of the cells. (direct-sarms.com)

Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)

BP-157 has been shown to increase the protein axin expression by promoting the gene's transcription. (direct-sarms.com)

CSCs exhibit certain properties, such as high expression of various anti-apoptotic proteins, expression of ABC pumps, and others, that would allow them to resist chemotherapeutic agents (Li et al. (docksci.com)

Lipoprotein receptor-related protein4

Adenomatous7

GSK33

Degradation6

LRP510

LRP62

Mutations5

Extracellular4

Pathway15

Phosphorylation2

Destruction complex1

Ligand binds1

Regulate3

Modulating protein-pro1

Gene6

Regulates3

Kinase5

GPCRs7

Plasma membrane1

Accumulation1

Complex3

Transmembrane protein1

Wnts1

Membrane2

SFRP1

Cell9

Cytoplasmic1

Steady-state levels1

Family4

Pathways3

Possess1

Signaling5

Subcellular2

Chromatin1

Interactions1

Growth2

Post-translational1

Transcription1

Expression1