AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation ScienceHealth Care
Avian Sarcoma VirusesAlpharetrovirusSarcoma, AvianSarcoma Viruses, MurineCell Transformation, ViralSarcomaChick EmbryoAvian leukosis virusOncogene Protein pp60(v-src)Genes, ViralSarcoma Viruses, FelineQuailSarcoma, ExperimentalKirsten murine sarcoma virusViral ProteinsRous sarcoma virusDefective VirusesCell Transformation, NeoplasticMoloney murine sarcoma virusRNA, ViralChickensDNA, ViralRNA-Directed DNA PolymeraseDucksBase SequenceHarvey murine sarcoma virusHelper VirusesRetroviridae ProteinsRetroviridaeIntegrasesOncogene Protein v-crkSarcoma, EwingNucleic Acid HybridizationOncogenesVirus ReplicationGammaretrovirusGene Products, gagCell LineSarcoma, KaposiSarcoma, SynovialGenes, srcReceptors, VirusAvian LeukosisSarcoma Virus, Woolly MonkeyFibroblastsProtein KinasesCoturnixGenes, SyntheticCells, CulturedIntegrase InhibitorsFusion Proteins, gag-oncRNA VirusesMolecular WeightCulture TechniquesAvian ProteinsMolecular Sequence DataVirus IntegrationDNA Restriction EnzymesSarcoma 180Moloney murine leukemia virusRibonuclease T1MutationAvian myeloblastosis virusRepetitive Sequences, Nucleic AcidVirus CultivationOncogenic VirusesRecombination, GeneticCloning, MolecularAmino Acid SequenceAntigens, ViralVaccinia virusPhosphoproteinsTemperatureTranscription, GeneticDNA, CircularSpecies SpecificityVirus AssemblyGenesDNA, RecombinantSimian virus 40TyrosineTransfectionCell-Free SystemVirus SheddingPhosphotyrosineVirionGenes, gagVirus DiseasesPhosphorylationReticuloendotheliosis virusDNAEpsilonretrovirusPlant VirusesSoft Tissue NeoplasmsDNA VirusesNucleic Acid ConformationProtein BiosynthesisSindbis VirusLeukemia Virus, FelineMeasles virus
Oncogene homologRousLeukosis virusEpidermal growth fMacrophage colonyGeneMurine sarcomaTyrosine kinasesGenesGardner-RasheedAntigensVectorsFelineProteinsExtracellular domainMonoclonal antibodiesHomologousSubgroupStrainsExpressionMolecularRetroviralFibroblastSignaling moleculesTranscription factorsBindsSimianOncogenesisTumor virusesSequencesDifferentiationHumanCellsGeneticReplicationSubfamilyConformational changeHerpesvirusesImmuneLatentRetroviruses
Oncogene homolog2
  • KRAS - (Kirsten rat sarcoma viral oncogene homolog) - One of many RAS proteins. (wikilectures.eu)
  • CRKL or v-crk sarcoma virus CT10 oncogene homolog (avian)-like is a protein kinase containing SH2 and SH3 (src homology) domains that activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion (1). (rockland.com)
Rous9
  • Src is the human homolog of the v-Src gene of the rous sarcoma virus, also designated avian sarcoma virus or ASV. (ningbobio.com)
  • The isolation of temperature-sensitive transformation-defective mutants of Rous sarcoma virus led to the hypothesis that the viral protein or proteins should be temperature-sensitive in its expression or function, and Dr. John Wyke and Rohrschneider found that expression of some of the cell-surface tumor antigens correlated with transformation, suggesting that they were under control of the transforming gene. (fredhutch.org)
  • The transforming protein of Rous sarcoma virus, Src, had just been identified by Dr. Ray Erikson's group using antibodies from tumor-bearing model organisms. (fredhutch.org)
  • Rohrschneider generated similar antisera and used them to good effect, performing some of the first immunoprecipitation and immunofluorescence experiments to identify the Src protein in Rous sarcoma virus-infected model organisms and to localize the protein to the cytoplasm. (fredhutch.org)
  • Oncogenes were primarily identified in viruses causing cancers in chicken (1911, by Peyton Rous). (wikilectures.eu)
  • Characterization of the LDL-A module mutants of Tva, the subgroup A Rous sarcoma virus receptor, and the implications in protein folding. (uchicago.edu)
  • cis-Acting RNA packaging locus in the 115-nucleotide direct repeat of Rous sarcoma virus. (org.ua)
  • Efficiency and selectivity of RNA packaging by Rous sarcoma virus Gag deletion mutants. (org.ua)
  • Expression of Rous sarcoma virus-derived retroviral vectors in the avian blastoderm: potential as stable genetic markers. (org.ua)
Leukosis virus2
  • [18] Cosset FL, Legras C, Thomas JL, Molina RM, Chebloune Y, Faure C, Nigon VM, Verdier G. Improvement of avian leukosis virus (ALV)-based retrovirus vectors by using different cis-acting sequences from ALVs. (org.ua)
  • The BIC gene is activated by promoter insertion at a retroviral integration site on chromosome 21q21 in B cell lymphomas induced by avian leukosis virus. (biomedcentral.com)
Epidermal growth f4
  • The tyrosine kinases of the epidermal growth factor receptor (EGFR) constitute the beginning of one signal transduction cascade leading to AP-1 activation and are known to control cell proliferation and differentiation. (biomedcentral.com)
  • The epidermal growth factor receptor (EGFR) is a tyrosine kinase which acts as a master switch leading to activation of the transcription factor, activator protein-1 (AP-1), and other related pathways. (biomedcentral.com)
  • Her2 (or ERBB2) (Human epidermal growth factor receptor 2) - tyrosin-kinase receptor protein, expressed on the breast cells controls the extent of growth. (wikilectures.eu)
  • and high protein levels of stomatin-like protein 2 and epidermal growth factor receptor ( 17 , 18 ). (spandidos-publications.com)
Macrophage colony1
  • Around this time, Dr. Chuck Sherr at St. Jude's and Dr. Richard Stanley at Albert Einstein identified the normal cellular Fms protein as the cell surface receptor for a growth factor known as the macrophage colony-stimulating factor or M-CSF. (fredhutch.org)
Gene11
  • Although the most preclinical and clinical studies of ROS1 gene fusions have been performed in lung cancer, ROS1 fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others. (wikipedia.org)
  • About 25% of breast cancer patients show overexpression of HER2 receptor caused mainly by HER2 gene amplification. (wikilectures.eu)
  • c-jun - This gene is the putative transforming gene of avian sarcoma virus 17. (wikilectures.eu)
  • Any of the processes by which cytoplasmic factors influence the differential control of gene action in viruses. (lookformedical.com)
  • p47v-crk (v-Crk) is the product of a transforming gene, v-crk, that was isolated from avian sarcoma viruses. (bdbiosciences.com)
  • Appropriate in vivo expression of a muscle-specific promoter by using avian retroviral vectors for gene transfer [corrected]. (org.ua)
  • [19] Benchaibi M, Mallet F, Thoraval P, Savatier P, Xiao JH, Verdier G, Samarut J, Nigon V. Avian retroviral vectors derived from avian defective leukemia virus: role of the translational context of the inserted gene on efficiency of the vectors. (org.ua)
  • Human immunodeficiency virus type 1 (HIV-1) can be inhibited by means of RNA silencing or interference (RNAi) using synthetic short interfering RNAs (siRNAs) or gene constructs encoding short hairpin RNAs (shRNAs) or long hairpin RNAs (lhRNAs). (biomedcentral.com)
  • The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. (edu.au)
  • It is becoming clear that vectors based upon adeno-associated virus (AAV) are the vectors of choice for certain gene therapy applications such as muscle delivery. (justia.com)
  • 2004. Virus-induced gene silencing in Solanum species . (berkeley.edu)
Murine sarcoma1
  • Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. (edu.au)
Tyrosine kinases1
  • Among the top 20 receptor tyrosine kinases identified in this analysis, 15 were identified in both cell lines and tumors, and among these were both ALK and ROS1. (wikipedia.org)
Genes3
  • This proto-oncogene, highly expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. (wikipedia.org)
  • Replication-defective vectors of reticuloendotheliosis virus transduce exogenous genes into somatic stem cells of the unincubated chicken embryo. (org.ua)
  • Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. (edu.au)
Gardner-Rasheed2
  • c-Fgr is a human non-receptor tyrosine kinase family member that was discovered by using a probe toward the v-Fgr portion of the cell-derived domain of Gardner-Rasheed feline sarcoma virus. (ningbobio.com)
  • He found that adhesion plaques also contained the oncoproteins of Abelson leukemia virus (Abl, now best known at the cause of chronic myelogenous leukemia) and the Susan McDonough and Gardner-Rasheed strains of feline sarcoma virus (Fms and Fgr), while, with colleague Dr. Bob Eisenman, the Myc oncoprotein was found in the nucleus. (fredhutch.org)
Antigens4
  • The Koch laboratory used antibodies from model organisms bearing oncorna-virus cancers as tools to identify transformation antigens. (fredhutch.org)
  • Rohrschneider focused initially on cell-surface proteins in cells infected with avian oncorna viruses, identifying the envelope and group-specific antigens (gag proteins). (fredhutch.org)
  • The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (CD3 COMPLEX). (edu.au)
  • The receptors appear to be preferentially located in epithelial sites and probably play a role in the recognition of bacterial antigens. (edu.au)
Vectors1
  • The present invention provides chimeric virus vectors that have been designed to exhibit one or more properties of interest (e.g., enhanced tissue tropism). (justia.com)
Feline2
  • Feline herpesvirus 1 (FHV-1) is a DNA virus that produces mainly upper respiratory tract disease in cats. (vin.com)
  • Despite available vaccines and the labile nature of the virus, FHV-1 is wide-spread in the feline population. (vin.com)
Proteins4
  • These viruses use distinct cell surface proteins as receptors to gain entry into avian cells. (elsevierpure.com)
  • however, the extracellular domain contains a 40-amino-acid, cysteine-rich region that is homologous to the ligand binding region of the low-density lipoprotein receptor (LDLR) proteins. (elsevierpure.com)
  • Proteins found in any species of virus. (lookformedical.com)
  • For instance, due to their genetic flexibility, viruses have developed various viral proteins and non-coding RNAs to interrupt several checkpoints of cGAS-STING. (frontiersin.org)
Extracellular domain1
  • Ligand binding elicits a conformational change of the extracellular domain leading to receptor dimerization and subsequent transphosphorylation of intracellular domain tyrosines. (biomedcentral.com)
Monoclonal antibodies1
  • Drug discovery efforts targeting this receptor and other pathway components have centred on monoclonal antibodies and small molecule inhibitors. (biomedcentral.com)
Homologous1
  • These cDNAs encode a longer and shorter form of the Tva receptor homologous to the Tva forms in quail. (elsevierpure.com)
Subgroup2
  • The subgroup A to E avian sarcoma and leukosis viruses (ASLVs) are highly related and are thought to have evolved from a common ancestor. (elsevierpure.com)
  • We have identified the mutations responsible for the block to virus entry in chicken lines resistant to infection by subgroup A ASLVs [ASLV(A)]. The tva genetic locus determines the susceptibility of chicken cells to ASLV(A) viruses. (elsevierpure.com)
Strains3
  • This may have implications for the development of virus strains to be used as live-attenuated virus vaccines. (biomedcentral.com)
  • The simple reason for this is that the virus has burned its way through chimpanzee populations for thousands of years, a long enough time for the virions which do not kill their host, at least not quickly, to outcompete the most lethal strains. (balloon-juice.com)
  • When a virus meets a new species for the first time it will burn through the immunologically- naive animals mercilessly, until a period of coevolution takes place in which resistance alleles spread in the host populations and the fiercest strains of virus lose out to strains which keep the host alive long enough to spread more widely. (balloon-juice.com)
Expression3
  • Line 7 2 tva r2 contains a 4-bp insertion in exon 1 that causes a change in the reading frame, which blocks expression of the Tva receptor. (elsevierpure.com)
  • This problem is theoretically prevented by intracellular expression of lhRNAs generating multiple siRNAs that target the virus simultaneously, thus reducing the chance of viral escape. (biomedcentral.com)
  • In particular embodiments, the chimeric viruses of the invention have enhanced transduction capability (e.g., transduction of skeletal muscle, cardiac muscle, glial cells, astrocytes, liver, retina and/or lung, etc.), enhanced levels of transgene expression and/or earlier onset of transgene expression. (justia.com)
Molecular3
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
  • Avian acute leukemia virus OK 10: analysis of its myc oncogene by molecular cloning. (uchicago.edu)
  • The molecular biology of RNA tumor virus. (org.ua)
Retroviral2
  • [4] Aronoff R, Hajjar AM, Linial ML. Avian retroviral RNA encapsidation: reexamination of functional 5' RNA sequences and the role of nucleocapsid Cys-His motifs. (org.ua)
  • Identification of a sequence likely to be required for avian retroviral packaging. (org.ua)
Fibroblast2
  • Lenvatinib is an oral multi-kinase inhibitor that inhibits mainly vascular endothelial growth factor receptor 1-3, fibroblast growth factor receptor (FGFR) 1-4, platelet-derived growth factor receptor (PDGFR) α, c-KIT, and RET ( 11 ). (spandidos-publications.com)
  • Hinsby AM, Olsen JV, Bennett KL, Mann M. Signaling initiated by overexpression of the fibroblast growth factor receptor-1 investigated by mass spectrometry. (bdbiosciences.com)
Signaling molecules1
  • Typical products of proto-oncogenes are signaling molecules, growth factors or growth factor receptors. (wikilectures.eu)
Transcription factors1
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
Binds2
  • Most neurons send their messages to recipient neurons by releasing a substance called a 'neurotransmitter' that binds to receptors on the target cell. (elifesciences.org)
  • The S1 subunit contains a receptor binding domain or RBD that binds with the specific receptors, while the S2 subunit helps membrane fusion. (openaccesspub.org)
Simian1
  • As well as solving the mystery of the origin of the virus, the findings prepare the way for future work exploring the history and behaviour of the simian form of HIV in its natural host. (balloon-juice.com)
Oncogenesis1
  • This was one of the initial discoveries that mutations in a cell surface receptor could initiate oncogenesis, just one year after the avian erythroblastosis virus oncogene was found to be a mutant EGF receptor. (fredhutch.org)
Tumor viruses1
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
Sequences2
  • DNA sequences, in cells of the T-lymphocyte lineage, that code for T-cell receptors. (edu.au)
  • DNA sequences encoding the delta chain of the T-cell receptor. (edu.au)
Differentiation2
  • The protein may function as a growth or differentiation factor receptor. (wikipedia.org)
  • Cellular processes such as proliferation, differentiation, and death are regulated by signal transduction pathways which commonly exert their function through receptor mediated activation. (biomedcentral.com)
Human5
  • Src was the first proto-oncogenic non-receptor tyrosine kinase characterized in human. (ningbobio.com)
  • Avian-to-human transmission of H9N2 subtype influenza A viruses: relationship between H9N2 and H5N1 human isolates. (uchicago.edu)
  • The natural binding of coronaviruses' spike (S) glycoprotein occurs with various receptors - ACE2, APN, DPP4, CEACAM, Sia, and O-acSia of human cells. (openaccesspub.org)
  • A virus identified in apes living in forests south of the Sanaga River is the closestfound to the human immunodeficiency virus. (balloon-juice.com)
  • SIVcpz does not cause an Aids-like illness among chimpanzees, despite its similarity to the human virus and the very close genetic relationship between chimps and humans. (balloon-juice.com)
Cells6
  • Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
  • Although these escape variants lost the ability to trans-inhibit HIV-1, they effectively outgrew the wild-type virus in competition experiments in SupT1 cells. (biomedcentral.com)
  • T-cell receptors composed of CD3-associated gamma and delta polypeptide chains and expressed primarily in CD4-/CD8- T-cells. (edu.au)
  • The chimeric virus can also have a reduced transduction capability with respect to one or more cells or tissues (e.g., liver), which can be desirable in terms of targeting the vector to the target tissue of interest and reducing dosage of vector to be administered. (justia.com)
  • BBS student Karen Barnard traveled to two international conferences to confab with other students and experts: The First International Symposium on Glycovirology and the Gordon Research Conference on Cells and Viruses. (cornell.edu)
  • Epstein-Barr virus (EBV) infection has been prominently associated with HPS, with clonal proliferation and the hyperactivation of EBV-infected T cells. (biomedcentral.com)
Genetic2
Replication2
  • However, HIV-lhNef demonstrated a severe production and replication defect, which we were able to solve by selecting spontaneous virus variants with truncated hairpin structures. (biomedcentral.com)
  • Viruses have optimized their evading tactics for superior replication and spreading to counteract host immunity. (frontiersin.org)
Subfamily1
  • A genus of the family HERPESVIRIDAE, subfamily ALPHAHERPESVIRINAE, consisting of herpes simplex-like viruses. (lookformedical.com)
Conformational change1
  • At the first stage of viral invasion, virus-derived double-stranded DNAs (dsDNAs) trigger the conformational change and activation of cGAS. (frontiersin.org)
Herpesviruses1
  • The former aims to stimulate discussions among scientists working in the emerging field of glycovirology, and the latter focuses on themes and covers systems ranging from bacteriophage to HIV and herpesviruses to viruses of C. elegans. (cornell.edu)
Immune1
  • However, viruses have evolved numerous strategies to hinder the cGAS-STING signal transduction, promoting their immune evasion. (frontiersin.org)
Latent2
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • Approximately 80% of FHV-1 infected cats develop a latent infection and serve as reservoirs for the virus. (vin.com)
Retroviruses1
  • Rohrschneider's strengths in raising antibodies and skillful immunofluorescence soon led him to investigate the subcellular localizations of the oncoproteins of other oncorna viruses, by then known by the current name of retroviruses. (fredhutch.org)