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  • viral antigens
  • There has recently been a considerable amount of interest regarding the possible association of HHV6 with multiple sclerosis (MS), based on the detection of HHV6 DNA in the brain, cerebrospinal fluid, or serum of affected individuals, antibody reactivity to viral antigens, and findings of elevated levels of CD46 (the receptor for HHV6). (dana.org)
  • antibodies
  • On the other hand, the IgG3 hinge-truncated antibodies IgG3m15 and IgGm17 showed higher bactericidal activity than both IgG1 and IgG3 regardless of the target antigen. (asm.org)
  • Immune protection against invasive meningococcal disease depends on recognition of bacterial surface antigens by antibodies, followed by activation of complement, leading to degradation of the bacteria by bacteriolysis, also named serum bactericidal activity (SBA). (asm.org)
  • By using monoclonal hapten (4-hydroxy-3-nitrophenacetyl [NP/NIP])-specific antibodies of all four IgG isotypes, we have demonstrated that IgG1 and IgG3 are best in inducing complement-mediated cellular lysis and IgG1 performs better than IgG3 when the antigen concentration on the target cells is high, while IgG3 performs better than IgG1 when the antigen concentration on the target cells is low ( 20 , 21 ). (asm.org)
  • In separate studies, IgG3 antibodies also showed higher SBA than IgG1 antibodies when the target antigen was sparsely expressed (as in the case of FHbp) ( 22 ), but IgG1 antibodies were more bactericidal than IgG3 antibodies when the target antigen was highly expressed, such as for PorA ( 23 ). (asm.org)
  • The agent-polymer-peptide complex may be delivered to target cells by, for example, a pre-targeting technique utilizing bispecific or multispecific antibodies or fragments, having at least one binding arm that recognizes the hapten and at least a second binding arm that binds specifically to a disease or pathogen associated antigen, such as a tumor associated antigen. (freepatentsonline.com)
  • CD antigens for cluster of differentiation, which indicates a defined subset of cellular surface receptors (epitopes) that identify cell type and stage of differentiation, and which are recognized by antibodies. (sinobiological.com)
  • cellular
  • In the past decade, the field of the cellular microbiology of group A Streptococcus ( S. pyogenes ) infection has made tremendous advances and touched upon several important aspects of pathogenesis, including receptor biology, invasive and evasive phenomena, inflammasome activation, strain-specific autophagic bacterial killing, and virulence factor-mediated programmed cell death. (asmscience.org)
  • Gaggar A, Shayakhmetov DM, Lieber A: CD46 is a cellular receptor for group B adenoviruses. (sysmex-flowcytometry.com)
  • iv) Constitutive expression of wild-type gH/gL (wt-gH/gL) restricted infection in all of the cell lines tested, a behavior typical of glycoproteins which bind cellular receptors. (pubmedcentralcanada.ca)
  • IgG1
  • IgG1 showed higher bactericidal activity than IgG3 when directed against PorA (an abundant antigen), while IgG3 was more bactericidal than IgG1 when directed against FHbp (a sparsely and variably distributed antigen). (asm.org)
  • binds
  • Each fiber monomer is comprised of an amino-terminus that is noncovalently anchored to the penton base, a carboxy-terminus globular domain that binds to the cell surface receptor, and a rod-like shaft that varies in length according to the Ad serotype. (pubmedcentralcanada.ca)
  • pathogenesis
  • A "two-hit" infection with HHV-6A appears to result in neurological deficits and pathologically, CNS inflammatory demyelination similar to human MS. Affected animals appear to develop immune reactivity to myelin antigens, indicating the possibility that mechanisms of mimicry may be involved in pathogenesis. (dana.org)
  • gene
  • Whereas TCR gene-modified T cells recognize peptide-major histocompatibility complex (pMHC), CAR recognize antigen in an MHC-independent fashion. (bloodjournal.org)
  • This unit describes quantitation of functional interactions between HIV envelope glcoprotein and target cell receptors, using assay of cell fusion‐dependent reporter gene activation. (currentprotocols.com)
  • In this study, we demonstrate how a recently identified gene associated with the development of childhood asthma is due to a novel dysregulated mechanism that controls the internalization rate of the T-cell antigen receptor in TH2 cells following allergen challenge. (gene.com)
  • cytotoxicity
  • Possible cytotoxicity of lymphocytes from HHV6-infected animals towards antigen-sensitized targets and capacity for immune viral clearance or neutralization will be explored. (dana.org)
  • reactivity
  • Longitudinal studies of reactivity to myelin antigens and to HHV6, and viral persistence/replication in relation to time-course of disease will be examined. (dana.org)
  • primary
  • The initial attachment of Ad to its primary receptor, which differs among Ad subgroups ( Table 1 ), is considered as one of the primary determinants to Ad tropism. (pubmedcentralcanada.ca)
  • human
  • Neisseria gonorrhoeae LOS phenotype C constitutes the first bacterial ligand to be described for the human C-type lectin receptor MGL. (biomedsearch.com)
  • activation
  • Angiotensin receptor blockers could be a proper first-line agent for postmenopausal females with hypertension as the activation of reninCangiotensinCaldosterone program is suggested as you possible system of postmenopausal hypertension. (techbizstrategy.com)
  • function
  • It has already been demonstrated that Afa/Dr adhesins recognize a glycosylphosphatidylinositol (GPI)-anchored protein, complement-regulating decay-accelerating factor (DAF, also known as CD55), as a receptor ( 55 ), Interestingly, Afa/Dr DAEC strains recognize the short consensus repeat 3 (SCR3) domain of DAF, which plays a pivotal role in the regulatory function of DAF. (asm.org)
  • AIDS
  • Dalgleish AC, Beverley PCL, Clapham PR, Crawford DH, Greaves MF, Weiss RA (1984) The CD4(T4) antigen is an essential component of the receptor for the AIDS retrovirus. (springer.com)
  • expression
  • We observed that after PMNL migration, expression of decay-accelerating factor (DAF, or CD55), the brush border-associated receptor for Afa/Dr adhesins, was strongly enhanced, increasing the adhesion of Afa/Dr DAEC bacteria. (asm.org)