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  • deliver antigens
  • Hildegund C.J. Ertl, M.D., director of The Wistar Institute Vaccine Center and senior author of the study, says using glycoprotein D to deliver antigens has a major advantage over other vaccine approaches. (bio-medicine.org)
  • induction
  • 5 , 6 The critical contribution of CD4 T cells to the immunopathogenesis of DED has been confirmed by the demonstration of CD4 T cells infiltrating the conjunctiva in DED patients 6 and the induction of DED following the adoptive transfer of CD4 T cells from the lymph nodes of DED mice into nude recipients. (arvojournals.org)
  • 7 However, the observations that increased frequencies of IL-17-secreting CD4 + T (Th17) cells are present within the lymph nodes of mice with DED, and that in vivo IL-17 neutralization inhibits the induction and progression of DED 8 , 9 implicate Th17 cells as a critical CD4 + effector cell population mediating DED. (arvojournals.org)
  • monocytes
  • Washington, DC (UroToday.com): Monocytes are an important component of innate and adaptive immunity due to their ability to phagocytose, produce cytokines, and present antigens. (urotoday.com)
  • They are characterized into three different subsets based on cell-surface markers-classical monocytes (CM), intermediate monocytes, and nonclassical monocytes. (urotoday.com)
  • The lack of TIR8/SIGIRR does not enhance TLR/IL-1R signaling in tubular epithelial cells as was observed in monocytes. (tum.de)
  • TIR8/SIGIRR is induced in monocytes treated with LPS or tumor necrosis factor and interferon-gamma in a dose-dependent manner but was downregulated in treated tubule epithelial cells. (tum.de)
  • interferes
  • The group now theorized whether classical monocyte inhibition through PD-1 interferes with antigen presentation and is prognostic of poor survival outcomes. (urotoday.com)
  • Alefacept is a bioengineered LFA-3/Immunoglobulin fusion protein that binds to the CD2 T-cell receptor and interferes with the ligation of LFA-3. (clinicaltrials.gov)
  • agonist
  • Usually, agonist binding to these receptors inhibits corepressor and promotes coactivator binding, resulting in increased transcription of target genes. (hindawi.com)
  • maturation
  • Endosomal maturation controls trafficking and degradation of macromolecules in eukaryotic cells and represents an important regulatory point in the endocytic pathway. (uio.no)
  • Infection
  • Cow factors including age, stage of lactation, and somatic cell score (SCC) history are known to influence the occurrence of mastitis infection ( 9 , 10 ). (frontiersin.org)
  • TIR8/SIGIRR does not suppress TLR signaling in tubular epithelial cells, which supports their role as sensors of microbial infection in the kidney. (tum.de)
  • biochemical
  • For example, blockade of impulses or of postsynaptic glutamate receptors causes a cascade of biochemical events that eventually leads to readjustment of critical molecular players on both sides of the synapse. (stanford.edu)
  • The crafting of genetic and biochemical strategies to characterize cancer antigens has yielded the insight that most patients mount tumor-specific T cell and antibody reactions ( 5 ). (aacrjournals.org)
  • immune system
  • It is likely that the autophagosomal/lysosomal pathway evolved primordially to recycle cell components, but further functionally developed as to become part of the immune system to defend against invading pathogens. (frontiersin.org)
  • We begin by presenting a general framework for thinking about the immune system in the context of cancer. (nih.gov)
  • proteins
  • Purpose: The use of tumor-derived proteins as cancer vaccines is complicated by tolerance to these self-antigens. (mdx.ac.uk)
  • Nucleoside transporters (NTs) are a group of membrane transport proteins which transport nucleoside substrates including adenosine across the membranes of cells and/or vesicles. (wikipedia.org)
  • Fragments of such proteins can then potentially act as antigens, substances that provoke an immune response. (scientificamerican.com)
  • SIGIRR
  • Toll-interleukin 1 receptor (IL-1R) (TIR)8/SIGIRR is an orphan receptor of the TLR/IL-1R family, which suppresses TLR signaling of immune cells and is highly expressed in the kidney. (tum.de)
  • This was because of TIR8/SIGIRR expression on resident intrarenal myeloid cells rather than tubular epithelial cells which express it on basolateral and luminal membranes. (tum.de)
  • Biology
  • We use state-of-the art methods to pin down the cell biology of changes in synaptic strength, of importance for adaptation of brain networks in learning and memory. (stanford.edu)
  • Renal Cell Carc
  • Throughout the article we emphasize clinically relevant research often applicable-but not limited-to the example of renal cell carcinoma. (nih.gov)
  • bacterial
  • Many pathogenic bacterial species are classified into serological types, distinguished by their carbohydrate-rich surface antigens. (asm.org)
  • protein
  • However, it is also induced under stress conditions, remodeling the eukaryotic cell by regulating energy, protein, and lipid homeostasis. (frontiersin.org)
  • Dengue virus selectively annexes endoplasmic reticulum-associated translation machinery as a strategy for co-opting host cell protein synthesis. (nih.gov)
  • survival
  • It has previously been shown that gefitinib-treated patients with epidermal growth factor receptor (EGFR) gene amplification or high polysomy had a statistically significant improvement in response, time to progression, and survival in non-small cell lung cancer (NSCLC). (jove.com)
  • intestinal
  • Furthermore, I will quantitatively investigate how mutations and the cell of origin act in concert to determine the functional characteristics of the pre-malignant clone that ultimately develops into an invasive intestinal tumour. (europa.eu)
  • mice
  • The functions of the DCs and regulatory T cells (Tregs) from RP105-deficient or control mice were determined by adding these cells to the lymph node cell culture. (biomedcentral.com)
  • Interferon-gamma (IFN-γ) and tumor necrosis factor-alpha production by spleen cells from RP105-deficient mice was increased in comparison with that from wild-type mice. (biomedcentral.com)
  • Frequencies of CD11b + cells and their chemokine expression were increased in the cornea of DED mice. (arvojournals.org)
  • Fourth, colitis can be induced in immunodeficient mice by transfer of naïve T cells [ 9 ]. (omicsonline.org)
  • novel
  • These studies are paralleled by the investigation of stem cell dynamics within established human CRCs by means of a novel marker independent lineage tracing strategy in combination with mathematical analysis techniques. (europa.eu)