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  • murine
  • To identify new antidiabetic mechanisms of ARBs, we studied the regulation of adiponectin by angiotensin II (Ang II) and different ARBs in murine 3T3-L1 adipocytes and obese Zucker rats. (ahajournals.org)
  • For these studies, we carried out Western blotting and immunohistochemistry with kidney tissue from wild-type mice and genetically modified mice lacking the major murine AT 1 R isoform, AT 1A (AT 1A KO), or with combined deficiency of both the AT 1A and AT 1B isoforms (AT 1AB KO). (ahajournals.org)
  • For the 3 antibodies tested, Western blots of protein homogenates from wild-type kidneys yielded distinct bands with the expected size range for AT 1 R. In addition, these bands appeared identical in samples from mice lacking 1 or both murine AT 1 R isoforms. (ahajournals.org)
  • vitro
  • In vitro studies show that apelin antagonizes Ang II signaling through the Ang II Type 1 receptor (AT1), but the precise molecular mechanism has not been elucidated. (ahajournals.org)
  • 1-3 Importantly, in addition to vasoconstriction induced by AngII, other pathological effects of AngII such as induction of growth and migration are blocked by nitric oxide (NO) in vitro. (ahajournals.org)
  • antagonistic
  • The angiotensin II (AII) antagonistic action of azilsartan (AZL) [2-ethoxy-1-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-1 H -benzimidazole-7-carboxylic acid] was investigated in radioligand binding and function studies. (aspetjournals.org)
  • valsartan
  • In addition, prolonged treatment with valsartan prevented all these changes without modifying either plasma cholesterol or bllod pressure levels.This supports that angiotensin II may play a role in the thrombotic complications of athrosclerosis. (ahajournals.org)
  • One month after MI, each strain was treated with vehicle, ACEi (enalapril, 20 mg/kg per day), or AT 1 -ant (valsartan, 50 mg/kg per day) for 5 months. (ahajournals.org)
  • activates
  • However, it remains unclear how mechanical stress activates AT1 receptor and how candesartan exerts inverse agonism. (ahajournals.org)
  • By serial studies using substituted cysteine accessibility mapping, we demonstrated that mechanical stress directly activates AT1 receptor by changing the conformation of AT1 receptor. (ahajournals.org)
  • potency
  • These differences may contribute to the characteristic binding kinetics of these agents to AT 1 receptors that result in their differential pharmacological potency and efficacy. (aspetjournals.org)
  • vasodilation
  • The coronary vasodilation produced by Ang-(1-7) and AVE 0991 was completely blunted in hypertrophic hearts. (clinsci.org)
  • These findings provide the first demonstration of impaired retinal endothelium-dependent vasodilation in type 1diabetes. (arvojournals.org)
  • effects
  • Our results demonstrate that SS may convey some of its atheroprotective effects through downregulation of AT 1 R in endothelial cells. (ahajournals.org)
  • 16,17 Moreover, the expression of AT 1 R is reduced in vascular smooth muscle cells exposed to an NO donor, 18,19 suggesting that SS may not only modulate the vascular response to Ang II through the opposing effects of NO but may also directly influence AT 1 R expression in vascular cells. (ahajournals.org)
  • In the present study, we hypothesized that SS may regulate the expression of AT 1 R in endothelial cells (ECs), which could account at least in part for the protective, antiatherogenic effects of SS. (ahajournals.org)
  • The aim of the present study was to investigate the coronary effects of Ang-(1-7) [angiotensin-(1-7)] in hypertrophic rat hearts. (clinsci.org)
  • however, it significantly decreases the cardioprotective effects of ACEi or AT 1 -ant. (ahajournals.org)
  • 1,2 ⇓ NO can be produced by essentially all cell types in the heart and is known to have profound effects on cardiac function. (ahajournals.org)
  • renal
  • Angiotensin (Ang) II plays an important role in the regulation of body fluid and sodium balance through the modulation of renal tubular functions. (ahajournals.org)
  • 1,2 In this regard, the ability of Ang II to stimulate Na/K-ATPase (NKA) activity in the renal proximal tubules is an important regulatory component of sodium absorption. (ahajournals.org)