• selective
  • PROPOSED COMMERCIAL APPLICATION: Potent and selective antagoists of A2B adenosine receptors have great commercial potential for the treatment of asthma and other allergic or autoimmune diseases. (sbir.gov)
  • the 3-unsubstituted 1-alkyl analogs resulted more A2B selective with the 8-[4-[(N-(2-hydroxyethyl)carboxamidomethyl)oxy]phenyl]-1-propylxanthine (60) showing the highest affinity (Ki = 1.2 nM) and selectivity (A1/A2B = 60, A2A/A2B = 1,790, A3/A2B = 360). (unicam.it)
  • Potent
  • Hence, (S)-2-phenylhydroxypropynylNECA (PHPNECA), with an EC50 = 0.22 μM, proved to be the most potent A2B agonist reported so far. (unicam.it)
  • Abstract
  • Abstract DESCRIPTION: (Adapted from the Investigator's Abstract): Adenosine administered as an aerosol to asthmatics causes bronchoconstriction, while in non-asthmatics adenosine causes bronchodilation. (sbir.gov)