Receptor activity modifying protein 1. Medical search. Frequent questions

Biochemical and functional evidence suggest that the calcitonin receptor-like receptor (CRLR) interacts with receptor activity-modifying protein-1 (RAMP1) to generate a calcitonin gene-related peptide (CGRP) receptor. (acs.org)
Although the role of such dimerization remains unknown, BRET experiments clearly demonstrated that CRLR can engage signaling partners, such as G proteins and β-arrestin, following CGRP stimulation, only in the presence of RAMP1. (acs.org)
In addition to shed new light on the CRLR−RAMP1 signaling complex, the BRET assays developed herein offer new biosensors for probing CGRP receptor activity. (acs.org)
CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. (antikoerper-online.de)
In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. (antikoerper-online.de)
The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface. (antikoerper-online.de)
Calcitonin gene-related peptide (CGRP) or adrenomedullin (AM) receptors are heteromers of the calcitonin receptor-like receptor (CLR), a class B G protein-coupled receptor, and one of three receptor activity-modifying proteins (RAMPs). (essex.ac.uk)
We have defined how CGRP and AM induce Gs-coupling in CLR-RAMP heteromers by measuring the effect of targeted mutagenesis in the CLR transmembrane domain on cAMP production, modeling the active state conformations of CGRP and AM receptors in complex with the Gs C-terminus and conducting molecular dynamics simulations in an explicitly hydrated lipidic bilayer. (essex.ac.uk)
Mutation of H3747.47b to alanine increased AM potency 100-fold in the CGRP receptor. (essex.ac.uk)
Selective agonists targeting these receptors, such as triptans and ditans, are effective in aborting acute migraine attacks and inhibit the in vivo release of calcitonin gene-related peptide (CGRP) in human and animal models. (lu.se)
The functional role of these receptors was examined ex vivo with a capsaicin/potassium induced 5-HT and CGRP release. (lu.se)
None of the 5-HT 1 receptors co-localized with CGRP-ir in C-fibres. (lu.se)
The 5-HT 1B and 5-HT 1D receptor antagonist, GR127935, could reverse the inhibitory effect of Lasmiditan (a selective 5-HT 1F receptor agonist) on CGRP release in the soma-rich TG but not in soma-poor TG or dura mater. (lu.se)
The aim of the present study was to examine the effect of the synthetic endocannabinoid (eCB) analogue, arachidonyl-2′-chloroethylamide (ACEA), on calcitonin gene-related peptide (CGRP) release in the dura and trigeminal ganglion (TG), as cannabinoids are known to activate G i/o -coupled cannabinoid receptors type 1 (CB1), resulting in neuronal inhibition. (ku.dk)
CGRP release was induced by either 60 mM K + (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay. (ku.dk)
The analysis of CGRP release data was combined with immunohistochemistry in order to study the cellular localization of CB1, cannabinoid receptor type 2 (CB2), CGRP and receptor activity modifying protein 1 (RAMP1), a subunit of the functional CGRP receptor, in the TG. (ku.dk)
Furthermore, 140 nM ACEA did not significantly modify neither K + - nor capsaicin-induced CGRP release. (ku.dk)
However, when the TRPV1 blocker AMG9810 (1 mM) was coapplied with ACEA, K + -induced CGRP release was significantly attenuated in the TG and dura. (ku.dk)
Interestingly both CGRP and PACAP act on receptors that share an accessory subunit called receptor activity modifying protein-1 (RAMP1). (sciencepop.org)
The GPCR, the calcitonin receptor-like receptor (CLR), forms a CGRP receptor with RAMP1, (the CGRPR), whereas CLR with RAMP2 or RAMP3 forms two subtypes of adrenomedullin receptor (AM1 and AM2 receptors). (coventry.ac.uk)
CGRP is also a potent agonist at the AMY1(a) receptor, a heterodimer between the calcitonin receptor (CTR) and RAMP1. (coventry.ac.uk)
1. The ability of the CGRP antagonist BIBN4096BS to antagonize CGRP and adrenomedullin has been investigated on cell lines endogenously expressing receptors of known composition. (aston.ac.uk)
It can discriminate between the CRLR/RAMP1 receptor expressed on SK-N-MC cells and the CGRP-responsive receptor expressed by the Col 29 cells used in this study. (aston.ac.uk)
At concentrations of up to 10 μM, it has no antagonist actions at the adrenomedullin, CRLR/RAMP2 receptor, unlike CGRP 8-37 . (aston.ac.uk)
with no effect of an antagonist (AC187) of a second CGRP-responsive receptor (the amylin-1 receptor, CTR [calcitonin receptor]/RAMP1). (kcl.ac.uk)
The combined findings highlight that αCGRP protects against cardiovascular dysfunction, signaling via the canonical CGRP receptor and acting when nitric oxide production is lost, such as in endothelial dysfunction associated with vascular disease. (kcl.ac.uk)
Conversely, mice lacking SP, CGRP or the SP receptor (neurokinin 1 receptor) show reduced pathology in both models of caecal TcdB injection and CDI. (nature.com)
Fig. 1: SP-mediated and CGRP-mediated neurogenic inflammation in a TcdB caecum injection model and in a CDI mouse model. (nature.com)
Calcitonin gene-related peptide and its receptors are also widely expressed in the enteric system and animal studies have suggested a role for CGRP in modulating intestinal neurotransmission, mobility, and secretion. (lillymedical.co.uk)
4, 5 Rodent studies have demonstrated alteration of gastrointestinal (GI) tract motility and secretions when given agents that antagonize CGRP or its receptors. (lillymedical.co.uk)
Constipation related to blocking the CGRP receptor was evaluated in a mouse study of transgenic mice expressing the human receptor activity-modifying protein 1 (hRAMP1) subunit of the CGRP receptor complex. (lillymedical.co.uk)
α-CGRP and β-CGRP, also known as CGRP I and II, respectively, belong to the calcitonin family of peptides comprising such members as calcitonin, amylin, calcitonin receptor-stimulating peptide, adrenomedullin 1, and intermedin. (bachem.com)
The amino acid sequences of CGRP peptides are well conserved among species, as illustrated in Scheme 1. (bachem.com)
In dogs, pigs and numerous other species, variants of the CGRP-like calcitonin receptor-stimulating peptide (CRSP) are expressed in place of β-CGRP. (bachem.com)
Scheme 1: Amino acid sequences of various CGRP peptides. (bachem.com)
Additionally, CGRP might be important in processes such as control of fetoplacental vascular tone, regulation of calcium metabolism and insulin secretion, acetylcholine receptor synthesis, peripheral nerve regeneration, and neurogenic inflammation. (bachem.com)
According to this historical classification CGRP1 receptors are more sensitive to the antagonistic properties of α-CGRP (8-37) ( 4013696 , 4034544 ) whereas CGRP2 receptors are more responsive to the agonistic CGRP analogs, (Cys(Acm) 2,7 -α-CGRP (human) ( 4039880 ) and (Cys(Et) 2,7 )-α-CGRP (human) ( 4039888 ). (bachem.com)
Interaction with RAMP1 resulted in a CGRP receptor, which is sensitive to α-CGRP (8-37), whereas binding to RAMP2 and RAMP3 led to receptors for adrenomedullin known as AM1 and AM2 receptors, respectively. (bachem.com)

The association of RAMP1 with the calcitonin receptor-like receptor (CL) constitutes the calcitonin gene-related peptide receptor, whereas RAMP2 or 3 with CL generates adrenomedullin receptors. (nih.gov)
As for their wild-type counterparts, fusion proteins linking CRLR and RAMP1 to the energy donor Renilla luciferase ( R luc) and energy acceptor green fluorescent protein (GFP) reach the cell surface only upon coexpression of CRLR and RAMP1. (acs.org)
The homodimerization of the coreceptor was further confirmed by the ability of RAMP1 to prevent cell surface targeting of a truncated RAMP1 that normally exhibits receptor-independent plasma membrane delivery. (acs.org)
The 5-HT 1D receptor co-localized with receptor activity-modifying protein 1 (RAMP1) in Aδ-fibres in the TG, while 5-HT 1B -ir was weakly expressed and 5-HT 1F -ir was not detected in these fibres. (lu.se)
2. On human SK-N-MC cells (expressing human calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 1 (RAMP1)), BIBN4096BS had a pA 2 of 9.95 although the slope of the Schild plot (1.37±0.16) was significantly greater than 1. (aston.ac.uk)
3. On rat L6 cells (expressing rat CRLR and RAMP1), BIBN4096BS had a pA 2 of 9.25 and a Schild slope of 0.89±0.05, significantly less than 1. (aston.ac.uk)

NKT cells were modified to express a GD2-specific chimeric antigen receptor (GD2 CAR), which enables the immune cells to target a molecule found on the surface of neuroblastoma cells, and interleukin-15 (IL-15), a natural protein that supports NKT cell survival. (ecancer.org)
CAR T cell therapy (or chimeric antigen receptor T cell therapy) is an example of cell-based gene therapy. (medlineplus.gov)
This gene provides instructions for making a protein, called the chimeric antigen receptor (CAR), that attaches to cancer cells. (medlineplus.gov)
The basic principles of chimeric antigen receptor design. (msdmanuals.com)

Receptor activity-modifying proteins (RAMPs) are a class of protein that interact with and modulate the activities of several Class B G protein-coupled receptors including the receptors for secretin, calcitonin (CT), glucagon, and vasoactive intestinal peptide (VIP). (wikipedia.org)
Currently, the function of RAMPs is divided into classes of activities. (wikipedia.org)
When associated with the Calcitonin receptor (CTR) or Calcitonin receptor-like (CALCRL) (below), RAMPs can change the selectivity of the receptor for a specific hormone. (wikipedia.org)
Association of RAMPs with either the CT or CALCRL proteins forms 6 different receptors from the calcitonin receptor family: Sexton PM, Morfis M, Tilakaratne N, Hay DL, Udawela M, Christopoulos G, Christopoulos A (2006). (wikipedia.org)
The receptor activity-modifying proteins (RAMPs) are a family of three single transmembrane proteins that have been identified as accessory proteins to some G-protein-coupled receptors (GPCRs). (nih.gov)
The best characterized receptor complexes formed by RAMPs and GPCRs are the calcitonin peptide family receptors. (nih.gov)
Amylin receptor subtypes are formed from calcitonin receptor (CTR) interactions with RAMPs. (nih.gov)
The data reveal key regions in RAMPs that are important for ligand binding and receptor interactions. (nih.gov)
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). (antikoerper-online.de)
RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. (antikoerper-online.de)
RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. (antikoerper-online.de)
The receptors for these peptides are unusual, comprising a G-protein-coupled receptor (GPCR) with receptor activity-modifying proteins (RAMPs). (coventry.ac.uk)
Receptor activity modifying proteins (RAMPs 1, 2 and 3) are a class of important accessory proteins that interact and regulate several G-protein coupled receptor (GPCR) activity by finely modulating ligand interaction and in some cases trafficking receptors to cell surface.Predominant roles of RAMPs include ligand selectivity in receptors for Calcitonin (CT) family of peptides that comprise calcitonin, calcitonin gene related peptide, amylin and Adrenome. (bone-abstracts.org)
Before joining NCI, Dr. Kondapaka, served as an Assistant Professor in the Department of Obstetrics and Gynecology at the University of Texas Medical Branch, where he studied the role of receptor activity modifying proteins (RAMPs 1-3) in altering association of the calcitonin receptor like receptor (CRLR) with its ligand. (cancer.gov)
Recent studies have shown that the previously cloned G protein-coupled orphan receptor, named calcitonin receptor-like receptor (CRLR), can interact with members of a new family of three single-transmembrane domain receptor activity-modifying proteins (RAMPs). (bachem.com)

Amylin is a 37-amino-acid peptide that activates its specific receptors, which are multisubunit G protein-coupled receptors resulting from the coexpression of a core receptor protein with receptor activity-modifying proteins, resulting in multiple receptor subtypes. (aspetjournals.org)
Type I receptors consist of BMPR1B (ALK6) and BMPR1A (also called ALK3), while type II receptors comprise BMPR2 and ActRII (Activin receptor type II) subtypes. (news-medical.net)

The amylin-based peptide, pramlintide, is used clinically to treat type 1 and type 2 diabetes. (aspetjournals.org)
The extracellular domain of CD6 is significantly related to the extracellular domain of the human and mouse T cell antigen CD5, the cysteine-rich domain of the bovine and mouse type I macrophage scavenger receptor, the extracellular domain of the sea urchin spermatozoa protein that crosslinks the egg peptide speract, the mammalian complement factor 1, and the human lung tumor antigen L3. (embl.de)
Synthetic peptide within Human Scavenging Receptor SR-BI aa 50-150 (N terminal). (abcam.com)
Supporting Information: LC-MS characterization of GSH-MDI reaction products, Tables of peptides matched to albumin or modified albumin, and MS/MS data on the GSH-MDI modified albumin peptide containing residues 411-428. (cdc.gov)

The high apparent constitutive activity of GPR40-Gα q was also reversed by a small-molecule GPR40 antagonist, and basal [ 35 S]GTPγS binding was prevented by the selective Gα q /Gα 11 inhibitor YM-254890. (aspetjournals.org)

A pharmacophore model can be established either in a ligand based manner, by superposing a set of active molecules with low binding energy [8] and extracting common chemical features that are essential for their bioactivity, or in a structure-based manner, by probing possible interaction points between the protein target and serotonins [9,10]. (lupinepublishers.com)
Such receptors exhibit unique ligand-binding specificities and mediate distinct signaling cascades, even though they could cross-interact with other TGF-β family ligands. (news-medical.net)
BMPR family of proteins is a valuable tool for studying ligand-receptor interactions, downstream signaling events, and determining therapeutic targets. (news-medical.net)
utilized a cell-free immunoprecipitation assay to analyze the neutralizing potential of the mouse monoclonal antibody 3F6 to hinder the BMPR2-ECD ligand-binding activity. (news-medical.net)
Antibody 3F6 reduces BMPR2-ECD ligand-binding activity in a modified immunoprecipitation assay. (news-medical.net)
Neutralizing the ligand-binding activity of BMPR2-ECD using various amounts of 3F6. (news-medical.net)
Results are quantified by ELISA and expressed as mean ± SEM relative to the ligand-binding activity of BMPR2-ECD in the absence of 3F6. (news-medical.net)

The likelihood is that the phenotype of RAMP2 KO mice is more connected with the abolition of most adrenomedullin (AM) signalling than effects on trafficking of other receptors, as those mice are almost identical to AM KO mice and mice lacking the Calcitonin-like receptor which are unable to form either AM1 or AM-2 adrenomedullin receptors (CLR/RAMP2 and CLR/RAMP3 respectively). (wikipedia.org)

The study aimed to evaluate the transcriptional levels of the natriuretic peptides (NP), endothelin (ET)-1, adrenomedullin (ADM), their receptors and long non-coding (Lnc) RNA MIAT, MALAT-1, CARMEN and XIST in rat cardiac tissue as cardiovascular biomarkers of aging. (unipi.it)
The ADM showed an opposite trend to that of the other peptides decreasing significantly as a function of age and presenting a counter-regulation of calcitonin receptor-like receptor (CLR) and receptor activity modifying protein (RAMP)-2. (unipi.it)
Both peptides show similar biological activity. (bachem.com)
The peptides are similar in their biological activities. (bachem.com)

the predicted activity was LD 50 and prediction was done on similarity clusters with the leaders chosen as the best docked ligands on the Peroxisome proliferatoractivated receptor gamma. (lupinepublishers.com)
In this paper, a docking study, performed to identify the geometric description of the pharmacophore in the interaction of this class of ligands with the peroxisome proliferatoractivated receptor gamma, is reported. (lupinepublishers.com)
Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)
The current studies provide novel insights into the pharmacology of GPR40 and indicate that G protein-coupled receptors which respond to fatty acids, and potentially to other lipid ligands, can be occupied by endogenous agonists before assay and that this may mask the pharmacology of the receptor and may be mistaken for high levels of constitutive activity. (aspetjournals.org)
Using the adhesion frequency assay, the force-clamp lifetime assay, the thermal fluctuation assay, and the molecular stiffness assays the Zhu lab has applied these 2D assays to the studies of interactions of the T cell receptors, CD4/8 coreceptors, and co-stimulatory/co-inhibitory receptors with their respective ligands. (meduniwien.ac.at)
Their ability to bind non-lipoprotein ligands suggests that they participate in other macrophage-associated host defense activities. (embl.de)

Accelerated Development With Increased Bone Mass and Skeletal Response to Loading Suggest Receptor Activity Modifying Protein-3 as a Bone Anabolic Target. (unc.edu)
Alterations occurring in BMPR expression and activity add up to cardiovascular diseases, fibrotic disorders, and skeletal abnormalities. (news-medical.net)
Taken orally, palovarotene selectively targets the gamma subtype of retinoic acid receptors that regulate skeletal development and ectopic bone in the retinoid signaling pathway. (medscape.com)

[ 1 ] In another clinical case series of 33 patients with meningitis, spanning a decade, at a single urban teaching hospital, S aureus was found to be the causative agent in 12 (36%) of the cases by using CSF cultures, PCR, and accessory gene regulator typing. (medscape.com)

Radioligand binding and cAMP production assays also confirmed that the fusion proteins retained normal functional properties. (acs.org)
The study aimed to examine the localization, genetic expression and functional aspects of 5- HT 1B/1D/1F receptors in the trigeminal system in order to further understand the molecular sites of action of triptans (5-HT 1B/1D ) and ditans (5-HT 1F ). (lu.se)
Leveraging the multiomic platform of key collaborator Immunai, Inc., Baylor researchers found that upregulation of the BTG anti-proliferation factor 1 (BTG1) gene in infused CAR NKT cells is indicative of cell exhaustion and restricts CAR NKT cell functional activity. (ecancer.org)
The B domain includes two functional domains: a receptor-binding domain, which defines the tropism of a toxin for a cell and a translocation domain that delivers the A domain across a lipid bilayer, either on the plasma membrane or the endosome. (springer.com)

transient receptor potential cation. (wikigenes.org)

In the cases of the other receptors mentioned, however, there is no evidence that they can do this, but instead function to regulate trafficking of receptors from the ER / golgi to the membrane. (wikipedia.org)
Recent studies have shown that various P2 receptors regulate invasiveness/EMT in different types of c. (bone-abstracts.org)
Peroxisome proliferator-activated receptors are ligandactivated transcription factors that regulate genes important in cell differentiation and various metabolic processes, especially lipid and glucose homeostasis [4]. (lupinepublishers.com)
Seo YJ, Jothikumar P, Suthar MS, Zhu C , Grakoui A (2016) Local Cellular and Cytokine Cues in the Spleen Regulate In Situ T Cell Receptor Affinity, Function, and Fate of CD8+ T Cells. (meduniwien.ac.at)

epithelial stromal interaction 1 [Sourc. (gsea-msigdb.org)
Yamasaki S, Sato T, Hidaka Y, Ozaki H, Ito H, Hirayama T, Takeda Y, Sugimura T, Tai A, Shimonishi Y (1990) Structure-activity relationship of Escherichia coli heat-stable enterotoxin: Role of Ala residue at position 14 in toxin-receptor interaction. (springer.com)

In cells lacking expression of Ca 2+ -mobilizing G proteins, coexpression of human GPR40 and Gα q allowed medium- and long-chain fatty acids to elevate intracellular [Ca 2+ ]. (aspetjournals.org)

Enzymatic hydrolysis of membrane phospholipids by phospholipases produces these lipid second messengers, as well as soluble second messengers such as inositol 1,4,5-trisphosphate, and also other molecules such as choline (Cho) that are released to the extracellular medium. (jneurosci.org)

Chapter 3: Receptor pharmacology. (wikipedia.org)
This article covers the pharmacology of these receptors, their structure, distribution, and potential involvement in disease. (coventry.ac.uk)
British Journal of Pharmacology , 137 (1), 80-86. (aston.ac.uk)
She obtained her Ph.D. in Molecular Pharmacology from the New York University, where she studied the molecular mechanisms regulating glucocorticoid receptor transcriptional activities. (cancer.gov)

The data suggest that hydrophobic interactions are more important for CLR activation than other class B GPCRs, providing new insights into the mechanisms of activation of this class of receptor. (essex.ac.uk)
Bacterial toxins also catalyze the non-covalent modification of host protein function or can modify host cell properties through direct protein-protein interactions. (springer.com)
The drug mediates interactions between these receptors, growth factors, and proteins within that pathway to reduce new abnormal bone formation. (medscape.com)

Secretory and membrane proteins are often post-translationally modified with sugar chains called, glycans. (neb.com)
Macrophage scavenger receptors are integral membrane proteins whose ability to bind and degrade modified LDL has implicated them in the process of atherosclerotic foam cell formation. (embl.de)

Our emerging clinical data demonstrates that these gene-modified T cells are very active in killing tumor cells initially, but they lose their ability to function within a few weeks. (ca.gov)
This experience points to the need to have a continuous source of gene-modified cells to maintain the ability to kill cancer cells. (ca.gov)
In this study, we hypothesize that gene-modified stem cells will allow a sustained production of active T cells with antitumor activity. (ca.gov)
Since there is a delay in the appearance of the T cells that come from stem cells to get out of the bone marrow and into the blood, we will give patients both gene-modified T cells for a first wave of antitumor activity and gene-modified stem cells which will provide a bridge until the stem cells have produced more T cells. (ca.gov)
The purpose of the current study is to give gene-modified T cells in combination with gene-modified stem cells to reprogram the immune system to recognize and kill cancer cells that have the NY-ESO-1 protein with sustained killing activity. (ca.gov)
In this study, the gene-modified immune cells will be given in combination with the gene-modified stem cells. (ca.gov)
To date, we have manufactured a batch of the lentiviral vector necessary to transfer the NY-ESO-1 TCR into stem cells and have demonstrated that this vector can gene-modify human stem cells. (ca.gov)
We have demonstrated that when mouse stem cells are gene-modified with this lentiviral vector, the stem cells take up residence in the bone marrow and produce appropriate blood cells. (ca.gov)
A preclinical study is also ongoing in mice to assess the safety of combining the gene-modified T cells and stem cells in mice. (ca.gov)
By interacting with mRNA, these therapies influence how much protein is produced from a gene, which can compensate for the effects of a genetic alteration. (medlineplus.gov)
Abnormal patterns of epigenetic modifications alter gene activity and, subsequently, protein production. (medlineplus.gov)

A method is described to dock a serotonin into a binding site in a peroxisome proliferator-activated receptor gamma on the basis of the complementarity of the inter-molecular atomic contacts. (lupinepublishers.com)
The molecular docking study was carried out to explore the binding mode of serotonin derivatives (Table 2) within the binding energy of peroxisome proliferator-activated receptor gamma 3ADX and Receptor activity-modifying protein 1 2YX8. (lupinepublishers.com)
The proteins (Peroxisome proliferator-activated receptor gamma left, Receptor activity-modifying protein 1 right) (RCSB PDB CODE: 3ADX, 2YX8). (lupinepublishers.com)

ISGs include several genes encoding ARTs, enzymes that catalyze ADP-ribosylation of proteins and nucleic acids using NAD + as cofactor. (fsu.edu)
Others do not alter genes themselves, but they change whether or how a gene's instructions are carried out to make proteins. (medlineplus.gov)
In cells, mRNA uses the information in genes to create a blueprint for making proteins. (medlineplus.gov)

Neuromodulatory transmitters engage G-protein coupled receptors (GPCRs), activating intracellular signaling cascades that then can directly activate or modify the properties of ion channels. (frontiersin.org)

cyclin I [Source:HGNC Symbol;Acc:HGNC:1. (gsea-msigdb.org)
elongation factor 1 [Source:HGNC Symbol. (gsea-msigdb.org)
F-box protein 33 [Source:HGNC Symbol;Ac. (gsea-msigdb.org)
arrestin beta 1 [Source:HGNC Symbol;Acc. (gsea-msigdb.org)

abstract = "1. (aston.ac.uk)

A novel murine plasma membrane protein has been identified in subpopulations of macrophages. (embl.de)
Transfected COS cells synthesized a native trimeric plasma membrane protein that bound labeled bacteria and acetylated LDL, but not yeast or Ficoll. (embl.de)

The results suggest that the novel protein is a macrophage-specific membrane receptor with a role in host defense, as it shows postnatal expression in macrophages, which are considered responsible for the binding of bacterial antigens and phagocytosis. (embl.de)
Macrophage scavenger receptors. (embl.de)

it exerts its effect on endothelial cells through multiple receptors [7]. (lupinepublishers.com)

chloride intracellular channel 1 [Sourc. (gsea-msigdb.org)

5-HT 1D receptor mRNA was the most prominently expressed, followed by the 5-HT 1B receptor and lastly the 5-HT 1F receptor. (lu.se)
ET-1 mRNA increased significantly as a function of age. (unipi.it)

Here we report that TcdB induces neurogenic inflammation by targeting gut-innervating afferent neurons and pericytes through receptors, including the Frizzled receptors (FZD1, FZD2 and FZD7) in neurons and chondroitin sulfate proteoglycan 4 (CSPG4) in pericytes. (nature.com)
Targeted delivery of the TcdB enzymatic domain, through fusion with a detoxified diphtheria toxin, into peptidergic sensory neurons that express exogeneous diphtheria toxin receptor (an approach we term toxogenetics) is sufficient to induce neurogenic inflammation and recapitulates major colonic histopathology associated with CDI. (nature.com)

A set of 35 derivatives of serotonin were taken from PubChem Database [12] and were divided into a training set (25 molecules) and a test set (10 molecules, in Italics), taken with the lowest docking energy (Table 1). (lupinepublishers.com)
The use of biological therapies targeting key proinflammatory molecules and their receptors has emerged as a powerful tool for the control of systemic inflammatory disorders in recent years. (bmj.com)

Fcγ receptor (FcγR) polymorphism influences the affinity of the receptor for Ig, which may, in turn, affect the efficacy of Ig-based therapies. (bmj.com)

The Fc portion of these biological agents binds specifically to cell surface Fcγ receptors (FcγR) and this may affect their half life and certain innate and adaptive immune responses, such as phagocytosis and antibody-dependent cellular cytotoxicity (ADCC). (bmj.com)

cell death inducing p53 target 1 [Sourc. (gsea-msigdb.org)
cell cycle associated protein 1 [Source. (gsea-msigdb.org)
defender against cell death 1 [Source:H. (gsea-msigdb.org)
1% of total cell population) that are mitotically quiescent and which have undergone epithelial to mesenchymal transition (EMT). (bone-abstracts.org)
1) After 30 years of research scientists do not know what it is in the cell for. (powershow.com)
A strategy in the treatment of cancer by harnessing the immune system, called adoptive cell therapy, is to use an individual's own immune cells (T cells) and genetically modify them to target them to kill the cancer. (ca.gov)
The specific receptor against cancer cells that will be transferred to the immune cells and stem cells is called NY-ESO-1 T cell receptor (or TCR). (ca.gov)
Researchers at Baylor College of Medicine/Texas Children's Cancer Center and collaborating institutions report interim results from a first-in-human phase 1 clinical trial evaluating the safety, antitumor activity and immunological characteristics of a genetically engineered natural killer T (NKT) cell immunotherapy for neuroblastoma, a childhood tumour that most commonly arises in the adrenal gland. (ecancer.org)
In this study, we found the CD62L biomarker expressed on the infused NKT cells, which we identified in our preclinical work, is predictive of both higher NKT cell in vivo expansion and antitumor activity in patients. (ecancer.org)
Gupta DD, Saha S, Chakrabarti MK (2005) Involvement of protein kinase C in the mechanism of action of Escherichia coli heat-stable enterotoxin (STa) in a human colonic carcinoma cell line, COLO-205. (springer.com)
The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. (embl.de)

In most cases, this is achieved by the use of chimeric and humanised monoclonal IgG antibodies (ie, infliximab, rituximab and adalimumab) or fusion proteins consisting of the molecule of interest fused to the constant region (Fc) of human IgG (ie, etanercept and abatacept). (bmj.com)

Excessive Ca 2 + entry through glutamate receptors activates a large array of potential neurotoxic mechanisms, which include activation of enzymes such as phospholipases, calpains and other proteases, protein kinases, nitric oxide synthetase, endonucleases, as well as reactive oxygen species (for review, see Sattler and Tymianski, 2000 ). (jneurosci.org)

Annals of Optometry and Contact Lens 2022;21(1):8-14. (annocl.org)
2022 Jan 31;18(1):e1009984. (unc.edu)
1 March 2022. (cdc.gov)

Bacterial toxins can be single proteins or oligomeric protein complexes that are organized with distinct AB structure-function properties. (springer.com)
May bind bacterial antigens in the protein MARCO. (embl.de)

They effect enzymatic activity, half-life, and receptor binding among other biological processes. (neb.com)
This provides mechanistic information for the essential function of this enzymatic activity for CHIKV replication. (fsu.edu)

G protein-coupled receptor kinase 5 [So. (gsea-msigdb.org)
As an example, in post-mortem brain of patients with Alzheimer's disease (AD), several studies have reported reduction of insulin, insulin-like growth factor 1 and insulin receptor and an increase in tau protein and glycogen-synthase kinase-3β compared to healthy controls suggesting an impairment of metabolism in the AD patient's brain. (lu.se)

Moreover, anchoring of S aureus to foreign substances modifies its susceptibility to antimicrobial agents. (medscape.com)

Overactivation of NMDA receptors is believed to induce neuronal death by increasing phospholipid hydrolysis and subsequent degradation. (jneurosci.org)

This last point is crucial, since it explains how upregulation of this receptor can contribute to an ascending spiral of RAGE-dependent cellular perturbation. (jci.org)
Bond and IJzerman, 2006 ), and pharmacological studies based on the dynamics of cellular Ca 2+ mobilization are also well known to be inappropriate to detect such activity. (aspetjournals.org)
The Bone Morphogenetic Protein Receptor ( BMPR ) family includes transmembrane receptors that play vital roles in tissue development and cellular signaling. (news-medical.net)
PARP10, the first identified cellular mono-ART, modifies and inhibits the protease function of CHIKV. (fsu.edu)
The viral non-structural protein 3, which encodes a mono-ADP-ribosylhydrolase, antagonizes cellular mono-ADP-ribosylation and reactivates the protease. (fsu.edu)

coiled-coil glutamate rich protein 1 [S. (gsea-msigdb.org)

Recombinant human protein Gal-3, EGFR, BMPR1A, and BMPR2 were obtained from Sino Biological. (news-medical.net)

The literature has suggested that bone mineral content is modulated by muscle mass and activity. (bone-abstracts.org)
Objectives: To examine the bone mineral density (BMD) response to i.v. pamidronate (Group 1) vs i.v. zoledronic acid (Group 2) in non-ambulatory children and young adults with severe cerebral palsy or other neuromuscular disorders.Methods: A total of 50 non-ambulatory children and young adults, (mean age 11.3 years, range 2.1 32) with low BMD and/or history of fractures were retrospectively studied. (bone-abstracts.org)
analyzed the impact of RN1 (a natural product extracted from Panax notoginseng ) on bone morphogenetic protein receptors (BMPR1A and BMPR2). (news-medical.net)
Two other patients also showed evidence of antitumor activity such as clearance of bone marrow involvement or reduction of metastatic tumour burden not reaching partial response criteria. (ecancer.org)

These results show that membrane damage by NMDA is preceded by inhibition of phospholipid synthesis and not by phospholipid degradation in the early stages of the excitotoxic process, and that NMDA receptor overactivation decreases phosphatidylcholine and phosphatidylethanolamine synthesis by inhibiting choline-ethanolaminophosphotransferase activity. (jneurosci.org)

This was also observed when human embryonic kidney (HEK) 293 cells were transfected with a GPR40-Gα q fusion protein. (aspetjournals.org)
The "self"-protein albumin in mouse airway fluid was uniquely modified by GSH-MDI at position 414K, a preferred site of MDI reactivity on human albumin. (cdc.gov)

Serotonin is a neurotransmitter involved in a wide variety of behaviors, including feeding and body-weight regulation, social hierarchies, aggression and suicidality, obsessive compulsive disorder, alcoholism, anxiety, and affective disorders [1-3]. (lupinepublishers.com)

These changes suggest a reduced metabolism and a lower activity of mitochondria in obese mice. (lu.se)

Furthermore, Lasmiditan works as a partial agonist on 5-HT 1B/1D receptors in clinically relevant dose regiments. (lu.se)

Chimeric antigen receptors (CAR) recognize specific proteins on the surface of tumor cells. (msdmanuals.com)
In contrast to TCR T cells, CAR T cells recognize only relatively large proteins on the surface of tumor cells. (msdmanuals.com)

Anatomy23

Organisms13

Diseases2

Chemicals and Drugs163

Analytical, Diagnostic and Therapeutic Techniques and Equipment16

Psychiatry and Psychology1

Phenomena and Processes34

Disciplines and Occupations2

Information Science3

Health Care1

CGRP38

RAMP16

Chimeric antigen receptor4

RAMPs15

Subtypes2

Peptide4

Antagonist1

Ligand7

RAMP31

Peptides4

Ligands8

Skeletal3

Accessory1

Functional4

Transient receptor1

Regulate4

Interaction2

Coexpression1

Extracellular1

Pharmacology4

Interactions3

Membrane Proteins2

Gene11

Peroxisome3

Genes3

GPCRs1

Source:HGNC Symbol4

Abstract1

Plasma membrane2

Macrophage2

Endothelial cells1

Intracellular1

MRNA2

Neurogenic inflammation2

Molecules2

Affinity1

Antibody1

Cell11

Fusion proteins1

Activates1

20223

Bacterial2

Enzymatic activity2

Kinase2

Substances1

Neuronal1

Cellular5

Glutamate1

Recombinant1

Bone4

Inhibition1

Human2

Regulation1

Metabolism1

Agonist1

Tumor cells2