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  • ERBB2
  • We investigated the therapeutic activity of an agonist mAb to mouse tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-2 (DR5) against ErbB2-driven breast cancer. (pnas.org)
  • We thus demonstrated that the combination of anti-DR5 and anti-ErbB2 mAbs might be an effective form of treatment for ErbB-2-overexpressing breast cancer. (pnas.org)
  • erbB-2 overactivity is associated with adverse biological characteristics and poor clinical outcomes 1 .Overexpression of erbB2 in cell lines leads to transformation in the absence of a ligand 2 . (apexbt.com)
  • Therefore, in a technical sense, ErbB2 remains an orphan receptor. (apexbt.com)
  • Postoperative ischemia could affect the evaluation of breast cancer tissue for steroid hormone receptors and c-erbB2 levels until fixation using formalin. (turkjsurg.com)
  • The misevaluation of steroid hormone receptors and c-erbB2 levels, which are important prognostic factors in the treatment of breast cancer, could change treatment options. (turkjsurg.com)
  • The aim of this study was to investigate the effects of postoperative ischemia on a breast cancer tissue sample, particularly on steroid hormone receptors and c-erbB2 expression level. (turkjsurg.com)
  • Steroid hormone receptors, estrogen receptors, progesterone receptors, and c-erbB2 expression of breast cancer tissue samples were evaluated using both techniques. (turkjsurg.com)
  • Two groups were created based on the results of steroid hormone receptors and c-erbB2 expression levels using the two histopathological techniques. (turkjsurg.com)
  • A mastectomy specimen should be examined at once to ensure accurate detection of steroid hormone receptors and c-erbB2 levels for the proper treatment of breast cancer patients. (turkjsurg.com)
  • The presence of estrogen receptors (ERs), progesterone receptors (PRs), and c-erbB2 oncogene are accepted as the most important prognostic factors ( 2 - 4 ). (turkjsurg.com)
  • Eventually, all processes may lead to the misevaluation of steroid hormone receptors and c-erbB2 levels, which have high prognostic value for the treatment of breast cancer, and thus, misevaluation may cause alteration in treatment options. (turkjsurg.com)
  • Two groups were created based on steroid hormone receptors and c-erbB2 results: the first group for results of the frozen technique (n=20) and the second group for results of the regular follow-up technique (n=20). (turkjsurg.com)
  • The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over 25,000 women with breast cancer have now been treated with trastuzumab (Herceptin), a recombinant antibody designed to block the receptor ErbB2. (nih.gov)
  • The ErbB2 receptor tyrosine kinase has been implicated as a critical growth factor receptor in both normal development and cancer. (nih.gov)
  • The other HER family member that has been successfully pursued as a therapeutic target in other solid tumors is HER-2 or ErbB2. (aacrjournals.org)
  • We report that the pentameric procyanidin (molecular weight of 1442 daltons) fraction isolated from cocoa was a potent inhibitor of tyrosine kinase ErbB2 expression, a receptor important in angiogenesis regulation. (biomedsearch.com)
  • Consistent with this primary observation, the cocoa flavonoid fraction also suppressed human aortic endothelial cell (HAEC) growth and decreased expression of two tyrosine kinases responsive to ErbB2 modulation, namely VEGFR-2/KDR and MapK 11/p38beta2. (biomedsearch.com)
  • chromosome
  • Her-2 immunohistochemical expression in oral squamous cell carcinomas is associated with polysomy of chromosome 17, not Her-2 amplification. (biomedsearch.com)
  • In some OSCC Her-2 immunohistochemical expression may be associated with chromosome 17 polysomy and not Her-2 amplification. (biomedsearch.com)
  • Staining
  • Intensity also follows the breast scoring system with the rule of thumb that score 3 staining is visible at ~5x, score 2 visible at 10-20x and 1+ visible requiring 40x magnification. (ganfyd.org)
  • hormone-receptor
  • Unexpectedly, Wip1 allows steroid hormone-receptor-positive cells but not alveolar progenitors to activate STAT5 (signal transducer and activator of transcription 5) in the virgin state. (nih.gov)
  • potent
  • A further five- to tenfold increase in its expression under influence of the long terminal repeat of Moloney murine leukemia virus was associated with activation of erbB-2 as a potent oncogene. (apexbt.com)
  • erbB-2 is a Potent Oncogene When Overexpressed in NIH/3T3 Cells. (apexbt.com)
  • Pathological
  • In addition, the change expressions of C-erbB-2 and CXCR4 in specimens tended to be correlated with pathological change to neo-adjuvant chemotherapy on full tissue sections and on TMAs in a Pearson chi-square analysis. (biomedsearch.com)
  • mice
  • Remarkably, treatment with a combination of anti-DR5 and anti-ErbB-2 mAbs induced complete response in a majority of mice. (pnas.org)