LigandsAntagonistsGeneProteinProteinsLigandNMDAExtracellularBiochemistryNeurotransmitterGenesSelectiveClass of receptorsBinds to the receptorTypes of opioid receptorsNuclear receptorsPharmacologySteroid receptorsProgesterone receptorsBindMoleculeMolecularAntigen ReceptorAndrogen receptorGlutamate receptorEstrogen receptorsAntibodiesNeuronsAgonistBrain receptorHormone receptorAntibodyAmino acidRegulationAntagonistSignalsSubtypesTranscriptionHumansOrphanAssayCharacterizationGPCRsNicotinicHormonesCellularSubunitsOlfactory receptMiceAChRCell membraneGlucocorticoidInhibitoryHistamine receptorsAdenosine receptorsAcetylcholine receptorsEndocytosisPolymorphisms
Ligands15
- Some of these compounds are still derived from adenosine or from the xanthine family, but researchers in this area have also discovered many selective adenosine receptor ligands that are entirely structurally distinct, giving a wide range of possible directions for future research. (wikipedia.org)
- Biassoni R. Human natural killer receptors, co-receptors, and their ligands. (springer.com)
- Ligands that cause physiologic changes with receptor binding, typically the naturally occurring ligands. (redorbit.com)
- Ligands that bind to the receptor and block the binding of agonists but that do not activate changes are known as antagonists. (redorbit.com)
- Molecules that bind to receptors, called ligands, can function as agonists , which stimulate the receptor to transmit signal information, or as antagonists , which inhibit , or prevent, the receptor from transmitting information. (britannica.com)
- It has been reported that the repertoire of GPCRs for endogenous ligands consists of approximately 400 receptors in humans and mice [ PMID: 12679517 ]. (ebi.ac.uk)
- Although their activating ligands vary widely in structure and character, the amino acid sequences of the receptors are very similar and are believed to adopt a common structural framework comprising 7 transmembrane (TM) helices [ PMID: 2111655 , PMID: 2830256 , PMID: 8386361 ]. (ebi.ac.uk)
- Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. (nature.com)
- Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. (nature.com)
- IPC No. U.S. Cocaine receptor binding ligands. (rti.org)
- IPC No. U.S. Kappa opioid receptor ligands. (rti.org)
- Ligands connect to specific receptor proteins based on the shape of the active site of the protein. (wikipedia.org)
- While numerous receptors are found in most cells, each receptor will only bind with ligands of a particular structure, much like how locks will only accept specifically shaped keys. (wikipedia.org)
- Nuclear receptors - While they are called nuclear receptors, they are actually located in the cytoplasm and migrate to the nucleus after binding with their ligands. (wikipedia.org)
- Olfactory receptor neurons are the primary sensory cell in a system designed to detect and discriminate between a large and diverse array of chemical ligands called odours. (els.net)
Antagonists8
- antipsychotics are often dopamine receptor antagonists while psychostimulants are typically indirect agonists of dopamine receptors. (wikipedia.org)
- The adenosine receptors are commonly known for their antagonists caffeine and theophylline , whose action on the receptors produces the stimulating effects of coffee , tea and chocolate . (wikipedia.org)
- Xanthine derivatives such as caffeine and theophylline act as non-selective antagonists at A 1 and A 2A receptors in both heart and brain and so have the opposite effect to adenosine, producing a stimulant effect and rapid heart rate. (wikipedia.org)
- Newer adenosine receptor agonists and antagonists are much more potent and subtype-selective, and have allowed extensive research into the effects of blocking or stimulating the individual adenosine receptor subtypes, which is now resulting in a new generation of more selective drugs with many potential medical uses. (wikipedia.org)
- In contrast, antagonists called beta-blockers can be used as drugs to lower blood pressure because they inhibit the receptors, which allows blood vessels to relax. (britannica.com)
- Kappa opioid receptor antagonists are provided that yield significant improvements in functional binding assays to kappa opioid receptors, and the use of these antagonists in treatment of disease states that are ameliorated by binding of the kappa opioid receptor such as heroin or cocaine addictions. (rti.org)
- NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin. (thefreedictionary.com)
- Initial studies suggested that angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), and (possibly) aldosterone antagonists might either prevent new onset and recurrent atrial fibrillation (AF) or reduce the rate of major adverse cardiovascular outcomes in these patients. (uptodate.com)
Gene25
- D 3 is encoded by the Dopamine receptor D 3 gene ( DRD3 ). (wikipedia.org)
- D 4 is encoded by the Dopamine receptor D 4 gene ( DRD4 ). (wikipedia.org)
- The D 4 receptor gene displays polymorphisms that differ in a variable number tandem repeat present within the coding sequence of exon 3. (wikipedia.org)
- Leptin receptor deficiency is caused by mutations in the LEPR gene. (medlineplus.gov)
- This gene provides instructions for making a protein called the leptin receptor, which is involved in the regulation of body weight. (medlineplus.gov)
- LEPR gene mutations that cause leptin receptor deficiency prevent the receptor from responding to leptin, leading to the excessive hunger and weight gain associated with this disorder. (medlineplus.gov)
- Because hypogonadotropic hypogonadism occurs in leptin receptor deficiency, researchers suggest that leptin receptor signaling is also involved in regulating the body's response to hormones that control sexual development, and that this response is affected by LEPR gene mutations. (medlineplus.gov)
- Andiran N, Celik N, Andiran F. Homozygosity for two missense mutations in the leptin receptor gene (P316:W646C) in a Turkmenian girl with severe early-onset obesity. (medlineplus.gov)
- A T-cell receptor gene rearrangement test evaluates the T-cells in a person's sample to determine whether the majority of T-cell rearrangement profiles are diverse or identical. (labtestsonline.org)
- ISCT, the International Society for Cell and Gene Therapy, the global professional society of clinicians, researchers, regulatory specialists, technologists and industry partners in the cell and gene therapy sector, today announces its objection to linking the benefits of cellular immunotherapy, in particular Chimeric Antigen Receptor (CAR) T-cell therapy, with recent market offerings for third party cryopreserving and banking of T-cells for future therapeutic use. (news-medical.net)
- These receptors often can enter the cell nucleus and modulate gene expression in response to the activation by the ligand. (google.com)
- They are generally intracellular receptors (typically cytoplasmic) and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days. (google.com)
- Fatty acids have been shown to activate gene transcription under the control of some evolutionarily primitive members of the steroid/thyroid superfamily of receptors. (google.com)
- In these creatures we removed the very gene that encodes the receptor Latrophilin and replaced it with modified variants," is how Langenhan explains the procedure. (innovations-report.com)
- More recently, and very controversially, someone in China used gene therapy to modify the CCR5 receptor in embryos to protect the babies from contracting HIV. (medscape.com)
- Your pathology report will tell you whether or not the breast cancer cells have too many copies of a gene called HER2 or too much of the receptor protein it makes. (breastcancer.org)
- Several studies have now shown no association between progesterone receptor gene +331G/A polymorphisms and breast or endometrial cancers. (wikipedia.org)
- Estrogen receptor (ER)3 gene expression in breast epithelium is an intricately regulated event. (nih.gov)
- Through gene targetting experiments (see text) it is now clear that all the ORNs expressing the same receptor send their axons to the same glomerulus even though the cells are widely distributed on the olfactory epithelium. (els.net)
- Ressler KJ, Sullivan SL, and Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. (els.net)
- TRAPS is due to a gene defect in a protein called tumor necrosis factor receptor, which leads to an increase of the patient's normal inflammatory response. (rheumatology.org)
- In the present issue of Hypertension , Tordjman et al 1 explore the role of the candidate gene, peroxisome proliferator-activated receptor (PPAR)-α (reviewed extensively and comprehensively in the Web site dedicated to PPAR: http://ppar.cas.psu.edu/), in the regulation of blood pressure and atherogenesis. (ahajournals.org)
- In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. (wikipedia.org)
- It belongs to the Low density lipoprotein receptor gene family. (wikipedia.org)
- Mutations in the gene encoding the LDL receptor are known to cause familial hypercholesterolaemia. (wikipedia.org)
Protein57
- Dopamine receptors are a class of G protein-coupled receptors that are prominent in the vertebrate central nervous system (CNS). (wikipedia.org)
- The D 1 -like family receptors are coupled to the G protein G sα . (wikipedia.org)
- The D 2 -like family receptors are coupled to the G protein G iα , which directly inhibits the formation of cAMP by inhibiting the enzyme adenylyl cyclase. (wikipedia.org)
- Dopamine receptors have been shown to heterodimerize with a number of other G protein-coupled receptors . (wikipedia.org)
- Dopamine receptor activation of Ca 2+ /calmodulin-dependent protein kinase II can be cAMP dependent or independent. (wikipedia.org)
- D1 receptor agonism and D2 receptor blockade also increases mRNA translation by phosphorylating ribosomal protein s6 , resulting in activation of mTOR. (wikipedia.org)
- The adenosine receptors (or P1 receptors ) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand . (wikipedia.org)
- Ligand-receptor binding can activate or inhibit downstream processes through a variety of mechanisms, such as G-protein activation (e.g. (redorbit.com)
- Receptor , molecule , generally a protein , that receives signals for a cell . (britannica.com)
- HFE, the protein incriminated in the pathogenesis of hereditary hemochromatosis, a disorder of progressive and toxic iron overload, competes with transferrin for binding to receptor, thereby impeding the uptake of iron from transferrin. (nih.gov)
- G protein-coupled receptors (GPCRs) constitute a vast protein family that encompasses a wide range of functions, including various autocrine, paracrine and endocrine processes. (ebi.ac.uk)
- The rhodopsin-like GPCRs (GPCRA) represent a widespread protein family that includes hormone, neurotransmitter and light receptors, all of which transduce extracellular signals through interaction with guanine nucleotide-binding (G) proteins. (ebi.ac.uk)
- The G protein-coupled receptor repertoires of human and mouse. (ebi.ac.uk)
- Fingerprinting G-protein-coupled receptors. (ebi.ac.uk)
- GCRDb: a G-protein-coupled receptor database. (ebi.ac.uk)
- G protein-coupled receptor list. (ebi.ac.uk)
- IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels. (ebi.ac.uk)
- Comprehensive repertoire and phylogenetic analysis of the G protein-coupled receptors in human and mouse. (ebi.ac.uk)
- Cholecystokinin receptors or CCK receptors are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) and gastrin . (rug.nl)
- Heterotrimeric G proteins play a critical role in the transduction of signals from the very large class of seven transmembrane G protein-coupled receptors (GPCRs). (vanderbilt.edu)
- Comprising α, β, and γ subunits, the G protein binds to an agonist-activated receptor, and this interaction triggers exchange of GDP for GTP in the GTPase domain of the G protein's α subunit. (vanderbilt.edu)
- The GDP-bound α subunit then reunites with βγ, preparing it to interact with another activated receptor protein (Figure 1). (vanderbilt.edu)
- However, the crystal structure provides only a static picture of the receptor-G protein interaction. (vanderbilt.edu)
- This led Vanderbilt Institute of Chemical Biology members Jens Meiler and Heidi Hamm and their laboratories to combine the crystal structure with experimental data to develop a dynamic model of the G-protein-receptor interaction [N. S. Alexander, et al. (vanderbilt.edu)
- Binding of an agonist to a G protein-coupled receptor leads to a conformational change that allows the α subunit of the G protein to bind to the receptor. (vanderbilt.edu)
- Scienitsts led by Kirill Martemyanov, Ph.D. - co-chair of the TSRI Department of Neuroscience - focused on a brain receptor called GPR158 after they noticed that levels of the GPR158 protein were very high in people with depression. (medicalnewstoday.com)
- Martemyanov explains that GPR158 brain receptors are called " orphan receptors " because it is not yet known what chemical the protein binds to. (medicalnewstoday.com)
- Methods and compositions are provided for treating several acute disease states associated with smooth muscle cell proliferation as well as the chronic process of atherogenesis utilizing oligopeptides corresponding to regions of the PDGF receptor protein. (google.ca)
- The TSHR antigen is primarily expressed in the epithelial cells of the thyroid follicles, but TSHR mRNA and protein have been reported in a variety of cell types, some of which show evidence of receptor activity (Table 1 ). (jci.org)
- If a particular molecule or protein, such as a hormone or neurotransmitter, floats past, dissolved in the plasma, the receptor registers that with this arm and passes the information on to the cell interior. (innovations-report.com)
- G-protein-coupled receptors, GPCRs for short, are the focus of the work performed by Dr. Tobias Langenhan and Dr. Robert Kittel. (innovations-report.com)
- Hundreds of G-protein-coupled receptors are encoded in the human genome, and the way in which they work is now very well understood," says Tobias Langenhan. (innovations-report.com)
- Immunohistochemical analysis was performed to determine protein expression levels and the specific cellular localization of COX isoenzymes and EP receptors. (medscape.com)
- According to a report published online yesterday by the journal Nature, the receptor responds to the taste of amino acids, the building blocks of protein. (scientificamerican.com)
- G protein-coupled receptors (GPCRs) are transmembrane proteins that act as key gatekeepers between external signals and cellular responses. (sciencemag.org)
- Changes associated with conformationally selective agonist binding shed light on G protein-coupled receptor activation. (sciencemag.org)
- The two proteins combine to form the G-protein coupled receptor T1R1-T1R3. (foodnavigator.com)
- Increased understanding of amino acid taste receptors may help nutritionists target the appetites of protein-malnourished children to provide good-tasting dietary supplements that kids will readily accept. (foodnavigator.com)
- "This will in turn help in the discovery of other taste receptors that may play a role in umami taste and aid in our understanding of protein appetites," he said. (foodnavigator.com)
- The progesterone receptor ( PR ), also known as NR3C3 or nuclear receptor subfamily 3, group C, member 3, is a protein found inside cells. (wikipedia.org)
- Gama-hidroksibuteratni receptor , ili GHB receptor ( GHBR ), originalno identifikovan kao GPR172A , je G protein-spregnuti receptor koji vezuje gama-hidroksibuternu kiselinu (GHB). (wikipedia.org)
- Nakon otkrića orfan G-protein spregnutog receptora GPR172A, utvrđeno je da je on zapravo GHB receptor. (wikipedia.org)
- In biochemistry and pharmacology , a receptor is a protein molecule that receives chemical signals from outside a cell. (wikipedia.org)
- In this sense, a receptor is a protein-molecule that recognizes and responds to endogenous chemical signals, e.g. an acetylcholine receptor recognizes and responds to its endogenous ligand, acetylcholine . (wikipedia.org)
- Transmembrane receptors include ion channel-linked (ionotropic) receptors, G protein-linked (metabotropic) hormone receptors, and enzyme-linked hormone receptors. (wikipedia.org)
- A molecule that binds to a receptor is called a ligand , and can be a protein or peptide (short protein), or another small molecule such as a neurotransmitter , hormone , pharmaceutical drug, toxin, or parts of the outside of a virus or microbe. (wikipedia.org)
- G protein-coupled receptors (metabotropic receptors) - This is the largest family of receptors and includes the receptors for several hormones and slow transmitters e.g. dopamine, metabotropic glutamate. (wikipedia.org)
- Researchers inactivated a protein that links GABAA receptors to the cell surface. (elsevier.com)
- They found that this protein prevented fear extinction training and the local application of NMDA from increasing the number of GABAΑ receptors on the cell surface and enhancing the inhibition of amygdala nerve cells. (elsevier.com)
- The researchers showed that by inactivating a protein involved in the localization of GABAA receptors in the amygdala, they prevented the recruitment of GABA-mediated inhibition and extinction of fear. (elsevier.com)
- Identification of the full set of proteins interacting with membrane receptors by high throughput experimental means is difficult because methods to directly identify protein interactions are largely not applicable to membrane proteins. (cmu.edu)
- The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. (elsevier.com)
- Previously, we have isolated and characterized a cytokinin-binding protein with the molecular mass of 70 kDa (CBP-70) and showed its receptor properties [1, (bio.net)
- The Low-Density Lipoprotein (LDL) Receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich LDL. (wikipedia.org)
- The receptor also recognizes the apoE protein found in chylomicron remnants and VLDL remnants (IDL). (wikipedia.org)
- e.g. a truncation of the receptor protein at residue number 660 leads to domains 3,4 and 5 of the EGF precursor domain being missing. (wikipedia.org)
- This precludes the movement of the receptor from the ER to the Golgi, and leads to degradation of the receptor protein. (wikipedia.org)
Proteins19
- Fang S, Anderson KM, Liao S. Receptor proteins for androgens. (springer.com)
- Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. (springer.com)
- For example, receptor-mediated endocytosis enables cells to ingest molecules such as proteins that are necessary for normal cell functioning. (britannica.com)
- Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. (nih.gov)
- At the molecular level, drugs like salvinorin A (the active ingredient of the hallucinogenic plant Salvia divinorum) work by activating specific proteins, known as receptors, in the brain and body. (redorbit.com)
- Acetylcholine receptor (AChR) antibodies are autoantibodies produced by the immune system that mistakenly target proteins called acetylcholine receptors that are located on skeletal muscle fibers. (labtestsonline.org)
- Chapman says researchers have known that gangliosides - a special type of lipid - and proteins work together as a receptor, but no one until now has been able to identify the specific proteins. (eurekalert.org)
- Using a cellular model, Chapman, physiology and neuroscience graduate student Min Dong and others identified two proteins that function alongside gangliosides as the receptor for botulinum neurotoxin B - one of the four types deadly to humans. (eurekalert.org)
- Another major class of receptors are intracellular proteins such as those for steroid and intracrine peptide hormone receptors. (google.com)
- However, their "target" cells contain cytoplasmic and/or nuclear proteins that serve as receptors of the hormone. (google.com)
- Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
- Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
- Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
- Receptor proteins can be classified by their location. (wikipedia.org)
- The aforementioned receptors are coupled to different intracellular effector systems via G proteins . (wikipedia.org)
- Unlike prior approaches that attempted to predict the global human interactome we used a computational strategy that only focused on discovering the interacting partners of human membrane receptors leading to improved results for these proteins. (cmu.edu)
- The predicted membrane receptor interactome provides a system-wide view, and generates new biological hypotheses regarding interactions between membrane receptors and other proteins. (cmu.edu)
- Researchers interested in specific membrane receptors can enter individual or sets of proteins and retrieve their rank-ordered interactions, along with the evidence supporting these predictions. (cmu.edu)
- The attachment of complement proteins, C3b/C4b to microbial membranes or immune complexes, a process commonly known as opsonization, facilitates the binding of opsonized material to cell receptors. (google.com)
Ligand25
- The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. (wikipedia.org)
- Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. (springer.com)
- The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in human. (springer.com)
- Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. (springer.com)
- This book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified. (google.com)
- AR is a ligand-activated transcription factor (TF) that belongs to the steroid hormone receptor (SHR) family within the nuclear receptor (NR) superfamily of TFs (for a review, see Huang et al. (springer.com)
- Ligand-specific dynamics of the androgen receptor at its response element in living cells. (springer.com)
- The nature of the ligand-receptor interaction poses a challenge for imaging-notably, the requirement for a low molecular concentration of the imaging probe to avoid saturating the receptor and increasing the background because of nonspecific uptake. (redorbit.com)
- Common to all receptors is the interaction of a ligand and the receptor, in which specific binding of the ligand to the receptor results in downstream biochemical or physiologic changes {7,8). (redorbit.com)
- Alternatively, some drugs lower the level of an agonist to decrease ligand-receptor interactions, for example, levothyroxine, which suppresses thyroid- stimulating hormone levels in the treatment of thyroid cancer (12). (redorbit.com)
- Note that to interact with an intracellular receptor, the ligand must first get past the cellular membrane. (google.com)
- Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. (jci.org)
- The peroxisome proliferator-activated receptor alpha (PPAR ) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. (hindawi.com)
- The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the superfamily of nuclear hormone receptors and play an important role in nutrient homeostasis [ 1 - 3 ]. (hindawi.com)
- In common with other steroid receptors, the progesterone receptor has a N-terminal regulatory domain, a DNA binding domain , a hinge section, and a C-terminal ligand binding domain. (wikipedia.org)
- The receptor releases a messenger once the ligand has connected to the receptor. (wikipedia.org)
- The endogenously designated -molecule for a particular receptor is referred to as its endogenous ligand. (wikipedia.org)
- E.g. the endogenous ligand for the nicotinic acetylcholine receptor is acetylcholine but the receptor can also be activated by nicotine and blocked by curare . (wikipedia.org)
- When a ligand binds to its corresponding receptor, it activates or inhibits the receptor's associated biochemical pathway. (wikipedia.org)
- Type 3: Kinase-linked and related receptors (see " Receptor tyrosine kinase " and " Enzyme-linked receptor ") - They are composed of an extracellular domain containing the ligand binding site and an intracellular domain, often with enzymatic-function, linked by a single transmembrane alpha helix. (wikipedia.org)
- Ligand binding is the first step in hormone regulation of mineralocorticoid receptor (MR) activity. (rcsb.org)
- These structures combined with mutagenesis studies reveal that maximal receptor activation involves an intricate ligand-mediated hydrogen bond network with Asn770 which serves dual roles: stabilization of the loop preceding the C-terminal activation function-2 helix and direct contact with the hormone ligand. (rcsb.org)
- The top part of the receptor is outside the neuron and binds neurotransmitters glutamate (green) and glycine (white) in its ligand-binding domains. (eurekalert.org)
- The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical). (wikipedia.org)
- Class 4 mutations inhibit the internalisation of the receptor-ligand complex. (wikipedia.org)
NMDA19
- Presynaptically, it reduces synaptic vesicle release while post synaptically it has been found to stabilize the magnesium on the NMDA receptor . (wikipedia.org)
- Woman's Anti-NMDA Receptor Encephalitis Misdiag. (scoop.it)
- Finally she found out she had anti-NMDA receptor encephalitis, a type of brain inflammation. (scoop.it)
- New Prize offered by The Anti-NMDA Receptor Encephalitis Foundation at the 54th annual Congress of the Canadian Neurological Sciences Federation. (scoop.it)
- 1. A score that predicts one year functional status in anti-NMDA receptor encephalitis patients. (scoop.it)
- In the first segment, Dr. David Lapides talks with Dr. Ramani Balu about his paper on a score that predicts one year functional status in anti-NMDA receptor encephalitis patients. (scoop.it)
- A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis From. (scoop.it)
- When applied to rat brain cells, they found the drug changed the frequency of its electrical activity by blocking the NMDA brain receptor. (medindia.net)
- If we could find a drug that attaches itself to this site and then locks together NMDA receptor subunits, that would be huge for fighting disability from stroke and Alzheimer's and other neurodegenerative diseases. (thefreedictionary.com)
- 2) The best experimental study supporting this hypothesis was conducted in healthy subjects undergoing an NMDA receptor antagonist to reproduce schizophreniform symptoms. (thefreedictionary.com)
- Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine. (thefreedictionary.com)
- Although glutamate and its postsynaptic NMDA receptor are normal components of nervous-system conduction, over-activation can mediate damage after SCI and other nervous-system insults (e.g., head injury, stroke, etc. (thefreedictionary.com)
- PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics. (thefreedictionary.com)
- This correlated with the ability of TNF[alpha] and TNFRII agonist antibodies to stimulate increased NMDA receptor activity as observed by increased intracellular [Ca.sup.2+] levels and NMDA receptor-evoked currents. (thefreedictionary.com)
- To obtain IgY antibodies against synthetic peptides of NR3A and NR3B subunits of the rat NMDA receptor , to recognize and follow the expression of these subunits in rat brain extract at different ages. (thefreedictionary.com)
- Aptinyx announced the presentation of preclinical data on its novel NMDA receptor modulator, NYX-458. (thefreedictionary.com)
- REL-1017 is an orally administered NMDA receptor (NMDAR) antagonist indicated to be active on the NMDAR ketamine binding site. (thefreedictionary.com)
- Patent and Trademark Office (USPTO) has issued a Notice of Allowance for Patent Application 15/812,599 related to certain methods of production for AV-101, VistaGen Therapeutics' (NASDAQ: VTGN) oral NMDA receptor glycine site antagonist in Phase 2 development for major depressive disorder (MDD). (thefreedictionary.com)
- The NMDA receptor (in green and magenta) is embedded in the neuronal cell membrane (black lollipop-like structures arranged in two rows). (eurekalert.org)
Extracellular2
- Everything suggests, therefore, that these receptors register movements of the extracellular space in comparison with the cell and transmit this information to the cell interior," is Robert Kittel's summary of the results. (innovations-report.com)
- It has been speculated that the domain may have ancestrally acted as a spacer to push the receptor beyond the extracellular matrix. (wikipedia.org)
Biochemistry1
- In this overview of tumor receptor imaging, aspects of receptor biochemistry and biology that underlie tumor receptor imaging are reviewed, with the estrogen-estrogen receptor system in breast cancer as an illustrative example. (redorbit.com)
Neurotransmitter1
- Acetylcholine receptors function as "docking stations" for acetylcholine, a chemical substance (neurotransmitter) that transmits messages between nerve cells. (labtestsonline.org)
Genes6
- Binding is a critical element in effecting a cellular response to a signal and is influenced by a cell's ability to express only certain receptor genes . (britannica.com)
- The human genome contains roughly 1,000 genes for olfactory-type receptors, which are expressed in olfactory sensory neurons . (britannica.com)
- Rearrangements in certain parts of their DNA called receptor genes are a normal part of their development. (labtestsonline.org)
- The hormone binds to the receptor and the complex binds to hormone response elements - stretches of DNA within the promoters of genes responsive to the hormone. (google.com)
- Females with depression, Sodhi discovered, had the highest levels of expression of several glutamate receptor genes, perhaps making them more prone to depression. (medicalnewstoday.com)
- The researchers further determined that the genes for T1R1 and T1R3, which make up the new receptor, display individual variation. (scientificamerican.com)
Selective3
- Selective estrogen-receptor response modulators (SERMs) such as tamoxifen or toremifene for pre- or post-menopausal women. (news-medical.net)
- Tamoxifen is the oldest and most-prescribed selective estrogen receptor modulator (SERM). (breastcancer.org)
- While tissue specific effects of selective androgen receptor modulators (SARMs) outside the brain have been reported, little is known about brain specific SARMs. (ingentaconnect.com)
Class of receptors3
- The D2 class of receptors produce the opposite effect, as they are G αi coupled receptors, and block the activity of adenylyl cyclase. (wikipedia.org)
- Now, while studying a specific class of receptors, scientists from the University of Würzburg have made an unexpected discovery. (innovations-report.com)
- Scientists from the University of Würzburg have now proven these abilities for a large class of receptors that had not been suspected of such properties previously. (innovations-report.com)
Binds to the receptor3
- In these cases, the anticancer agent tamoxifen can be effective because it binds to the receptor. (britannica.com)
- The leptin receptor is turned on (activated) by a hormone called leptin that attaches (binds) to the receptor, fitting into it like a key into a lock. (medlineplus.gov)
- After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA . (wikipedia.org)
Types of opioid receptors2
- as eight different types of opioid receptors, but the four best-described are designated mu (μ), kappa (κ), delta (δ), and sigma (σ). (britannica.com)
- Scientists know of four distinct types of opioid receptors, but until now the structure of the 'salvia receptor', and the details about how salvinorin A and other drugs interact with it, was a mystery. (redorbit.com)
Nuclear receptors5
- Nuclear Receptors are, physiologically and pharmacologically, a critical superfamily of transcription factors. (rsc.org)
- currently, 13% of FDA-approved drugs target nuclear receptors. (rsc.org)
- This meeting will address the new roles and novel crosstalk mechanisms that are emerging for many of the 48 human nuclear receptors, in health and disease. (rsc.org)
- As demonstrated in progesterone receptor-deficient mice, the physiological effects of progesterone depend completely on the presence of the human progesterone receptor (hPR), a member of the steroid-receptor superfamily of nuclear receptors. (wikipedia.org)
- Intracellular receptors are those found inside the cell, and include cytoplasmic receptors and nuclear receptors . (wikipedia.org)
Pharmacology2
- This review discusses receptor pharmacology, the biology of tumor receptors, and special considerations for tumor receptor imaging, with the estrogen receptor (ER) as an illustrative example. (redorbit.com)
- Once we see the structure of the receptor, it becomes easier for us to develop drugs that target the receptor in ways that might be beneficial for medical therapy," said Bryan Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology at UNC and one of the paper's authors. (redorbit.com)
Steroid receptors4
- Examples of progress in radionuclide receptor imaging for 3 receptor systems- steroid receptors, somatostatin receptors, and growth factor receptors-are highlighted, and recent investigations of receptor imaging with other molecular imaging modalities are reviewed. (redorbit.com)
- This discussion is followed by highlights of recent work in the imaging of steroid receptors, somatostatin receptors (SSTRs), and growth factor receptors, as examples of 3 different types of tumor receptors. (redorbit.com)
- Steroid receptors of the nuclear receptor family are all transcription factors . (google.com)
- Origin of the response to adrenal and sex steroids: Roles of promiscuity and co-evolution of enzymes and steroid receptors. (google.com)
Progesterone receptors3
- Normal breast cells and some types of breast cancer cells have estrogen receptors (ER) and progesterone receptors (PR) on their surface or inside (in the nucleus or other parts of the cell). (cancer.ca)
- Progesterone is necessary to induce the progesterone receptors. (wikipedia.org)
- An expert panel was convened to consider new evidence that might prompt changes to clinical practices that were established with the 2010 Guideline Recommendations for Immunohistochemical (IHC) Testing of Estrogen and Progesterone Receptors (ER/PgR) in Breast Cancer. (cap.org)
Bind9
- Small molecules, such as hormones outside the cell or second messengers inside the cell, bind tightly and specifically to their receptors. (britannica.com)
- While many receptors sit at the cell membrane , exposing an outer surface to bind molecules that cannot penetrate the cell, other receptors are located inside the cell and bind to hormones that pass through the cell membrane. (britannica.com)
- The μ receptors, which readily bind morphine, are thought to mediate euphoria, respiratory depression, and physical addiction and to block pain pathways in the brain. (britannica.com)
- The study found that compared to other receptors, the binding site on KOR is enormous, allowing drugs to bind to it in more than one way. (redorbit.com)
- For example, when a mast cell within the body encounters an allergen, specialized receptors on the mast cell bind to the allergen, resulting in the release of histamine by the mast cell. (dictionary.com)
- Lee, Y. K., Parker, K. L., Choi, H. S. & Moore, D. D. Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers. (nature.com)
- When such chemical signals bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. (wikipedia.org)
- Modulating antibodies bind to two receptor molecules on the cell surface and accelerate internalization, triggering endocytosis and degradation. (labcorp.com)
- Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis. (labcorp.com)
Molecule3
- Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). (springer.com)
- Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. (springer.com)
- They show that a receptor for a molecule called brain-derived neurotrophic factor (BDNF) governs neurogenesis induced by antidepressants, and is required for sensitivity to these drugs. (scienceblogs.com)
Molecular11
- These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand. (google.com)
- Chang CS, Kokontis J, Liao ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. (springer.com)
- Advances in molecular cancer biology have revealed an ever-increasing number of tumor targets, many of which are receptors, such as the epidermal growth factor (EGF) receptor (EGFR) (4). (redorbit.com)
- Tumor receptor imaging emphasizes important emerging themes in molecular imaging: characterizing tumor biology, identifying therapeutic targets, and delineating the pharmacodynamics of targeted cancer therapy (5,6). (redorbit.com)
- Availability of the crystal structure of transferrin receptor 1, along with those of transferrin and HFE, opened research on molecular mapping of the transferrin-HFE- transferrin receptor interfaces by correlated synchrotron-generated hydroxyl radical footprinting and cryo-electron microscopy. (nih.gov)
- The nuclear receptor (NR) field was born in the mid 1980s, when the molecular cloning of several hormone receptors led to the realization that they share a common structure. (jci.org)
- This was a huge advance but begged the identification of the molecular receptors for hormones that acted in this way, and there was little recognition that there could be a common mechanism by which multiple hormones functioned in this fashion. (jci.org)
- Buck L and Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. (els.net)
- Shepherd GM (1994) Discrimination of molecular signals by the olfactory receptor neuron. (els.net)
- The study provides evidence of molecular mechanisms that shuttle GABAA receptors to the cell surface during extinction. (elsevier.com)
- The odorant must possess certain molecular properties-it must be water soluble and have high vapor pressure and low polarity-in order to interact with the olfactory receptors and produce signals that can be interpreted as odor. (smartdraw.com)
Antigen Receptor3
- As a leading technology provider, Creative Biolabs has established CellRapeutics™ Chimeric Antigen Receptor (CAR) Technology platform. (slideshare.net)
- This would also enhance the effectiveness of newer cancer immunotherapies like Chimeric-Antigen Receptor T cell (CAR-T). (news-medical.net)
- A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack. (news-medical.net)
Androgen receptor14
- Caffo O, Maines F, Veccia A, Kinspergher S, Galligioni E. Splice variants of androgen receptor and prostate cancer. (springer.com)
- The contribution of different androgen receptor domains to receptor dimerization and signaling. (springer.com)
- Alternatively spliced androgen receptor variants. (springer.com)
- Post-translational modification of the androgen receptor. (springer.com)
- Koryakina Y, Ta HQ, Gioeli D. Androgen receptor phosphorylation: biological context and functional consequences. (springer.com)
- Kumar R, Atamna H, Zakharov MN, Bhasin S, Khan SH, Jasuja R. Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy. (springer.com)
- Androgen receptor-mediated non-genomic regulation of prostate cancer cell proliferation. (springer.com)
- Cloning of human androgen receptor complementary DNA and localization to the X chromosome. (springer.com)
- A soluble androgen receptor in the cytoplasm of rat prostate. (springer.com)
- The androgen receptor in health and disease. (springer.com)
- Maintaining and reprogramming genomic androgen receptor activity in prostate cancer. (springer.com)
- Shukla GC, Plaga AR, Shankar E, Gupta S. Androgen receptor-related diseases: what do we know? (springer.com)
- A corticoid receptor and a progesterone receptor evolved in cyclostomes, and an androgen receptor evolved in gnathostomes. (google.com)
- Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. (ingentaconnect.com)
Glutamate receptor2
- At a finer scale, we discovered robust differences in glutamate receptor expression between the species. (sciencemag.org)
- The study also suggests new glutamate receptor targets for development of treatments for depression and identifies biochemical markers that could be used to assess suicide risk, she said. (medicalnewstoday.com)
Estrogen receptors3
- However, in some types of breast cancer, the cells no longer express estrogen receptors, and tamoxifen is ineffective in these individuals. (britannica.com)
- ERDs sit in the estrogen receptors in breast cells. (breastcancer.org)
- Cells with estrogen receptors grow and multiply when estrogen attaches to the receptors. (breastcancer.org)
Antibodies9
- AChR antibodies impede communication between nerves and skeletal muscles, inhibit muscle contraction, and cause rapid muscle fatigue by preventing activation of the acetylcholine receptors. (labtestsonline.org)
- Binding antibodies attach to the receptors on nerve cells and may initiate an inflammatory reaction that destroys the receptors. (labtestsonline.org)
- Blocking antibodies may sit on the receptors, preventing acetylcholine from binding. (labtestsonline.org)
- Modulating antibodies may cross-link the receptors, causing them to be taken up into the muscle cell and removed from the neuromuscular junction. (labtestsonline.org)
- The oligopeptides can be used to block PDGF binding and activation for numerous applications, and can serve as immunogens to raise receptor-specific antibodies. (google.ca)
- Monoclonal antibodies were obtained for this receptor . (bio.net)
- Several antibodies were able to regulate the basic function of the receptor: activation of cytokinin-dependent RNA synthesis . (bio.net)
- Hara H, Hayashi K, Ohta K, Itoh N, Nishitani H, Ohta M. Detection and characterization of blocking-type antiacetylcholine receptor antibodies in sera from patients with myasthenia gravis. (labcorp.com)
- Rhabdomyosarcoma cell line can be used for the isolation of soluble acetylcholine receptor for assaying blocking and modulating antibodies. (labcorp.com)
Neurons5
- In the second strain of mutants, in which the receptor was deleted in adulthood, there was a significant decrease in the number of newly-generated hippocampal neurons. (scienceblogs.com)
- In the third strain, deletion of the receptor from differentiated neurons had no apparent effect. (scienceblogs.com)
- Firestein, Stuart J(Apr 2001) Olfactory Receptor Neurons. (els.net)
- Lin and colleagues show that during fear conditioning, the number of GABAA receptors on the surface of neurons in the amygdala decreases, reducing the extent of inhibition of the neurons in this brain "fear center. (elsevier.com)
- When fear is extinguished by dissociating fear cues from unpleasant stimuli, the number of GABAA receptors on the cell surface of the amygdala neurons increases. (elsevier.com)
Agonist5
- The D 2 Lh form may function as a classical post-synaptic receptor, i.e., transmit information (in either an excitatory or an inhibitory fashion) unless blocked by a receptor antagonist or a synthetic partial agonist . (wikipedia.org)
- Numerous laboratories have worked to identify the exact mechanism by which binding of the Gα subunit to an agonist-bound receptor results in GDP-GTP exchange. (vanderbilt.edu)
- A crystal structure of the agonist-activated β 2 adrenergic receptor bound to G s (β 2 AR-G s )(S. G. F. Rasmussen, et al. (vanderbilt.edu)
- now report a high-resolution crystal structure of human A 2A adenosine receptor bound to a potent agonist, which provides insight into the structural basis of activation. (sciencemag.org)
- The present work analyzed the learning performance of male Wistar rats kindled with a convulsant inverse agonist of the GABA A-benzodiazepine receptor complex, methyl β-carboline-3-carboxylate (β-CCM). (mendeley.com)
Brain receptor4
- New research uncovers a brain receptor that could explain why some people experience major depressive disorder after a stressful event, while others do not. (medicalnewstoday.com)
- So, Martemyanov and colleagues examined the behavior of this brain receptor in mice that had been subjected to chronic stress . (medicalnewstoday.com)
- It is the absence of a vital brain receptor that makes schizophrenics experience turbulence in their brains, new research reveals. (medindia.net)
- A brain receptor activated by glutamate, which when excessively stimulated may cause cognitive defects in Alzheimer's disease. (thefreedictionary.com)
Hormone receptor18
- Hormone receptor-positive (HR-positive or HR+) breast cancer is a type of breast cancer that feeds on the presence of estrogen and progesterone hormones in the body to grow. (news-medical.net)
- There are two types of hormone receptor positive breast cancer, according to the type of hormone that the receptor is associate with. (news-medical.net)
- The pathology report will show the results of a hormone receptor assay, which portrays whether the breast cancer cells are hormone-receptor positive. (news-medical.net)
- Retrieved on July 17, 2019 from https://www.news-medical.net/health/Hormone-Receptor-Positive-Breast-Cancer.aspx. (news-medical.net)
- If you've been told that you have hormone-receptor-negative breast cancer, you may be worried. (breastcancer.org)
- It's important to know that treatments such as surgery, radiation therapy, and chemotherapy are very effective against breast cancer - whether it is hormone-receptor-positive or hormone-receptor-negative. (breastcancer.org)
- And research suggests that hormone-receptor-negative breast cancers may respond better to chemotherapy than hormone-receptor-positive breast cancers do. (breastcancer.org)
- So even though you aren't receiving hormonal therapy, you're likely getting treatment that's very effective for hormone-receptor-negative breast cancer. (breastcancer.org)
- And, like people with hormone-receptor-positive cancer, you're doing everything you can to treat the breast cancer. (breastcancer.org)
- Ask your doctor about any clinical trials enrolling people with hormone-receptor-negative breast cancer. (breastcancer.org)
- Hormone receptor testing is done at the time of diagnosis for breast cancer or when breast cancer comes back after treatment (recurs). (cancer.ca)
- Hormone receptor status testing is often done at the same time as the HER2 status test . (cancer.ca)
- Knowing the hormone receptor status of the tumour helps doctors predict how well hormonal therapy will work and what other treatments may be effective. (cancer.ca)
- Hormone receptor status also affects prognosis and survival for breast cancer. (cancer.ca)
- Hormone receptor status testing is done on a tissue sample taken with a biopsy . (cancer.ca)
- Tumours that are hormone receptor negative (ER- and PR-) are not treated with hormonal therapy. (cancer.ca)
- Hormone receptor status may be re-checked at this time. (cancer.ca)
- Breast cancer may respond to hormonal therapy if the recurrence is several years after the first diagnosis of breast cancer and the first tumour was hormone receptor negative. (cancer.ca)
Antibody2
- An acetylcholine receptor (AChR) antibody test is used to help diagnose myasthenia gravis (MG) and to distinguish it from other conditions that may cause similar symptoms, such as chronic muscle fatigue and weakness. (labcorp.com)
- Receptor antibody levels tend to rise several weeks before symptoms increase in patients with established MG. Remission after thymectomy is associated with a progressive decline in antibody levels. (labcorp.com)
Amino acid3
- Our results," the authors write, "demonstrate that T1R1 and T1R3 combine to function as a broadly tuned amino acid receptor. (scientificamerican.com)
- A special transcription activation function (TAF), called TAF-3, is present in the progesterone receptor-B, in a B-upstream segment (BUS) at the amino acid terminal. (wikipedia.org)
- N-m(ethyl)-d-a(spartate) , an amino acid derivative that binds selectively to the receptor . (thefreedictionary.com)
Regulation3
- Veillette A. Immune regulation by SLAM family receptors and SAP-related adaptors. (springer.com)
- The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
- Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis. (nature.com)
Antagonist1
- Drugs directed toward tumor receptor systems most frequently use a receptor antagonist, for example, tamoxifen, which blocks estrogen binding to the ER. (redorbit.com)
Signals5
- NK cell effector functions are governed by the balance of potentially opposing signals from a diverse array of both activating and inhibitory receptors on the cell surface that are not rearranged from germ-line receptor segments, unlike B and T cell receptors (BCRs, TCRs) on lymphocytes. (springer.com)
- In the hypothalamus, the binding of leptin to its receptor triggers a series of chemical signals that affect hunger and help produce a feeling of fullness (satiety). (medlineplus.gov)
- The activated receptor then transmits signals to the cell cytoplasm and/or nucleus, thereby effectuating migration and proliferation. (google.ca)
- Estrogen sends signals through the receptors that tell breast cancer cells to grow. (breastcancer.org)
- A similar picture was found to do with hearing: Larvae without receptors required far louder signals for a flight reflex compared with healthy specimens. (innovations-report.com)
Subtypes3
- There are at least five subtypes of dopamine receptors, D 1 , D 2 , D 3 , D 4 , and D 5 . (wikipedia.org)
- Furthermore, D 1-2 receptor subtypes are found at 10-100 times the levels of the D 3-5 subtypes. (wikipedia.org)
- The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. (elsevier.com)
Transcription1
- PPARα is a nuclear receptor, one in a family of at least 3 transcription factors that have been connected to cell metabolism and differentiation. (ahajournals.org)
Humans4
- The receptors are widely expressed in humans. (medscape.com)
- Currently, Dong and others are working to identify receptors for the other types of botulinum neurotoxin fatal to humans. (innovations-report.com)
- Charles Zuker of the University of California, San Diego and colleagues discovered and tested the receptor, dubbed T1R1+3, in both mice and humans. (scientificamerican.com)
- Membrane receptor-activated signal transduction pathways are integral to cellular functions and disease mechanisms in humans. (cmu.edu)
Orphan3
- So-called orphan brain receptors may explain why some people develop depression after a traumatic event. (medicalnewstoday.com)
- Nuclear hormone receptors regulate diverse metabolic pathways and the orphan nuclear receptor LRH-1 (also known as NR5A2) regulates bile acid biosynthesis 1 , 2 . (nature.com)
- Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development. (nature.com)
Assay4
- Knowledge of receptor expression is key for therapy directed at tumor receptors and traditionally has been obtained by assay of biopsy material. (redorbit.com)
- Although this information traditionally has been obtained by in vitro assay of biopsy material, recent studies have highlighted the complementary value of tumor receptor imaging for measuring regional tumor receptor expression, which can be quite heterogeneous. (redorbit.com)
- A very practical consideration is that imaging can assess receptor expression at sites that are challenging to sample and assay, such as bone metastases. (redorbit.com)
- Development of an assay for modulating antiacetylcholine receptor autoantibodies using human rhabdomyosarcoma cell line. (labcorp.com)
Characterization1
- Tumor receptor imaging offers complementary information that includes evaluation of the entire tumor burden and characterization of the heterogeneity of tumor receptor expression. (redorbit.com)
GPCRs2
- More specifically, their attention is directed at a special class of this receptor super-family, known as adhesion GPCRs. (innovations-report.com)
- And, the scientists have now been able to present an initial, surprising result to the public: "We were able to demonstrate that a special receptor from the group of adhesion GPCRs is involved in the perception of mechanosensory stimuli," says Robert Kittel. (innovations-report.com)
Nicotinic1
- Ongoing exposure to nicotine produces upregulation of beta2 nicotinic acetylcholine receptors (nAChRs), which is associated with nicotine dependence. (fda.gov)
Hormones6
- Receptors for steroid hormones (e.g., estrogen ) are among the latter group. (britannica.com)
- People with leptin receptor deficiency also have hypogonadotropic hypogonadism, which is a condition caused by reduced production of hormones that direct sexual development. (medlineplus.gov)
- However, for the majority of women with breast cancer, the abnormal cancer cells contain receptors that are activated in the presence of these hormones. (news-medical.net)
- vitamin D ..." "... receptors for the classic steroid hormones (glucocorticoid, progesterone, aldosterone, androgen, and estrogen) appeared more recently in evolutionary time. (google.com)
- These receptors are where the hormones attach to the cells. (cancer.ca)
- Breast cancer cells that have ER and PR receptors need these hormones to grow and divide. (cancer.ca)
Cellular5
- Receptors play key roles in many cellular processes. (britannica.com)
- Receptors mediating antiviral responses of the innate and adaptive immune systems act together in an autophagosome-like cellular compartment. (sciencemag.org)
- These findings provide new insight into the activities of chemokine receptors on both hematopoietic and non-hematopoietic cells and indicate that these molecules have both a more widespread cellular expression pattern and a wider biological role than first envisaged. (nih.gov)
- Each receptor is linked to a specific cellular biochemical pathway. (wikipedia.org)
- The present invention relates generally to compounds and methods for identifying polymorphism in a cellular receptor, and more particularly, to compounds and methods for identifying and typing single nucleotide polymorphisms that code for a complement receptor and applying these polymorphisms to delineation of disease susceptibility and severity. (google.com)
Subunits1
Olfactory recept1
- Each olfactory receptor neuron has 8-20 cilia that are whip-like extensions (they mark the beginning of sensory transduction). (smartdraw.com)
Mice6
- Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
- Compromised intestinal lipid absorption in mice with a liver-specific deficiency of the liver receptor homolog 1. (nature.com)
- With this in mind, Li et al generated several strains of mutant mice lacking the BDNF receptor TrkB. (scienceblogs.com)
- The mutants lacking the TrkB receptor in the NPCs were then treated with fluoxetine (Prozac), imipramine (a tricyclic antidepressant) or saline (salt water) for 3 weeks and the amount of time they took to begin feeding was recorded and compared to healthy control mice. (scienceblogs.com)
- We have developed a simple and sensitive method for conditional cell ablation in transgenic mice, called 'toxin receptor-mediated cell knockout. (mendeley.com)
- We expressed the diphtheria toxin (DT) receptor in transgenic mice using a hepatocyte-specific promoter and found that injection of DT caused fulminant hepatitis. (mendeley.com)
AChR2
- 085933: Acetylcholine Receptor (AChR)-modulating. (labcorp.com)
- Myasthenia gravis is an autoimmune disorder manifested by muscle weakness caused by the loss or dysfunction of acetylcholine receptors (AChR) of skeletal muscle. (labcorp.com)
Cell membrane1
- The enkephalin receptor (gray) threads through the cell membrane. (eurekalert.org)
Glucocorticoid1
- 2010 )). In addition to AR, the SHR family contains the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), progesterone receptor (PR), and the estrogen receptor (ER). (springer.com)
Inhibitory2
- This receptor has an inhibitory function on most of the tissues in which it is expressed. (wikipedia.org)
- Crystal structure of the human natural killer cell inhibitory receptor KIR2DL1-HLA-Cw4 complex. (springer.com)
Histamine receptors3
- For example, H1-type histamine receptors in the airways contribute to allergy symptoms, whereas H2-type receptors in the stomach promote the secretion of acid. (britannica.com)
- The histamine then binds to histamine receptors in other cells of the body, which initiate the response known as inflammation as well as other responses. (dictionary.com)
- Antihistamine drugs work by preventing the binding of histamine to histamine receptors. (dictionary.com)
Adenosine receptors1
- Caffeine keeps you awake by blocking adenosine receptors. (wikipedia.org)
Acetylcholine receptors1
- When it reaches the muscle fiber, it binds to one of many acetylcholine receptors and activates it, initiating muscle contraction. (labtestsonline.org)
Endocytosis1
- The cytosolic C-terminal domain contains ~50 amino acids, including a signal sequence important for localizing the receptors to clathrin-coated pits and for triggering receptor-mediated endocytosis after binding. (wikipedia.org)
Polymorphisms2
- It is currently unknown which if any polymorphisms in this receptor are of significance to cancer. (wikipedia.org)
- A method and a package for identifying single nucleotide polymorphisms in complement receptor is useful in identifying individual susceptibility to a disease. (google.com)