• D 3 is encoded by the Dopamine receptor D 3 gene ( DRD3 ). (wikipedia.org)
  • D 4 is encoded by the Dopamine receptor D 4 gene ( DRD4 ). (wikipedia.org)
  • The D 4 receptor gene displays polymorphisms that differ in a variable number tandem repeat present within the coding sequence of exon 3. (wikipedia.org)
  • Leptin receptor deficiency is caused by mutations in the LEPR gene. (medlineplus.gov)
  • This gene provides instructions for making a protein called the leptin receptor, which is involved in the regulation of body weight. (medlineplus.gov)
  • LEPR gene mutations that cause leptin receptor deficiency prevent the receptor from responding to leptin, leading to the excessive hunger and weight gain associated with this disorder. (medlineplus.gov)
  • Because hypogonadotropic hypogonadism occurs in leptin receptor deficiency, researchers suggest that leptin receptor signaling is also involved in regulating the body's response to hormones that control sexual development, and that this response is affected by LEPR gene mutations. (medlineplus.gov)
  • Andiran N, Celik N, Andiran F. Homozygosity for two missense mutations in the leptin receptor gene (P316:W646C) in a Turkmenian girl with severe early-onset obesity. (medlineplus.gov)
  • A T-cell receptor gene rearrangement test evaluates the T-cells in a person's sample to determine whether the majority of T-cell rearrangement profiles are diverse or identical. (labtestsonline.org)
  • ISCT, the International Society for Cell and Gene Therapy, the global professional society of clinicians, researchers, regulatory specialists, technologists and industry partners in the cell and gene therapy sector, today announces its objection to linking the benefits of cellular immunotherapy, in particular Chimeric Antigen Receptor (CAR) T-cell therapy, with recent market offerings for third party cryopreserving and banking of T-cells for future therapeutic use. (news-medical.net)
  • These receptors often can enter the cell nucleus and modulate gene expression in response to the activation by the ligand. (google.com)
  • They are generally intracellular receptors (typically cytoplasmic) and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days. (google.com)
  • Fatty acids have been shown to activate gene transcription under the control of some evolutionarily primitive members of the steroid/thyroid superfamily of receptors. (google.com)
  • In these creatures we removed the very gene that encodes the receptor Latrophilin and replaced it with modified variants," is how Langenhan explains the procedure. (innovations-report.com)
  • More recently, and very controversially, someone in China used gene therapy to modify the CCR5 receptor in embryos to protect the babies from contracting HIV. (medscape.com)
  • Your pathology report will tell you whether or not the breast cancer cells have too many copies of a gene called HER2 or too much of the receptor protein it makes. (breastcancer.org)
  • Several studies have now shown no association between progesterone receptor gene +331G/A polymorphisms and breast or endometrial cancers. (wikipedia.org)
  • Estrogen receptor (ER)3 gene expression in breast epithelium is an intricately regulated event. (nih.gov)
  • Through gene targetting experiments (see text) it is now clear that all the ORNs expressing the same receptor send their axons to the same glomerulus even though the cells are widely distributed on the olfactory epithelium. (els.net)
  • Ressler KJ, Sullivan SL, and Buck LB (1993) A zonal organization of odorant receptor gene expression in the olfactory epithelium. (els.net)
  • TRAPS is due to a gene defect in a protein called tumor necrosis factor receptor, which leads to an increase of the patient's normal inflammatory response. (rheumatology.org)
  • In the present issue of Hypertension , Tordjman et al 1 explore the role of the candidate gene, peroxisome proliferator-activated receptor (PPAR)-α (reviewed extensively and comprehensively in the Web site dedicated to PPAR: http://ppar.cas.psu.edu/), in the regulation of blood pressure and atherogenesis. (ahajournals.org)
  • In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. (wikipedia.org)
  • It belongs to the Low density lipoprotein receptor gene family. (wikipedia.org)
  • Mutations in the gene encoding the LDL receptor are known to cause familial hypercholesterolaemia. (wikipedia.org)
  • Fang S, Anderson KM, Liao S. Receptor proteins for androgens. (springer.com)
  • Holland SJ, Gale NW, Gish GD, Roth RA, Songyang Z, Cantley LC, Henkemeyer M, Yancopoulos GD, Pawson T. Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells. (springer.com)
  • For example, receptor-mediated endocytosis enables cells to ingest molecules such as proteins that are necessary for normal cell functioning. (britannica.com)
  • Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. (nih.gov)
  • At the molecular level, drugs like salvinorin A (the active ingredient of the hallucinogenic plant Salvia divinorum) work by activating specific proteins, known as receptors, in the brain and body. (redorbit.com)
  • Acetylcholine receptor (AChR) antibodies are autoantibodies produced by the immune system that mistakenly target proteins called acetylcholine receptors that are located on skeletal muscle fibers. (labtestsonline.org)
  • Chapman says researchers have known that gangliosides - a special type of lipid - and proteins work together as a receptor, but no one until now has been able to identify the specific proteins. (eurekalert.org)
  • Using a cellular model, Chapman, physiology and neuroscience graduate student Min Dong and others identified two proteins that function alongside gangliosides as the receptor for botulinum neurotoxin B - one of the four types deadly to humans. (eurekalert.org)
  • Another major class of receptors are intracellular proteins such as those for steroid and intracrine peptide hormone receptors. (google.com)
  • However, their "target" cells contain cytoplasmic and/or nuclear proteins that serve as receptors of the hormone. (google.com)
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • Receptor proteins can be classified by their location. (wikipedia.org)
  • The aforementioned receptors are coupled to different intracellular effector systems via G proteins . (wikipedia.org)
  • Unlike prior approaches that attempted to predict the global human interactome we used a computational strategy that only focused on discovering the interacting partners of human membrane receptors leading to improved results for these proteins. (cmu.edu)
  • The predicted membrane receptor interactome provides a system-wide view, and generates new biological hypotheses regarding interactions between membrane receptors and other proteins. (cmu.edu)
  • Researchers interested in specific membrane receptors can enter individual or sets of proteins and retrieve their rank-ordered interactions, along with the evidence supporting these predictions. (cmu.edu)
  • The attachment of complement proteins, C3b/C4b to microbial membranes or immune complexes, a process commonly known as opsonization, facilitates the binding of opsonized material to cell receptors. (google.com)
  • The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. (wikipedia.org)
  • Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. (springer.com)
  • The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in human. (springer.com)
  • Crystal structure of a lectin-like natural killer cell receptor bound to its MHC class I ligand. (springer.com)
  • This book equips the researcher with techniques for exploring the unprecedented number of new receptor systems now emerging and the so-called "orphan" receptors whose activating ligand has not been identified. (google.com)
  • AR is a ligand-activated transcription factor (TF) that belongs to the steroid hormone receptor (SHR) family within the nuclear receptor (NR) superfamily of TFs (for a review, see Huang et al. (springer.com)
  • Ligand-specific dynamics of the androgen receptor at its response element in living cells. (springer.com)
  • The nature of the ligand-receptor interaction poses a challenge for imaging-notably, the requirement for a low molecular concentration of the imaging probe to avoid saturating the receptor and increasing the background because of nonspecific uptake. (redorbit.com)
  • Common to all receptors is the interaction of a ligand and the receptor, in which specific binding of the ligand to the receptor results in downstream biochemical or physiologic changes {7,8). (redorbit.com)
  • Alternatively, some drugs lower the level of an agonist to decrease ligand-receptor interactions, for example, levothyroxine, which suppresses thyroid- stimulating hormone levels in the treatment of thyroid cancer (12). (redorbit.com)
  • Note that to interact with an intracellular receptor, the ligand must first get past the cellular membrane. (google.com)
  • Members of the nuclear receptor (NR) superfamily of ligand-regulated transcription factors play important roles in reproduction, development, and physiology. (jci.org)
  • The peroxisome proliferator-activated receptor alpha (PPAR ) is a ligand-activated transcription factor involved in the regulation of a variety of processes, ranging from inflammation and immunity to nutrient metabolism and energy homeostasis. (hindawi.com)
  • The peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the superfamily of nuclear hormone receptors and play an important role in nutrient homeostasis [ 1 - 3 ]. (hindawi.com)
  • In common with other steroid receptors, the progesterone receptor has a N-terminal regulatory domain, a DNA binding domain , a hinge section, and a C-terminal ligand binding domain. (wikipedia.org)
  • The receptor releases a messenger once the ligand has connected to the receptor. (wikipedia.org)
  • The endogenously designated -molecule for a particular receptor is referred to as its endogenous ligand. (wikipedia.org)
  • E.g. the endogenous ligand for the nicotinic acetylcholine receptor is acetylcholine but the receptor can also be activated by nicotine and blocked by curare . (wikipedia.org)
  • When a ligand binds to its corresponding receptor, it activates or inhibits the receptor's associated biochemical pathway. (wikipedia.org)
  • Type 3: Kinase-linked and related receptors (see " Receptor tyrosine kinase " and " Enzyme-linked receptor ") - They are composed of an extracellular domain containing the ligand binding site and an intracellular domain, often with enzymatic-function, linked by a single transmembrane alpha helix. (wikipedia.org)
  • Ligand binding is the first step in hormone regulation of mineralocorticoid receptor (MR) activity. (rcsb.org)
  • These structures combined with mutagenesis studies reveal that maximal receptor activation involves an intricate ligand-mediated hydrogen bond network with Asn770 which serves dual roles: stabilization of the loop preceding the C-terminal activation function-2 helix and direct contact with the hormone ligand. (rcsb.org)
  • The top part of the receptor is outside the neuron and binds neurotransmitters glutamate (green) and glycine (white) in its ligand-binding domains. (eurekalert.org)
  • The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical). (wikipedia.org)
  • Class 4 mutations inhibit the internalisation of the receptor-ligand complex. (wikipedia.org)
  • Presynaptically, it reduces synaptic vesicle release while post synaptically it has been found to stabilize the magnesium on the NMDA receptor . (wikipedia.org)
  • Woman's Anti-NMDA Receptor Encephalitis Misdiag. (scoop.it)
  • Finally she found out she had anti-NMDA receptor encephalitis, a type of brain inflammation. (scoop.it)
  • New Prize offered by The Anti-NMDA Receptor Encephalitis Foundation at the 54th annual Congress of the Canadian Neurological Sciences Federation. (scoop.it)
  • 1. A score that predicts one year functional status in anti-NMDA receptor encephalitis patients. (scoop.it)
  • In the first segment, Dr. David Lapides talks with Dr. Ramani Balu about his paper on a score that predicts one year functional status in anti-NMDA receptor encephalitis patients. (scoop.it)
  • A score that predicts 1-year functional status in patients with anti-NMDA receptor encephalitis From. (scoop.it)
  • When applied to rat brain cells, they found the drug changed the frequency of its electrical activity by blocking the NMDA brain receptor. (medindia.net)
  • If we could find a drug that attaches itself to this site and then locks together NMDA receptor subunits, that would be huge for fighting disability from stroke and Alzheimer's and other neurodegenerative diseases. (thefreedictionary.com)
  • 2) The best experimental study supporting this hypothesis was conducted in healthy subjects undergoing an NMDA receptor antagonist to reproduce schizophreniform symptoms. (thefreedictionary.com)
  • Regulation of NMDA receptor desensitization in mouse hippocampal neurons by glycine. (thefreedictionary.com)
  • Although glutamate and its postsynaptic NMDA receptor are normal components of nervous-system conduction, over-activation can mediate damage after SCI and other nervous-system insults (e.g., head injury, stroke, etc. (thefreedictionary.com)
  • PSD-95/SAP90 appears to mediate the role of the NMDA receptor in determining the MAC of inhalational anesthetics. (thefreedictionary.com)
  • This correlated with the ability of TNF[alpha] and TNFRII agonist antibodies to stimulate increased NMDA receptor activity as observed by increased intracellular [Ca.sup.2+] levels and NMDA receptor-evoked currents. (thefreedictionary.com)
  • To obtain IgY antibodies against synthetic peptides of NR3A and NR3B subunits of the rat NMDA receptor , to recognize and follow the expression of these subunits in rat brain extract at different ages. (thefreedictionary.com)
  • Aptinyx announced the presentation of preclinical data on its novel NMDA receptor modulator, NYX-458. (thefreedictionary.com)
  • REL-1017 is an orally administered NMDA receptor (NMDAR) antagonist indicated to be active on the NMDAR ketamine binding site. (thefreedictionary.com)
  • Patent and Trademark Office (USPTO) has issued a Notice of Allowance for Patent Application 15/812,599 related to certain methods of production for AV-101, VistaGen Therapeutics' (NASDAQ: VTGN) oral NMDA receptor glycine site antagonist in Phase 2 development for major depressive disorder (MDD). (thefreedictionary.com)
  • The NMDA receptor (in green and magenta) is embedded in the neuronal cell membrane (black lollipop-like structures arranged in two rows). (eurekalert.org)
  • Everything suggests, therefore, that these receptors register movements of the extracellular space in comparison with the cell and transmit this information to the cell interior," is Robert Kittel's summary of the results. (innovations-report.com)
  • It has been speculated that the domain may have ancestrally acted as a spacer to push the receptor beyond the extracellular matrix. (wikipedia.org)
  • In these cases, the anticancer agent tamoxifen can be effective because it binds to the receptor. (britannica.com)
  • The leptin receptor is turned on (activated) by a hormone called leptin that attaches (binds) to the receptor, fitting into it like a key into a lock. (medlineplus.gov)
  • After progesterone binds to the receptor, restructuring with dimerization follows and the complex enters the nucleus and binds to DNA . (wikipedia.org)
  • This review discusses receptor pharmacology, the biology of tumor receptors, and special considerations for tumor receptor imaging, with the estrogen receptor (ER) as an illustrative example. (redorbit.com)
  • Once we see the structure of the receptor, it becomes easier for us to develop drugs that target the receptor in ways that might be beneficial for medical therapy," said Bryan Roth, MD, PhD, the Michael Hooker Distinguished Professor of Pharmacology at UNC and one of the paper's authors. (redorbit.com)
  • Small molecules, such as hormones outside the cell or second messengers inside the cell, bind tightly and specifically to their receptors. (britannica.com)
  • While many receptors sit at the cell membrane , exposing an outer surface to bind molecules that cannot penetrate the cell, other receptors are located inside the cell and bind to hormones that pass through the cell membrane. (britannica.com)
  • The μ receptors, which readily bind morphine, are thought to mediate euphoria, respiratory depression, and physical addiction and to block pain pathways in the brain. (britannica.com)
  • The study found that compared to other receptors, the binding site on KOR is enormous, allowing drugs to bind to it in more than one way. (redorbit.com)
  • For example, when a mast cell within the body encounters an allergen, specialized receptors on the mast cell bind to the allergen, resulting in the release of histamine by the mast cell. (dictionary.com)
  • Lee, Y. K., Parker, K. L., Choi, H. S. & Moore, D. D. Activation of the promoter of the orphan receptor SHP by orphan receptors that bind DNA as monomers. (nature.com)
  • When such chemical signals bind to a receptor, they cause some form of cellular/tissue response, e.g. a change in the electrical activity of a cell. (wikipedia.org)
  • Modulating antibodies bind to two receptor molecules on the cell surface and accelerate internalization, triggering endocytosis and degradation. (labcorp.com)
  • Clinical correlations of antibodies that bind, block, or modulate human acetylcholine receptors in myasthenia gravis. (labcorp.com)
  • Structural basis for recognition of the nonclassical MHC molecule HLA-G by the leukocyte Ig-like receptor B2 (LILRB2/LIR2/ILT4/CD85d). (springer.com)
  • Structure of natural killer receptor 2B4 bound to CD48 reveals basis for heterophilic recognition in signaling lymphocyte activation molecule family. (springer.com)
  • They show that a receptor for a molecule called brain-derived neurotrophic factor (BDNF) governs neurogenesis induced by antidepressants, and is required for sensitivity to these drugs. (scienceblogs.com)
  • These cutting-edge techniques cover mining from curated databases, identifying novel receptors by high throughput screening, molecular methods to identify mRNA encoding receptors, radioligand. (google.com)
  • Chang CS, Kokontis J, Liao ST. Molecular cloning of human and rat complementary DNA encoding androgen receptors. (springer.com)
  • Advances in molecular cancer biology have revealed an ever-increasing number of tumor targets, many of which are receptors, such as the epidermal growth factor (EGF) receptor (EGFR) (4). (redorbit.com)
  • Tumor receptor imaging emphasizes important emerging themes in molecular imaging: characterizing tumor biology, identifying therapeutic targets, and delineating the pharmacodynamics of targeted cancer therapy (5,6). (redorbit.com)
  • Availability of the crystal structure of transferrin receptor 1, along with those of transferrin and HFE, opened research on molecular mapping of the transferrin-HFE- transferrin receptor interfaces by correlated synchrotron-generated hydroxyl radical footprinting and cryo-electron microscopy. (nih.gov)
  • The nuclear receptor (NR) field was born in the mid 1980s, when the molecular cloning of several hormone receptors led to the realization that they share a common structure. (jci.org)
  • This was a huge advance but begged the identification of the molecular receptors for hormones that acted in this way, and there was little recognition that there could be a common mechanism by which multiple hormones functioned in this fashion. (jci.org)
  • Buck L and Axel R (1991) A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. (els.net)
  • Shepherd GM (1994) Discrimination of molecular signals by the olfactory receptor neuron. (els.net)
  • The study provides evidence of molecular mechanisms that shuttle GABAA receptors to the cell surface during extinction. (elsevier.com)
  • The odorant must possess certain molecular properties-it must be water soluble and have high vapor pressure and low polarity-in order to interact with the olfactory receptors and produce signals that can be interpreted as odor. (smartdraw.com)
  • As a leading technology provider, Creative Biolabs has established CellRapeutics™ Chimeric Antigen Receptor (CAR) Technology platform. (slideshare.net)
  • This would also enhance the effectiveness of newer cancer immunotherapies like Chimeric-Antigen Receptor T cell (CAR-T). (news-medical.net)
  • A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack. (news-medical.net)
  • Caffo O, Maines F, Veccia A, Kinspergher S, Galligioni E. Splice variants of androgen receptor and prostate cancer. (springer.com)
  • The contribution of different androgen receptor domains to receptor dimerization and signaling. (springer.com)
  • Alternatively spliced androgen receptor variants. (springer.com)
  • Post-translational modification of the androgen receptor. (springer.com)
  • Koryakina Y, Ta HQ, Gioeli D. Androgen receptor phosphorylation: biological context and functional consequences. (springer.com)
  • Kumar R, Atamna H, Zakharov MN, Bhasin S, Khan SH, Jasuja R. Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy. (springer.com)
  • Androgen receptor-mediated non-genomic regulation of prostate cancer cell proliferation. (springer.com)
  • Cloning of human androgen receptor complementary DNA and localization to the X chromosome. (springer.com)
  • A soluble androgen receptor in the cytoplasm of rat prostate. (springer.com)
  • The androgen receptor in health and disease. (springer.com)
  • Maintaining and reprogramming genomic androgen receptor activity in prostate cancer. (springer.com)
  • Shukla GC, Plaga AR, Shankar E, Gupta S. Androgen receptor-related diseases: what do we know? (springer.com)
  • A corticoid receptor and a progesterone receptor evolved in cyclostomes, and an androgen receptor evolved in gnathostomes. (google.com)
  • Here we show that SARMs upregulate androgen receptor levels in brain following castration and antagonize impairments in hippocampus-dependent novel location recognition and spatial memory retention in apoE4 female mice. (ingentaconnect.com)
  • In the second strain of mutants, in which the receptor was deleted in adulthood, there was a significant decrease in the number of newly-generated hippocampal neurons. (scienceblogs.com)
  • In the third strain, deletion of the receptor from differentiated neurons had no apparent effect. (scienceblogs.com)
  • Firestein, Stuart J(Apr 2001) Olfactory Receptor Neurons. (els.net)
  • Lin and colleagues show that during fear conditioning, the number of GABAA receptors on the surface of neurons in the amygdala decreases, reducing the extent of inhibition of the neurons in this brain "fear center. (elsevier.com)
  • When fear is extinguished by dissociating fear cues from unpleasant stimuli, the number of GABAA receptors on the cell surface of the amygdala neurons increases. (elsevier.com)
  • The D 2 Lh form may function as a classical post-synaptic receptor, i.e., transmit information (in either an excitatory or an inhibitory fashion) unless blocked by a receptor antagonist or a synthetic partial agonist . (wikipedia.org)
  • Numerous laboratories have worked to identify the exact mechanism by which binding of the Gα subunit to an agonist-bound receptor results in GDP-GTP exchange. (vanderbilt.edu)
  • A crystal structure of the agonist-activated β 2 adrenergic receptor bound to G s (β 2 AR-G s )(S. G. F. Rasmussen, et al. (vanderbilt.edu)
  • now report a high-resolution crystal structure of human A 2A adenosine receptor bound to a potent agonist, which provides insight into the structural basis of activation. (sciencemag.org)
  • The present work analyzed the learning performance of male Wistar rats kindled with a convulsant inverse agonist of the GABA A-benzodiazepine receptor complex, methyl β-carboline-3-carboxylate (β-CCM). (mendeley.com)
  • New research uncovers a brain receptor that could explain why some people experience major depressive disorder after a stressful event, while others do not. (medicalnewstoday.com)
  • So, Martemyanov and colleagues examined the behavior of this brain receptor in mice that had been subjected to chronic stress . (medicalnewstoday.com)
  • It is the absence of a vital brain receptor that makes schizophrenics experience turbulence in their brains, new research reveals. (medindia.net)
  • A brain receptor activated by glutamate, which when excessively stimulated may cause cognitive defects in Alzheimer's disease. (thefreedictionary.com)
  • NK cell effector functions are governed by the balance of potentially opposing signals from a diverse array of both activating and inhibitory receptors on the cell surface that are not rearranged from germ-line receptor segments, unlike B and T cell receptors (BCRs, TCRs) on lymphocytes. (springer.com)
  • In the hypothalamus, the binding of leptin to its receptor triggers a series of chemical signals that affect hunger and help produce a feeling of fullness (satiety). (medlineplus.gov)
  • The activated receptor then transmits signals to the cell cytoplasm and/or nucleus, thereby effectuating migration and proliferation. (google.ca)
  • Estrogen sends signals through the receptors that tell breast cancer cells to grow. (breastcancer.org)
  • A similar picture was found to do with hearing: Larvae without receptors required far louder signals for a flight reflex compared with healthy specimens. (innovations-report.com)
  • There are at least five subtypes of dopamine receptors, D 1 , D 2 , D 3 , D 4 , and D 5 . (wikipedia.org)
  • Furthermore, D 1-2 receptor subtypes are found at 10-100 times the levels of the D 3-5 subtypes. (wikipedia.org)
  • The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. (elsevier.com)
  • Knowledge of receptor expression is key for therapy directed at tumor receptors and traditionally has been obtained by assay of biopsy material. (redorbit.com)
  • Although this information traditionally has been obtained by in vitro assay of biopsy material, recent studies have highlighted the complementary value of tumor receptor imaging for measuring regional tumor receptor expression, which can be quite heterogeneous. (redorbit.com)
  • A very practical consideration is that imaging can assess receptor expression at sites that are challenging to sample and assay, such as bone metastases. (redorbit.com)
  • Development of an assay for modulating antiacetylcholine receptor autoantibodies using human rhabdomyosarcoma cell line. (labcorp.com)
  • Tumor receptor imaging offers complementary information that includes evaluation of the entire tumor burden and characterization of the heterogeneity of tumor receptor expression. (redorbit.com)
  • More specifically, their attention is directed at a special class of this receptor super-family, known as adhesion GPCRs. (innovations-report.com)
  • And, the scientists have now been able to present an initial, surprising result to the public: "We were able to demonstrate that a special receptor from the group of adhesion GPCRs is involved in the perception of mechanosensory stimuli," says Robert Kittel. (innovations-report.com)
  • Receptors play key roles in many cellular processes. (britannica.com)
  • Receptors mediating antiviral responses of the innate and adaptive immune systems act together in an autophagosome-like cellular compartment. (sciencemag.org)
  • These findings provide new insight into the activities of chemokine receptors on both hematopoietic and non-hematopoietic cells and indicate that these molecules have both a more widespread cellular expression pattern and a wider biological role than first envisaged. (nih.gov)
  • Each receptor is linked to a specific cellular biochemical pathway. (wikipedia.org)
  • The present invention relates generally to compounds and methods for identifying polymorphism in a cellular receptor, and more particularly, to compounds and methods for identifying and typing single nucleotide polymorphisms that code for a complement receptor and applying these polymorphisms to delineation of disease susceptibility and severity. (google.com)
  • Posttranslational proteolysis clips the TSH receptor (TSHR) into two subunits (referred to as α, or A, and β, or B) ( 15 , 16 ), linked to each other by disulfide bonds. (jci.org)
  • Each olfactory receptor neuron has 8-20 cilia that are whip-like extensions (they mark the beginning of sensory transduction). (smartdraw.com)
  • Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
  • Compromised intestinal lipid absorption in mice with a liver-specific deficiency of the liver receptor homolog 1. (nature.com)
  • With this in mind, Li et al generated several strains of mutant mice lacking the BDNF receptor TrkB. (scienceblogs.com)
  • The mutants lacking the TrkB receptor in the NPCs were then treated with fluoxetine (Prozac), imipramine (a tricyclic antidepressant) or saline (salt water) for 3 weeks and the amount of time they took to begin feeding was recorded and compared to healthy control mice. (scienceblogs.com)
  • We have developed a simple and sensitive method for conditional cell ablation in transgenic mice, called 'toxin receptor-mediated cell knockout. (mendeley.com)
  • We expressed the diphtheria toxin (DT) receptor in transgenic mice using a hepatocyte-specific promoter and found that injection of DT caused fulminant hepatitis. (mendeley.com)
  • For example, H1-type histamine receptors in the airways contribute to allergy symptoms, whereas H2-type receptors in the stomach promote the secretion of acid. (britannica.com)
  • The histamine then binds to histamine receptors in other cells of the body, which initiate the response known as inflammation as well as other responses. (dictionary.com)
  • Antihistamine drugs work by preventing the binding of histamine to histamine receptors. (dictionary.com)
  • The cytosolic C-terminal domain contains ~50 amino acids, including a signal sequence important for localizing the receptors to clathrin-coated pits and for triggering receptor-mediated endocytosis after binding. (wikipedia.org)
  • It is currently unknown which if any polymorphisms in this receptor are of significance to cancer. (wikipedia.org)
  • A method and a package for identifying single nucleotide polymorphisms in complement receptor is useful in identifying individual susceptibility to a disease. (google.com)