Receive study of epirubicin. Medical search. Frequent questions

Almost all patients who had stable disease or a minimal clinical response, or those who had postoperative involvement of the axillary lymph nodes (38/60), received adjuvant chemotherapy. (medscape.com)
A randomized multicenter phase III study was conducted to compare the sequential docetaxel followed by epirubicin/cyclophosphamide combination with that of FEC regimen as adjuvant chemotherapy in women with axillary node-positive early breast cancer. (bioncology.gr)
The sequential docetaxel followed by epirubicin/cyclophosphamide adjuvant chemotherapy regimen resulted in improved five-year DFS in women with axillary node-positive early breast cancer at the expense of increased but manageable myelotoxicity. (bioncology.gr)
Epirubicin-cyclophosphamide adjuvant chemotherapy plus tamoxifen administered concurrently versus sequentially: randomized phase III trial in postmenopausal node-positive breast cancer patients. (ox.ac.uk)
Six cycles of postoperative adjuvant chemotherapy with cyclophosphamide 500 mg/m 2 , epirubicin 75 mg/m 2 and fluorouracil 500 mg/m 2 (CEF regimen) were administered, following which an increase in the size of the ipsilateral sternal lymph nodes was observed. (spandidos-publications.com)
13. Intravesical adjuvant chemotherapy for superficial transitional cell bladder carcinoma: results of a randomized trial with epirubicin comparing short-term versus long-term maintenance treatment. (nih.gov)
METHODS: In the randomized, controlled Mammary.5 trial, we studied 639 formalin-fixed paraffin-embedded specimens obtained from 710 premenopausal women with node-positive breast cancer who had received either cyclophosphamide, epirubicin, and fluorouracil (CEF) or cyclophosphamide, methotrexate, and fluorouracil (CMF) as adjuvant chemotherapy. (mcmaster.ca)
Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC). (cdc.gov)
assess the feasibility of QOL evaluation in a The QLQ-C30 was assessed by the same cohort of Tunisian women with early breast physician (A.M.) at 2 points of time: just cancer receiving adjuvant chemotherapy. (who.int)

This is a post hoc subanalysis of a prospective non-interventional study in 1,197 patients with breast cancer receiving up to 3 cycles of doxorubicin or epirubicin plus cyclophosphamide and NEPA. (karger.com)
17. [Intravesical instillation of doxorubicin or epirubicin for chemoprophylaxis of superficial bladder cancer--the fifth study of the Japanese Urological Cancer Research Group for Adriamycin/Farumorubicin]. (nih.gov)
In total, 1174 adult patients with previously untreated, non-metastatic, centrally confirmed TNBC (stage T1c N1-2 or T2-4 N0-2 per AJCC) were randomised 2:1 to neoadjuvant pembrolizumab 200 mg Q3W or placebo, both given with 4 cycles of paclitaxel plus carboplatin, followed by 4 cycles of doxorubicin or epirubicin plus cyclophosphamide. (congressupdateoncology.be)
Patients who had not previously received adjuvant (postoperative) therapy with an anthracycline were treated with doxorubicin (or epirubicin in the case of 36 women) and cyclophosphamide alone (138 women) or with trastuzumab (143 women). (qxmd.com)

In comparison to this the Epirubicin therapy contains fluorouracil/epirubicin/cyclophosphamide (FEC). (wikipedia.org)
Three large randomized studies have directly compared the epirubicin-containing regimen fluorouracil/epirubicin/cyclophosphamide (FEC) with CMF in the adjuvant setting. (wikipedia.org)
Herceptin in combination with capecitabine or 5-fluorouracil and cisplatin is indicated for the treatment of adult patients with HER2 positive metastatic adenocarcinoma of the stomach or gastro-esophageal junction who have not received prior anti-cancer treatment for their metastatic disease. (medicines.org.uk)
Adjuvant cyclophosphamide-epirubicin-fluorouracil (CEF) postoperative chemotherapy was administered, and lymphadenectomy of right-sided parasternal lymphatic metastases with pleural drainage was subsequently performed. (spandidos-publications.com)
Patients received every 2 weeks irinotecan 180 mg/m 2 as 1 h infusion on day 1, folinic acid 100 mg/m 2 intravenously days 1-2, and fluorouracil as a 400 mg/m 2 bolus and then 600 mg/m 2 continuous infusion over 22 hours days 1-2. (biomedcentral.com)
Relative dose intensity of epirubicin was 0.98, of paclitaxel 0.97, of cyclophosphamide 0.99, of methotrexate 0.98 and of fluorouracil 0.99. (ucy.ac.cy)
In one study, an intensive cyclophosphamide/epirubicin/fluorouracil (CEF-120) regimen (epirubicin given in a dose of 60 mg/m 2 on days 1 and 8) was compared with a conventional cyclophosphamide/methotrexate/fluorouracil (CMF) regimen. (azurewebsites.net)
In Study 1, an intensified cyclophosphamide/epirubicin/fluorouracil (CEF-100) regimen (epirubicin given in a dose of 50 mg/m 2 on days 1 and 8) was compared with a conventional CMF regimen (n=461). (azurewebsites.net)
Studies 2 and 3 compared cyclophosphamide/epirubicin/fluorouracil regimens where only the dose of epirubicin varied. (azurewebsites.net)
A prospective validation pharmacogenomic study in the adjuvant setting of colorectal cancer patients treated with the 5-fluorouracil/leucovorin/oxaliplatin (FOLFOX4) regimen. (cdc.gov)
Compare overall survival in patients with resected gastric adenocarcinoma treated with epirubicin, cisplatin, and infusional fluorouracil (5-FU) vs 5-FU bolus and leucovorin calcium before and after 5-FU plus radiotherapy. (nih.gov)

The combination of Epirubicin and tamoxifen lead to an increase survival in node-positive postmenopausal women with hormone receptor-positive breast tumours. (wikipedia.org)
PATIENTS AND METHODS:Four-hundred and eighty-five patients with node-positive operable disease were randomized to receive tamoxifen (20 mg/day) concomitantly (CON) or sequentially (SEQ) to EC chemotherapy (epirubicin 75 mg/m(2) + cyclophosphamide 600 mg/m(2) on day 1, every 21 days for four cycles). (ox.ac.uk)
CONCLUSION:This study fails to show an advantage of one treatment arm over the other, but a trend, albeit non-significant, appears to favor the sequential addition of tamoxifen to epirubicin + cyclophosphamide and, as such, warrants further investigation. (ox.ac.uk)
In the second study, 301 patients were randomised to receive tamoxifen 20 mg/day alone for 4 years and 303 patients were randomised to receive tamoxifen for 4 years in combination with epirubicin 50 mg/m 2 on days 1 and 8 every 4 weeks for 6 cycles. (azurewebsites.net)
Although there was no significant difference between the two arms with regard to disease free survival and overall survival, there was a trend in favour of the combined use of epirubicin and tamoxifen. (azurewebsites.net)

However, only few studies have examined the correlation between bladder cancer and instillation agent sensitivity. (nih.gov)
instillations of mitomycin C have a prolonged effect on bladder function that is not seen after saline solution or epirubicin instillation. (uantwerpen.be)
Rapidly growing bladder tumors were treated by intravesical instillation of alpha1-oleate, Epirubicin or Mitomycin C alone or in combination. (port.ac.uk)
2. [Intravesical instillation of epirubicin in the prophylactic treatment of recurrent superficial bladder cancer]. (nih.gov)
5. [Intravesical instillation with epirubicin as a prophylactic treatment for superficial bladder cancer--using two different schedules]. (nih.gov)
6. Early and large-dose intravesical instillation of epirubicin to prevent superficial bladder carcinoma recurrence after transurethral resection. (nih.gov)
9. [Continuous intravesical instillation of epirubicin immediately after transurethral resection of superficial bladder cancer: a prospective controlled study]. (nih.gov)
11. Randomized study of single instillation of epirubicin for superficial bladder carcinoma: long-term clinical outcomes. (nih.gov)
14. A single instillation of epirubicin after transurethral resection of bladder tumors prevents only small recurrences. (nih.gov)

Epirubicin (75 mg/m 2 by intravenous bolus) followed by paclitaxel (175 or 200 mg/m 2 by 3-hour intravenous infusion) was administered on day 1 of each cycle of 21 days. (medscape.com)
We modified the dosage of paclitaxel from 200mg/m 2 to 175mg/m 2 during the study, based on evidence of the same efficacy with the lower dose. (medscape.com)
in combination with paclitaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease and for whom an anthracycline is not suitable. (medicines.org.uk)
Patients who had previously received adjuvant anthracycline were treated with paclitaxel alone (96 women) or paclitaxel with trastuzumab (92 women). (qxmd.com)

Epirubicin is favoured over doxorubicin, the most popular anthracycline, in some chemotherapy regimens as it appears to cause fewer side-effects. (wikipedia.org)
Additionally the administration of more dose intensive epirubicin-containing regimens to patients with metastatic breast cancer has been associated with improved response rates, but not increased overall survival. (wikipedia.org)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (medicines.org.uk)
The present study investigated the cost-effectiveness of Olara + Dox compared with Dox and five other standard-of-care regimens from the US payer perspective. (hindawi.com)
In studies 2, 3 and 4, the higher dose epirubicin-containing regimens produced a significantly greater RR than the lower dose epirubicin-containing regimens. (azurewebsites.net)
DR and TTF were also significantly longer in Study 3 and TTP was significantly longer in Study 4 for the higher dose epirubicin regimens. (azurewebsites.net)

Our study investigated if long-term therapeutic efficacy is improved by repeated treatment cycles and by combining alpha1-oleate with low-dose chemotherapy. (port.ac.uk)
One treatment cycle arrested tumor growth, with a protective effect lasting at least 4 weeks in mice receiving 8.5 mM of alpha1-oleate alone or 1.7 mM of alpha-oleate combined with Epirubicin or Mitomycin C. Repeated treatment cycles extended protection, defined by a lack of bladder pathology and a virtual absence of bladder cancer-specific gene expression. (port.ac.uk)
He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, and capecitabine. (biomedcentral.com)
He received 3 more cycles of trastuzumab containing regimen postoperatively. (biomedcentral.com)
Forty-seven (96%) patients received all 9 cycles of chemotherapy. (ucy.ac.cy)
After definitive surgery, patients received adjuvant pembrolizumab or placebo for nine cycles or until recurrence or unacceptable toxicity. (congressupdateoncology.be)
group, n=753), or to three cycles of docetaxel followed by three cycles of cyclophosphamide, epirubicin, and ﬂ uorouracil Department of Oncology, (control group, n=747). (onlinepdfcatalog.com)

Epirubicin monotherapy was shown to be therapeutically equivalent to doxorubicin monotherapy in patients who had to receive previous chemotherapy for advanced breast cancer. (wikipedia.org)

This phase I study evaluated the addition of capecitabine to epirubicin/docetaxel combination therapy as first-line treatment for advanced breast cancer. (nih.gov)
Twenty-three female patients with advanced breast cancer received capecitabine (765-1060 mg/m2 twice daily on days 1-14 of a 3-week treatment cycle) in combination with epirubicin and docetaxel (75 mg/m2 i.v. on day 1). (nih.gov)
The addition of capecitabine to docetaxel/epirubicin combination therapy provides a well-tolerated and active first-line chemotherapy regimen in patients with advanced breast cancer, and merits phase II/III evaluation. (nih.gov)
All patients in the study will get capecitabine and trastuzumab, two drugs that are often used to treat this cancer. (mycancergenome.org)

The mechanism of action of epirubicin is similar to that of doxorubicin and other anthracycline drugs. (wikipedia.org)

Purpose: We studied functional damage in the bladder after intravesical. (uantwerpen.be)
Rats in 3 groups received intravesical instillations of mitomycin C, epirubicin or saline. (uantwerpen.be)
Rats in group 4 received no intravesical instillations and served as normal controls. (uantwerpen.be)
3. The effect of repeat transurethral resection on recurrence and progression rates in patients with T1 tumors of the bladder who received intravesical mitomycin: a prospective, randomized clinical trial. (nih.gov)
4. Intravesical epirubicin versus doxorubicin for superficial bladder tumors (stages pTa and pT1): a randomized prospective study. (nih.gov)
7. Effect of prophylactic treatment with intravesical epirubicin on recurrence of superficial bladder cancer--The 6th Trial of the Japanese Urological Cancer Research Group (JUCRG): a randomized trial of intravesical epirubicin at dose of 20mg/40ml, 30mg/40ml, 40mg/40ml. (nih.gov)
8. Comparison of three schedules of intravesical epirubicin in patients with non-muscle-invasive bladder cancer. (nih.gov)
12. Should all patients with non-muscle-invasive bladder cancer receive early intravesical chemotherapy after transurethral resection? (nih.gov)

Seventy patients treated at three Italian cancer centers between 2005 and 2012 entered the study. (biomedcentral.com)
Patients treated with TACE ( n = 367) and patients allocated to SBRT ( n = 35) were enrolled in this study. (biomedcentral.com)
Patients treated with SBRT have received more prior HCC treatments compared to TACE patients. (biomedcentral.com)
Patients treated with SBRT who received prior TACE were not included in the TACE group. (biomedcentral.com)

Apart from MG, one study reported that approximately 15% of thymomas are associated with other paraneoplastic diseases, and the onset of these diseases can herald the presence of a treatable tumor. (medscape.com)
The aim of this study was to evaluate the conservative management and prognosis of primary vaginal endodermal sinus tumor and rhabdomyosarcoma in children. (oncotarget.com)
range, 7-44 months) were included in this study, comprising 17 patients with endodermal sinus tumor and 7 patients with rhabdomyosarcoma. (oncotarget.com)
Patients in the trial will receive porfimer sodium, an anti-cancer drug, on day 1 of the trial and undergo surgery to remove the tumor along with photodynamic therapy on day 3. (mesotheliomalaw.net)
This is a Phase II study for people age 18 and older who have been diagnosed with malignant mesothelioma, have a measurable tumor, have no brain metastases, and haven't had radiation therapy in 4 weeks or surgery in 6 weeks. (mesotheliomalaw.net)
This is a Phase II study for people age 18 and older who have been diagnosed with unresectable malignant mesothelioma, have a measurable tumor with no brain metastases, have not had any chemotherapy for this cancer, have not had radiation therapy within the last 4 weeks or surgery in the last 2 weeks, and have had no previous PTK787/ZK 222584. (mesotheliomalaw.net)
The study will examine the effectiveness of PTK787/ZK 222584, which may stop the growth of tumor cells by blocking the enzymes necessary for tumor cell growth, in the treatment of patients with unresectable malignant mesothelioma. (mesotheliomalaw.net)
This is a Phase II study for people age 18 and older who have been diagnosed with malignant mesothelioma, have a measurable tumor, have gone through no more than one previous chemotherapy regimen for the treatment of malignant mesothelioma, and who have not received gemcitabine and epirubicin before. (mesotheliomalaw.net)
Synergy with Epirubicin was detected at the lower alpha1-oleate concentration and in vitro, alpha1-oleate was shown to enhance the uptake and nuclear translocation of Epirubicin, by tumor cells. (port.ac.uk)
The experimental treatment was the H. leucospilota body wall protein extract, while the control treatment was epirubicin hydrochloride (EPI), an established anti-tumor drug. (envirobites.org)
Trastuzumab is recommended in patients diagnosed with metastatic cancer of the stomach and of gastro-esophageal junction who did not earlier receive anti-cancer therapy due to disseminated disease and whose tumor cells show HER2 overexpression. (czytelniamedyczna.pl)
In this exploratory study, pCR with preoperative anti-HER2 therapy and chemotherapy correlated with the levels and phosphorylation status of specific baseline signal pathway proteins in tumor cells. (biomedcentral.com)

We recruited 244 patients (130 treated with epirubicin and 114 treated with mitomycin C). Genomic DNA was used to examine the XRCC1 rs2854509 and rs3213255 genotypes by Taqman PCR analysis. (nih.gov)
administration of mitomycin C or epirubicin in rats. (uantwerpen.be)

Here we evaluated the efficacy and toxicity of a combination of aprepitant, palonosetron, and dexamethasone as antiemetic prophylaxis in sarcoma patients receiving ifosfamide and doxorubicin chemotherapy, and examined the potential of aprepitant to affect the pharmacokinetics of ifosfamide, which is primarily metabolized by CYP3A4. (springer.com)

Previous studies had suggested a synergism between cisplatin and etoposide, and some authors had reported interesting response rates with either of the two combinations: etoposide/cisplatin (EP)[4] or etoposide/doxorubicin (Adriamycin)/cisplatin (EAP). (cancernetwork.com)

Equimolar doses of epirubicin and doxorubicin have been shown to be therapeutically equivalent in patients with metastatic breast cancer. (wikipedia.org)
Advanced Breast Cancer: Data from 4 open-label, multicentre, phase 3 studies support the use of Pharmorubicin for the treatment of patients with locally advanced or metastatic breast cancer. (azurewebsites.net)

The impact of breast cancer therapy on patients' QOL has been extensively studied in the literature [2,3]. (who.int)
This study is being done to see if tucatinib works better than placebo to help patients who have a specific type of breast cancer called HER2 positive breast carcinoma. (mycancergenome.org)
The breast cancer in this study is either metastatic (spread into other parts of the body) or cannot be removed completely with surgery. (mycancergenome.org)
The E-T-CMF regimen is well tolerated, as adjuvant treatment, in patients with operable breast cancer with promising activity and deserves further evaluation in phase III studies. (ucy.ac.cy)
Early Breast Cancer: Data from 2 multicentre, randomised phase 3 studies support the use of Pharmorubicin 100 to 120 mg/m 2 for the adjuvant treatment of patients with axillary-node-positive breast cancer and no evidence of distant metastatic disease (Stage II or III). (azurewebsites.net)
There is evidence for a dose-response and dose-toxicity relationship for epirubicin in breast cancer, and to a lesser extent for lymphoma. (azurewebsites.net)
TUESDAY, Sept. 19, 2023 (HealthDay News) - For female survivors of childhood cancer, the risk for subsequent breast cancer (SBC) is more than twofold higher for those who receive a cumulative dose of 200 mg/mÂ² or more of doxorubicin compared with those who never receive doxorubicin, according to a study published online Sept. 11 in Nature Medicine . (e-healthdomains.com)
Our findings support that it may be reasonable to initiate early breast cancer screening in female childhood cancer survivors who have received â ¥200 mg/mÂ² cumulative doxorubicin dose," the authors write. (e-healthdomains.com)
Clinical and genetic risk factors for epirubicin-induced cardiac toxicity in early breast cancer patients. (cdc.gov)
It is concluded that there were impairments in executive functions related to working memory, focused attention, inhibitory control and general impulsivity in the group of women with breast cancer who received chemotherapy. (bvsalud.org)

The association between DNA repair gene polymorphisms and bladder cancer risk has been widely studied. (nih.gov)
The aim of this study was to examine the association between polymorphisms of DNA repair genes, namely X-ray repair cross-complementing group I (XRCC1) rs2854509 and rs3213255, and bladder cancer recurrence risk. (nih.gov)
Epirubicin also induced changes in vesical volume and compliance but only that in bladder compliance achieved statistical significance. (uantwerpen.be)
Recently, clinical safety and efficacy of the alpha1-oleate complex was demonstrated in a placebo-controlled study of nonmuscle invasive bladder cancer. (port.ac.uk)
The results suggest that bladder cancer development may be prevented long-term in the murine model, by alpha1-oleate alone or in combination with low-dose Epirubicin. (port.ac.uk)

Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of diffuse large B cell lymphoma (DLBCL), but the overexpression of multidrug resistance (MDR) transporter proteins, especially P-glycoprotein (P-gp), renders epirubicin ineffective. (greenmedinfo.com)
Some studies reveal the potential role of melatonin in chemotherapeutic synergy and MDR. (greenmedinfo.com)

Forty-six patients with locally advanced or metastatic gastric cancer received a median of 3 courses each. (cancernetwork.com)

Dox or epirubicin with Ifo and/or dacarbazine) [ 7 ]. (hindawi.com)

Participants will receive five doses of the vaccine at study Weeks 0, 4, 8, 16 and 24. (nih.gov)
This relationship is steeper and therefore more evident for doses of epirubicin above 90 mg/m 2 . (azurewebsites.net)

Epirubicin has a different spatial orientation of the hydroxyl group at the 4' carbon of the sugar - it has the opposite chirality - which may account for its faster elimination and reduced toxicity. (wikipedia.org)
Toxicity studies in animals have indicated that on a weight (mg per mg) basis Pharmorubicin has a better therapeutic index and less systemic and cardiac toxicity than doxorubicin. (azurewebsites.net)

It is marketed by Pfizer under the trade name Ellence in the US and Pharmorubicin or Epirubicin Ebewe elsewhere. (wikipedia.org)

In addition, the combination of alpha1-oleate and Epirubicin reduced the size of established tumors. (port.ac.uk)
Studies have demonstrated that high-TMB gastric cancer tumors have a survival advantage over those with low TMB. (jhoponline.com)

In Study 1, the CEF-100 regimen produced a significantly higher RR, a significantly longer TTP and a significantly longer TTF than the CMF regimen. (azurewebsites.net)

All patients with hormone-responsive tumours received hormonal treatment after completion of all other treatment modalities. (medscape.com)

Epirubicin is primarily used against breast and ovarian cancer, gastric cancer, lung cancer and lymphomas. (wikipedia.org)
Patients with histologically confirmed metastatic gastric cancer who failed docetaxel-containing first-line therapy and who received FOLFIRI in second line were eligible for the study. (biomedcentral.com)
On this basis, we conducted a retrospective study in order to evaluate the activity and safety of FOLFIRI given as a second-line therapy in a cohort of docetaxel-pretreated metastatic gastric cancer patients. (biomedcentral.com)
At the 2021 European Society for Medical Oncology virtual meeting, researchers presented results from a study of 105 patients with advanced gastric cancer who were treated with nivolumab as a ≥3 line of therapy to analyze the clinical implications of TMB and insertion-deletion burden in this study group. (jhoponline.com)

The median survival rates markedly better than those achieved with epirubicin monotherapy. (wikipedia.org)

We report a phase I/II study of increasing dose of gemcitabine with raltitrexed in patients with advanced adenocarcinoma of the pancreas. (ispub.com)
The study was conducted at three different dose levels with raltitrexed at 3mg/m2 and increasing gemcitabine levels. (ispub.com)
We have performed a phase I/II study of increasing dose of gemcitabine with raltitrexed in patients with advanced adenocarcinoma of the pancreas in order to define maximal tolerated dose (MTD) and clinical benefit response (CBR) for the combination. (ispub.com)
The study will examine the effectiveness of combining pemetrexed disodium and gemcitabine in the treatment of malignant mesothelioma. (mesotheliomalaw.net)
Patients in the study will receive gemcitabine once a week for two weeks and pemetrexed disodium once in week two. (mesotheliomalaw.net)

Not studied for the treatment of established nausea and vomiting. (nih.gov)
Patients with FEC100 treatment of the study were relapse-free and an overall survival rate at 5 years higher as in FEC 50 treatment. (wikipedia.org)
In the later phase (phase 3), researchers study whether the treatment works better than the current standard therapy. (mayo.edu)
This phase I/II trial studies the side effects and best dose of liposomal cytarabine-daunorubicin CPX-351 (CPX-351) when given with fludarabine phosphate, cytarabine, and filgrastim and to see how well they work in treating younger patients with acute myeloid leukemia that has come back after treatment (relapsed) or is not responding to treatment (is refractory). (mayo.edu)
Importantly, patients randomized to treatment with primary G-CSF prophylaxis received significantly greater chemotherapy relative dose intensity (RDI) than control patients who did not receive prophylaxis. (jnccn.org)
Safety assessments will be performed at a minimum of once every three weeks throughout study treatment and 30 days after the last dose of study drugs. (mycancergenome.org)
This is a Phase III trial for people age 18 and over who have been diagnosed with malignant pleural mesothelioma within the last 3 months and have not yet received any chemotherapy treatment. (mesotheliomalaw.net)
One group will receive active symptom control treatment solely while the other two groups will receive active symptom control treatment along with a type of chemotherapy. (mesotheliomalaw.net)
Patients will receive treatment at specialist clinics and examined after 15, 18 and 21 weeks, and every 8 weeks thereafter. (mesotheliomalaw.net)
The study will examine whether photodynamic therapy, which uses light and drugs that make cancer cells more sensitive to light to kill cancer cells, combined with surgery is an effective treatment for mesothelioma. (mesotheliomalaw.net)
in combination with docetaxel for the treatment of those patients who have not received chemotherapy for their metastatic disease. (medicines.org.uk)
Regardless of the stage of the cancer, participation in a clinical trial of new treatments for IBC is also a good option because IBC is rare, has a poor prognosis (outcome), and these studies often allow access to drugs not available for standard treatment. (cancer.org)
in each one, cultures of the six individual cell lineages received the experimental treatment, and separate cultures of each cell lineage also received the control treatment for comparison. (envirobites.org)
We believe that the results of our study should be considered in updates of the SBC surveillance guidelines for survivors and can inform future treatment protocols for newly diagnosed childhood cancer patients. (e-healthdomains.com)
These data may provide candidate biomarkers to stratify initial treatment and potential combination therapies for future study. (biomedcentral.com)
A clinical trial is a research study that tests a new approach to treatment. (cancer.net)
of heart Failure Treatment study. (qxmd.com)
Background: The aim of this study was to investigate the long-term side effects of treatment for childhood Hodgkin's lymphoma with chemotherapy only on growth, bone mineral density (BMD), body composition, and thyroid function. (prinsesmaximacentrum.nl)
The objective of the present study was to and on-treatment questionnaire. (who.int)

After a mean follow up of 27 months elapse-free survival of patients who received EC 120 was significantly longer than that of patients who received EC 90. (wikipedia.org)
Melatonin significantly enhanced the epirubicin-induced cell proliferation suppression, epirubicin-induced apoptosis, and reduced the IC50 value of epirubicin. (greenmedinfo.com)

Epirubicin is an anthracycline drug used for chemotherapy. (wikipedia.org)
Yuehan Wang, from the Princess MÃ¡xima Center for Pediatric Oncology in Utrecht, Netherlands, and colleagues pooled individual patient data for 17,903 female childhood cancer survivors from six studies, of whom 4.4 percent developed an SBC, to assess associations with individual anthracycline agents and any interactions with chest radiotherapy. (e-healthdomains.com)

The aim of Epirubicin as adjuvanted therapy is to eradicate micro metastasis and prolong disease free survival. (wikipedia.org)
The aim of our study was to compare SOX2, NANOG and OCT4 mRNA expression levels in whole blood between advanced small-cell lung cancer (SCLC) patients and healthy controls, and to correlate mRNA expression with progression-free survival (PFS) after first-line chemotherapy and overall survival (OS) in advanced SCLC patients. (sagepub.com)
Randomized study in the Western world failed to show improvement in survival with extended lymph node dissection (D2 lymphadenectomy). (czytelniamedyczna.pl)
The mean 5-year survival in women and men estimated for patients diagnosed between 2000 and 2002 in Europe based on the EUROCARE-4 study is 23.4% (1). (czytelniamedyczna.pl)
In this study, we aimed to develop a gene signature to predict survival outcomes of DLBCL patients based on the autophagy-related genes (ARGs). (frontiersin.org)

The possible mechanisms of melatonin sensitize DLBCL cells to epirubicin were explored by western blotting, cytochrome C release, and pulldown assay. (greenmedinfo.com)
Further, melatonin synergized with epirubicin to promote the activation of the mitochondria-mediated apoptosis pathway and increased the accumulation of epirubicin in DLBCL cells by inhibiting the expression and function of P-gp. (greenmedinfo.com)
Epirubicin was subsequently discovered to upregulate the expression of P-gp by activating the NF-κB pathway in the DLBCL cells. (greenmedinfo.com)
Our results demonstrated that melatonin inactivates the NF-κB pathway and downregulates the expression of P-gp, ultimately sensitizing DLBCL cells to the epirubicin that suppresses their growth. (greenmedinfo.com)

In a prospective non-interventional study involving 2,173 patients, we showed that use of the oral fixed combination of netupitant 300 mg and palonosetron 0.5 mg (NEPA) for prevention of chemotherapy (Ctx)-induced nausea and vomiting has beneficial effects on the quality of life (QoL) of patients with various types of cancers receiving highly or moderately emetogenic Ctx. (karger.com)

Forty-six patients received a median of five courses. (cancernetwork.com)

The study is to examine the effectiveness of combination chemotherapy with or without Bevacizumab, a monoclonal antibody, in patients with malignant mesothelioma. (mesotheliomalaw.net)
There will be two groups of people in the study, one will receive combination chemotherapy with Bevacizumab and one without it. (mesotheliomalaw.net)

However, the enhanced delivery of chemotherapy dose intensity enabled by the use of G-CSF in these studies was associated with a significant reduction in all-cause mortality. (jnccn.org)

In vitro liver microsomal studies show that granisetron's major route of metabolism is inhibited by ketoconazole, suggestive of metabolism mediated by the cytochrome P-450 3A subfamily. (nih.gov)

Arm II: (Experimental): Patients receive epirubicin IV over 3-15 minutes and cisplatin IV over 1 hour on day 1 and 5-FU IV continuously on days 1-21 during course 1. (nih.gov)

In the present study, we investigated the activity and safety of FOLFIRI given as a second-line therapy in metastatic gastric or gastro-esophageal junction cancer patients who experienced disease progression on or after first-line docetaxel-containing chemotherapy. (biomedcentral.com)
health doctor phentermine posts PATIENTS WITH BRONCHOSPASTIC DISEASE SHOULD, IN GENERAL, NOT RECEIVE BETA BLOCKERS. (msmvps.com)

Patients will get trastuzumab injections from the study site staff on the first day of every cycle. (mycancergenome.org)
We randomly assigned 234 patients to receive standard chemotherapy alone and 235 patients to receive standard chemotherapy plus trastuzumab. (qxmd.com)

Although new technology and clinical studies have contributed to a more comprehensive understanding of when and how to apply this widely-adopted therapeutic modality, some of these new findings and techniques have yet to be incorporated into a guideline appropriate for Taiwan. (bvsalud.org)

OUTLINE: This is a randomized, multicenter study. (nih.gov)

Measuring the maintenance of daily life activities using the functional living index-emesis (FLIE) in patients receiving moderately emetogenic chemotherapy. (jamanetwork.com)

Most patients who underwent modified radical mastectomy received radiation therapy to the chest wall and regional lymph node areas. (medscape.com)
Therefore, these patients have mainly received prior HCC therapy. (biomedcentral.com)

Further improvement of cancer care infrastructure and public education is still needed before reliable QOL studies can be performed. (who.int)
Afin d'estimer la faisabilité d'une évaluation de la qualité de vie dans une cohorte de patients cancéreux tunisiens, nous avons présenté le questionnaire QLQ-C30 de l'EORTC à 23 femmes traitées par chimiothérapie adjuvante en ambulatoire pour un cancer du sein à un stade précoce, au début du traitement et pendant le troisième cycle de chimiothérapie. (who.int)
Il est nécessaire d'améliorer encore l'infrastructure de soins et la sensibilisation du public en matière de cancer si l'on veut réaliser des études fiables sur la qualité de vie des cancéreux. (who.int)
Although cancer incidence is increasing in the developing world [1], few studies have examined QOL issues for cancer patients in these areas. (who.int)
Raltitrexed, as a single agent in pancreatic cancer has been evaluated in only one study, published in 1996 [ 3 ]. (ispub.com)
There will be 20 patients participating in this study, which the Roswell Park Cancer Institute sponsors. (mesotheliomalaw.net)
Both drugs work to stop cancer and the study will consider if the combination of the two together is a more effective way to treat cancer patients. (mesotheliomalaw.net)
Studies on the anti-cancer effects of H. leucospilota's bioactive peptides are lacking, so the scientists set out to determine if these combined proteins possessed any benefits. (envirobites.org)
To study anti-cancer properties, they then selected three cancer human cell lines (referred to here as HepG2, A549, and Panc02) and three "normal" human cell lines (referred to here as NIH-3T3, HaCaT, and 16HBE). (envirobites.org)
Respondent stated in grant application 1 R01 CA136530-01A1 that 6 out of 33 patients responded positively to dasatinib when only 4 patients were enrolled and none responded and that the 4 CT scans presented in Figure 14 were from the lung cancer study when they were not. (nih.gov)

Diseases8

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Phenomena and Processes1

Information Science1

Health Care4

Adjuvant chemotherapy9

Doxorubicin or epirubicin4

Fluorouracil11

Tamoxifen5

Instillation9

Paclitaxel4

Regimens6

Cycles7

Chemotherapy for advanced breast cancer1

Capecitabine4

Mechanism of act1

Intravesical8

Patients treated4

Tumor12

Mitomycin2

Pharmacokinetics1

Adriamycin1

Metastatic breast cancer2

Breast cancer10

Bladder5

Chemotherapeutic2

Locally advanced or metastatic1

Dacarbazine1

Doses2

Toxicity2

Ellence1

Tumors2

Regimen1

Tumours1

Gastric cancer4

Monotherapy1

Gemcitabine5

Treatment19

Significantly2

Anthracycline2

Survival5

DLBCL4

NEPA1

Median1

Combination chemotherapy2

Dose intensity1

Metabolism1

Experimental1

Disease2

Trastuzumab2

CLINICAL STUDIES1

Multicenter study1

Moderately emetogenic1

Therapy2

Cancer10