• The injectable CRAB drugs (Copaxone, Rebif, Avonex, and Betaseron) have been demonstrated in clinical trials to significantly reduce relapse rates in about one third of patients taking them. (wheelchairkamikaze.com)
  • In subjects presenting with a first clinical demyelinating event that is suggestive of MS, treatment with interferon beta can delay the occurrence of further attacks and the onset of MS. This study investigated the effects of two dosing frequencies of subcutaneous interferon beta-1a (Rebif) in subjects with a first clinical demyelinating event. (ms-selfie.blog)
  • Approval was based on two randomized Phase III open-label rater-blinded studies comparing treatment with alemtuzumab to high-dose subcutaneous interferon beta-1a (Rebif) in patients with relapsing remitting MS who were either new to treatment (CARE-MS I) or who had relapsed while on prior therapy (CARE-MS II). (medscape.com)
  • I tried Avonex, beta-feron and Rebif. (shift.ms)
  • GENEVA, Switzerland, December 12 (HSMN NewsFeed) -- Serono (virt-x: SEO and NYSE: SRA) announced today the initiation of a Phase III clinical trial to evaluate the effect of two dosage regimens of the new formulation of Rebif (interferon beta-1a 44 mcg, three times a week or once a week) on the time to conversion to multiple sclerosis (MS) in people with first clinical symptoms suggestive of the disease. (salesandmarketingnetwork.com)
  • Rebif (interferon beta-1a) is a disease-modifying drug used to treat relapsing forms of multiple sclerosis (MS) and is similar to the interferon beta protein produced by the human body. (salesandmarketingnetwork.com)
  • Bayer Schering Pharma AG, Germany, announced that top-line, three-year data from the CAMMS223 Phase II clinical trial comparing alemtuzumab with Rebif® (interferon beta-1a) for the treatment of multiple sclerosis were presented this weekend at the 23rd Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) in Prague. (worldpharmanews.com)
  • Merck makes the most of its portfolio of mature drugs, and top-seller Rebif (interferon beta-1a) for relapsing-remitting multiple sclerosis held up fairly well despite fierce competition from newer, oral therapies such as Biogen Idec's Tecfidera (dimethyl glutamate) and Novartis' Gilenya (fingolimod). (pmlive.com)
  • Interferon Beta formulations presented with different prescription patterns, persistence, adherence, healthcare resource utilisation and costs, with Rebif® being used in younger patients and with less MS-related hospital admissions. (biomedcentral.com)
  • However, the drug's efficacy was seen to be excellent, cutting the relapse rate in patients by 75% compared to the comparator drug, Serono's blockbuster Rebif (interferon beta-1a). (pharmatimes.com)
  • In the United States, Rebif is co-marketed by Serono, Inc. and Pfizer Inc. Rebif has been proven to delay the progression of disability, reduce the frequency of relapses and reduce MRI lesion activity and area[2]. (salesandmarketingnetwork.com)
  • I also had the Rebif injections with it's own auto- inject function but 'needle night' would often cause me distress and quite often cause rather large bruises. (shift.ms)
  • Rebif , which was approved in Europe in 1998 and in the US in 2002, is registered in more than 80 countries worldwide. (salesandmarketingnetwork.com)
  • Raptiva is expected to reduce Serono's dependence on multiple sclerosis drug Rebif, which currently accounts for around 45 per cent of sales but is coming under increased pressure from competitors. (swissinfo.ch)
  • The move should reduce Serono's dependence on one product, multiple sclerosis drug Rebif, which accounts for 45% of sales. (swissinfo.ch)
  • Drug: Rebif (IFNß-1-a, Merck Europe B.V. (who.int)
  • Rebif is not approved for treatment of chronic progressive MS. Rebif is available in a 22 mcg and 44 mcg ready-to-use pre-filled syringe and a titration pack, and can be stored at room temperature for up to 30 days if a refrigerator is not available. (salesandmarketingnetwork.com)
  • Patients, especially those with depression, seizure disorders, or liver problems, should discuss treatment with Rebif with their doctors. (salesandmarketingnetwork.com)
  • This means that from a clinical perspective once weekly Rebif is as good as 3x per week Rebif. (ms-selfie.blog)
  • The trial, called the REFLEX study ( Rebif FLEXible dosing in early MS), will involve 480 patients considered at risk of developing MS because of a recently experienced isolated demyelinating event and of typical magnetic resonance imaging (MRI) brain scans. (salesandmarketingnetwork.com)
  • Furthermore, Campath is given just once a year, while Rebif is administered three times a week, providing another significant treatment advantage. (pharmatimes.com)
  • The REFLEX study will also evaluate the effect of the new formulation of Rebif on cognitive function as measured by the Paced Auditory Serial Addition Test (PASAT)[1]. (salesandmarketingnetwork.com)
  • A Titration Pack containing 6 doses of 8.8 mcg (0.2 mL) and 6 doses of 22 mcg (0.5 mL) is available for use during the titration period in both REBIF prefilled syringes and REBIF Rebidose autoinjectors. (nih.gov)
  • In two identical RMS Phase III studies (OPERA I and OPERA II), OCREVUS demonstrated superior efficacy on the three major markers of disease activity by reducing relapses per year by nearly half, slowing the worsening of disability and significantly reducing MRI lesions compared with Rebif (high-dose interferon beta-1a) over the two-year controlled treatment period. (salesandmarketingnetwork.com)
  • The FDA approval of Lemtrada was based on two pivotal randomized phase III open-label rater-blinded studies comparing treatment with Lemtrada to Rebif (high-dose subcutaneous interferon beta-1a) in patients with relapsing remitting MS who were either new to treatment (CARE-MS I) or who had relapsed while on prior therapy (CARE-MS II). (centerwatch.com)
  • Genzyme Corporation (Nasdaq: GENZ) and Bayer HealthCare Pharmaceuticals Inc. today announced study results showing that patients with early relapsing-remitting multiple sclerosis (RRMS) taking once-yearly cycles of alemtuzumab reduced their risk of relapse by 74 percent and the risk of sustained accumulation of disability by 71 percent compared to patients treated with the active comparator Rebif® (high-dose interferon beta-1a). (sclerose.info)
  • During the clinical trials, Ocrevus appeared to reduce disability progression and significantly reduce the number of lesions seen on MRI scans compared to Rebif. (mstrust.org.uk)
  • Rebif is available in the form of injection with a strength of 22mcg/0.5mL or 44mcg/0.5mL and it is prescribed for the treatment of Multiple sclerosis. (pranonne.com)
  • Rebif is a pre-filled syringe medication and it should not be administered on your own. (pranonne.com)
  • Do not use such products with Rebif injection in order to avoid the occurrence of unfortunate events. (pranonne.com)
  • It is not known if Rebif injection is safe and effective for use in children. (pranonne.com)
  • As with clinically isolated syndrome and relapsing-remitting MS, treatment with Rebif is intended to slow the progression of the disease. (mytherapyapp.com)
  • in clinical trials people taking Ocrevus had about 50% fewer relapses than people taking Rebif . (mstrust.org.uk)
  • Discontinue REBIF if clinical symptoms and laboratory findings consistent with TMA occur ( 5.6 ). (nih.gov)
  • Common non-serious adverse events in the trial included infusion-associated reactions in the alemtuzumab patients and flu-like symptoms in patients using Rebif. (sclerose.info)
  • The recommended dose of REBIF is either 22 mcg or 44 mcg injected subcutaneously three times per week. (nih.gov)
  • beta interferon-1a (Rebif): injected under the skin three times a week. (msif.org)
  • Campath is given just once a year, while Rebif is given three times a week. (pharmatimes.com)
  • According to the MS Society, beta interferon therapies, including Rebif, are rated 'moderate' in terms of effectiveness. (mytherapyapp.com)
  • Subtipo de interferón beta-1 que posee una metionina en la posición 1, una cisteína en la posición 17 y es glucosilada en la posición 80. (bvsalud.org)
  • His Rebif shots seem to accumulate in acting as a toxin to his system as the week goes by. (becomingafamilycaregiver.com)
  • switched to Rebif in 1998, now flu there e tomes a week, and still had involuntary movements of my arms & legs. (drugs.com)
  • Brain volume loss was reduced and more people with no evidence of disease progression (NEDA) were seen in those taking Ocrevus compared to those taking Rebif. (mstrust.org.uk)
  • We cannot say for certain that Rebif is safe for breastfeeding, but limited evidence suggests that the risk is small. (infantrisk.com)
  • A few specific studies about the behavior of Rebif in human milk suggest that the amount that makes it to the baby is very small, and even less of that is actually absorbed by the baby's gut. (infantrisk.com)
  • Although all the effects of Rebif are not yet fully established, some effects on the immune system are known. (mytherapyapp.com)
  • Can you give me any information that I can share with my neurologist about Rebif? (infantrisk.com)