• Cancer genetics breast/ovarian cancer bowel cancer endocrine tumors Examples of genetic syndromes that are commonly seen in the genetics clinic include chromosomal rearrangements (e.g. (wikipedia.org)
  • These probes have been used in the analysis of various cases of constitutional chromosomal rearrangements in human pathology including complex intrachromosomal rearrangements. (nih.gov)
  • This comparative approach allows tracing of chromosomal rearrangements that occurred during bird evolution. (kent.ac.uk)
  • Thus, the aim of this study was to describe the karyotype structure of the Ringed Kingfisher ( Megaceryle torquata Linnaeus, 1766) and Green Kingfisher ( Chloroceryle americana Gmelin, 1788) and also compare them with related species in order to identify chromosomal rearrangements. (pensoft.net)
  • Chromosome painting is a useful technique for distinguishing specific chromosomes (fragments), elucidating the genetic relationships of different genomes or chromosomes, and identifying chromosomal rearrangements. (arborbiosci.com)
  • Also, the analyses indicate that chromosomal rearrangements occurred independently within the distinct lineages of S . marmoratus complex, which resulted in the appearance of distinct karyotypic variants in a non-linear fashion related to diploid numbers and in the appearance of similar non-homologous chromosomes. (scielo.br)
  • This study aimed to analyze the karyotypic differences between M. gouazoubira and M. nemorivaga species identifying the chromosomal rearrangements that distinguished them. (unesp.br)
  • F. Finally, the effects of chromosomal rearrangements on non-coding elements in the genome can best be studied by deleting an entire locus by. (schleiden-eifel.de)
  • This review emphasizes the potential of analysing chromosomal rearrangements as a means to rapidly define candidate disease loci for further investigation. (neurotransmitter.net)
  • Cytogenetics is the study of chromosomes and chromosome abnormalities. (wikipedia.org)
  • We have used comparative genomic hybridisation to analyse 19 constitutional chromosome abnormalities detected by G band analysis, including seven deletions, five supernumerary marker chromosomes, two interstitial duplications, and five chromosomes presenting with abnormal terminal banding patterns. (bmj.com)
  • Others have applied CGH to the study of constitutional chromosome abnormalities detected postnatally. (bmj.com)
  • Although the structural chromosome abnormalities in these cases were too small to identify the origin of the extra genomic material based on banding pattern, none of the abnormalities described by these authors can be considered to be subtle or cryptic. (bmj.com)
  • Few sex-autosome chromosome abnormalities have been documented in domestic animal species. (karger.com)
  • In humans, Y-autosome chromosome abnormalities may occur at a rate of 1/2,000 live births, whereas in the domestic pig only 2 Y-autosome reciprocal translocations have been previously described. (karger.com)
  • Changes in the structure or quantity of chromosomes , which are strands of condensed genetic material, are known as chromosomal aberrations or abnormalities. (schleiden-eifel.de)
  • However, within populations there can be found abnormalities involving the structure or number of chromosomes . (schleiden-eifel.de)
  • Compared to autosomes and the X chromosome, relatively few numerical or structural cytogenetic abnormalities have been reported for ECAY. (veteriankey.com)
  • Abnormalities that affect autosomes (the 22 paired chromosomes that are alike in males and females) are more common than those that affect sex chromosomes (X and Y). (msdmanuals.com)
  • Numerical abnormalities may involve a part of, or the entire, chromosome. (msdmanuals.com)
  • CGH has been widely applied to detect gains and losses of DNA sequences on specific chromosomes in the study of solid tumours, 1 but has not been extensively used to study unbalanced constitutional karyotypes. (bmj.com)
  • Finally, the integration of both molecular cytogenetic and phylogenetic approaches allowed the determination of specific chromosomes possibly involved in rearrangements and a better understanding about the evolutionary processes involved in the differentiation of Synbranchus genus. (scielo.br)
  • You can use random sequence oligonucleotides to identify single nucleotide polymorphisms (SNPs) as well as small scale chromosome events, primarily insertions or deletions [ 5,6 ]. (idtdna.com)
  • The only true Y chromosome structural rearrangements, reported so far, are large-scale ECAY deletions in 64,XY sex reversal mares (Raudsepp et al. (veteriankey.com)
  • Genetic polymorphisms range in size from single nucleotides (SNPs) to large scale insertions, deletions, or rearrangements that span several millions of base pairs [ 1 , 2 ]. (biomedcentral.com)
  • Chromosome 2 deletions or duplications that cause MAND lead to an abnormal amount of MBD5 protein. (medlineplus.gov)
  • It is also unknown whether the loss or gain of other genes in chromosome 2 deletions or duplications contribute to the features of MAND. (medlineplus.gov)
  • We used fluorescence in situ hybridization (FISH) with DNA probes derived from bivariate fluorescence activated flow sorting of primate chromosomes. (nih.gov)
  • In cases where human and primate karyotypes differ by chromosome rearrangements, reverse painting of primate probes resulted in a subregional delineation of the human homologous chromosomes. (nih.gov)
  • Hybridization of human chromosomes with painting probes derived from both gibbons showed that, with the exception of human chromosomes 15, 18, 21, 22 and the sex chromosomes, each chromosome was differentiated in at least two and up to six segments. (nih.gov)
  • Pinkel D., Detection of aneuploidy and aneuploidy-inducing agents in human lymphocytes using fluorescence in situ hybridization with chromosome specific DNA probes, Mutat. (gse-journal.org)
  • Eastmond D.A., Rupa D.S., Hasegawa L.S., Detection of hyperdiploidy and chromosome breakage in interphase human lymphocytes following exposure to the benzene metabolite hydroquinone using multicolor fluorescence in situ hybridization with DNA probes, Mutat. (gse-journal.org)
  • Hybridization of various chicken probes to two different chromosomes or to only the short or long chromosome arm of one chromosome pair in the species representing the orders Passeriformes, Strigiformes, and Columbiformes revealed translocations and chromosome fissions during species radiation. (kent.ac.uk)
  • Thus comparative analysis with chicken chromosome-specific painting probes proves to be a rapid and comprehensive approach to elucidate the chromosomal relationships of the extant birds. (kent.ac.uk)
  • Human chromosome-specific probes for the entire karyotype were hybridized to metaphase spreads of the Atlantic bottlenose dolphin, Tursiops truncatus, to directly compare the evolutionary conservation of chromosomal segments between these two distantly related species. (tamu.edu)
  • The development of chromosome- or genome-specific probes is fundamental for chromosome painting. (arborbiosci.com)
  • The possibility for developing such probes specifically painting homoeologous chromosomes in allopolyploid species has been questioned since that chromosomes belonging to the same homoeologous group share highly conserved sequences. (arborbiosci.com)
  • This indicated that the relationship among D/M/U was closer than that among D/A/B as well as D with genomes H/R/Ss/Sc/Y/P/N/J. Our successful development of 4D-specific oligo probe library may serve as a model for developing oligo probes specific for other homoeologous chromosomes. (arborbiosci.com)
  • The probes have been used for molecular hybridizations (fluorescence in situ hybridization, or FISH) in clinical cytogenetics, Y chromosome mapping, sequencing, gene discovery, and comparative Y chromosome studies between the horse and other equids/ Perssodactyls. (veteriankey.com)
  • Therefore, microdissected Y-chromosome probes are good for FISH but not suitable for cloning and sequencing of the male-specific or pseudoautosomal regions of the chromosome. (veteriankey.com)
  • Comparison of the human with the sheep genomes by use of human chromosome-specific painting probes. (cnr.it)
  • Striking homologies in the chromosomes of the different species were noted, indicating a high degree of evolutionary conservation in avian karyotypes. (kent.ac.uk)
  • In two species, the quail and the goose, all chicken paints specifically labeled their corresponding chromosomes. (kent.ac.uk)
  • In three pheasant species as well as in the American rhea and blackbird, GGA4 hybridized to chromosome 4 and additionally to a single pair of microchromosomes. (kent.ac.uk)
  • No painted chromosome was observed for the other alien species. (arborbiosci.com)
  • Phylogenomic studies using chromosome painting confirms the high conservation of DNA between even distantly related species [ 13 ]. (biomedcentral.com)
  • A total of 93 BAC clones were used to localize the chromosome complement of the species and 588 genes were annotated, thus almost reaching the 2.5% of the genome sequences. (metasystems-international.com)
  • In addition, chromosomes with a high number of linked genes that are conserved, even in distant species, were detected. (metasystems-international.com)
  • This kind of result widens the knowledge of this species' chromosome dynamics and evolution. (metasystems-international.com)
  • In both species the actives nucleolar organizer regions were observed in the terminal position of chromosome pairs 1 and 2. (unesp.br)
  • The telomeric sites were located at all the chromosomes ends and at the half of X-chromosome q arm in both species. (unesp.br)
  • The authors justifiably conclude that chromosome counts can be misleading when interpreting the evolutionary histories of polyploid species, especially when "diploidization" doesn't result in a diploid at all. (molecularecologist.com)
  • The highly skewed distribution of recombination events towards the chromosome ends in zebra finches and other estrildid species may function to minimize crossovers in the inverted regions. (biomedcentral.com)
  • These are some of the most common cytogenetically visible rearrangements in humans - for example , the pericentric inversion of chromosome 9 is found in over. (schleiden-eifel.de)
  • Humans normally have 46 chromosomes in each cell, divided into 23 pairs. (medlineplus.gov)
  • examples include aneuploidy (atypical chromosome number), deletion (loss of part of a chromosome), duplications (extra copies of a region of a chromosome), inversion (when part of a chromosome breaks off and reattaches in reverse. (schleiden-eifel.de)
  • In 1944 it was realized that genetic transformation in bacteria was due to DNA and not protein and that DNA was the molecule responsible for heredity in genes and chromosomes [ 8 ]. (biomedcentral.com)
  • A comparison of human and chimpanzee genes in the region of this inversion indicates that two genes-ROCK1 and USP14-that are adjacent on chimpanzee chromosome 17 (which corresponds to human chromosome 18) are more distantly positioned on human chromosome 18. (schleiden-eifel.de)
  • Because even small segments of chromosomes can span many genes, chromosomal disorders are characteristically dramatic and often fatal. (schleiden-eifel.de)
  • Such changes may result in quantitative alteration of genes or rearrangement of genes. (schleiden-eifel.de)
  • Identifying genes on each chromosome is an active area of genetic research. (medlineplus.gov)
  • Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. (medlineplus.gov)
  • Chromosome 2 likely contains 1,200 to 1,300 genes that provide instructions for making proteins. (medlineplus.gov)
  • Nesthor Perez 2.3 Mechanisms of Structural Variation Cytogenetic Techniques: Chromosome Painting: Nesthor Perez 2.3 Mechanisms of Structural Variation Cytogenetic Techniques: Nesthor Perez 2.3 Mechanisms of Structural Variation Cytogenetic Techniques: Fluorescent in Situ Hybridization (FISH): Nesthor Perez (FISH) Nesthor Perez Outline 1. (studylib.net)
  • Spectral karyotyping analysis (also called chromosome painting) uses chromosome-specific multicolor fluorescent in situ hybridization (FISH) techniques that improve the visibility of certain defects, including translocations and inversions. (msdmanuals.com)
  • The seven chromosome pairs of KJJ81 subgenomes exhibit highly conserved synteny, indicating a very recent hybridization event. (biomedcentral.com)
  • Constitutional chromosome studies involving conventional GTG band cytogenetic analysis, however, often show unbalanced karyotypes which cannot be fully defined because the extra material is too small to have a recognisable banding pattern. (bmj.com)
  • Thus, it is possible chromosomal fissions in macrochromosomes resulted in the increase of the diploid number, whereas chromosome fusions have originated the karyotypes with low diploid number. (pensoft.net)
  • Avian karyotypes are characterized by internal variation in the size of chromosomes, presenting two distinct groups, macrochromosomes and microchromosomes. (pensoft.net)
  • Among the analyzed specimens, a large degree of cytogenetic variation related to diploid numbers and karyotype structure was observed, with karyotypes showing 2n=42, 44 and 46 chromosomes. (scielo.br)
  • For example, diploidization appears to happen at different rates at different chromosomes/loci in fish and maize . (molecularecologist.com)
  • Whole chromosome painting by FISH analysis corroborated the reciprocal nature of the chromosomal exchanges between the Y chromosome and SSC13. (karger.com)
  • Comprehensive analysis of pan-cancer genomes revealed clusters of DNA copy-number-neutral rearrangements-termed balanced chromothripsis-across diverse tumour types resulting in the acquisition of known cancer driver events. (nature.com)
  • However, in most cases, these patterns of chromothripsis differed from those in cancer genomes as the rearrangements were largely restricted to a single daughter cell and lacked the canonical oscillations in DNA copy-number states 2 . (nature.com)
  • The distribution of conserved chromosomal segments and the specific rearrangement patterns found between the two genomes are presented and discussed. (tamu.edu)
  • The maintenance of a single centromere per chromosome is critical for establishing bipolar microtubule attachments to the mitotic spindle and achieving high-fidelity genome segregation 17 . (nature.com)
  • In the present study, we attempted to construct a wheat chromosome 4D-specific oligo probe library by selecting 4D-specific sequences in reference genome of common wheat cv. (arborbiosci.com)
  • As a result, important data about its genome organization and evolution were obtained, such as the lesser gene density of the large metacentric pair compared with the other metacentric chromosomes, which supports the theory of a sex proto-chromosome pair. (metasystems-international.com)
  • used chromosome painting to investigate the paradoxical genome number in C. cordifolia , and it turns out that the chromosome counts of C. cordifolia were not what they seemed. (molecularecologist.com)
  • The extant genome of C. cordifolia originated from its tetraploid progenitor through descending dysploidy, whereby the origin of four translocation ("fusion") chromosomes reduced the original number of linkage groups from 16 to 12. (molecularecologist.com)
  • Oligo painting was successfully used to define the 4D breakpoints in CS deletion lines involving 4D and two wheat-Haynaldia villosa 4D-4V translocation lines. (arborbiosci.com)
  • karyotype is actually our ancestors, with all the produced condition caused by a new combination fusion (DSP7 + DSP19) and the Y/autosome translocation giving increase on the multiple intercourse chromosome method. (torkinibinhibitor.com)
  • Pulsed-field gel electrophoresis and reverse chromosome painting showed that one case arose from an interstitial or terminal deletion and two from the de novo inheritance of derivative translocation chromosomes. (nih.gov)
  • This might be because rearrangements in the gene-poor Y chromosome have milder effect on the phenotype, as a result of which the affected individuals escape attention and are not subjected to cytogenetic analysis. (veteriankey.com)
  • The addition of colours not only simplifies chromosome identification compared to the analysis of classical banding based on grey values, but colour segmenting also provides simple coloured landmarks for further fine analysis by classical banding. (nih.gov)
  • The Precise Breakpoint Mapping in Paracentric Inversion 10q22.2q23.3 by Comprehensive Cytogenomic Analysis, Multicolor Banding, and Single-Copy Chromosome Sequencing. (metasystems-probes.com)
  • Multicolor banding, chromosomal microarray analysis, chromosome microdissection with reverse painting, and single-copy sequencing of the rearranged chromosome were performed to determine the length and position of the inverted region as well as to rule out a genetic imbalance at the breakpoints. (metasystems-probes.com)
  • In classical banding (eg, G [Giemsa]-banding, Q [fluorescent]-banding, and C-banding), a dye is used to stain bands on the chromosomes. (msdmanuals.com)
  • G- and R-banding comparison of sheep (Ovis aries L.) chromosomes. (cnr.it)
  • ZOO-FISH and R-banding reveal extensive conservation of human chromosome regions in euchromatic regions of river buffalo chromosomes. (cnr.it)
  • Here we tracked micronucleated chromosomes with live-cell imaging and show that acentric fragments cluster in close spatial proximity throughout mitosis for asymmetric inheritance by a single daughter cell. (nature.com)
  • The stochastic inheritance of chromosome fragments by both newly formed daughter cells could in part contribute to the alternating DNA copy-number states that are characteristic of chromothripsis 2 . (nature.com)
  • The review provides a brief account of the structure of somatic and meiotic chromosomes, stressing the high conservation of structure in plants and animals, with emphasis on aspects that require further research. (biomedcentral.com)
  • We measured the meiotic recombination rate in two regions of chromosome 5, containing or not an NLR gene cluster. (metasystems-international.com)
  • These studies implicate a potential mechanism suppressing the loss of genetic material after chromosome pulverization, although how distinct patterns of rearrangements arise in cancer and germline disorders remains unclear. (nature.com)
  • Here we report a case of donor cell-derived acute myeloid leukaemia with 3q26.2 involvement/MECOM rearrangement and chromosome 20q deletion. (lidsen.com)
  • 2q37 deletion syndrome is caused by a deletion of genetic material near the end of the long (q) arm of chromosome 2, at a location designated 2q37. (medlineplus.gov)
  • Loss (deletion) or gain (duplication) of a small piece of chromosome 2 at position q23.1 can cause MBD5 -associated neurodevelopmental disorder (MAND). (medlineplus.gov)
  • Sequencing of daughter cell pairs derived from micronucleated mother cells demonstrated that complex rearrangements are indeed a common outcome of micronucleus formation. (nature.com)
  • All the other chromosomes are still arranged in pairs of two, but. (schleiden-eifel.de)
  • Two copies of chromosome 2, one copy inherited from each parent, form one of the pairs. (medlineplus.gov)
  • Chromosome 2 is the second largest human chromosome, spanning about 243 million building blocks of DNA (base pairs) and representing almost 8 percent of the total DNA in cells. (medlineplus.gov)
  • 2009), chromosome flow sorting and microdissection technology, and various genomic DNA amplification systems (Telenius et al. (veteriankey.com)
  • Chromosome piece of art together with Akodon paranaensis chromosome 21 (a smaller metacentric akodont gun) fresh paint exposed full homology with all the tiniest acrocentric Deltamys sp. (torkinibinhibitor.com)
  • The males of M. nemorivaga showed one acrocentric chromosome without its corresponding pair, but it was homologous to distal half of q arm of X-chromosome. (unesp.br)
  • As each chromosome contains a single centromere, it remains unclear how acentric fragments derived from shattered chromosomes are inherited between daughter cells during mitosis 6 . (nature.com)
  • De Novo Centromere Formation in Pericentromeric Region of Rice Chromosome 8. (zhangtaolab.org)
  • In particular, a distinction between those inversions which cover both chromosome arms and thus include the centromere (pericentric inversions) and those which are restricted to a single chromosome arm (paracentric inversions) has often been made [ 9 ]. (biomedcentral.com)
  • Inversions are intrachromosomal structural mutations which result in the reversal of gene order (and no change in the genic content of a chromosome) [ 4 ]. (biomedcentral.com)
  • In addition, karyotype comparisons in Alcedinidae show a heterogeneity in the size and morphology of macrochromosomes, and chromosome numbers ranging from 2n = 76 to 132. (pensoft.net)
  • The standard karyotype constitution of M. gouazoubira (2n=70 and FN=70) is similar to M. nemorivaga (2n=68 and FN=70) and the differences between them are the number of B chromosomes and the morphology of X chromosome. (unesp.br)
  • wp-content/uploads/2023/03/logo_color.png 0 0 raincastle /wp-content/uploads/2023/03/logo_color.png raincastle 2020-06-01 00:00:00 2023-05-03 10:56:09 Development and application of oligonucleotide-based chromosome painting for chromosome 4D of Triticum aestivum L. (arborbiosci.com)
  • Furthermore, in the pheasants fission of the ancestral galliform chromosome 2 could be documented. (kent.ac.uk)
  • All human chromosomal paints, except the Y probe, hybridized to Tursiops counterparts, and every dolphin chromosome was painted except for the smallest submetacentric pair. (tamu.edu)
  • Here especially highlighted variations of FISH are molecular combing, chromosome orientation-FISH (CO-FISH), telomere-FISH, parental origin determination FISH (POD-FISH), FISH to resolve the nuclear architecture, multicolor-FISH (mFISH) approaches, among other applied in chromoanagenesis studies, Comet-FISH, and CRISPR-mediated FISH-applications. (frontiersin.org)
  • Eggen A., Solinas T.S., Fries R.A., Cosmid specific for sequences encoding a microtubule associated protein, MAPIB, contains a polymorphic microsatellite and maps to bovine chromosome 20q14, J. Hered. (gse-journal.org)
  • Libert F., Lefort A., Okimoto R., Womack J., Georges M., Construction of a bovine genomic library of large yeast artificial chromosome clones, Genomics 18 (1993) 270-276. (gse-journal.org)
  • An important breakthrough in horse Y chromosome research came with the availability of new genomics tools and resources, such as large-insert genomic bacterial artificial chromosome (BAC) libraries (for review, see Rubes et al. (veteriankey.com)
  • Bahri-Darwich I., Vaiman D., Olsaker I., Oustry A., Cribiu E.P., Assignment of bovine synteny groups U27 and U8 to R-banded chromosome 12 and 27, respectively, Hereditas 120 (1994) 261-265. (gse-journal.org)
  • The most recurrent numerical alterations were gains in rat chromosome 4 (RNO4) and losses in RNO15. (biomedcentral.com)
  • Thirteen type I loci from HSA4q, HSA6p, HSA7q and HSA12q were comparatively FISH-mapped in four river buffalo and sheep chromosomes. (cnr.it)
  • Since the genetic code was deciphered much has been learnt about the chromosome structure shared by all organisms from yeast to human. (biomedcentral.com)
  • Additionally, there are two reports about infertile stallions having XXY sex chromosomes - an equine counterpart to human Kleinfelter syndrome (Kubien et al. (veteriankey.com)
  • Mechanistically, the CIP2A-TOPBP1 complex prematurely associates with DNA lesions within ruptured micronuclei during interphase, which poises pulverized chromosomes for clustering upon mitotic entry. (nature.com)
  • This means that the existence of a new pericentric inversion or centromeric transfer in comparison with additional akodontines, with a posterior combination Sexually explicit media rearrangement giving rise to be able to DKE4. (torkinibinhibitor.com)
  • Morgan, Sturtevant, Bridges and Muller constructed the first genetic linkage maps from recombination studies in crosses made in the fruit fly and from cytological preparations of its polytene salivary gland chromosomes [ 4 - 6 ]. (biomedcentral.com)
  • In an organism, any visible abnormality in chromosome number or structure from the diploid set is known as chromosomal aberration . (schleiden-eifel.de)
  • If a normal diploid cell is 2n, the chromosome content of a double tetrasomic cell is designated. (schleiden-eifel.de)
  • Cai L., Taylor J. F., Wing R.A., Gallagher D.S., Woo S.S., Davis S.K., Construction and characterization of a bovine bacterial artifical chromosome library, Genomics 29 (1995) 413-425. (gse-journal.org)
  • This polymorphism is primarily attributed to the various amount of Y heterochromatin, though earlier studies also suggest variation in the euchromatic portion of the chromosome (Power, 1988). (veteriankey.com)
  • Mitotic clustering facilitates the reassembly of acentric fragments into rearranged chromosomes lacking the extensive DNA copy-number losses that are characteristic of canonical chromothripsis. (nature.com)
  • However, most fragments derived from pulverized chromosomes are acentric and cannot directly bind to spindle microtubules 14 . (nature.com)
  • The mechanisms of transmission of both discontinuous and continuous characteristics across the generations were unknown before Mendel's laws were explained at the turn of the 20th Century by the behavior of chromosomes in germ cells [ 2 , 3 ]. (biomedcentral.com)
  • These studies reaffirmed that chromosome structure and behavior in somatic and germ cell divisions were common to all plants and animals. (biomedcentral.com)
  • Thus, distinct patterns of chromothripsis can be explained by the spatial clustering of pulverized chromosomes from micronuclei. (nature.com)
  • In particular, G band analysis usually does not show the chromosomal origin of small marker chromosomes or of a small amount of extra material detected on otherwise normal chromosomes. (bmj.com)
  • Improvements in the resolution of chromosome analysis has followed closely the introduction of innovative technology. (biomedcentral.com)
  • The analysis of C-bands showed all centromeric and pericetromeric regions were heterochromatic, except the Y chromosome. (unesp.br)
  • The chromosome painting analysis showed total homeology of the X-chromosome M. gouazoubira probe with the whole p arm and proximal half of q arm of X-chromosome from M. nemorivaga. (unesp.br)
  • High-resolution chromosome analysis uses special culture methods to obtain a high percentage of prophase and prometaphase spreads. (msdmanuals.com)
  • Oligo painting using the probe library confirmed its specificity, shown by that only chromosome 4D could be painted in three wheat genotypes and CS nulli-tetrasomic line N4AT4D. (arborbiosci.com)
  • Two assignments were made that were not expected from the painting results (MC4R and GRIA1) and one assignment of a gene from a region where the painting study was not informative (ANT1). (iastate.edu)
  • The main part deals with examples of modern FISH-applications, highlighting unique possibilities of the approach, like the possibility to study individual cells and even individual chromosomes. (frontiersin.org)
  • Here we show that pulverized chromosomes from micronuclei spatially cluster throughout mitosis and identify the CIP2A-TOPBP1 complex as an essential regulator of this process. (nature.com)