Considering the current knowledge on the function of mammalian LOX isoforms in ECM remodeling, we propose that LOXL2/L3/L4 members might have preferentially been involved in making cross-linked collagen IV-based basement membrane, whereas the diversification of LOX/L1/L5 forms contributed to chordate/vertebrate-specific ECM innovations, such as elastin and fibronectin. (nature.com)
We discuss these findings in relation to conformational rearrangements in the fibronectin molecule. (tamu.edu)
Data is presented supporting a mechanism of cell attachment to fibronectin involving multiple weak interactions between cellular receptors and substrate molecules, although some steps in the attachment process appear to disobey the requirements for such a mechanism. (tamu.edu)
11. Transactivation of the epidermal growth factor receptor mediates muscarinic stimulation of focal adhesion kinase in intestinal epithelial cells. (nih.gov)
13. A role for epidermal growth factor receptor, c-Src and focal adhesion kinase in an in vitro model for the progression of colon cancer. (nih.gov)
Glioblastoma multiforme (GBM) is a highly aggressive and heterogeneous form of primary brain tumors, driven by a complex repertoire of oncogenic alterations, including the constitutively active epidermal growth factor receptor (EGFRvIII). (cancerindex.org)
Proteins4
Indeed, proteins affected in hereditary PPK fulfill various functions, including mechanical stabilization (e.g. defects of keratins or desmosomal proteins), cell signaling and cell-to-cell communication (e.g. alterations of signaling, transport, receptors). (biomedcentral.com)
Nano-flow cytometry revealed that the EV output from individual glioma cell lines was highly heterogeneous, such that only a fraction of vesicles contained specific proteins (including EGFRvIII). (cancerindex.org)
Hyperactivation of these pathways drives tumorigenesis and supports tumor growth.2 Signaling pathway proteins that are commonly activated by physiological responses include growth factor receptor (e.g. (technologynetworks.com)
Particular embodiments of the disclosure concern modulation of particular immune cell surface proteins to enhance adoptive cell therapy, and in specific cases the immune cells are lymphoid cells, including at least T cells, tumor infiltrating lymphocytes, or B cells, for example. (justia.com)
10. Integrins induce activation of EGF receptor: role in MAP kinase induction and adhesion-dependent cell survival. (nih.gov)
Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. (biomedcentral.com)
We discovered that T cells armed with FGL2-blocking single-chain variable fragments (T-αFGL2) are able to induce tumor-specific CD8 + T RM cells, which prevent glioblastoma recurrence, a major obstacle in achieving long term survivors. (researchsquare.com)
T cells armed with FGL2-blocking single-chain variable fragments (T-αFGL2) were able to induce tumor-specific CD8 + T RM cells. (researchsquare.com)
Autoimmune T Ijrmphocytes can be used under appropriate conditions to induce resistance to the specific autoimmune disease that they usually produce. (nih.gov)
Dissociate1
deacetylases are divided a transcription of buildings to be, and dissociate receptor of mitochondrial ions heat transferase kinases and between mitochondrial loss anomalies within conditions. (evakoch.com)
Muscarinic1
Stimulated muscarinic acetylcholine receptors (M2Rs) release Gβγ subunits, which slow heart rate by activating a G protein-gated K + channel (GIRK). (elifesciences.org)
Heparin1
A novel synthetic peptide from the B1 chain of laminin with heparin-binding and cell adhesion-promoting activities. (umn.edu)
Molecule2
In fact, as shown in Table 1 , HS was reported as the receptor molecule for DENV-2 in Vero cells, [ 26 , 29 ] whereas for DENV-1 and -4 a proteinaceous receptor was identified in the same cell line. (medscape.com)
Previous work on the fj gene suggested that it functions as a regional signaling molecule regulating growth and differentiation in specific portions of the PD axis in the leg and wing. (sdbonline.org)
Nuclear3
Much of this toxicity is ascribed to the nuclear receptor activity of TCDD. (nih.gov)
Src and Abl), lipid kinases (e.g. phosphoinositide 3-kinases, PI3Ks), as well as nuclear receptors (e.g. the estrogen receptor). (technologynetworks.com)
In the nucleus, the facilitated binding of T3-TR to a common nuclear receptor called RXR makes a heterodimer-T3-TR-RXR complex which in turn binds to thyroid hormone DNA response elements, regulating the consequent gene transcription through the action of co-repressors and co-activators [ 8 ]. (biomedcentral.com)
Cells17
Since the initial finding of highly sulfated HS as a putative primary receptor for DENV in certain types of mammalian cells, [ 26 ] the antiviral efficacy of polyanionic compounds of diverse structures has been demonstrated in vitro . (medscape.com)
They are single cells, typically micrometers in length, and present a specific spectrum of interactions with their human host. (oncohemakey.com)
How can cells, while differentiating and implementing their specific epigenetic programs, form tissues and organs and organisms? (uncommondescent.com)
9. The activated insulin-like growth factor I receptor induces depolarization in breast epithelial cells characterized by actin filament disassembly and tyrosine dephosphorylation of FAK, Cas, and paxillin. (nih.gov)
15. Role of extracellular matrix-cell interaction and epidermal growth factor (EGF) on EGF-receptors and actin cytoskeleton arrangement in infantile pituitary cells. (nih.gov)
17. Laminin-10 mediates basal and EGF-stimulated motility of human colon carcinoma cells via alpha(3)beta(1) and alpha(6)beta(4) integrins. (nih.gov)
Tissue-resident memory T cells (T RM ) specific to previously encountered pathogens have been characterized, but tumor-specific T RM cells in brain have not been reported in the literature. (researchsquare.com)
These tumor-specific CD8 + T RM cells are tumor reactive and transplantable. (researchsquare.com)
The induced tumor-specific CD69 + CD62L - CD8 + T RM cells, displayed a highly expanded T cell receptor repertoire. (researchsquare.com)
CD103 binds to epithelial E-cadherin, while CD69 blocks cellular egress via inhibition of the function of Sphingosine-1-phosphate receptor-1 (S1PR1) 9 , both help T RM cells retain in peripheral tissues. (researchsquare.com)
Indeed, FGL2-specific polyclonal antibodies showed antitumor activity against GBM tumor cells in syngeneic mouse models 23 . (researchsquare.com)
The generation of a signal concentration gradient allows cells to use a directional sensing program to generate "front"-specific responses at the region where the signal is the highest and "rear" specific responses where the signal is the lowest. (mechanobio.info)
In specific embodiments, the disclosure concerns adoptive cell therapy cancer treatment in which tumor-1 infiltrating lymphocytes and/or engineered T cells are modified to increase their efficacy as a cancer treatment. (justia.com)
In specific cases, the cells are engineered for knock out of one or more genes, such as Signaling Threshold Regulating Transmembrane Adaptor 1 (SIT1), Bone Marrow Stromal Cell Antigen 2 (BST2), and/or programmed cell death protein 1 (PD-1). (justia.com)
Thus, in specific embodiments, the expression of SIT1, BST2, and PD-1 is altered through genetic modification that results in improved T cell resistance or TIL resistance to immunosuppression compared to T cells or TIL, respectively, that do not have deliberate modification of expression of these genes. (justia.com)
These two branches control heart rate by stimulating different G protein-coupled receptors (GPCRs), which in turn activate ion channels that modify the electrical properties of cardiac pacemaker cells ( DiFrancesco, 1993 ). (elifesciences.org)
Capital t cell receptor (TCR)-gene-modified Capital t?cells for adoptive cell transfer may mediate goal clinical reactions in most cancers and other malignancies. (biobender.com)
Mutations1
The absence of the factor, or mutations in their receptors, lead to growth cone navigational errors. (mechanobio.info)
Cellular3
All these polyanionic compounds acted as HS-mimetic substances, interfering with the interaction of E glycoprotein with the cellular HS receptor. (medscape.com)
C , Cross section of a frog neuromuscular junction reveals three juxtaposed cellular elements: the perisynaptic Schwann cell, nerve terminal (N), and muscle fiber (M). The perisynaptic Schwann cell body (S indicates nucleus) and its processes cap the nerve terminal, but the processes do not wrap around the nerve terminal region facing acetylcholine receptors on muscle. (jneurosci.org)
These findings are the first to show tumor-specific brain resident CD8 + T RM generation via adoptive cellular treatment and may have promising implications for cancer immunotherapy. (researchsquare.com)
Epithelial1
Many epithelial pipes arise seeing that little elongate and pals simply by controlled morphogenetic procedures including oriented cell department, cell rearrangements, and adjustments in cell form. (biobender.com)
Molecules2
Receptor-binding transiently activates Cdc42/Rac1 GTPase and subsequent recruitment of adhesion molecules and components of the actin polymerizing module (e.g. (mechanobio.info)
Acetyl-CoA is been to the testing of the Golgi cartilage, where it consists as the centrosome of molecules that regulates co-transfection titles of aldehydes and receptors. (evakoch.com)
Cell14
Cell-ECM interactions operate through an integrated set of sensor and effector circuits that use several classes of receptors and signal transduction pathways. (jci.org)
Inhibition of cell attachment was obtained by species-specific antifibronectin antibodies, which presumably recognize a distinct antigenic structure in the protein located at, or in the immediate vicinity of, the cell-binding site. (tamu.edu)
The extracellular matrix (ECM) is an intricate network composed of an array of multidomain macromolecules organized in a cell/tissue-specific manner. (uncommondescent.com)
5. PTP alpha regulates integrin-stimulated FAK autophosphorylation and cytoskeletal rearrangement in cell spreading and migration. (nih.gov)
18. Matrix-specific FAK and MAPK reorganization during Caco-2 cell motility. (nih.gov)
These tumor-specific CD8 + T RM displayed a unique highly expanded T cell receptor repertoire distinct from that found in peripheral tissues. (researchsquare.com)
Cell membranes are highly enriched in signaling receptors, transmembrane mechanosensors, pumps and channels, and, depending on their makeup, can recruit and retain a pool of mechanosensors important in the field of mechanobiology. (mechanobio.info)
In neuronal growth cones, filopodia protrusion is induced when an attractive cue binds to its receptor on the cell surface. (mechanobio.info)
Specific embodiments provide methods and compositions for eliminating SIT1, BST2, and PD-1 having a direct or indirect role in T cell suppression, thereby overcome T cell suppression. (justia.com)
One of the main processes leading to the shaping of the three-dimensional body plan of higher organisms is the dynamic rearrangement of cell populations. (biologists.com)
To clarify the system for advancement of Epstein-Barr trojan (EBV)-positive T- or NK-cell neoplasms, we focused in the costimulatory receptor Compact disc137. (biobender.com)
Description: A sandwich quantitative ELISA assay kit for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in samples from tissue homogenates, cell lysates or other biological fluids. (clinical-trial-logistics.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in tissue homogenates, cell lysates and other biological fluids. (clinical-trial-logistics.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Platelet Derived Growth Factor Receptor Beta (PDGFRb) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (clinical-trial-logistics.com)
Neural3
In coherence with this observation, the promoter region of slug (a neural crest specific gene) contains a binding site for transcription factors involved in the activation of Wnt-dependent target genes, suggestive of a direct role of Wnt signaling in neural crest specification. (wikipedia.org)
Researchers have demonstrated that the expression of dominate-negative Fgf receptor in ectoderm explants blocks neural crest induction when recombined with paraxial mesoderm. (wikipedia.org)
While these findings have led to the development of mouse models of these diseases, little is known at the systems level about how these disease genes impact the function of a specific neural circuit. (nih.gov)
Protein4
In specific embodiments, the modulation of expression concerns downregulation of expression of multiple genes, including in at least some cases to non-detectable levels, such as determined by any standard means in the art (at the RNA and/or protein level, for example). (justia.com)
The higher rate of Gβγ release is attributable to a faster G protein coupled receptor - G protein trimer association rate in M2R compared to β2AR. (elifesciences.org)
The activated receptor catalyzes removal of GDP from the G protein alpha subunit (Gα i ), which allows intracellular GTP to bind. (elifesciences.org)
GTP, gap and article), 3) organization of the catabolism upon Following of the such back-to-back acid, and components production, germ and dissociation, with partial X to the severe XIAP, 4) physiological resulting and cycle protein microRNA, and 5) GTP haem and allowing of the tissue-specific new metalloproteinase. (evakoch.com)
GTPase1
2. EGF receptor mediates adhesion-dependent activation of the Rac GTPase: a role for phosphatidylinositol 3-kinase and Vav2. (nih.gov)
Mice1
Among entry inhibitors, the oligosaccharide PI-88 was assayed in a murine model of type I and II interferon receptor-deficient mice inoculated with DENV-2 by intravenous route. (medscape.com)
Transcription1
This receptor is for role, reddish-brown ligase, and many ubiquitination but at the such response tends the 18S members of the transcription from momentum sphingolipids, ligand, and vivo functions. (evakoch.com)
Highly1
The Glucose is suggested well, so such receptors develop highly working developed. (siriuspixels.com)
Tissues1
This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. (biomedcentral.com)
Activity1
the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). (nih.gov)
Expression1
Tissue-specific expression analysis indicated high expression levels of dy in the epidermis, head and fat body of late-stage larvae. (sdbonline.org)
Form1
and (5) form deposits capable of surviving in the new environment 10 ( Fig. 19-1, A ). The basic biology, molecular mechanisms, and genetic and epigenetic changes that drive these steps are extremely complex and probably differ depending on the source of the metastasis and specific type of tumor. (basicmedicalkey.com)
Effects1
Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands. (nih.gov)
Cancer1
Plasma Androgen Receptor Copy Number Status at Emergence of Metastatic Castration-Resistant Prostate Cancer: A Pooled Multicohort Analysis. (tuni.fi)
Release1
Stimulated β2 adrenergic receptors (β2ARs) also release Gβγ subunits, but GIRK is not activated. (elifesciences.org)
Data1
Data table showing topics related to specific cancers and associated disorders. (cancerindex.org)
Support1
Find support for a specific problem in the support section of our website. (mdpi.com)