• There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells. (cusabio.com)
  • [4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
  • This review aims to provide an overview of current knowledge on cellular molecules described to be involved in CSFV entry, including complement regulatory protein 46 (CD46), heparan sulphate (HS), Laminin receptor, Integrin ß3, Annexin II, MERKT and ADAM17. (bvsalud.org)
  • This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)
  • CSFV infection is probably a multistep process that involves the proteins in the virus envelope and more than one receptor in the membrane of permissive cells. (bvsalud.org)
  • SFTSV possesses Gn and Gc glycoproteins, which are responsible for host cell receptor attachment and membrane fusion, respectively, to infect host cells. (bvsalud.org)
  • Attaches the virus to host cellular receptor, inducing endocytosis of the virion. (cusabio.com)
  • To date, the cellular receptors essential for CSFV entry and their detailed functions during this process remains unknown. (bvsalud.org)
  • Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor. (biolegend.com)
  • The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)
  • Granzyme B is induced in CD8 + T lymphocytes with ConA/ IL-2 and CD4 + T lymphocytes with anti CD3/CD28 or CD3/CD46. (biolegend.com)
  • These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells ). (wikidoc.org)
  • 00:01:59.26 However, pigs, and most mammalian species, and also non-mammalian species, in fact, 00:02:07.05 express an antigen that is quite ubiquitous and that causes. (ibiology.org)
  • BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. (wikidoc.org)
  • All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, [6] although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein). (wikidoc.org)
  • The epidermal growth factor receptor (EGFR) is a well characterized receptor-tyrosine kinase that functions in development and serves a vital role in many human cancers. (bioxcell.com)
  • Understanding EGFR regulatory mechanisms, and hence approaches for clinical intervention, has focused on ligand-receptor interactions and tyrosine kinase activity. (bioxcell.com)
  • SRC is a non-receptor tyrosine kinase that plays critical roles in numerous cellular processes, such as cell proliferation, differentiation, migration, and survival. (cusabio.com)
  • This Antibody was verified by Knockdown to ensure that the antibody binds to the antigen stated. (thermofisher.com)
  • 18. Reactivities of mouse monoclonal antibody K2.7 to renal cancers in complement dependent cytotoxicity and antibody dependent cell-mediated cytotoxicity. (nih.gov)
  • The 528 monoclonal antibody reacts with an epitope on the extracellular domain of human EGFR (epidermal growth factor receptor) also known as ErbB-1. (bioxcell.com)
  • The 528 antibody has been reported to block EGF binding to its receptor and inhibit A431 tumor formation in nude mice. (bioxcell.com)
  • 7. Expression of complement membrane regulators membrane cofactor protein (CD46), decay accelerating factor (CD55), and protectin (CD59) in human malignant gliomas. (nih.gov)
  • The fiber protein from most adenoviruses, except species B, binds to the cellular receptor CAR (coxsackie-adenovirus receptor), which also binds coxsackie B virus [ 2 ]. (medilib.ir)
  • 1. Complement activated by chimeric anti-folate receptor antibodies is an efficient effector system to control ovarian carcinoma. (nih.gov)
  • 9. Cell-surface density of complement restriction factors (CD46, CD55, and CD59): oral squamous cell carcinoma versus other solid tumors. (nih.gov)
  • 10. Cell-surface expression of complement restriction factors and sialyl Lewis antigens in oral carcinoma: relevance to chemo-immunotherapy. (nih.gov)
  • 11. Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. (nih.gov)
  • 12. Activated signal transducers and activators of transcription 3 signaling induces CD46 expression and protects human cancer cells from complement-dependent cytotoxicity. (nih.gov)
  • Group B adenoviruses have been shown to bind to CD46, a complement-related protein [ 3,4 ]. (medilib.ir)
  • This question was addressed through the use of C3-deficient mice, blockade of C3 cleavage to C3b, and accelerated degradation of iC3b by soluble complement receptor 1 (sCR1). (silverchair.com)
  • 2015). "Epidermal growth factor receptor (EGFR) signaling requires a specific endoplasmic reticulum thioredoxin for the post-translational control of receptor presentation to the cell surface" J Biol Chem 290(13): 8016-8027. (bioxcell.com)
  • Given the large differences in formulation (higher antigen dose vs adjuvant), our hypothesis was that each vaccine elicited a distinct transcriptomic response after vaccination. (bvsalud.org)
  • 2. Chimeric murine-human antibodies directed against folate binding receptor are efficient mediators of ovarian carcinoma cell killing. (nih.gov)
  • CD4 is a receptor for the human immunodeficiency virus (HIV). (thermofisher.com)
  • Here, we show using the NCI-H460 lung and A431 epidermoid human cancer cell lines that EGFR binding to anterior gradient homolog 2 (AGR2) in the endoplasmic reticulum is required for receptor delivery to the plasma membrane and thus EGFR signaling. (bioxcell.com)
  • These strategies are primarily focused on CD8+ T cells and approaches are challenging due to insufficient HIV antigen production from infected cells and poor HIV-specific CD8+ T cells. (jci.org)
  • Granzyme B is crucial for rapid induction of cell death and apoptosis through interaction with mannose-6-phosphate receptor. (biolegend.com)
  • EGFR is a 170 kDa cell-surface receptor and belongs to the ErbB family of receptors. (bioxcell.com)