Natriuretic peptideProteinsResiduesAntimicrobial peptidesProduction of reactive oxygenOxygenProtein and peptideHighly reactiveRepeatedly reactiveCross-reactive antibodiesAntibodyTrypsinAcute phase reAntibodiesAmino acidSARS-CoVCysteineMimicsPreferentiallyEnzymeSerineSynthesisHepcidinPolymersChemokinesEpitopesReactivitySpecimensVitroFluorOccursComplexesConventionalReactionInhibitoryFunctionalProduced by the liverAlleleEpithelialResidueImmuneClinicalEnzymesAmyloidStrainsStructuralClonesInfectionVaccineSubstratesPathogenesisSequenceLibrariesOralInvolveHydrophobicCellActiveChainsChemicalLiver
Natriuretic peptide3
- And at the Buck, Newman and Stubbs will be evaluating the use of biomarkers that are often available in clinical labs ― insulin, C-reactive protein, cystatin, and natriuretic peptide tests ― for use as outcome measures that are responsive to treatment interventions and that can be used to track outcomes in future research on aging. (medscape.com)
- We have addressed whether B-type natriuretic peptide (BNP) and high-sensitive C-reactive protein (hsCRP) in admission samples may improve risk stratification in chest pain patients with suspected ACS. (biomedcentral.com)
- Two siblings aged 5 and 15 years from Connecticut were dehydrogenase, and pro-brain natriuretic peptide, an indicator hospitalized with petechial rash, oral mucositis, and severe of poor cardiac function (Table). (cdc.gov)
Proteins15
- Conventional methods involve the reaction of polymers which have one reactive end with the reactive residues of proteins/peptides. (chemistryviews.org)
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). (cathdb.info)
- The first library the researchers constructed was focused on SARS-CoV-2 and contained 2,107 peptides representing spike and nucleocapsid proteins with an average of 38 peptides covering each amino acid position. (scienceboard.net)
- They detected significantly more SARS-CoV-2 peptides enriched in convalescent samples compared to controls for both spike and nucleocapsid proteins. (scienceboard.net)
- An intramolecular click reaction results in the formation of a photoswitchable bridge, which can be used for controlling conformational domains in peptides and proteins. (beilstein-journals.org)
- Photoswitchable bridges that are site-specifically incorporated into proteins allow the conformation and activity of proteins to be modulated by light. (beilstein-journals.org)
- It is used for the treatment of paraffin embedded tissue sections to expose antigen binding sites for antibody labeling and for digestion of proteins from brain tissue samples for prions in Transmissible Spongiform Encephalopathies (TSE) research. (sigmaaldrich.com)
- Pre-activated OVA multimers FS reactive with amine residues thus provide an efficient carrier for auto-vaccination against 9C90 kDa autologous proteins. (2011globalhealth.org)
- A total of 20 serological reactive proteins were identified, including 4 novel antigens. (uib.no)
- Bioactive Proteins and Peptides from Food Sources. (eurekaselect.com)
- Exorphins, or opioid peptides derived from food proteins such as wheat and milk (e.g. exogenous sources) have similar structure to endogenous opioid peptides, with a tyrosine residue located at the amino terminal or bioactive site. (eurekaselect.com)
- Immunomodulatory peptides derived from tryptic hydrolysates of rice and soybean proteins act to stimulate superoxide anions (reactive oxygen species-ROS), which triggers non-specific immune defense systems. (eurekaselect.com)
- Antioxidant properties that prevent peroxidation of essential fatty acids have also been shown for peptides derived from milk proteins. (eurekaselect.com)
- Amino acids, peptides, and proteins. (medlineplus.gov)
- Cells treated with NGI-1 produced morphologically unaltered viable influenza virus with sequence-neutral glycosylation changes (primarily reduced site occupancy) in the hemagglutinin and neuraminidase proteins. (cdc.gov)
Residues5
- With this delayed gradient procedure, the yield and purity of the crude peptides was maximized and the racemization of cysteine residues was reduced. (peptide.com)
- Addition of multiple isocyanates to the peptide occurs via polymerization of the isocyanate at the N-terminus, rather than via addition of multiple isocyanate molecules to varied residues within the peptide. (cdc.gov)
- The introduction of galactose residues can be especially advantageous for structural studies because it provides a means of selectively labeling specific sites on biomolecules. (thermofisher.com)
- Many bioactive peptides have in common structural properties that include a relatively short peptide residue length (e.g. 2-9 amino acids), possessing hydrophobic amino acid residues in addition to proline, lysine or arginine groups. (eurekaselect.com)
- 2006 ) Sequence requirements for Lon-dependent degradation of the Escherichia coli transcription activator SoxS: identification of the SoxS residues critical to proteolysis and specific inhibition of in vitro degradation by a peptide comprised of the N-terminal 21 amino acid residues. (academictree.org)
Antimicrobial peptides3
- These include the production of reactive oxygen species, the release of antimicrobial peptides, and the recently discovered expulsion of their nuclear contents to form neutrophil extracellular traps. (nih.gov)
- Epithelial cells also produce antimicrobial peptides such as defensins and cathelicidins that kill microbes by disrupting their membranes or interfering with their metabolism. (stemcelldaily.com)
- PMN may display neutrophil extracellular traps (NETs), consisting of nuclear DNA, decorated with histones, enzymes, and antimicrobial peptides. (biomedcentral.com)
Production of reactive oxygen1
- Induction of nitric oxide and production of reactive oxygen species are as well regulated by chemokine signal via calcium mobilization and diacylglycerol production. (genome.jp)
Oxygen6
- These results together with previous reports suggested the involvement of reactive oxygen species (ROS) in the pathogenesis of RA. (nature.com)
- Data suggest that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction. (novusbio.com)
- Catalases (CAT) and superoxide dismutases (SOD) are antioxidant metalloenzymes necessary for life in oxygen-metabolizing cells to regulate reactive oxygen species (ROS) levels. (anr.fr)
- Reactive oxygen species (ROS) generation in NTDT patients is caused by 2 major mechanisms. (hindawi.com)
- Oxidative damage by reactive oxygen species (generated by free globin chains and labile plasma iron) is believed to be one of the main contributors to cell injury, tissue damage, and hypercoagulability in patients with thalassemia. (hindawi.com)
- These 3 clinical entities are the ones suggested such that reactive oxygen species are an integral player in the development of disease specific complications. (hindawi.com)
Protein and peptide3
- The effective synthesis and delivery of polymer conjugates of protein and peptide therapeutics are challenges in clinical development. (chemistryviews.org)
- HA-MAL can be used for site specific protein and peptide modification at the cysteine amino acid site. (creativepegworks.com)
- both at protein and peptide level, combined with subsequent identification using LC-tandem mass spectrometry. (uib.no)
Highly reactive3
- Diisocyanates are highly reactive chemical compounds widely used in the manufacture of polyurethanes. (cdc.gov)
- Proteinase K is a stable and highly reactive serine protease. (sigmaaldrich.com)
- These results prove that OVAglu multimers are highly reactive and stable. (2011globalhealth.org)
Repeatedly reactive4
- The current HIV diagnostic algorithm consists of a repeatedly reactive immunoassay (IA), followed by a supplemental test, such as the Western blot (WB) or indirect immunofluorescence assay (IFA). (cdc.gov)
- From July 2011 through February 2012, 10 specimens with repeatedly reactive Architect results were tested with both a WB and a Food and Drug Administration (FDA)-approved HIV-1/HIV-2 antibody differentiation assay (Multispot HIV-1/HIV-2 Rapid Test [Multispot], Bio-Rad Laboratories), and from March 2012 through February 2013, only with a Multispot (27 specimens). (cdc.gov)
- These repeatedly reactive specimens were then tested with a more specific test, the Cambridge Biotech HIV-1 Western Blot Kit (Calypte Biomedical Corporation, Rockville, MD). (cdc.gov)
- A repeatedly reactive specimen by HIV-1/HIV-2 EIA should be tested by HIV-1 Western blot (or another licensed HIV-2 supplemental test). (cdc.gov)
Cross-reactive antibodies3
- We further demonstrate that these cross-reactive antibodies preferentially bind to endemic coronavirus peptides, suggesting that the response to SARS-CoV-2 at these regions may be constrained by previous coronavirus exposure. (scienceboard.net)
- A successful vaccine will need to target a piece of the virus that's similar across strains, eliciting 'cross-reactive' antibodies to fight them all. (gra.org)
- It is similar across many diverse strains of HIV-1, and Kong and his colleagues discovered the immune system can develop cross-reactive antibodies toward the fusion peptide. (gra.org)
Antibody4
- The team identified antibody reactivity against 229 SARS-CoV-2 peptides in convalescent and 95 SARS-CoV-2 peptides in negative control samples. (scienceboard.net)
- Treatment of paraffin embedded tissue sections to expose antigen binding sites for antibody labeling. (sigmaaldrich.com)
- and hydroxylamines usually does not inactivate the antibody, as sometimes occurs with amine-reactive labeling. (thermofisher.com)
- All specimens were tested using the Synthetic Peptide Enzyme Immunoassay (EIA) (Genetic Systems HIV-1/HIV-2 Peptide EIA) for the detection of antibody to human immunodeficiency virus type 1 or type 2 (HIV-1 or HIV-2) or both (Bio-Rad Laboratories, Redmond, WA). (cdc.gov)
Trypsin1
- This peptide has two symmetrically spaced trypsin binding sites. (rcsb.org)
Acute phase re2
- SAA protein is an acute phase reactant, like C-reactive protein (CRP), and is synthesized by hepatocytes under the transcriptional regulation of cytokines, including interleukin (IL)-1, IL-6 and tumor necrosis factor (TNF). (medscape.com)
- C-reactive protein (CRP) is an acute-phase reactant and a marker for underlying systemic inflammation, including atherosclerosis and plaque rupture with ensuing thrombus formation [ 11 - 13 ]. (biomedcentral.com)
Antibodies3
- The novel technology platform is being developed by teams at TGen and NAU and allows for the construction of highly diverse peptide libraries bound to DNA barcodes, which can be used to probe antibodies in a high-throughput manner. (scienceboard.net)
- Our findings highlight sites at which the SARS-CoV-2 response appears to be shaped by previous coronavirus exposures, and which have potential to raise broadly-neutralizing antibodies," said senior author, John Altin, PhD, assistant professor in TGen's infectious disease branch. (scienceboard.net)
- Early HIV IAs used either viral lysate antigens (first generation) or synthetic peptides and recombinant antigens (second generation) and detected only immunoglobulin G (IgG)-class antibodies. (cdc.gov)
Amino acid5
- The direct observation of isocyanate binding to the N-terminus of peptides under these experimental conditions is in good agreement with previous studies on the relative reaction rate of isocyanate with amino acid functional groups. (cdc.gov)
- Efforts to mimic nature typically utilize amino acids and amino acid derivatives to form peptidomimetics having amide bonds.Presented here is a new class of synthetic sequence-defined polymers which do not use peptide bonds. (pnnl.gov)
- In contrast to common bivalent thiol reactive azobenzene switches [1-5] , the PSCaa described here ( Scheme 1 ) is an α-amino acid containing, besides an azobenzene unit, a vinyl function that can react specifically with a cysteine within a putative conformational domain of a peptide or a protein by light-induced thiol-ene click reaction [6-9] . (beilstein-journals.org)
- The smallest synthetic peptide recognized by JK36 was an 8-amino acid peptide that contains amino acids (aa) 226 to 233 (VVAAEMEE) of NS3. (umassmed.edu)
- The smallest peptide recognized by JK46 was an 11-amino acid peptide that contains aa 224 to 234 (TRVVAAEMEEA). (umassmed.edu)
SARS-CoV3
- A second library consisted of 244,000 peptides covering the full proteomes of all viruses known to infect humans, including endemic seasonal coronaviruses (HCoV-229E, HCoV-OC43, HCoV-NL63, HCoV-HKU1), SARS-CoV, and MERS-CoV. (scienceboard.net)
- They compared SARS-CoV-2 reactivity profiles with patterns of peptides from the second constructed peptide library which included endemic human coronavirus strains. (scienceboard.net)
- The N166 epitope, while not correlated to any endemic coronaviruses, what highly conserved with SARS-CoV peptides in the analysis. (scienceboard.net)
Cysteine2
- Slower heating on a temperature gradient (Figure 1C and 1D) also improved the yield and purity of crude peptides but with less racemization of cysteine. (peptide.com)
- On comparing i,i+4 and i,i+7 spacings of PSCaa and cysteine in a model peptide without a preferred conformation, it was seen that the thiol-ene click reaction takes place efficiently in both cases. (beilstein-journals.org)
Mimics1
- We also find that the inhibitor displays a strong and unique structural identity, with a notable lack of minor conformational isomers that characterise most reactive site loop mimics examined to date as well as SFTI-1. (rcsb.org)
Preferentially1
- In each case, the isocyanates react preferentially with the N-terminus of the peptide. (cdc.gov)
Enzyme3
- Each protomer contains a deep hydrophobic pocket which is proposed to constitute the active site of the enzyme. (iucr.org)
- Finally, combined quantum mechanical/molecular mechanical (QM/MM) modelling of the IdmH reaction shows that the active site of the enzyme provides an appropriate environment to promote indane-ring formation, supporting the assignment of IdmH as the key Diels-Alderase catalysing the final step in the biosynthesis of indanomycin through a similar mechanism to other recently characterized Diels-Alderases involved in polyketide-tailoring reactions. (iucr.org)
- Antihypertensive peptides, known as Angiotensin I converting enzyme (ACE) inhibitors have been derived from milk, corn and fish protein sources. (eurekaselect.com)
Serine1
- The peptide predicted from this insert is very similar to the Kunitz family of serine proteinase inhibitors. (embl.de)
Synthesis3
- Ashutosh Chilkoti and colleagues, Duke University, Durham, NC, USA, developed a high-yield synthesis of site-specific protein/peptide-polymer therapeutics by using a modular approach involving recombinant expression, enzymatic attachment of an azido group to the protein/peptide, and polymer coupling by a copper-free click reaction (pictured). (chemistryviews.org)
- The only requirement for this method is that the protein or peptide must have a defined peptide sequence at its C-terminus, which is easily achieved by recombinant expression or by solid-phase synthesis. (chemistryviews.org)
- Microwave heating (Figure 1A) accelerates peptide synthesis and improves the purity of crude peptides . (peptide.com)
Hepcidin1
- The master regulator of iron balance in humans is hepcidin, a peptide produced by the liver [ 20 ]. (hindawi.com)
Polymers3
- The researchers demonstrated the concept with green fluorescent protein and exendin-4, a peptide drug for treatment of type 2 diabetes, and several polymers including biodegradable polycarbonates and polyphosphoesters, zwitterionic polymers, and linear poly(ethylene glycol) (PEG). (chemistryviews.org)
- This makes it applicable to a large subset of protein/peptide drugs and to diverse water-soluble polymers. (chemistryviews.org)
- This sequential reactivity provides advancement over prior methods used to form conventional sequence-defined peptide polymers because it provides completely new polymeric architectures, as compared to conventional peptide, peptoid, or nucleic acid polymers. (pnnl.gov)
Chemokines1
Epitopes2
- Our findings indicate that CD patients possess T cells capable of responding to immuno-dominant hordein epitopes and homologous avenin peptides ex vivo , but the frequency and consistency of these T cells in blood is substantially higher after oral challenge with barley compared to oats. (fabresearch.org)
- Of these peptides, 70 were enriched in both sample types and were clustered together into 10 putative epitopes within the spike protein and 9 putative epitopes within the nucleotide protein. (scienceboard.net)
Reactivity2
- However, there is interest in the possibility of Peptide reactivity exploiting these same experimental approaches to distinguish between different forms of chemical aller- gens - as individual materials are primarily associated with one or the other form of sensitization in humans. (cdc.gov)
- These opportunities are surveyed here against a background of the immunobiology of allergic sensitization and current state-of-the-art approaches to measurement of peptide/protein reactivity. (cdc.gov)
Specimens1
- In this report, fourth-generation, IA-reactive specimens with a negative supplemental test but detectable HIV-1 RNA were classified as acute HIV infection. (cdc.gov)
Vitro2
- Whilst clinical feeding studies generally support the safety of oats ingestion in CD, the avenin protein from oats can stimulate intestinal gluten-reactive T cells isolated from some CD patients in vitro . (fabresearch.org)
- In vitro , immunogenic avenin peptides were susceptible to digestive endopeptidases and showed weak HLA-DQ2.5 binding stability. (fabresearch.org)
Fluor2
- Galactose oxidase-modified lipopolysaccharides (LPS) have been modified with Alexa Fluor 488 hydrazide ( A10436 ) to probe for LPS-binding sites on cells. (thermofisher.com)
- Tide Fluor™ superior fluorescent labelling dyes, optimised for labelling nucleotides and peptides. (stratech.co.uk)
Occurs2
- Usually 80-90% of coupling to reactive sites occurs within the first 2 to 4 minutes of reaction time. (peptide.com)
- This adhesion occurs as part of the transitory initial encounters between T cells and Antigen Presenting Cells before T cell activation , when T cells are roaming the lymph nodes looking at the surface of APCs for peptide:MHC complexes the T-cell receptors are reactive to. (wikidoc.org)
Complexes1
Conventional1
- Rapid conventional heating (Figure 1B), although slower within a minute of microwave heating, produces nearly identical results as microwave heating in improving the purity and yield of crude "difficult" peptides. (peptide.com)
Reaction5
- Inter-chain hydrogen bonding in the hydrophobic regions causes poor solvation of the peptide chains and slowed reaction rates. (peptide.com)
- Heating disrupts the hydrogen bonding between peptide chains leading to increased reaction rates in addition to rate acceleration normally observed due to increased temperature. (peptide.com)
- Peptide chains on the surface of the resin beads are exposed to the reaction mixture and react rapidly at room temperature or with mild heating while racemization is slow. (peptide.com)
- To investigate the reaction catalysed by IdmH, 88% of the backbone NMR resonances were assigned, and using chemical shift perturbation of [ 15 N]-labelled IdmH it was demonstrated that indanomycin binds in the active-site pocket. (iucr.org)
- Keratinocytes also secrete a number of cytokines that may function to induce a local inflammatory reaction and recruit immune cells to the site of infection. (stemcelldaily.com)
Inhibitory1
- Members of this family have a duplicated structure and generally possess two distinct inhibitory sites. (wikipedia.org)
Functional4
- The infrequent occurrence of aldehydes and ketones in biomolecules has stimulated the development of techniques to selectively introduce these functional groups, thus providing unique sites for chemical modification and greatly extending the applications of the probes found in this section. (thermofisher.com)
- This binding site is unmasked by a limited concentration range of the organometallic sulfhydryl-reactive agent p-chloromercuribenzoic acid (PCMB) suggesting that functional expression of this binding site may depend on the redox state of the milieu of the brain. (nova.edu)
- The possible functional significance of this novel non-AT1, non-AT2 binding site for angiotensin peptides as a mediator of non-traditional actions of Ang II in the brain, e.g., stimulation of dopamine release from the striatum, as a peptidase, or as a clearance receptor, and the importance of the state of the internal environment of the brain to its function is reviewed. (nova.edu)
- Advances here will enable recovery of bioactive peptides with minimal destruction thus enabling utilization by returning these active peptides to functional food or specific nutraceutical applications. (eurekaselect.com)
Produced by the liver1
- C-reactive protein (CRP) is produced by the liver. (medlineplus.gov)
Allele1
- HLA-DR15 was the restriction allele for recognition of these peptides by both JK36 and JK46. (umassmed.edu)
Epithelial1
- This protein is highly expressed at the site of erythropoietin production in the proximal convoluted tubule epithelial cells of the renal cortex. (novusbio.com)
Residue2
- active site residue. (embl.de)
- The addition of a Leu or Pro residue to the N-terminus of a His-His, dipeptide will enhance antioxidant activity and facilitate further synergy with non-peptide antioxidants (e.g. (eurekaselect.com)
Immune5
- Building on their identification of the fusion peptide as a vaccine target, Kong and his team are developing a novel vaccination strategy that uses sequential immunization, a kind of double-shot approach to boost the immune response. (gra.org)
- What's significant about this approach is that even if the envelope glycoprotein of a particular strain of HIV-1 looks different from the one in the vaccine, the immune system will still know to attack it - as long as the fusion peptide is the same or similar. (gra.org)
- Immune cell infiltration analysis and cytokine production were performed by flow cytometry, PCR and ELISPOT in the tumor site and in the spleen of animals, 17 days after the tumor injection. (bmj.com)
- Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. (genome.jp)
- After activation C3b can bind covalently, via its reactive thiolester, to cell surface carbohydrates or immune aggregates. (lu.se)
Clinical2
- Therefore, the team hopes the work provides a general methodology for the clinical and commercial development of protein/peptide-polymer conjugates as biologic drugs. (chemistryviews.org)
- Overall, the Abili-T clinical study is expected to enroll 180 patients at approximately 30 clinical sites and top-line data is expected during the first half of 2016. (aol.com)
Enzymes1
Amyloid1
- Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. (embl.de)
Strains1
- The first shot would target a variety of HIV-1 fusion peptide sequences, covering most known strains of the virus. (gra.org)
Structural1
- Structural elucidation of isocyanate-peptide adducts using tandem mass spectrometry. (cdc.gov)
Clones1
- In the present paper, we have defined a dengue serotype-cross-reactive epitope recognized by two CD4+ CD8- cytotoxic T lymphocyte (CTL) clones, JK36 and JK46. (umassmed.edu)
Infection4
- Central to their function is their ability to be recruited to sites of infection, to recognize and phagocytose microbes, and then to kill pathogens through a combination of cytotoxic mechanisms. (nih.gov)
- Because current laboratory IAs detect HIV infection earlier than supplemental tests, reactive IA results and negative supplemental test results very early in the course of HIV infection have been erroneously interpreted as negative ( 2 ). (cdc.gov)
- Polymorphonuclear neutrophils (PMN) are the most abundant granulocytes and first ones arriving at infection sites. (biomedcentral.com)
- Despite the pivotal role of leukocytes during fasciolosis in vivo, very little is known on early interactions between PMN and F. hepatica [ 11 ], even though PMN are the first granulocytes to be recruited to infection sites [ 13 ]. (biomedcentral.com)
Vaccine2
- Through his work at the NIH Vaccine Research Center, Kong helped identify the fusion peptide as a vulnerable site on HIV-1. (gra.org)
- Since launching his lab in 2020 at the Emory Vaccine Center, Kong has focused on expanding his investigation of the fusion peptide and developing more novel methods to target it. (gra.org)
Substrates4
- N-acylated peptide esters as substrates. (caltech.edu)
- A series of N-acetylated peptide esters of varying length have been evaluated as substrates of α-chymotrypsin. (caltech.edu)
- Finally, some reactive esters of N-acetylated amino acids have been evaluated as substrates of α-chymotrypsin. (caltech.edu)
- GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. (cathdb.info)
Pathogenesis1
- The role of dengue virus-specific serotype-cross-reactive T lymphocytes in recovery from and pathogenesis of dengue virus infections is not known. (umassmed.edu)
Sequence1
- The inhibitor was designed by fusing together a pair of reactive loops based on a sequence derived from SFTI-1 to create a backbone-cyclized disulfide-bridged 16-mer peptide. (rcsb.org)
Libraries1
- We fed participants a meal of oats (100 g/day over 3 days) to measure the in vivo polyclonal avenin-specific T cell responses to peptides contained within comprehensive avenin peptide libraries in 73 HLA-DQ2.5 + CD patients. (fabresearch.org)
Oral1
- Oral barley challenge efficiently induced cross-reactive avenin/hordein-specific T cells in most CD patients, whereas wheat or rye challenge did not. (fabresearch.org)
Involve1
- The separation and purification of bioactive peptides which will involve development of automated and continuous systems is an important field for Food chemists. (eurekaselect.com)
Hydrophobic1
- Synthesizing hydrophobic peptides is often difficult. (peptide.com)
Cell1
- The remaining free glutaraldehyde sites were subsequently saturated with a tenfold molar excess of PADRE peptide to provide additional T cell help. (2011globalhealth.org)
Active2
- A partial model of the locus of the active site which interacts with the R' 1 CONH- group of a substrate of the form R' 1 CONHCHR 2 COR' 3 is proposed. (caltech.edu)
- For brain AT1 receptors, there is a controversy regarding the identity of the active angiotensin peptide in the brain which is addressed in this review. (nova.edu)
Chains2
- With gradient heating, racemization affects only the 10-20% of peptide chains that had not already reacted at lower temperature. (peptide.com)
- In gradient heating, the majority of the peptide chains react at lower temperatures where the racemization reactions are slow and less diasteriomeric impurities are formed. (peptide.com)
Chemical1
Liver2
- The major sites of involvement in AA amyloidosis are the kidney, liver, and spleen. (medscape.com)
- While this binding site has similarities to a previously described soluble angiotensin-binding protein found in liver that is unmasked by PCMB, it has many different characteristics. (nova.edu)