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  • active metabolite
  • The 1-methyl-4-phenyl-pyridinium ion (MPP(+)), an active metabolite of the neurotoxin, N-methyl-4-phenyl-1,2,3,6 tetrahydropyridine (MPTP), induces death in rat pheochromocytoma (PC12) cells, suggesting a cell model of Parkinson's disease (PD). (biomedsearch.com)
  • Tyrosinase
  • Incubation of LAS with tyrosinase or rat liver microsomes in the presence of GSH gave two mono-GSH and two di-GSH conjugates, formed from trapping of the o-quinones. (uic.edu)
  • dopamine
  • 2-Hydroxyestradiol is a catechol estrogen and in this regard bears some structural resemblance to the catecholamines dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline). (wikipedia.org)
  • vivo
  • Catechol O-methyl transferase catalyzes O-methylation of mutagenic flavonoids: Metabolic inactivation as a possible reason for their lack of carcinogenicity in vivo J. Biol. (springer.com)
  • secretion
  • Ultrastructure of intermediate lobe of the pituitary and melanocyte-stimulating hormone secretion in oestrogen-induced kidney tumours in male hamsters. (forum-shemale.com)
  • This metabolite has several physiological consequences: the ability to influence intracellular signalling, adenohypophyseal hormone secretion, radical and quinone formation, and inhibition of tumor formation. (wikipedia.org)
  • cytotoxicity
  • The cytotoxicity and genotoxicity of PAH o-quinones are being studied in human lung cells as it pertains to causality in human lung cancer. (upenn.edu)
  • testosterone
  • Excessive weight: Obese men transform some of their testosterone into estrogen through the action of the enzyme aromatase , which is amply present in fat cells. (askdrray.com)
  • hormone
  • The authors suggested that 2-hydroxylated estrogens may mediate the action of the hormone parent, having properties distinct but relevant to the physiology or pathophysiology of a target organ. (aacrjournals.org)
  • 2-meOE2 has a higher binding affinity for sex hormone-binding globulin (SHBG) than E2 and 2-OH-E2 and has no affinity for the estrogen receptor. (wikipedia.org)