• Description: A sandwich quantitative ELISA assay kit for detection of Human Reactive Oxygen Species Modulator 1 (ROMO1) in samples from tissue homogenates, cell lysates or other biological fluids. (sebov-detection.com)
  • Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse Reactive oxygen species modulator 1 in samples from serum, plasma, tissue homogenates and other biological fluids. (sebov-detection.com)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of for Reactive Oxygen Species Modulator 1 (ROMO1)) in Tissue homogenates, cell lysates and other biological fluids. (sebov-detection.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of "Reactive Oxygen Species Modulator 1 (ROMO1)" in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (sebov-detection.com)
  • T cells and TCR will be obtained from blood and tumor tissue and tested for neoantigen specificity and tumor reactivity. (unimedizin-mainz.de)
  • Furthermore, the tissue specificity of these pathogenic mtDNA mutations might be associated with tRNA metabolism and nuclear modifier genes. (chinagene.cn)
  • The SPECIFICANCER team delves deeper into the biological laws that govern tissue specificity in cancer and reveals intricate webs of genetic interactions. (cancergrandchallenges.org)
  • The mechanisms underlying this tissue specificity in cancer remain mostly elusive. (cancergrandchallenges.org)
  • The Cancer Grand Challenges SPECIFICANCER team aims to clarify the complex mechanisms of tissue specificity, guided by an overarching philosophy that the tissue's pre-existing characteristics - including its epigenetics, microenvironment and cell-cell interactions - dictate whether a mutated gene can drive tumorigenesis. (cancergrandchallenges.org)
  • Central to the team's aims is the development of the first functional atlas of tissue specificity, a comprehensive map of the cellular networks that allow drivers to initiate cancers in certain tissues but not others. (cancergrandchallenges.org)
  • By unlocking the molecular mechanisms underpinning tissue specificity in tumours, the team would provide a foundation for rational interventions and therapeutic choices made by physicians and people with cancer throughout the patient journey. (cancergrandchallenges.org)
  • In a study recently published in Nature Communications , SPECIFICANCER unlocks new information about the tissue specificity of KRAS - which, despite being one of the most commonly mutated cancer-driving genes (oncogenes), drives only a few cancer types: lung, colorectal, pancreatic and endometrial cancers, and myelomas. (cancergrandchallenges.org)
  • The concept of co-mutations not only extends our basic understanding of cancer genetics and tissue specificity - it could also transform our ability to predict how a person would respond to certain drugs," Kevin explains. (cancergrandchallenges.org)
  • For example, BRAF is another oncogene with distinct patterns of tissue specificity. (cancergrandchallenges.org)
  • These duplicated genes maintain a high degree of sequence similarity, but differ greatly in their substrate specificity and tissue expression patterns. (biomedcentral.com)
  • The detoxification of the reactive by-products of normal metabolism cannot achieved by the systems outlined above. (bionity.com)
  • Immunotherapy based on the adoptive transfer of ex vivo expanded and activated autologous tumor-reactive lymphocytes can mediate tumor regression in cancer patients. (unimedizin-mainz.de)
  • The UniCAR is only activated upon cross-linking through a soluble tumor-targeting module carrying the UniCAR binding epitope, thereby achieving highest tumor specificity. (unimedizin-mainz.de)
  • These partially ionized gases deliver a therapeutic cocktail of reactive oxygen and nitrogen species safely at body temperature and without genotoxic side effects. (mdpi.com)
  • Enzo Life Sciences ROS-ID® ROS/RNS detection kit is designed to directly monitor real time reactive oxygen and/or nitrogen species (ROS/RNS) production in live cells using fluorescence microscopy. (enzolifesciences.com)
  • PTEN is a dual-specificity protein tyrosine phosphatase. (rcsb.org)
  • They reduce production of reactive oxygen species and promote endogenous antioxidant defense systems. (peptide.wiki)
  • Cotreatment of cells with the antioxidant, N-acetyl cysteine (NAC), or the p38MAPK inhibitor, SB203580 (SB), verified the activation specificity. (utmb.edu)
  • Examples of these specific detoxification systems are the glyoxalase system, which removes the reactive aldehyde methylglyoxal, [3] and the various antioxidant systems that eliminate reactive oxygen species. (bionity.com)
  • These systems therefore solve the specificity problem by possessing such broad substrate specificities that they metabolise almost any non-polar compound. (bionity.com)
  • The cellular formation of reactive oxygen species (ROS) represents an evolutionary ancient antimicrobial defense system against microorganisms. (frontiersin.org)
  • their malleability suggests complex mechanisms operate to control cellular dynamics and the specificity of cellular responses and functions extending well beyond the peroxisome itself. (tech-strategy.org)
  • This is since these species are derived from normal cellular constituents and usually share their polar characteristics. (bionity.com)
  • Thereafter, we investigated the Mg-deficient effects on gas exchange and chlorophyll a fluorescence in the upper and lower leaves, and Mg, reactive oxygen species (ROS) and methylglyoxal (MG) metabolisms in the roots, lower and upper leaves. (biomedcentral.com)
  • C) This publication is well suited to inform subsequent work aimed at developing new therapeutics for SCI, including but not limited to bioinformatics, apoptosis/nonapoptosis checkpoint inhibitors, and drug development for enhanced specificity and reduced side effects. (e-neurospine.org)
  • 11.Xia X J,Wang Y J,Zhou Y H,et al.Reactive oxygen species are involved in brassinosteroids-induced stress tolerance in cucumber[J].Plant Physiol,2009,150(2):801-814. (nefu.edu.cn)
  • Here, we report that SAA in plants requires at least two different signals: an autopropagating wave of reactive oxygen species (ROS) that rapidly spreads from the initial site of exposure to the entire plant and a stress-specific signal that conveys abiotic stress specificity. (unr.edu)
  • A safety concern of TCR gene transfer is the risk of pairing between introduced and the naturally expressed endogenous TCR chains, resulting in the generation of self-reactive T cells. (unimedizin-mainz.de)
  • The recently established non-invasive quantitative plate assay, which uses the fluorescent probes CM-H 2 DCFDA and CellTracker™ Green CMFDA and measures the fluorescence in whole zebrafish larvae, was applied to assess changes in reactive oxidative species (ROS) and glutathione (GSH) after exposure to the investigated pesticides. (springeropen.com)
  • ROS may originate from mitochondria and/or NADPH oxidases but the exact oxygen sensing mechanisms, as well as the question of whether increased or decreased ROS cause HPV, are under debate. (ersjournals.com)
  • In phase I, enzymes such as cytochrome P450 oxidases introduce reactive or polar groups into xenobiotics. (bionity.com)
  • One of the most significant current discussions in Cu biochemistry relates to the mechanisms of the positive and negative actions of Cu ions based on the generation of reactive oxygen species, including radicals that can interact with DNA molecules. (mdpi.com)
  • Traditionally the perspective on reactive oxygen species (ROS) has centered on the role they play as carcinogenic or cancer-causing radicals. (degruyter.com)
  • Free radicals and other reactive species play seminal roles in many psychological and pathophysiological processes. (enzolifesciences.com)
  • Being one of the strongest reductants and radical scavenger, it absorbs unstable oxygen, nitrogen, and sulphur-centered radicals. (pharmaceuticalintelligence.com)
  • Many of them are foreign to our some cases, xenobiotics are chemically reactive, and in other organism, so-called xenobiotics. (cdc.gov)
  • However, if it is engulfed, it manipulates the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system to release reactive oxygen species into the extracellular space to cause local damage. (medscape.com)
  • Both the ratio of apoE:C on the emulsions upon serum incubation and the alpha-helical content of apoE were inversely correlated with particle size, indicating that these factors may be involved in tile emulsion size-dependent receptor specificity in vivo. (zhangqiaokeyan.com)
  • Some of the early signaling events include alteration of intracellular Ca 2+ concentration, production of secondary signaling molecules such as inositol phosphate and reactive oxygen species (ROS) as well as activation of kinase cascades. (beds.ac.uk)
  • The inhalation, ingestion or cases, they are metabolized to yield reactive compounds. (cdc.gov)
  • 15.Hodges D M,Delong J M,Forney C F,et al.Improving the thiobarbituric acid-reactive-substances assay for estimating lipid peroxidation in plant tissues containing anthocyanin and other interfering compounds[J].Planta,1999,207(4):604-611. (nefu.edu.cn)
  • This new classification system rendered a 99.7% specificity and 85% sensitivity for diagnosis. (medscape.com)
  • This large ratio and the high specificity of DFO for trivalent metal ions discounted the possibility of inhibition of ROS generation by direct sequestration of divalent manganese , and implied the trace presence of a trivalent metal. (cdc.gov)
  • An underlying feature is increased production of reactive oxygen species. (ox.ac.uk)
  • Peroxisomes are metabolically plastic which is due in part to the enzyme-mediated production of and protection from reactive oxygen species (ROS) and the broad specificity in substrates these oxidative reactions confer [7]. (tech-strategy.org)
  • selection of hypermutable (mutator) increased risk for deamination [email protected] alleles based on alterations in DNA because of the production of reactive repair genes. (cdc.gov)
  • Unlike that of other anti- oxygen and nitrogen intermediates tuberculosis drugs, resistance to inside host macrophages. (cdc.gov)
  • Our data identify a specific reactive oxygen species→ASK1→p38-MAPK pathway in the heart and establish that ASK1 inhibitors protect the heart from hypertension-induced cardiac remodeling. (ox.ac.uk)
  • Our further investigations have shown that targeting glutaminase 1 reduces the stemness characteristics of HCC by upregulating reactive oxygen species and downregulating the Wnt/beta-catenin pathway [ 12 , 14 ]. (biomedcentral.com)
  • Moreover, microorganisms have developed defense mechanisms against ROS, an example for an arms race between species. (frontiersin.org)
  • ASK1 was activated during ischemia in adult rat hearts, but not on reperfusion, consistent with activation by moderate (not high) reactive oxygen species levels. (ox.ac.uk)
  • Our current aim was to assess the mechanism underlying tile receptors-specificity of apoE-carrying lipoproteins. (zhangqiaokeyan.com)
  • Specificity is a narrow range of substances that an imaging probe will react to. (cheekyscientist.com)
  • These enzyme complexes act to incorporate an atom of oxygen into nonactivated hydrocarbons, which can result in either the introduction of hydroxyl groups or N-, O- and S-dealkylation of substrates. (bionity.com)
  • Facile oxidation, by a peracid, of the parent [60]fulleropyrrolidine gave clean conversions into the product molecules, in which the tertiary amine is transformed into a quaternary amine bearing an oxygen atom. (cnrs.fr)
  • A third group was circulatory bilirubin may have a physi- recruited which consisted of 50 apparently ological function to protect against disease healthy control subjects (17 females and 23 processes that involve oxygen and peroxyl males). (who.int)
  • The apparent ability of manganese in its divalent form to promote formation of reactive oxygen species (ROS) within a cortical mitochondrial-synaptosomal (P2) fraction was completely abolished by the addition of one five hundredth of its molarity of desferroxamine (DFO), a trivalent metal chelator. (cdc.gov)
  • ASK1 was not activated by IL1β in cardiomyocytes and activation in perfused hearts was due to increased reactive oxygen species. (ox.ac.uk)
  • Here we describe how to perform a multiple-specificity study in peptide ligands using this technique. (peptide.wiki)
  • If you study popular areas such as ion flux or reactive oxygen species (ROS), there will be several options to select from. (cheekyscientist.com)
  • Ferric ion was able to dampen the reactive oxygen species-generating capacity of manganous chloride, whereas manganic ion markedly promoted this property attributed to manganous ion. (cdc.gov)