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  • renal
  • Finally, the current trends in research involving the role of stem cells, renal hibernation and the role of the innate immune response are highlighted with the aim of exploiting these mechanisms to achieve reduced kidney damage during ischemia. (numonthly.com)
  • Finally, the common thread behind all these approaches, namely empowering the renal mitochondria during ischemia is emphasized. (numonthly.com)
  • Treatment with exogenous H2S rescued CSE knockout mice from the injury and mortality associated with renal ischemia. (ox.ac.uk)
  • Last, the level of renal CSE mRNA at the time of organ procurement positively associated with GFR 14 days after transplantation. (ox.ac.uk)
  • rats
  • Sixty male Sprague-Dawley rats were randomly divided into sham-operated control, ischemia-reperfusion, and probucol-treated groups. (hindawi.com)
  • The one that follows shows how hydrogen was able to provide protection in Wistar rats against TIAs (transient ischemic events), where a section of the brain is briefly deprived of oxygen but not long enough for a complete stroke to take place. (life-enhancement.com)
  • In a test of cognitive function, hydrogen-treated rats performed better than the rats subjected to ischemia but not receiving hydrogen in the Morris water maze, where animals have to find a submerged platform in a container of water in order to climb onto the platform to discontinue treading water. (life-enhancement.com)
  • It took the hydrogen-treated rats a shorter length of time to find the hidden platform. (life-enhancement.com)
  • NADPH
  • Among them, NADPH oxidases are transmembrane enzymes dedicated to producing superoxide (O 2− ) by transferring an electron from NADPH to molecular oxygen and play important roles in cardiovascular pathophysiology. (mdpi.com)
  • neuroprotection
  • Of interest is the finding that neuroprotection conferred by nimesulide (reduction of infarct size and neurological deficits and improvement of rotarod performance) was also observed when treatment was delayed until 24 h after ischemia. (cogprints.org)
  • cardioprotective
  • 9 It is entirely conceivable that the combination of different cardioprotective principles at different time points during reperfusion might provide additive protective effects. (asahq.org)
  • 13 Thus, the impact of aging on the cardioprotective effects of β blockade, anesthetic postconditioning and their interaction with reactive oxygen species needs to be determined in future studies. (asahq.org)
  • neuronal
  • Using in vivo and neuronal OGD models, it was recently established that mTORC1 (mammalian Target of Rapamycin Complex-1), a protein complex downstream of PI3K-Akt pathway, is one of the players deregulated after ischemia and OGD. (frontiersin.org)
  • hydrogen
  • Hydrogen peroxide (H 2 O 2 ) significantly increased OPG production from ASCs in vitro, and OPG production from the ASCs transplanted into the ischemia-reperfusion-injured heart was also observed. (pubmedcentralcanada.ca)
  • While the animals in this study received hydrogen gas by inhalation, we have written earlier in this series (see, especially, our introductory article in the June 2012 issue of Life Enhancement magazine) on how hydrogen gas can be obtained conveniently (a gift of certain gut bacteria) in appropriate quantities and periods of time by consuming the LCFOS (long chain fructooligosaccharides) type of dietary fiber. (life-enhancement.com)
  • accumulation
  • Importantly, there was a significant inverse correlation between the level of ROS accumulation during ischemia and the latency until which the cell underwent ΔΨ m loss (r=−0.89). (ahajournals.org)
  • However, reducing the ROS accumulation during ischemia may not suffice to prevent cell death. (ahajournals.org)
  • Orchiectomy was performed to evaluate protein expression of E-selectin which is an endothelial cell adhesion molecule and mediates neutrophil adhesion to vascular endothelium, myeloperoxidase activity (a mark of neutrophil accumulation in the testis), malondialdehyde level (an indicator of reactive oxygen species), and spermatogenesis. (hindawi.com)
  • These findings indicate that probucol can protect testicular spermatogenesis by reducing overgeneration of reactive oxygen species by inhibiting E-selectin protein expression and neutrophil accumulation in the testis. (hindawi.com)
  • subsequently
  • This protocol will enable readers to successfully establish a porcine model of segmental intestinal ischemia and subsequently isolate and culture intestinal stem cells for the study of epithelial repair following injury. (jove.com)
  • stroke
  • i.p.) or vehicle were administered immediately after stroke and additional doses were given at 6, 12, 24, 36 and 48 h after ischemia. (cogprints.org)
  • cognitive
  • Injuries that occur in response to these events are often manifested as severe cognitive and motor disturbances over time. (mdpi.com)
  • heart
  • Current methods for real time detection of reactive oxygen species (ROS) in the intact heart have provided limited opportunity to distinguish between compartmental sources. (ahajournals.org)
  • The availability of a clinically approved ex situ heart perfusion device now allows DCD heart preservation in a normothermic beating state and minimizes exposure to incremental cold ischemia. (frontiersin.org)
  • The application of a tailored approach to DCD heart transplantation that focuses on organ resuscitation at the time of procurement, ex situ preservation, and pre-transplant assessments of organ viability has facilitated the successful clinical application of DCD heart transplantation. (frontiersin.org)
  • underwent
  • Eligible two hundred and thirty-eight consecutive patients (123 males, mean age 58.4 ± 10.0 years) who underwent first-time diagnostic coronary angiography were included in this study. (biomedcentral.com)
  • We demonstrated that IMD might be used as a biomarker to predict CAD and its severity in patients who underwent first time diagnostic coronary angiography. (biomedcentral.com)
  • perfusate
  • While there seems to be no 'stock standard' volume to use, it's worth taking the time to think about as a larger volume may affect the detection limit of elements you are wanting to measure in your perfusate. (adinstruments.com)
  • Keep in mind that over time, the H + buffering capacity, and energy sources of your perfusate will dwindle. (adinstruments.com)
  • metabolic
  • Reactive hyperemia after intermittent ischemia, which leads to vasodilation through regional metabolic changes as well as secondary endothelium-mediated smooth muscle cell relaxation. (ahajournals.org)
  • Furthermore
  • Furthermore, the elevated number of caspase-3 and neural/glial antigen 2 (NG-2) double-labeled positive cells was attenuated by DIDS after ischemia anoxic injury. (mdpi.com)
  • periods of time
  • The specimens are cut into small pieces followed by random distribution into a 48-well plate, containing RPMI medium in addition to a substance of interest such as cytokines or chemokines alone or in combination for defined periods of time. (jove.com)