CatalysisEnzymesBiocatalysisKineticsModels, MolecularSubstrate SpecificityCatalytic DomainModels, ChemicalBinding SitesQuantum TheoryCrystallography, X-RayProtein ConformationMutagenesis, Site-DirectedAmino Acid SequenceMolecular Sequence DataHydrogen-Ion ConcentrationThermodynamicsEnzyme StabilityEscherichia coliDecarboxylationHydrogenHydrogen BondingHistidineStatic ElectricityTetrahydrofolate DehydrogenaseStructure-Activity RelationshipHydrolysisProtein BindingOxidation-ReductionMolecular ConformationMutationRecombinant ProteinsSolventsProtein Structure, TertiaryStereoisomerismMolecular StructurePseudomonasSpectrophotometryAmino Acid SubstitutionProtonsMolecular Dynamics SimulationProtein Structure, SecondaryNADPOxidoreductasesCysteineChromatography, High Pressure LiquidSequence Homology, Amino AcidTemperatureComputer SimulationNuclear Magnetic Resonance, BiomolecularBase SequenceMagnetic Resonance SpectroscopyWaterProteinsBacterial ProteinsCloning, MolecularOxygenEnzyme ActivationAdenosine TriphosphateAmino AcidsMolecular WeightRNA, CatalyticAntibodies, CatalyticAspartic AcidMetalsMagnesiumSequence AlignmentConserved SequenceLysineProton-Translocating ATPasesNucleic Acid ConformationManganeseFlavinsArginineAlkenesProtein Structure, QuaternaryCyclizationDimerizationFlavin-Adenine DinucleotideDiethyl PyrocarbonateCrystallizationIminesNADAsparaginePhosphatesCircular DichroismChemistry, OrganicLewis AcidsElectron Spin Resonance SpectroscopyHemePalladiumZincEscherichia coli ProteinsCobamidesSpectrophotometry, UltravioletProtein FoldingAlanineIsomerismElectronsCations, Divalent