Proteasome Endopeptidase ComplexProteolysisUbiquitinBiodegradation, EnvironmentalUbiquitinationUbiquitin-Protein LigasesCysteine EndopeptidasesMolecular Sequence DataUbiquitinsMultienzyme ComplexesEndoplasmic Reticulum-Associated DegradationAmino Acid SequenceCell LineHydrolysisMutationProtein BindingKineticsProtein Processing, Post-TranslationalCells, CulturedRNA StabilityPeptide HydrolasesEndoplasmic ReticulumProteasome InhibitorsRNA, MessengerF-Box ProteinsCysteine Proteinase InhibitorsAutophagySignal TransductionProtein Structure, TertiaryPhosphorylationProtein TransportProtein StabilityHeLa CellsEndopeptidasesModels, BiologicalProtease InhibitorsBase SequenceProteinsTime FactorsSubstrate Specificitybeta-Transducin Repeat-Containing ProteinsCullin ProteinsI-kappa B ProteinsCell Line, TumorPolyubiquitinSKP Cullin F-Box Protein LigasesBlotting, WesternHEK293 CellsSaccharomyces cerevisiae ProteinsLigasesSaccharomyces cerevisiaeEndocytosisUbiquitin-Protein Ligase ComplexesDown-RegulationUbiquitin-Conjugating EnzymesElectrophoresis, Polyacrylamide GelCarrier ProteinsRecombinant Fusion ProteinsRecombinant ProteinsFibroblastsChromatography, High Pressure LiquidCell Cycle ProteinsEndopeptidase ClpHalf-LifeMembrane ProteinsEscherichia coliRNA, Small InterferingRNA InterferenceImmunoprecipitationBacterial ProteinsCalpainNuclear ProteinsImmunoblottingCell NucleusTranscription, GeneticDNA-Binding ProteinsOxidation-ReductionApoptosisExoribonucleasesTemperatureMolecular ChaperonesNF-kappa BGene Expression RegulationPeptide FragmentsProtein FoldingProto-Oncogene Proteins c-mdm2PlasmidsTranscription FactorsS-Phase Kinase-Associated ProteinsHydrogen-Ion ConcentrationPseudomonasBinding SitesCytoplasmProtein BiosynthesisOxygenasesAnaphase-Promoting Complex-CyclosomeCattleMolecular WeightCycloheximideLiver