DEAM can be acetylated to produce diethyl acetamidomalonate (useful in amino-acid synthesis), or can be added with 3-substituted 2,4-diketones to boiling acetic acid to afford in maximal yield variously substituted ethyl pyrrole-2-carboxylates of interest for porphyrin synthesis. (wikipedia.org)
The review is summarized and systematized the published data on the multicomponent reactions of ethyl trifluoroacetoacetate, carbonyl compounds (aldehydes and ketones), and nucleophilic reagents. (researchgate.net)
Synthesis6
A new method of synthesis of 2-(1,2-diferrocenylvinyl)benz- and azabenzimidazoles (3a-f), (4a-f) and 1'H,3'H(Me)-spiro-[(aza)benzimidazoline-2',3-(1,2-diferrocenylcyclopropenes)] (5a-f) via reactions of diferrocenyl(methylsulfanyl)cyclopropenylium iodide (1) with aromatic o -diamines (2a-f) in the presence of Et 3 N (80 °C - 82 °C ) is described. (scirp.org)
Ruthenium-catalysed olefin metathesis reactions have been playing an important role in various fields of organic synthesis in the past three decades. (beilstein-journals.org)
Diethyl malonate is an exceptionally versatile organic compound, widely acclaimed for its role in organic synthesis. (vedaoils.com)
Diethyl malonate finds significant application in pharmaceutical synthesis as it acts as a building block for numerous drugs. (vedaoils.com)
This approach to the synthesis of the diethyl alkyl(substituted pheny1)malonates which are intermediates in the synthesis of important biologically active barbiturates is easy, efficient, and currently the most general in the area. (smu.ca)
In the present work, the catalytic activity of [RuHCl(CO)(PPh3)3] in the homogeneous form and also supported on graphene oxide nanosheets in the efficient synthesis of phenacyl benzoate derivatives by the reaction of aldehydes with diethyl 2-(ethoxymethylene)malonate (DEMM) via hydrogen transfer is reported. (inorgchemres.org)
Alkyl4
The methylene group (−CH2−) in the middle of the malonic part of the diethyl malonate molecule is neighboured by two carbonyl groups (−C(=O)−). The hydrogen atoms on the carbon adjacent to the carbonyl group in a molecule is significantly more acidic than hydrogen atoms on a carbon adjacent to alkyl groups (up to 30 orders of magnitude). (wikipedia.org)
Nucleophilic substitution of chlorine in the ironcyclopentadienyl hexafluorophosphates of chlorobenzene, isomeric chlorotoluenes and dichlorobenzenes (1 ) with the anions generated from diethyl alkylmalonates (2) and (3) leads to the formation of ironcyclopentadienyl complexes of diethyl alkyl(substituted pheny1)malonates (4) and (5). (smu.ca)
The described complexes have been demetallated giving diethyl alkyl(substituted pheny1)malonates in >50% overall yield from the cations (1). (smu.ca)
The Krapcho decarboxylation of alkyl malonate derivatives has been adapted to aqueous microwave conditions. (organic-chemistry.org)
Ester1
Diethyl malonate, also known as DEM, is the diethyl ester of malonic acid. (wikipedia.org)
Sodium hydroxide1
The use of a conventional base may give base hydrolysis products - for example, sodium hydroxide would simply produce sodium malonate and the alcohol, while other alkoxide salts will cause scrambling by transesterification. (wikipedia.org)
Compounds3
Diethyl malonate is used in the preparation of several medicinally useful compounds including vigabatrin, phenylbutazone, nalidixic acid, and rebamipide. (wikipedia.org)
The Bischler-Napieralski reaction of N-(5-benzyloxy-3, 4-dimethoxyphenethyl)-3-(3-ethoxycarbonyl-4-methoxyphenyl) propionamide (XX) also gave a mixture of 3, 4-dihydroisoquinolines which was derived to the 1, 2, 3, 4-tetrahydroisoquinolines and separated into 8-hydroxy (XXIV) and 6-hydroxy (XXV) compounds. (go.jp)
Diethyl N -Boc-iminomalonate, prepared on multi-gram scale, served as a stable and highly reactive electrophilic glycine equivalent which reacted with organomagnesium compounds affording substituted aryl N -Boc-aminomalonates. (organic-chemistry.org)
Aryl2
A high-efficiency and practical Cu-catalyzed cross-coupling of readily available aryl bromides (or chlorides) with malonates provides versatile α-aryl-esters. (organic-chemistry.org)
The reaction tolerates a variety of aryl and aliphatic substitutions. (organic-chemistry.org)
Intermediates1
Tyrosine residues act as intermediates in proton coupled electron transfer reactions (PCET) in proteins. (rsc.org)
Acetic acid1
Diethyl malonate can be nitrosated with excess sodium nitrite in acetic acid to afford diethyl oximinomalonate, catalytic hydrogenolysis of which in ethanol over Pd/C affords diethyl aminomalonate (DEAM). (wikipedia.org)
Esters1
The recent advances in the study of the Hantzsch and Biginelli reactions involving polyfluoroalkyl-3-oxo esters are analyzed. (researchgate.net)
Catalytic1
Diverse reaction capabilities from Conventional batch reactions to Fixed-bed catalytic, Photo-reactions, Microwave, high pressure-high temperature, electrolytic & continuous flow reactions. (clearsynth.com)
Anion2
An excess of the anion employed in reactions with the m- and p-dichlorobenzene complexes leads to substitution of both chlorine atoms and formation of isomeric phenylenedimalonate complexes (8). (smu.ca)
For salt additives, a strong correlation was found between the pKa of the anion and the reaction rate, suggesting a straightforward base-catalyzed hydrolysis. (organic-chemistry.org)
Derivatives1
Several pesticides are also produced from diethylmalonate, including sethoxydim and the derivatives of 2-amino-4-chloro-6-methoxypyrimidine. (wikipedia.org)
Carbon1
The anhydrous ethanol co-vaporized with diethyl phthalate and sodium metal is added dropwise to the mixture of diethyl malonate, carbon tetrachloride and magnesium, heated to start the reaction, and the temperature is controlled to smooth the reaction. (everychina.com)
Yield2
The present approach shows the significant outcomes such as yield up to 94%, catalyst‐free reaction, easy workup procedure and shorter period of reaction time. (researchgate.net)
A base-catalyzed Michael-type addition of sodium diethyl malonate to N -Boc-α-amidoalkyl- p -tolyl sulfones in tetrahydrofuran followed by hydrolysis of the adducts in refluxing 6 M aqueous hydrochloric acid affords β 3 -amino acid hydrochlorides in high yield and excellent purity. (organic-chemistry.org)
Mixture3
The mixture of XI and XII was submitted to the Mannich reaction and the product was methylated with diazomethane to 1, 2, 3, 10, 11-pentamethoxyprotoberberine (XIV). (go.jp)
After 2hr at 0 °C, the reaction mixture was stirred at RT for overnight. (ambeed.com)
The reaction mixture was diluted with H20 (640 mL) and 2M NaOH (500 mL). (ambeed.com)
Functional1
With its exceptional reactivity and functional groups, diethyl malonate plays a pivotal role in the design and development of intricate organic structures. (vedaoils.com)
Undergoes1
The reaction involves the formation of an enolate intermediate, which then undergoes a nucleophilic attack by the electrophilic benzaldehyde. (syntheticchemicallab.com)
Benzaldehyde1
55 It was found that the solventfree reaction of ETFAA 1a, benzaldehyde, and ammonium acetate at 100 C proceeded with the loss of the water molecule to aff ord partially dehydrated 2-hydroxy-2,6-bis(trifl uoromethyl)-1,2,3,4-tetrahydropyridine-3,5-dicarboxylate 6. (researchgate.net)
Decarboxylation1
At the heart of its significance lies its remarkable ability to engage in diverse reactions, including esterification and decarboxylation. (vedaoils.com)
Aqueous1
The reaction is typically carried out in an aqueous medium, and the resulting product is purified by recrystallization or distillation. (syntheticchemicallab.com)
The utility of this chemistry is further demonstrated by the tests of the novel catalysts (up to 10 −2 mol %) in different metathesis reactions such as cross metathesis (CM), ring-closing metathesis (RCM) and ring-opening cross metathesis (ROCM). (beilstein-journals.org)
Chemistry needs reaction, friendship needs interaction, while trust lies in between. (kairunt.com)
Catalyst1
In these reactions, C-C and sp2-C-O bonds were formed by applying the ruthenium catalyst. (inorgchemres.org)
Slowly1
Then add anhydrous diethyl ether, heat for 1h, add the diethyl ether solution of phenylacetyl chloride (add slowly, not to make the reaction too intense). (everychina.com)
Nucleophilic1
Several kinds of 2-substituted quinoline 1-oxides were prepared by the reaction of 2-chloroquinoline 1-oxide and lepidine 1-oxide with various nucleophilic reagents. (go.jp)
Base2
The extent of resonance stabilization of this compound's conjugate base is suggested by the three resonance forms below: Diethyl malonate is produced from the reaction of the sodium salt of chloroacetic acid with sodium cyanide, which produces the nitrile. (wikipedia.org)
The carbanion (2) formed by reacting diethyl malonate (1) with a suitable base can be alkylated with a suitable electrophile. (wikipedia.org)
Design1
Nature knows best: an amazing reaction cascade is uncovered by design and discovery. (academicinfluence.com)
Production2
Diethyl malonate is a valuable component in the production of agrochemicals. (vedaoils.com)
The production of nylon comes from a reaction with hexamethylene diamine, also supplied by Parchem. (crefap.org)
Approach1
A novel approach to study PCET reactions illustrates the importance of solvent-slaved protein motions in copper nitrite reductase catalysis. (rsc.org)
Water1
After the reaction is completed, cool and add water, separate the oil layer, and evaporate the diethyl ether under reduced pressure to obtain diethyl(phenylacetyl)malonate. (everychina.com)
Products1
In the case of medical products (CE/IVD), the buyer, if he resells the products, must fulfill his obligations regarding material and reaction control, traceability, post-marketing control at his own risk. (atmemi.pics)