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  • large neutral
  • We recently have identified the vertebrate proteins which mediate Na+-independent exchange of large neutral amino acids corresponding to transport system L. This transporter consists of a novel amino acid permease-related protein (LAT1 or AmAT-L-lc) which for surface expression and function requires formation of disulfide-linked heterodimers with the glycosylated heavy chain of the h4F2/CD98 surface antigen. (tcdb.org)
  • Levodopa is rapidly absorbed from the proximal small intestine by the large neutral amino acid (LNAA) transport carrier system. (selfdecode.com)
  • Protein
  • He is given nicotinic acid and placed on a high protein diet and quickly recovers. (medbullets.com)
  • Protein digestion occurs by hydrolysis of the peptide bonds between amino acids. (karelsavry.us)
  • The result of the combined action of the endopeptidases is that the large protein molecules are broken down into a number of smaller polypeptides with a large number of amino and carboxy terminals for the exopeptidases to act on. (karelsavry.us)
  • peptide
  • In denatured proteins most of the peptide bonds are accessible to digestive enzymes, and consequently denatured (i.e. cooked) proteins are more readily hydrolysed to their constituent amino acids. (karelsavry.us)
  • Endopeptidases cleave proteins by hydrolysing peptide bonds between specific amino acids throughout the molecule. (karelsavry.us)
  • Exopeptidases remove amino acids one at a time from either the amino or carboxyl end of the molecule, again by the hydrolysis of the peptide bond. (karelsavry.us)
  • The natriuretic peptide (NP) family is comprised of four peptide hormones, each with a common 17 amino acid ring structure. (ifcc.org)
  • This 32-amino acid peptide also contained a 17-amino acid ring (Figure 1). (ifcc.org)
  • Metabolism
  • Inborn errors of amino acid metabolism are chiefly inherited as autosomal recessive conditions. (medassignments.com)
  • In contrast, according to NHANES III, the average diet in the United States is acid-producing, with an NEAP of positive 48 mEq/d.2 This is the equivalent of 4.9 g HCl being added to our metabolism every day. (raypeatforum.com)
  • kidney
  • Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. (uniprot.org)
  • The ANP gene is also expressed in the kidney, where alternative processing of the precursor generates a 32-amino acid substance- urodilatin, one of the factors that regulate sodium and water handling in the kidney. (ifcc.org)
  • second, via degradation by the zinc-containing enzyme, neutral endopeptidase, a non-specific membrane-bound enzyme present in the kidney and vascular beds that cleaves NPs and opens the ring structure, thus inactivating the peptides. (ifcc.org)
  • 95% of an administered oral dose of levodopa is pre-systemically decarboxylated to dopamine by the L-aromatic amino acid decarboxylase (AAAD) enzyme in the stomach, lumen of the intestine, kidney, and liver. (selfdecode.com)
  • Aminoaciduria
  • Bröer reviews Hartnup disease, an autosomal disease first discovered in 1956, characterized by a neutral aminoaciduria accompanied by a photo-sensitive rash and cerebellar ataxia. (medbullets.com)
  • Finally, there is dicarboxylic aminoaciduria, which is due to a defective transporter for anionic amino acids. (medbullets.com)
  • serum
  • Although both 2-wk-old Cbs(-/-) and Cth(-/-) mice had normal renal architecture, their serum/urinary amino acid profiles largely differed from wild-type mice. (jove.com)