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  • type 2 diabet
  • The obese Zucker rat is a model of hyperinsulinemia and type 2 diabetes. (ahajournals.org)
  • A novel potassium channel opener compound, NN414, selective for the SUR1/Kir6.2 subtype of the ATP-sensitive potassium channel, was used to examine the effect of reducing β-cell workload in the male Vancouver diabetic fatty (VDF) Zucker rat model of mild type 2 diabetes. (diabetesjournals.org)
  • We examined the levels of advanced glycation end products (AGEs), nuclear factor-kappaB (NF- B) activation and inducible nitric oxide synthase (iNOS) expression in LECs during cataract development using the Zucker diabetic fatty (ZDF) rat, an animal model of type 2 diabetes. (hindawi.com)
  • Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes. (cbdepot.eu)
  • These data indicate that ZDSD rats develop many of the neural complications associated with type 2 diabetes and are a good animal model for preclinical investigations of drug development for diabetic neuropathy. (hindawi.com)
  • glucose metabolism
  • Figure 1: Age-dependent evolution of glucose metabolism in ZDF rats. (pelvipharm.com)
  • Exercise training or chronic treatment with angiotensin-converting enzyme (ACE) inhibitors can ameliorate glucose intolerance, insulin resistance of muscle glucose metabolism, and dyslipidemia associated with the obese Zucker rat. (physiology.org)
  • In this context, the present study was undertaken to determine whether 6 wk of exercise training and 6 wk of administration of the ACE inhibitor trandolapril, in combination, could improve the glucose intolerance, insulin resistance of muscle glucose metabolism, and dyslipidemia (as reflected by plasma free fatty acid levels) associated with the obese Zucker rat to a greater degree than either intervention used individually. (physiology.org)
  • Blood Glucose
  • Rosiglitazone treatment (10 mg/kg orally, 4 weeks) caused significant decreases in plasma insulin, blood glucose, and blood pressure while causing an increase in renal sodium excretion compared with untreated obese rats. (ahajournals.org)
  • We then performed selective breeding using the fa/fa male rats that exhibited relatively high blood glucose levels at 10 weeks of age, resulting in establishment of a diabetic strain that we designated Hos:ZFDM- Lepr fa (ZFDM). (hindawi.com)
  • improves
  • This proves that pioglitazone treatment improves healthy follicle growth in these PCO model rats with insulin resistance. (biomedcentral.com)
  • Hege Wergedahl, Kjetil Berge, Pavol Bohov, Karl-Johan Tronstad, Lise Madsen and Rolf K. Berge, " Long Term Treatment with Tetradecylthioacetic Acid Improves the Antioxidant Status in Obese Zucker (fa/fa) Rats", Drug Metabolism Letters (2008) 2: 138. (eurekaselect.com)
  • Rosiglitazone
  • In rosiglitazone-treated obese rats, the inhibitory effect of dopamine on Na,K-ATPase was significantly restored. (ahajournals.org)
  • Here, we used the insulin-sensitizing agent rosiglitazone to investigate the cellular mechanisms linking insulin resistance in the obese Zucker rat heart with increased susceptibility to ischemic injury. (ox.ac.uk)
  • Rats were treated for 7 or 14 days with 3 mg/kg per os rosiglitazone. (ox.ac.uk)
  • Rosiglitazone treatment normalized the insulin resistance and restored GLUT4 protein levels in obese rat hearts. (ox.ac.uk)
  • Glucose uptake during ischemia was also normalized by rosiglitazone treatment, thereby preventing the greater loss of ATP and restoring recovery of contractile function to that of lean rat hearts. (ox.ac.uk)
  • We conclude that rosiglitazone treatment, by normalizing glucose uptake, protected obese rat hearts from ischemic injury. (ox.ac.uk)
  • The vascular dysfunction in Zucker diabetic fatty (ZDF) rats was evaluated at different ages along with the effect of treatment with rosiglitazone (Rosi) on endothelial function and mechanical remodeling. (biomedcentral.com)
  • angiotensin
  • Gudbrandsen, O.A. Cod Residual Protein Prevented Blood Pressure Increase in Zucker fa/fa Rats, Possibly by Inhibiting Activities of Angiotensin-Converting Enzyme and Renin. (mdpi.com)
  • Angiotensin-converting enzyme activity in retinas of streptozotocin-induced and Zucker diabetic rats. (arvojournals.org)
  • The effect of angiotensin II (AngII) on the activity of Na,K-ATPase in retinas from normal rats was also studied in vitro. (arvojournals.org)
  • Oleic Acid
  • Linoleic-acid-fed rats (PL and SL) exhibited reduced insulin-immunoreactive staining of the pancreatic islets, enhanced macrophage infiltration in adipose tissue, and an elevated plasma tumor necrosis factor-alpha concentration when compared with oleic-acid-fed rats (PO and SO). (biomedsearch.com)
  • complications
  • The completion of the experiments proposed in this application will allow for a fuller, more integrated understanding of the microcirculatory complications associated with Syndrome X and the ability to ameliorate developing impairments in the Zucker rat than presently exists. (grantome.com)
  • The Zucker Diabetic Fatty (ZDF) rat fed a lipid-rich diet, closely mimics human adult onset of type II diabetes and its related complications. (pelvipharm.com)
  • obese rat
  • Yohimbine reversed clonidine effects equipotently in lean and obese rat islets (pA2 values of 7.48 +/- 0.57 vs 7.43 +/- 0.58). (islandscholar.ca)
  • At 12 months of age, obese rat hearts were insulin resistant with decreased GLUT4 protein expression. (ox.ac.uk)
  • During ischemia, glucose uptake was lower and depletion of ATP was greater in obese rat hearts, thereby significantly impairing recovery of contractile function during reperfusion. (ox.ac.uk)
  • Gynostemma pentaphyllum did not significantly reduce glucose levels at 120 min in the lean strain, in contrast to the 20% decrease seen in the obese rat. (gynostemma.org)
  • significantly
  • Previously, we have reported that a high-isoflavone soy protein isolate (HISPI) diet is associated with significantly heavier body weights and reduced liver steatosis in obese Zucker rats (OZR) compared to a casein diet. (rsc.org)
  • Anandamide (10 µM, 2h) significantly improved the vasorelaxant responses to acetylcholine in aortae and femoral arteries from Zucker Diabetic Fatty rats but not Zucker lean rats. (cbdepot.eu)
  • By contrast, anandamide (1 µM, 2h) significantly blunted acetylcholine-induced vasorelaxation in third-order mesenteric arteries (G3) from Zucker Diabetic Fatty rats. (cbdepot.eu)
  • The activity of ACE in retinas obtained from the same groups of STZ and ZDF rats was significantly reduced at all time points examined in both models (-43% and -55%, respectively). (arvojournals.org)
  • In a glucose tolerance test in obese and lean Zucker rats pretreatment with Gynostemma pentaphyllum 250 mg/kg demonstrated glucose levels were significantly less 2 hours post challenge (20%) in the Gynostemma pentaphyllum obese rats compared to the control group. (gynostemma.org)
  • attributable
  • Micropuncture studies revealed that the increase in GFR in obese Zucker rats was attributable to the increases in the single nephron plasma flow rate and glomerular transcapillary hydraulic pressure. (kjim.org)
  • femoral
  • Endothelium-dependent vasorelaxation of the femoral artery was blunted at low doses in ZDF rats at 11 weeks of age and attenuated at all doses in ZDF rats at 19 weeks of age. (biomedcentral.com)
  • chronic
  • Chander PN, Gealekman O, Brodsky SV, Elitok S, Tojo A, Crabtree M, Gross SS, Goligorsky MS (2004) Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen. (springer.com)
  • Glycolysis
  • The insulin-resistant Zucker fa/fa rat has elevated hepatic glycolysis and activities of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 (PFK2). (physiology.org)
  • Cumulatively, this study provides support for coordinate roles for glucokinase and PFK2 in the elevated hepatic glycolysis in fa/fa rats. (physiology.org)
  • food intake
  • In this study, dehydroepiandrosterone's effect at decreasing food intake and body weight in the obese Zucker rat was investigated. (diabetesjournals.org)
  • Food-intake and body weight gain was also lower in rats supplemented with HCA-SX compared to their control counterparts. (springer.com)
  • However, unlike liraglutide-treated rats, NRTN-mediated improvements were not associated with reduced body weight or food intake. (diabetesjournals.org)
  • Vascular
  • Vascular reactivity of epineurial arterioles, blood vessels that provide circulation to the sciatic nerve, to acetylcholine and calcitonin gene-related peptide was impaired in ZDSD rats. (hindawi.com)