• Myocardial ischemia-reperfusion (I/R) injury is an important health concern in myocardial infarction and situations such as angioplasty and cardiac surgeries. (usask.ca)
  • A myocardial infarction, also known as a heart attack, often result in the formation of fibrosis. (wikipedia.org)
  • A myocardial infarction is an ischemic event, or a restriction of blood flow to body tissue, such as by atherothrombosis. (wikipedia.org)
  • The tissue destroyed by the infarction is replaced with non-functioning fibrosis, restoring some of the structural integrity of the organ but resulting in impaired myocardial function. (wikipedia.org)
  • This timing makes postconditioning relevant from the clinical perspective, in which limitation of irreversible myocardial damage following a coronary thrombosis and ST-elevation myocardial infarction remains a major objective [3]. (justia.com)
  • 4] disclose in Cardiovasc Drugs Ther (2007) 21:253-256, that GLP-1 alone did not decrease myocardial infarction but in combination with the GLP-1 breakdown inhibitor valine pyrrolidide (VP) a significant reduction in myocardial infarction occurred. (justia.com)
  • The administration of bone marrow-derived mesenchymal stem cells (BMSCs) is emerging as a promising approach for I/R injury-induced myocardial infarction due to its multiple differentiation potential(7, 8). (researchsquare.com)
  • These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction. (elifesciences.org)
  • In cardiovascular diseases such as atherosclerosis and its main sequelae, ischemic stroke and acute myocardial infarction (AMI), macrophage functions are central to both disease development and healing. (elifesciences.org)
  • Cell death occurs and finally leads to myocardial infarction. (biomedcentral.com)
  • Cell apoptosis occurs, such as by activation of caspase-3 activity, and finally leads to myocardial infarction [ 1 ]. (biomedcentral.com)
  • Acute myocardial infarction (AMI) is a major cause of morbidity and mortality worldwide. (radcliffecardiology.com)
  • However it causes unwanted side effects, and may induce myocardial infarction [ 4 ]. (walshmedicalmedia.com)
  • Myocardial infarction is a common heart disease, which is myocardial necrosis caused by acute and persistent coronary ischemia and hypoxia. (nmn-bio.com)
  • Although rapid restoration of blood flow and reperfusion is the main measure in the treatment of myocardial infarction, myocardial cells that are ischemic for a specific period of time may suffer progressive damage or even death when their blood supply is restored. (nmn-bio.com)
  • NMN ( Nicotinamide Mononucleotide ) is an important coenzyme that is considered to have potential in improving myocardial infarction and promoting recovery of cardiac function. (nmn-bio.com)
  • Research shows that vesicles secreted by NMN-treated stem cells (referred to as NVs) may become a new method for treating myocardial infarction. (nmn-bio.com)
  • These N-Vs vesicles not only improved cardiac function after myocardial infarction in rats, but also promoted blood vessel formation and reduced tissue damage. (nmn-bio.com)
  • In 2023, a study published by Nanjing Medical University in 'Stem Cell Reviews and Reports' proved that NMN can improve myocardial infarction and promote angiogenesis. (nmn-bio.com)
  • Mesenchymal stem cell-derived extracellular vesicles are cardioprotective in acute myocardial infarction. (nmn-bio.com)
  • Aims: The purpose of this study was to determine the feasibility of a new positron emission tomography (PET) imaging approach using an 18 F-labelled α v β 3 integrin antagonist ( 18 F-Galacto-RGD) to monitor the integrin expression after myocardial infarction. (elsevierpure.com)
  • Conclusion: Regional 18 F-Galacto-RGD accumulation suggests up-regulation of α v β 3 integrin expression after myocardial infarction, which peaks between 1 and 3 weeks and remains detectable until 6 months after reperfusion. (elsevierpure.com)
  • abstract = "Aims: The purpose of this study was to determine the feasibility of a new positron emission tomography (PET) imaging approach using an 18F-labelled αvβ3 integrin antagonist (18F-Galacto-RGD) to monitor the integrin expression after myocardial infarction. (elsevierpure.com)
  • The cardioprotective effects of Nar are well documented in the healthy state, in myocardial infarction, and in daunorubicin-, doxorubicin-, and high-glucose-induced cardiotoxicity [ 2 , 12 - 17 ]. (hindawi.com)
  • The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and lowincome countries necessitates the development of myocardial salvaging/protection interventions, to be applied alongside standard reperfusion therapies. (sun.ac.za)
  • Patients often present with chest pain, have ST-segment elevation on electrocardiogram, and elevated cardiac enzyme levels consistent with a myocardial infarction. (medscape.com)
  • Stroke and myocardial infarction are among the most common causes of mortality and disability in the world. (cdc.gov)
  • Myocardial I/R injury may induce cell apoptosis and autophagy by activating oxidative stress and upregulating inflammatory mediators, ultimately resulting in irreversible fibrotic damage ( 3 ). (spandidos-publications.com)
  • The myocardial apoptosis and inflammation have been recognized as features of I/R injury. (hindawi.com)
  • Wogonin could suppress apoptosis in rats experienced myocardial I/R [ 25 ]. (hindawi.com)
  • Compared to rats, AGS display robust myocardial ischemic tolerance following DHCA (both reduced myocardial necrosis and apoptosis). (duke.edu)
  • The results demonstrated that Vitexin pretreatment significantly reduced neuronal apoptosis, and inhibited caspase‑3 activity, apoptosis regulator BAX protein expression and malondialdehyde levels in sevoflurane‑induced newborn rats. (spandidos-publications.com)
  • Together, the results of the current study suggest that the protective effect of vitexin reduces sevoflurane‑induced neuronal apoptosis through HIF‑1α‑, VEGF‑ and p38‑associated signaling pathways in newborn rats. (spandidos-publications.com)
  • In addition, PEMF treatment also reduced the apoptosis of myocardial cells by up-regulating the expression of anti-apoptosis protein B-cell lymphoma 2 (Bcl-2) and down-regulating the expression of pro-apoptosis protein (Bax). (pemfglobal.com)
  • Res effectively suppress the cardiomyocytes hypertrophy and apoptosis induced by ISO, characterized by the reduction of the myocardial cell surface area, the ANP gene expression, the LDH and MDA leakage amount and the rate of cell apoptosis, while decrease of the protein expression of GRP78, GRP94 and CHOP, and reverse the expression of Bcl-2 and Bax. (karger.com)
  • In summary, Res treatment effectively suppressed myocardial hypertrophy and apoptosis at least partially via inhibiting ER stress. (karger.com)
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
  • Mitochondrial dysfunction and oxidative damage are major contributors to myocardial apoptosis during I/R injury. (wustl.edu)
  • All of these factors are known to result in myocardial apoptosis(5) and the acceleration of allograft rejection or chronic allograft dysfunction. (researchsquare.com)
  • through bioinformatics, we found that nlrp3 , gsdmd , il-1\xce\xb2and other hub proteins of pyroptosis were highly expressed in ivdd sd rats, and network pharmacology discovered that dhjsd may control cellular senescence, apoptosis, and pyroptosis in order to treat ivdd. (brain-knowledge-engine.org)
  • Reperfusion injury refers to the tissue damage inflicted when blood flow is restored after an ischemic period of more than about ten minutes. (benbest.com)
  • Cryonics patients frequently experience ischemic & reperfusion injury between the time when the heart stops and cryostorage begins. (benbest.com)
  • In this article I attempt to evaluate the nature & extent of ischemic & reperfusion injury -- primarily focused on the impact for cryonics (although certainly relevant to stroke and cardiac arrest). (benbest.com)
  • I focus my attention on ischemic/reperfusion injury to the brain. (benbest.com)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • The role of glycogen depletion prior to prolonged ischemia was examined as a potential mechanism of ischemic preconditioning. (utmb.edu)
  • In a retrospective study, the relationships between the time of day the animals were sacrificed, pre-ischemic myocardial glycogen content, and post-ischemic functional recovery were assessed in non-conditioned and ischemically preconditioned hearts. (utmb.edu)
  • Preconditioned hearts received 5 min of ischemia followed by a 5-min recovery period prior to the 40-min ischemic period. (utmb.edu)
  • However, time of day did not correlate significantly with post-ischemic recovery of heart rate x developed pressure (HR x DP) or end-diastolic pressure (EDP) in either the non-conditioned or preconditioned hearts. (utmb.edu)
  • The results imply that the cardioprotection of ischemic preconditioning cannot be explained solely by myocardial glycogen depletion. (utmb.edu)
  • Asimakis, GK 1996, ' Myocardial glycogen depletion cannot explain the cardioprotective effects of ischemic preconditioning in the rat heart ', Journal of Molecular and Cellular Cardiology , vol. 28, no. 3, pp. 563-570. (utmb.edu)
  • The re-establishing of blood flow to an ischemic zone is called reperfusion [ 1 ]. (biomedcentral.com)
  • 2002 - defended ahead of time his PhD thesis in Pathologic Physiology entitled «Comparative evaluation of the cardioprotective efficacy of local and distant ischemic adaptation of the myocardium» dedicated to myocardial protection against ischemia injury in the experiment. (almazovcentre.ru)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • Ischemia-reperfusion injury (IRI) is a syndrome affecting the myocardium upon blood flow restoration following a sufficiently long interruption, such as encountered in a coronary thrombosis or heart surgery [1,2]. (justia.com)
  • However, focal accumulation in the infarct area started at day 3 (uptake ratio = 1.91 ± 0.22 vs. remote myocardium), peaked between 1 (3.43 ± 0.57) and 3 weeks (3.43 ± 0.95), and decreased to 1.96 ± 0.40 at 6 months after reperfusion. (elsevierpure.com)
  • 7 The metabolism of fatty acids and glucose undergoes adaptive changes in the myocardium due to ischemia-reperfusion injury after cardiopulmonary resuscitation (CPR). (dirjournal.org)
  • Immature calcium handling in immature myocardium raises intracellular calcium concentrations after ischemia and reperfusion. (medscape.com)
  • AIMS: Hypoxia-inducible factor-1 (HIF-1) has been reported to promote tolerance against acute myocardial ischaemia-reperfusion injury (IRI). (ox.ac.uk)
  • Some authors have proposed a unifying hypothesis stating that in susceptible individuals, notably women, neurohormonal stimulation results in acute myocardial dysfunction, as reflected by the characteristic left ventricular wall-motion abnormality of TCM. (medscape.com)
  • The findings of the present study indicated that inhibition of miR‑132 may ameliorate myocardial I/R injury by inhibiting oxidative stress and pyroptosis through activation of PGC‑1α/Nrf2 signalling by targeting SIRT1. (spandidos-publications.com)
  • It has been reported that SIRT1/peroxisome proliferator-activated receptor gamma coactivator (PGC)-1α/nuclear factor erythroid-2-related factor 2 (Nrf2) signalling can mediate oxidative stress, which plays an important role in myocardial I/R injury ( 14 , 15 ). (spandidos-publications.com)
  • Myocardial antioxidant and oxidative stress changes due to sex hormones. (phypha.ir)
  • Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
  • These findings were further confirmed when HIF-1 stabilization in the rat and murine heart resulted in smaller myocardial infarct sizes (both in vivo and ex vivo), decreased mitochondrial oxidative stress, and inhibited MPTP opening following IRI, effects which were also found to be dependent on HKII. (ox.ac.uk)
  • Post-resuscitation myocardial injury is evidently due to oxidative stress, calcium overload, neutrophil accumulation, microvascular damage, and abnormal energy metabolism, among other causes. (dirjournal.org)
  • Facilitation of glucose utilization contributes to the protective effect of AKT signaling to reduce infarct size and improve myocardial function in a heart subjected to I/R [ 15 ]. (biomedcentral.com)
  • We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-γ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)
  • After heart transplantation, the donor heart preservation with normoxic CM was associated with shorter re-beating time, histopathological scores, and left ventricular systolic diameter, higher ejection fraction, and fractional shortening of transplanted hearts. (researchsquare.com)
  • Meanwhile, the myocardial injury marker CTNI was upregulated considerably ( P = 0.014, P = 0.021), and the left ventricular function of the animal heart also markedly deteriorated with the downregulation of ATP after CPR. (dirjournal.org)
  • The undifferentiated clonal cell line, H9c2, derived from left ventricular rat heart tissue, has been extensively used in cardiovascular research. (sun.ac.za)
  • Patients with TCM are found to shift toward the glucose pathway despite relatively normal myocardial perfusion and lack of ischemia in left ventricular segments. (medscape.com)
  • Our laboratory combines comparative biology approaches in multiple organisms with translational functional genomics to study the mechanisms underlying perioperative myocardial injury, with a particular emphasis on endogenous cardioprotective responses involving attenuation of nuclear factor-kappa B regulated inflammatory signaling and changes in myocardial fuel utilization. (duke.edu)
  • Interestingly, this winter cardioprotective phenotype is associated not only with suppression of metabolic demand, but also with a fuel shift from myocardial carbohydrate to fatty acid (FA) metabolism. (duke.edu)
  • The molecular events by which this precisely controlled increased reliance on myocardial FA utilization is cardioprotective in hibernators while it adversely impacts post-I/R cardiac efficiency and function in non-hibernators represent a significant knowledge gap. (duke.edu)
  • Furthermore, the hibernator cardioprotective phenotype is also associated with reduced myocardial NF-κB activity, reduced expression of downstream cytokines and neutrophil extravasation following cardiac surgery. (duke.edu)
  • Comparative evaluation of metformin and liraglutide cardioprotective effect in rats with impaired glucose tolerance. (almazovcentre.ru)
  • Inhibition of Sema4D attenuates pressure overload-induced pathological myocardial hypertrophy via the MAPK/NF-\\xce\\xbaB/NLRP3 pathways. (brain-knowledge-engine.org)
  • Dexmedetomidine abates myocardial ischemia reperfusion injury through inhibition of pyroptosis via regulation of miR-665/MEF2D/Nrf2 axis. (brain-knowledge-engine.org)
  • METHODS AND RESULTS: Stabilization of myocardial HIF-1 was achieved by pharmacological inhibition of prolyl hydroxylase (PHD) domain-containing enzyme using GSK360A or using cardiac-specific ablation of von Hippel-Lindau protein (VHL(fl/fl)) in mice. (ox.ac.uk)
  • Conclusions: SAHA prevents I/R induced-mitochondrial dysfunction and loss, and reduces myocardial ROS production when given before or after the ischemia. (wustl.edu)
  • In heart transplantation, donor hearts inevitably suffer from ischemia/reperfusion (I/R) injury, which leads to primary graft dysfunction and affects patients' survival rate. (researchsquare.com)
  • To investigate the feasibility and usefulness of 2-deoxy-2-( 18 F)-fluoro-D-glucose positron emission tomography/computed tomography [( 18 F)-FDG PET/CT] as a novel examination in the surveillance of abnormal myocardial energy metabolism and cardiac dysfunction after cardiopulmonary resuscitation (CPR). (dirjournal.org)
  • Myocardial dysfunction remains a leading problem in the early period following the return of spontaneous circulation (ROSC) after cardiac arrest. (dirjournal.org)
  • Some in vitro experiments demonstrated that early intervention in cardiac metabolism disorder attenuated myocardial damage and dysfunction. (dirjournal.org)
  • These factors affect the way in which the immature heart handles calcium, which, in turn, contributes to the myocardial dysfunction observed after CPB. (medscape.com)
  • Using a clinically relevant model of surgical deep hypothermic circulatory arrest (DHCA) combined with targeted metabolomic and proteomic profiling, we are investigating how changes in hibernation-specific myocardial expression/activity of PPARα nuclear receptor and downstream target genes (FGF21) following cardiac surgery can provide cardioprotection by increasing myocardial fatty acid oxidation and inhibiting NF-κB regulated pro-inflammatory responses. (duke.edu)
  • We feel that developing strategies to help 'switch' myocardial metabolism to resemble that naturally occurring in mammalian hibernators represents a transformative approach that could ultimately have an important positive impact in patients undergoing cardiac surgery and transplantation, as well as in victims of cardiac arrest, stroke, trauma and hypothermia, in addition to fundamentally advancing the field of nuclear receptor biology and myocardial substrate metabolism under extremes of physiology. (duke.edu)
  • 2007 - Head of Research Laboratory of Myocardial Metabolism, Almazov Federal Heart, Blood and Endocrinology Centre (Almazov National Medical Research Centre). (almazovcentre.ru)
  • Glucose metabolism is an essential factor for myocardial self-repair after CPR. (dirjournal.org)
  • 18 F) FDG PET/CT, as a non-invasive technology, can monitor myocardial energy metabolism and cardiac function by tracking changes in glucose metabolism after CPR. (dirjournal.org)
  • Impaired energy metabolism was closely related to myocardial damage after cardiopulmonary resuscitation (CPR). (dirjournal.org)
  • 18 F)-fluoro-D-glucose positron emission tomography/computed tomography can be used to evaluate myocardial damage after CPR by monitoring abnormal glucose metabolism. (dirjournal.org)
  • Glucose and fatty acids are important energy substrates for myocardial metabolism. (dirjournal.org)
  • Therefore, it is crucial in the clinical setting to detect myocardial metabolism conditions in real-time to evaluate the latent cardiac injury and make optimum treatment plans during the ROSC. (dirjournal.org)
  • [ 6 ] These include multivessel coronary artery spasm, impaired cardiac microvascular function, impaired myocardial fatty acid metabolism, acute coronary syndrome with reperfusion injury, and endogenous catecholamine-induced myocardial stunning and microinfarction. (medscape.com)
  • The accumulation of cardiac lactate was attenuated by PLCA during myocardial I/R, and infarct size was smaller in rats treated with PLCA (1 mg/kg) than in those treated with caffeic acid (1 mg/kg). (biomedcentral.com)
  • Effects of three types of bariatric interventions on myocardial infarct size and vascular function in rats with type 2 diabetes mellitus. (almazovcentre.ru)
  • We provide a new insight into this potential drug for the treatment of myocardial I/R injury. (biomedcentral.com)
  • Coronary heart disease, also known as coronary artery disease, is one of the most common causes of myocardial damage, affecting over three million people in the United States. (wikipedia.org)
  • DCM is a cardiac pathological condition in patients with DM characterized by the appearance of aberrant myocardial morphology and cardiac functions in the truancy of other factors, such as coronary artery disease, hypertension, and prominent valvular disease [ 3 ] . (encyclopedia.pub)
  • Isolated rat hearts (n=48) were perfused in the retrograde mode with modified Krebs-Henseleit buffer, and following the induction of 30 min global ischemia, ascorbate (150 µM) and/or catechin (5 µM) were added directly into the perfusate during 90 min reperfusion. (usask.ca)
  • After an equilibration perfusion, isolated rat hearts were given 40 min of global ischemia followed by 30 min of reperfusion. (utmb.edu)
  • The present study aimed to investigate the roles of miR‑132 in myocardial ischaemia/reperfusion (I/R) injury and the underlying mechanisms. (spandidos-publications.com)
  • However, despite numerous studies on myocardial I/R injury, deeper insight into the underlying mechanisms of myocardial I/R injury is needed. (spandidos-publications.com)
  • However, few studies have focused on the role of miR-132 in myocardial I/R injury and the underlying mechanisms. (spandidos-publications.com)
  • In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms. (pemfglobal.com)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
  • The key mechanisms underlying myocardial I/R injury include increased intracellular calcium concentration, sudden generation of reactive oxygen species (ROS) and inflammatory cytokines, adenosine triphosphate (ATP) depletion, and development of metabolic acidosis. (researchsquare.com)
  • Focus areas: mechanisms of myocardial protection against ischemia-reperfusion injury, development of targeted drug delivery using nanocarriers. (almazovcentre.ru)
  • Aims: The FDA-approved histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA, Vorinostat) has been shown to induce cardiomyocyte autophagy and blunt ischemia/reperfusion (I/R) injury when administered at the time of reperfusion. (wustl.edu)
  • Researchers used surgery to induce coronary artery occlusion in rats, causing heart tissue damage and simulating a heart attack. (nmn-bio.com)
  • Methods: Mouse and cultured cardiomyocytes (neonatal rat ventricular myocytes and human embryonic stem cell-derived cardiomyocytes) I/R models were used to investigate the effects of SAHA on mitochondria. (wustl.edu)
  • We aimed to investigate the effect of PLCA on hypoxia/reoxygenation (H/R) in neonatal rat ventricular myocytes (NRVM) and on myocardial I/R in rats. (biomedcentral.com)
  • 50% loss of mtDNA content in the border zones of mouse hearts, but SAHA pretreatment and reperfusion treatment alone reverted mtDNA content and mitochondrial mass to control levels. (wustl.edu)
  • The sympathetic/catecholamine theory is gaining momentum, because TCM was induced in rats exposed to physical stress and, in some instances, was prevented by pretreatment with an alpha blocker or beta blocker. (medscape.com)
  • Methods and results: Male Wister rats were subjected to 20 min transient left coronary artery occlusion followed by reperfusion. (elsevierpure.com)
  • Whether triggered by multivessel spasm, thrombosis, epicardial vessel occlusion, or direct myocardial toxicity remains to be seen. (medscape.com)
  • The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)
  • Myocardial scarring is the accumulation of fibrous tissue resulting after some form of trauma to the cardiac tissue. (wikipedia.org)
  • Mechanistically this is accompanied by preservation of myocardial PPARα activity in AGS, which is significantly downregulated in the rat, and a metabolic phenotype consistent with the development of mitochondrial substrate flux "bottlenecks" in rats (myocardial accumulation of acylcarnitines and ceramides, organic acid profiles consistent with compromised citric acid cycle flux) compared to AGS. (duke.edu)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Previous studies have shown that ischemia/reperfusion (I/R) injury acts as a significant role in PGD(4), contributing to adverse short- and long-term clinical outcomes in the recipients. (researchsquare.com)
  • It is noteworthy to mention the fact that these protective agents have been used in the clinical setting for various purposes for a long time. (magiran.com)
  • Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. (sun.ac.za)
  • Thirteen male Sprague-Dawley rats were randomly divided into a sham group (n = 4), CPR group (n = 4), and trimetazidine (TMZ) + CPR group (n = 5). (dirjournal.org)
  • We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
  • HIF-1 reduces ischaemia-reperfusion injury in the heart by targeting the mitochondrial permeability transition pore. (ox.ac.uk)
  • Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
  • The phenomenon may be modelled in an experimental setting, in this case on an isolated rat heart. (justia.com)
  • Postconditioning using N-Ac-GLP-1(7-34)amide N-terminally blocked and C-terminally truncated results in a limitation of ischemia-reperfusion injury in an isolated rat heart. (justia.com)
  • Ischaemia-reperfusion (I/R) injury is the most important and common cause of myocardial damage and subsequent heart failure worldwide ( 1 , 2 ). (spandidos-publications.com)
  • The invention pertains to a polypeptide for the protection against heart ischemia-reperfusion injury. (justia.com)
  • One object of the present invention is to provide a therapy of heart ischemia-reperfusion injury by applying GLP-1 analogues which can be administered as single component and avoiding administration of the drug with a second compound. (justia.com)
  • The present invention is based on the surprising finding that the peptides of the invention have protective cardiovascular effects without simultaneous administration of other compounds, specifically they have protective effects on the heart against ischemia-reperfusion injury. (justia.com)
  • The lack of effective treatments to reduce the consequences of myocardial ischemia-reperfusion injury and the increased reliance on percutaneous and surgical treatments for coronary and valvular disease or end-stage heart failure make it critically important to identify new targets and strategies for cardioprotection. (duke.edu)
  • Hibernators such as arctic ground squirrels (AGS) depress their metabolic, heart, and respiratory rates as well as their core body temperature to enter a state called torpor during which they exhibit remarkable resistance to myocardial I/R injury and ventricular dysrhythmias normally associated with hypothermia. (duke.edu)
  • Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
  • Therefore, attenuating myocardial I/R injury during the heart transplant procedure would have a favorable impact on improving short- and long-term graft function and recipient's survival(6). (researchsquare.com)
  • The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
  • The glycogen content of the rat heart varies in a 24-h rhythm. (utmb.edu)
  • With ischemia in coronary heart disease, impairment of the oxygen supply and metabolic disorder both occur [ 2 ]. (biomedcentral.com)
  • 1├óÔé¼ÔÇ£3 cTns, structural proteins unique to the heart, are sensitive and specific biochemical markers of myocardial damage. (radcliffecardiology.com)
  • In a rat model of heart disease, NMN improved cardiac function, increased vascularization, and reduced tissue damage by modulating hepatocyte-derived vesicles. (nmn-bio.com)
  • The researchers found that untreated stem cell vesicles increased the density of arterioles and capillaries in heart tissue from rats after a heart attack. (nmn-bio.com)
  • Furthermore, it was revealed that treatment with vitexin induced hypoxia inducible factor 1α subunit (HIF‑1α) and vascular endothelial growth factor (VEGF) protein expression, and suppressed phosphorylated‑p38 MAP kinase (p38) protein expression in sevoflurane‑induced newborn rat. (spandidos-publications.com)
  • Cardiomyocytes were isolated and subjected to 6 h hypoxia followed by 18 h reperfusion. (biomedcentral.com)
  • further research indicated that myocardial hypertrophy induced by sema4d was closely related to the expression of the pyroptosis-related proteins pp65, nlrp3 , caspase-1, asc, gsdmd , il-18 and il-1\xce\xb2. (brain-knowledge-engine.org)
  • Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
  • Ischemia and reperfusion can cause serious brain damage in stroke or cardiac arrest. (benbest.com)
  • Reperfusion treatment has a potential risk of worsening tissue damage after ischemia, which can accelerate the deterioration of cardiac function [ 2 ]. (hindawi.com)
  • They then injected untreated stem cell vesicles and NMN-treated stem cell vesicles at the edge of tissue damage in rats. (nmn-bio.com)
  • Abnormal glycolysis is an important manifestation of myocardial damage after CPR. (dirjournal.org)
  • Commercial kits were used to measure the levels of serum myocardial enzymes and inflammatory factors. (spandidos-publications.com)
  • Apparent histologic injury and elevated levels of serum myocardial enzymes and inflammatory factors were observed in the myocardial I/R model. (spandidos-publications.com)
  • A significant increment was seen in female serum level of nitrite compared with males after 3h reperfusion. (phypha.ir)
  • The expression levels of the myocardial injury marker cardiac troponin I (CTNI) in serum were tested at 6 hours after CPR or TMZ + CPR. (dirjournal.org)
  • Effect of Gualou Xiebai Decoction on pulmonary fibrosis in rats based on pyroptosis pathway]. (brain-knowledge-engine.org)
  • Model of Chronic Thromboembolic Pulmonary Hypertension in Rats Caused by Repeated Intravenous Administration of Partially Biodegradable Sodium Alginate Microspheres. (almazovcentre.ru)
  • Before ischemia, acute troglitazone treatment had no effect on LV function, electrocardiogram, or substrate utilization. (diabetesjournals.org)
  • Therefore, patients and physicians need therapeutic interventions that are applicable at the time of surgery. (usask.ca)
  • The number and function of circulating endothelial progenitor cells (EPCs) were increased in PEMF treating rats. (pemfglobal.com)
  • Furthermore, the secreted factor in the macrophage-conditioned tradition medium of Mg-Al LDH group was more suitable for the bone differentiation of rat bone marrow stem cells (rBMSCs) and the Ned 19 angiogenic behavior of human being umbilical vein endothelial cells (HUVECs). (arcillaresearch.com)
  • Another ATP-driven pump helps keep extracellular calcium ions (Ca 2+ ) 10,000 times more concentrated than within the cytoplasm. (benbest.com)
  • In times of high metabolic demand and adequate availability of oxygen, elevated calcium in mitochondria can increase ATP production by stimulation of three enzymes in the Krebs citric acid cycle: pyruvate dehydrogenase, alpha-ketoglutarate and isocitrate dehydrogenase. (benbest.com)
  • This figure outlines the time course for normoxic (A) and ischemia-reperfusion (B) experiments. (justia.com)
  • Normoxic CM and hypoxic CM were isolated from rat BMSCs cultured under normoxic (20% O 2 ) or hypoxic (1% O 2 ) condition. (researchsquare.com)
  • [ 3 , 4 ] Further refinements in CPB hardware and techniques, perfusion methods, myocardial and brain protection over the past seven decades contributed to improved outcomes of surgical treatment of CHD. (medscape.com)
  • Haematoxylin and eosin staining was performed to observe the injury of myocardial tissues. (spandidos-publications.com)
  • miR‑132 was significantly upregulated and SIRT1 was markedly downregulated in I/R myocardial tissues. (spandidos-publications.com)
  • Ischemia is the condition suffered by tissues & organs when deprived of blood flow -- mostly the effects of inadequate nutrient & oxygen. (benbest.com)
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • Development of a software and hardware system for remote myocardial conditioning based on local abdominal decompression. (almazovcentre.ru)
  • An in vitro model of premature myocardial senescence was established as previously reported [ 19 ]. (hindawi.com)
  • Autoradiographic analysis and in vivo PET imaging were used to determine myocardial 18 F-Galacto-RGD uptake at different time points following reperfusion. (elsevierpure.com)
  • Autoradiographic analysis and in vivo PET imaging were used to determine myocardial 18F-Galacto-RGD uptake at different time points following reperfusion. (elsevierpure.com)
  • During ischemia, this pathway is suppressed and instead glucose is largely utilized, resulting in impaired cardiac function. (medscape.com)
  • In this regard, laser acupuncture at ST-36 has been found to increase pain threshold in rabbits [18] and suppress visceral traction pain in rats [19]. (biomedgrid.com)
  • A therapeutic drug that targets ischemia reperfusion (I/R) injury is needed and has yet to be developed. (biomedcentral.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • The time course of focal tracer uptake paralleled vascular density as measured by CD31 immunohistochemical analysis. (elsevierpure.com)
  • Other evidence for this theory has been demonstrated through myocardial imaging studies using catecholamine analogues, that evaluated cardiac sympathetic activity. (medscape.com)
  • In conclusion, this study showed strong protection by ascorbate, which could be used in clinically relevant situations, and is the first to report the protection by catechin at this dose under conditions of myocardial ischemia-reperfusion injury. (usask.ca)
  • Recent studies have shown that the exposure to clinically relevant doses of narcotic drugs, such as isoflurane and sevoflurane, leads to neurological disorders in rats and mice ( 3 , 4 ). (spandidos-publications.com)
  • Bone marrow mesenchymal stem cells (BMSCs) have been reported to attenuate myocardial I/R injury via their paracrine effects, which can be enhanced by hypoxic preconditioning. (researchsquare.com)
  • This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
  • Very recently, beneficial effects of naringenin have been demonstrated in old rats. (hindawi.com)
  • These results suggested that naringenin has antiaging effects on myocardial cells. (hindawi.com)
  • A very recent publication has also provided evidence that Nar has beneficial effects in the livers of old rats [ 18 ]. (hindawi.com)
  • Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, together, the data have prompted us to investigate the effects of Nar in a cellular model of aged myocardial cells. (hindawi.com)
  • Wildland fire, air pollution and cardiovascular health: is it time to focus on the microvasculature as a risk assessment tool? (frontiersin.org)
  • has been used to keep fit and prevent cardiovascular diseases for a long time in the folk [ 15 ]. (hindawi.com)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)