• The acute oral toxicity test of the polyherbal was evaluated in albino rats using a single-dose based on behavioral changes and mortality. (ajol.info)
  • Agavaceae) methanolic crude extract in gentamicin-induced nephrotoxicity in male Wistar albino rats. (ugm.ac.id)
  • Although, slight changes were observed in some biochemical parameters and histology of the kidney and liver at high doses when compared with control rats. (ajol.info)
  • In this study, we investigated the effect of orally administered crude oil contaminated diet on some biochemical parameters of wistar rat. (ajol.info)
  • Methods: Pharmacokinetic parameters of riluzole were determined in Wistar rats after single-dose co-administration with ciprofloxacin and grapefruit juice. (researchgate.net)
  • Objective This study aimed to validate the use of Ca-apt-1, an RNA aptamer, that we generated previously as a probe for immunostaining of Candida albicans in rat tongue paraffin-fixed tissue sections Material and Methods The performance of Ca-apt-1 as a detector molecule was compared with that of anti- C. albicans polyclonal antibody (PcAb), which was used as a positive control. (unair.ac.id)
  • Methods: Acute toxicity study was performed by administering a single oral dose of 5000 mg/kg body weight of the extract to 5 rats while distilled water was given to another 5 rats (control), and the animals were observed for 14 days. (edu.ng)
  • METHODS: Aβ42 immunolabeling of 12 Wistar rat brains (3-18 months of age) and brain sections from six human subjects. (lu.se)
  • To prevent cisplatin induced kidney toxicity we used a combination of dietary plant extracts, particularly, hydro-alcoholic extract of Tribulus terrestris (TT), Boerhaavia diffusa (BD) and Terminalia chebula (TC) in rats. (scialert.net)
  • This present study assessed the toxicity effect of the ethanol leaf extract of PGC in rats. (ajol.info)
  • The results indicated dose-related effects of methanolic extract on paw edema, hyperalgesia and serum IL-6 level reduction in rats. (jcimjournal.com)
  • This research aimed to evaluate toxicity and safety of consuming chloroform extract of S. trifasciata leaf (CESTL) in acute phase using female Wistar rats as model animal. (ugm.ac.id)
  • Hence this present experiment is designed to evaluate the anti-ulcer activity of Cucumis sativus ethanolic extract in wister albino rat model. (florajournal.com)
  • This study investigated the antiulcer activity of aqueous extract of unripe Musa paradisiacal (plantain) peels in rats using ethanol, aspirin, indomethacin and pyloric ligation-induced ulcer models. (academicjournals.org)
  • The analgesic and anti-inflammatory activity of the defatted ethanolic extract of leaves of Anthocephalus cadamba in wistar rats was studied. (rjptonline.org)
  • The doses of the extract of Feretia apodanthera administered the rats through the oral route were 100, 200, and 400 mg/kg. (alexjvs.com)
  • Purpose: To evaluate the acute and sub-acute toxicity profile of the aqueous leaf extract of Nymphaea lotus L in Wistar rats. (edu.ng)
  • Thereafter, 50, 100 and 200 mg/kg doses of the extract were administered to different groups of 5 rats each daily for 28 days while control received distilled water. (edu.ng)
  • This study is carried out on Wistar rats to evaluate the hepatoprotective activity of Argemone mexicana L aerial part extracts against CCL_4 induced acute liver damages. (airitilibrary.com)
  • Collectively, the data describe decreased adrenomedullary response to cholinergic stimulation in spontaneously diabetic rats as early as 2 weeks after the onset of diabetes and that a similar, although more severe, hyposecretion occurs after acute, severe hypoglycemia. (diabetesjournals.org)
  • The highest level at which no acute airway irritation as based on both breathing pattern and frequency was observed in both rat strains was 14 mg/m3. (cdc.gov)
  • Comparative metabolism study of ß-lapachone in mouse, rat, dog, monkey, and human liver microsomes using liquid chromatography-tandem mass spectrometry. (medlineplus.gov)
  • 24 ] have also shown that 0.2% of G-rutin (a rutin-glucose derivative), given in a 20% casein diet for a period of one month to streptozotocin-induced diabetic rats, decreased thiobarbituric acid reactive substance (TBARS) in kidneys. (molvis.org)
  • Rutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation. (molvis.org)
  • Non-Status Epilepticus female rats show seizure-like behaviors in the chronic phase of Pilocarpine experimental model. (scielo.br)
  • Morphological changes of coagulating gland of Wistar rats submitted to the experimental chronic alcoholism were noted. (unesp.br)
  • Subjects were 29 Wistar rats bred at the Experimental Psychology Department Animal House. (bvsalud.org)
  • Finally, experimental candidiasis was evaluated in in vivo models with Wistar female rats. (who.int)
  • Objective : Using a model of carbon tetrachloride (CCl4)-induced hepatotoxicity in rats, we evaluated the effects of commercial herbal extracts used most commonly in the metropolitan area of Monterrey, Mexico. (edu.mx)
  • Voss C, Zerban H, Bannasch P, Berger MR. Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats. (who.int)
  • The administration of WBF at 1 mg/g body weight in Wistar rats with diabetes induced by STZ in a period of 21 days, did not alter physiological parameters (consumption of food and water, urine volume), biochemical markers (total cholesterol, HDL cholesterol and triglycerides), liver enzymes (gamma-GT, AST and ALT), and weight of organs (liver and pancreas) as well as fecal excretion of proteins and lipids. (ufla.br)
  • Assessment of the toxic effects of levetiracetam on biochemical, functional, and redox parameters of salivary glands in male Wistar rats. (bvsalud.org)
  • Therefore, the current work investigated the effects of LEV on the biochemical, functional, and redox parameters of the parotid and submandibular glands in rats . (bvsalud.org)
  • Adequate design of juvenile toxicity studies in rats, for instance with respect to dose levels per age group, requires an understanding of age-dependent pharmacokinetics. (aspetjournals.org)
  • This age-dependent HPGL profile will be instrumental for hepatic drug clearance prediction when designing juvenile toxicity studies in Wistar rats. (aspetjournals.org)
  • The screening is carried according to the method of (Houghton and Raman, 1998) and exploratory tests of subacute oral toxicity are carried in vivo on Wistar albinos rats in accordance with the OECD guidelines (423). (phytojournal.com)
  • We used 40 male offspring from 14 Wistar rats which received purple grape juice or water by gavage daily for 42 days at a dose of 7 microliters/g. (scirp.org)
  • In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
  • The present work profiles the hepatocellularity number in male Wistar rats as a function of age. (aspetjournals.org)
  • The total of 21 male Wistar rats aged 37 d old were divided into three groups, namely ethanol, ethanol-curcumin, and control groups. (jcimjournal.com)
  • In view of this and on account of the interleukin (IL)-6's role in inflammation and pain induction, this study investigated the effects of Achillea santolina extracts on inflammation which was induced by complete Freund's adjuvant (CFA) in male Wistar rats. (jcimjournal.com)
  • Twenty adult male Wistar rats were divided into two groups. (bvsalud.org)
  • Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. (nature.com)
  • For this, male Wistar rats ( Rattus norvegicus albinus) were randomly divided into 3 groups (n = 10/group) Control ( 0.9% saline solution ), LEV100 (100 mg/kg), and LEV300 (300 mg/kg). (bvsalud.org)
  • Histological examination was also performed on the liver and kidney of the rats. (edu.ng)
  • Diabetes was induced experimentally in overnight fasted Rats by intraperitoneal injection of Nicotinamide, 15 min prior to intraperitoneal injection of Streptozotocin (60 mg/kg). (ijpsr.com)
  • To further investigate the potential susceptibility of rats to infection with human HEV, we experimentally injected nude rats with G3 HEV and monitored virus growth. (cdc.gov)
  • RESULTS: In healthy Wistar rats, we find intracellular Aβ42 (iAβ42) in neurons throughout the brain at all ages, but levels vary greatly between brain regions. (lu.se)
  • Supporting behavioral data showed that in both rat strains morphine increased, and naltrexone decreased, sucrose consumption. (helsinki.fi)
  • Adrenal catecholamine release in response to ACh was significantly decreased at 2, 8, and 16 weeks after the onset of diabetes compared with age-matched, nondiabetic control rats. (diabetesjournals.org)
  • Catecholamine release in response to perfusion with 20 mM K + was the same in adrenals from diabetic and control rats. (diabetesjournals.org)
  • The present study aimed at investigating the effects of curcumin on the motor coordination and the estimate of the total number of cerebellar Purkinje cells of adolescent Wistar rats exposed to ethanol. (jcimjournal.com)
  • Curcumin may exert beneficial effects on the motor coordination of adolescent rats exposed to ethanol via undetermined hormetic mechanisms. (jcimjournal.com)
  • Twenty four (24) wistar rats weighing between 125-180g were randomly grouped into four (4) of six animals each. (ajol.info)
  • Twenty four(24) adult wistar rats of both sexes weighing 171g-250g were used for the study. (journalcra.com)
  • Rats bearing mutant genes which are phenotypically expressed in the animals. (lookformedical.com)
  • Curcumin (dose 0.34 mg / 50 g BW) and turmeric powder (54 mg / 50 g BW) were given orally for 9 weeks to 2 week old Wistar rats which were fed high fat diet. (alliedacademies.org)
  • The present research aims to examine a periodontal disease model in which specific pathogen-free Wistar rats are orally exposed to Porphyromonas gingivalis associated with Fusobacterium nucleatum . (bvsalud.org)
  • Our study showed that four weeks following infection with Porphyromonas gingivalis and Fusobacterium nucleatum bone loss in Wistar rats could be identified. (bvsalud.org)
  • On postpartum day ten, Group I rat pups received an intraperitoneal injection of saline. (molvis.org)
  • Age-related changes in the dorsal skin histology in Mini and Wistar rats. (uchicago.edu)
  • Although HPGL is known for adult rats, information on the influence of age on HPGL is missing. (aspetjournals.org)
  • A rodent maternal separation model was here used to study the long-term effects of different early-life rearing conditions on adult behavior, HPA axis activity and long-term voluntary alcohol intake in female rats. (ku.dk)
  • Rats treated with indomethacin or piroxicam in the presence of either β-CD or HP-β-CD exhibited normal tissues. (scite.ai)
  • In-vitro metabolic inhibition studies using rat and human liver microsomes and intestinal absorption studies of riluzole in a rat everted gut-sac model were conducted to elucidate the mechanism of interaction. (researchgate.net)
  • The present findings are in line with and expand on previous studies on the long-term effects of maternal separation in female rats with regard to behavior, HPA axis activity and voluntary alcohol intake. (ku.dk)
  • All the studies reported here were performed on rats (Wistar, female). (cdc.gov)
  • In this study, Alko Alcohol (AA) and Wistar rats went through operant lever pressing training where the task was to choose the more profitable of two options. (helsinki.fi)
  • The results suggest that opioid agonists could improve decision-making in cost-benefit settings in rats that are naturally prone to high alcohol drinking. (helsinki.fi)
  • To investigate whether rutin retards selenite-induced cataractogenesis in Wistar rat pups. (molvis.org)
  • Group II and III rat pups received a subcutaneous injection of sodium selenite. (molvis.org)
  • 0.001) for rat pups until 3 weeks of age compared with adults. (aspetjournals.org)
  • The data illustrate the general pattern of body mass acquisition in rats, in the presence and absence of water or food restriction, along a period corresponding to a typical behavioral experiment. (bvsalud.org)
  • The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. (elsevierpure.com)
  • Rats, Inbred WF are a strain of laboratory rats that are commonly used in medical research due to their consistent genetic makeup and susceptibility to various diseases. (lookformedical.com)
  • The susceptibility of rats to human HEV genotypes is controversial. (cdc.gov)
  • also reported that human HEV (presumably G1) was transmissible to Wistar laboratory rats ( 6 ). (cdc.gov)
  • recently reported that G1, G2, and G3 do not infect laboratory rats ( 7 ), and we found in a previous study that laboratory rats are not susceptible to G1, G3, or G4 HEV ( 8 ). (cdc.gov)
  • We have demonstrated previously that spontaneously diabetic BB-Wistar rats exhibit decreased adrenal medullary catecholamine secretion in response to splanchnic nerve terminal stimulation. (diabetesjournals.org)
  • Conversely, nondiabetic BB-Wistar rats made diabetic with streptozocin (STZ) and maintained in a hyperglycemic state did not exhibit catecholamine hyposecretion 2 weeks after STZ administration. (diabetesjournals.org)
  • Fig. 2: T2D-ZDF rats exhibit abnormal hypothalamic CS/DS-GAG sulfation patterns. (nature.com)
  • General multipurpose rat model for safety and efficacy tests also for infection research. (animalab.eu)
  • Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. (nature.com)
  • The PBPK rat model by Chan (2006) is helpful and provides a very good description of the processes although these are no species extrapolation and no risk assessment tools applied to this model. (cdc.gov)
  • CONCLUSION: Expression of iAβ42 in healthy Wistar rats predominates in the same structures where iAβ accumulates and Aβ plaques initially form in the much used, Wistar based McGill-R-Thy1-APP rat model for AD. (lu.se)
  • The difference between wild-type Wistar rats and these AD model rats, with respect to Aβ42, is therefore quantitative rather that qualitative. (lu.se)
  • This, taken together with our human results, indicate that the McGill rat model in fact models the underlying wild-type neuronal population-specific vulnerability to Aβ42 accumulation. (lu.se)
  • The 6 rats were randomly assigned to 2 groups, injected intravenously with 500 µL of an HEV sample suspension through the tail vein, and monitored for 3 months. (cdc.gov)
  • Zaringhalam J, Manaheji H, Mghsoodi N, Farokhi B, Mirzaiee V . Spinal mu-opioid receptor expression and hyperalgesia with dexamethasone in chronic adjuvant- induced arthritis in rats. (jcimjournal.com)
  • This study aims to compare the hypolipidemic activity of curcumin and turmeric powder in wistar rats fed by high-fat diet. (alliedacademies.org)
  • Anti-inflammatory activity of some Iraqi plants using intact rats. (jcimjournal.com)
  • Leaves exhibited significant analgesic activity and anti-inflammatory activity in wistar rats. (rjptonline.org)
  • In the present study, pharmacokinetics of CIP following IN and IV administration to rats was investigated and compared. (researchgate.net)
  • To study this hypothesis, we isolated adrenal glands from control and spontaneously diabetic BB-Wistar rats, perfused them with ACh, and measured catecholamine secretion. (diabetesjournals.org)
  • Inflammatory symptoms such as hyperalgesia and paw edema in CFA-injected rats' paw were measured by radiant heat and plethysmometer during different stages of study respectively. (jcimjournal.com)
  • After training, rats were administered subcutaneously with opioid agonist morphine or opioid antagonist naltrexone to study the impact of opioidergic mechanisms on cost/benefit decisions. (helsinki.fi)
  • The aim of the present study was to investigate systematically the body weight development of rats submitted to controlled water or food restriction for about 7 months, as compared to animals under an ad Lib regimen. (bvsalud.org)
  • Prior studies have shown that it is necessary to place ligatures around molars to study periodontal destruction in rats. (bvsalud.org)
  • Fig. 1: T2D-ZDF rats have reduced PNN structures in the Arc. (nature.com)
  • At the end of each week, blood sample (2ml) was drawn from the median cantus vein of the eyes of the rats with the aid of a capillary tube and the plasma samples prepared for the biochemical tests. (ajol.info)