• Thirty adult male Sprague-Dawley rats were randomly divided into five experimental groups (6 rats per group). (researchgate.net)
  • To explore the health effects of multi-heavy metal exposure, Sprague Dawley (SD) rats were orally given one dose of heavy metal mixtures (HMMs). (cdc.gov)
  • A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. (nih.gov)
  • Male Sprague-Dawley rats were randomly divided into six groups consisted of 3-5 animals. (scialert.net)
  • Adult male Sprague-Dawley rats, 200-230 g purchased from Faculty of Veterinary Medicine, Universiti Putra Malaysia and acclimatised at the animal house of the Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. (scialert.net)
  • In this experiment, Sprague-Dawley rats were randomly divided into 4 groups: control, chronic unpredictable mild stress (CUMS), acupuncture, and fluoxetine groups. (medscimonit.com)
  • A total of thirty (30) Sprague-Dawley rats were randomly divided into sham, model and sevoflurane groups with 10 animals per group. (ajol.info)
  • Male Sprague-Dawley rats (270-330g) were divided into 4 groups randomly and were anesthetized by sodium pentobarbital (50-60 mg/kg-ip). (vin.com)
  • Male Sprague-Dawley rats (n = 150) were randomly divided into 5 groups: the sham, the sham + 2.8 atmospheres absolute (ATA) HBO group, the SAH group, the SAH + 2.0ATA HBO group, the SAH + 2.8ATA HBO group. (karger.com)
  • A total of 72 male Sprague Dawley rats (215±15 g) were randomly divided into three groups (n=24/group): The sham operation, model and exercise intervention groups, with the latter undergoing 4 weeks of swimming training. (iasp-pain.org)
  • meats, biological trials were conducted on Albino rats of the Sprague-Dawley albino rats. (who.int)
  • Wistar rats) [155], failed to influence food intake during a 1 h ad libitum feeding period, moderate to high doses of CBD (4.4 mg·kg −1 , i.p. [58]. (researchgate.net)
  • Forty male Wistar rats were randomly divided into four groups. (hindawi.com)
  • One hundred and eight female Wistar rats were randomly divided in nine groups. (nih.gov)
  • Forty five aged male wistar rats were divided randomly into three equal number groups (n = 15). (scialert.net)
  • 28 adult female Wistar rats with regular estrous cycles were randomly divided into four groups. (nel.edu)
  • A total of 60 adult male Wistar rats weighing 300?500 g were used in the study. (tubitak.gov.tr)
  • Study assessed the hypoglycemic effect of C. schweinfurthii aqueous and total crude leaf and pulp extracts on blood glucose levels in Wistar albino rats. (academicjournals.org)
  • To investigate the effect of simvastatin on glucose homeostasis in streptozotocin induced type 2 diabetic rats. (hindawi.com)
  • Diabetic rats were induced by a single intraperitoneal injection of STZ. (hindawi.com)
  • the simvastatin intervention rats had a higher FPG compared to the diabetic rats and were more easily be induced to diabetes at the end of 4 weeks, FPG level of simvastatin treatment rats was increased compared with diabetic model rats after 12 weeks. (hindawi.com)
  • The target of the present study is to investigate the effect of simvastatin on FPG in STZ-induced diabetic rats. (hindawi.com)
  • "We studied the changes in redox metabolism through monitoring antioxidant enzyme activities, the level of cell injury by examining DNA damage and activation of the prosurvival Akt kinase as well as the degree of tissue damage through the activation of the fibrotic process in the liver and kidneys of diabetic rats," ​ they wrote. (nutraingredients-usa.com)
  • The present study investigated hypoglycemic effects with normal and diabetic rats being administrated orally without or with ECE at 200 and 800 mg/kg for 15 days. (mdpi.com)
  • Researchers in Serbia found that diabetic lab rats orally administered with the probiotic Lactobacillus paraplantarum BGCG11 experienced a reduced level of DNA damage in the liver and kidney, compared to control rats that didn't receive probiotics. (nutraingredients-usa.com)
  • Three days before exposure, rats were given PWE orally and treatment continued for 2 more days. (blogspot.com)
  • 2013. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats. (raysahelian.com)
  • The right middle cerebral artery (MCA) was ligated in 34 inbred, spontaneously hypertensive male rats, which were then randomly divided into three groups. (lu.se)
  • These data indicate that simvastatin intervention rats may cause hyperglycemia by impairing the function of islet β cells and have an adverse effect on glucose homeostasis, especially on FPG level. (hindawi.com)
  • Additionally, rats in the supplementation group exhibited decreased hyperglycemia and reduced DNA damage in the liver and kidney. (nutraingredients-usa.com)
  • The results demonstrated that propofol-induced impairment in spatial learning and memory of rats and promoted oxidative stress, neuronal injury and apoptosis in rat hippocampal tissues. (degruyter.com)
  • This study aimed to evaluate the effects of TQ on spatial memory and hippocampal long-term potentiation (LTP) in rats with thioacetamide (TAA)-induced liver injury and hepatic encephalopathy. (magiran.com)
  • After behavioral tests were completed, serum, feces, and hippocampal tissue of rats were collected. (medscimonit.com)
  • Here, we used ultra-high performance liquid chromatography-tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) to analyze DOX-induced HF in rats, to explain the toxicological pathways of DOX to the heart, especially the combined proteomic technology, to provide more information for the study of its pathogenesis. (frontiersin.org)
  • A previous study identified that in vivo treatment with EGCG reduced I/R injury by inhibiting the nuclear factor-κB and activator protein 1 pathways in rat hearts ( 11 ). (spandidos-publications.com)
  • When combined with an HS, an UCCAO is associated with ischemic neuronal injury in the ipsilateral hemisphere of adult rat brain, which can be attenuated by therapeutic hypothermia. (medsci.org)
  • Various reports have also shown that long term dietary supplementation of polyphenols improved the cognitive performance in aged rats (Balu et al . (scialert.net)
  • In this study, we evaluated whether the single-nucleotide polymorphism (SNP) rs198585630 of 5-HT 1A receptor is associated with cognitive alterations in rats after microwave exposure with a frequency of 2.856 GHz and an average power density of 30 mW/cm 2 . (frontiersin.org)
  • Rats carrying rs198585630 C allele exhibited increased mRNA and protein expression of 5-HT 1A receptor and were more susceptible to 30 mW/cm 2 microwave exposure, showing cognitive deficits and inhibition of brain electrical activity. (frontiersin.org)
  • Overall, esketamine mitigates propofol-induced cognitive dysfunction and brain injury in rats by activating mBDNF/TrkB/PI3K signaling. (degruyter.com)
  • The classical three-point bending and impact tests were carried out for three rat bone groups: control (SHO), the humerus of animals under the conditions of established osteopenia (OVX), and bones of rats receiving nesfatin-1 after ovariectomy (NES). (mdpi.com)
  • Normal control rats were fed with standard diet, others were fed with high-fat diet. (hindawi.com)
  • 0.05).Immunohistochemical analysis revealed that the expression of LC3 and Beclin 1 in rat ameloblasts in the experimental groups was positive compared to control group. (fluoridealert.org)
  • Group 1 (control) were given clean drinking water and rat chow, group 2 were given intra-muscular (IM) quinine injection 10mg/kg body weight + water + rat chow. (researchgate.net)
  • Beside the control group, each rat received a corresponding dose of HMMs 215, 464 or 1000 mg per kg body weight (bwt), respectively. (cdc.gov)
  • The study was carried out with an aqueous extract of the roots of Asparagus racemosus utilizing three doses viz 800 mg/kg, 1600 mg/kg and 3200 mg/kg for its diuretic activity in comparison with standard drug (furosemide) and control (normal saline) rats after doing acute toxicity study. (raysahelian.com)
  • The animals were randomly divided into four groups as control (n = 10) and treatment (n = 30). (academicjournals.org)
  • For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). (nih.gov)
  • The rats were randomly divided into 2 groups named A (uncoated/control) and B (biocomposite coated). (tubitak.gov.tr)
  • Diabetic GK rats and control animals were randomly assigned to receive E4 or vehicle by intravitreal injection. (molvis.org)
  • The animals were randomly divided into two groups: group C (control) and group AT (macerated adipose tissue grafting). (bvsalud.org)
  • 1992) that chloroquine treatment of rats eventually would lead to infertility by resulting in late germ cell developmental with depletion of spermatids (Abayomi O, 1992).This suggested the requirement for the quinine to occupied a place as a male contraceptive agent in humans (Osinubi et al. (researchgate.net)
  • Experimental manipulations that increase "anxiety" or "fear" increase startle response amplitudes in rats (see, for example, Davis, 1992 ). (jneurosci.org)
  • In this study, the effect of gallic acid (GA) as an activator of AMP-activated protein kinase (AMPK) on memory and anxiety-like behaviors in rats with HE caused by bile duct ligation (BDL) was investigated. (magiran.com)
  • The present study investigated the antiulcer activity of Udumbara Ghanasatwa at two graded doses by pylorus ligation model in rats. (ijpsonline.com)
  • 1. Homogenates of rat liver, spleen, heart and kidney form lipid peroxides when incubated in vitro and actively catalyse peroxide formation in emulsions of linoleic acid or linolenic acid. (scienceopen.com)
  • Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
  • In addition, Townsend et al ( 12 ) reported that EGCG reduced signal transducers and activators of transcription-1 phosphorylation and protected cardiac myocytes against I/R-induced apoptotic cell death in isolated rat hearts. (spandidos-publications.com)
  • Furthermore, administration of EGCG in vitro was observed to prevent apoptosis of cardiomyocytes by regulating pro-apoptotic and anti-apoptotic proteins, including B cell lymphoma-2 (Bcl-2) and Bcl-2-associated X protein, and by simultaneously regulating caspase-3 in isolated rat hearts ( 13 ). (spandidos-publications.com)
  • exposure concentration on particle retention in histologic sections from rats and humans. (cdc.gov)
  • Because rats lack respiratory bron- age of particles in the interstitium is increased with increased dose (exposure concentration, years chioles, they have simple acini. (cdc.gov)
  • Aim of this study was to investigate the effects of Grape Seed Extract (GSE), as a potent antioxidant on spatial memory in rats with Alzheimer's Disease (AD). (scialert.net)
  • The rat model of Alzheimer's disease was induced by local injection of Ibotenic acid (Ibo) into brain Nucleus Basalis Magnocellularis (NBM) or meynert bilaterally (Ibo, 6 μg μL -1 each site) under stereotaxic surgery. (scialert.net)
  • The purpose of the current study is to investigate the effect of aquatic Rosa damascena extract against the oxidative damage induced by aluminum chloride intoxication in Alzheimer's model of Wister rats. (scienceopen.com)
  • Here we investigated the anti-inflammatory effect of GTE on lipopolysaccharides (LPS)-induced retinal inflammation in rats and explored the underlying mechanism. (nature.com)
  • Ocular inflammation was induced in adult rats by injecting 1 mg/kg LPS into the left footpad. (nature.com)
  • The results show that injection of Ibo into NBM of rats could impair spatial memory capacity. (scialert.net)
  • 1999). In the earlier study we examined whether long-term feeding with grape seed extract (100 mg kg -1 for 30 days) would forestall the improvement effects of spatial memory in healthy aged rats. (scialert.net)
  • Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. (nel.edu)
  • To comparatively investigate the effects melatonin and oxytetracycline as antioxidants on autologous intraperitoneal ovary transplantation in rats. (nel.edu)
  • Although both melatonin and oxytetracycline were found to be effective in autologous intraperitoneal pelvic ovary transplantation, melatonin is more effective against both the ovarian necrosis and tissue MDA level in rats. (nel.edu)
  • Sapmaz E, Ayar A, Celik H, Sapmaz T, Kilic N, Yasar M. Effects of melatonin and oxytetracycline in autologous intraperitoneal ovary transplantation in rats. (nel.edu)
  • To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. (nih.gov)
  • After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats were sacrificed on the 21st day. (nih.gov)
  • Moreover, knocking down BDNF partially reversed esketamine-mediated activation of the mBDNF/TrkB/PI3K signaling pathway and inhibition of neuronal apoptosis in propofol-induced rats. (degruyter.com)
  • In this study, effects of L-Carnitine on apoptosis in the ischemic isolated rat hearts were investigated. (vin.com)
  • Group 3 and 4 were given, IM quinine 10mg/kg body weight + water + rat chow and graded proportions of extract of Telfairia occidentalis of 4.5g, and 6.0g, respectively. (researchgate.net)
  • The simvastatin intervention rats were fed with simvastatin during the experiment process, and the simvastatin treatment rats were fed with simvastatin after diabetes rats were induced. (hindawi.com)
  • Toward this goal, we observed the different effect between simvastatin intervention rats and simvastatin treatment rats, especially on FPG levels of various periods. (hindawi.com)
  • A sample of 60 women referred to a rheumatology clinic in Tabriz were randomly divided into intervention (220 mg zinc sulfate daily) and placebo groups. (who.int)
  • We previously demonstrated that GTE is a potent anti-inflammatory and anti-oxidative agent in the eye, alleviating the endotoxin-induced acute anterior uveitis and sodium iodate-induced retinal degeneration in rats 13 , 14 , suggesting a potential treatment for ocular diseases. (nature.com)
  • In the present study, we showed that LPS could be used to establish a retinal inflammatory model on SD rats as well. (nature.com)
  • They found that rats that were supplemented with the probiotic, either before or both before and after diabetes was induced, experienced antidiabetogenic and anti-inflammatory activities at the systemic and tissue levels. (nutraingredients-usa.com)
  • Effects of swimming on pain and inflammatory factors in rats with lumbar disc herniation. (iasp-pain.org)
  • The study evaluates the ability of osteoprogenitors treated with platelet-derived growth factor BB (PDGF-BB) delivered on vinyl styrene microbeads (VSM) to regenerate rat calvarial critical-size defects (CSDs). (allenpress.com)
  • 6 It has been shown that these microbeads are capable of delivering transforming growth factor-β (TGF-β) to rat calvarial critical-size defects. (allenpress.com)
  • The aim of the present study is to evaluate the efficacy of this alloplast to carry and deliver osteoprogenitor cells to rat calvarial critical-size defects. (allenpress.com)
  • To evaluate the immunoexpression of BMP-2 protein on the bone repairing of critical size defects (CSD) surgically created in rat calvaria and treated by autogenous macerated adipose tissue. (bvsalud.org)
  • Effects of LPS injection on the hypothalamic and testicular mRNA expression levels of reproductive factors in male rats. (nel.edu)
  • The present study demonstrated that the hypothalamic mRNA expression level of the kisspeptin receptor was decreased by the injection of lipopolysaccharide (LPS) (500 μg/kg) in male rats, and it was suggested that such changes might contribute to reductions in serum luteinizing hormone levels. (nel.edu)
  • Iwasa T, Matsuzaki T, Tungalagsuvd A, Munkhzaya M, Kuwahara A, Yasui T, Irahara M. Effects of LPS injection on the hypothalamic and testicular mRNA expression levels of reproductive factors in male rats. (nel.edu)
  • While Group 5 were given rat chow + water + 6.0g of Telfairia occidentalis. (researchgate.net)
  • The rats were randomly assigned to three groups in treatment group. (academicjournals.org)
  • METHOD: We conducted a prospective longitudinal study with 174 participants randomly assigned to two groups: SUS Group and Streamline Group. (scielo.br)
  • Meanwhile, 24 h after paracetamol administration, the level of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) were found to be reduced in rats that were pretreated with zerumbone compared to group that was treated with paracetamol only. (scialert.net)
  • The rats were randomly divided into non-operation group (n=20) and operation group (n=10). (researchsquare.com)
  • Infarct size and thalamic atrophy did not differ between the groups and graft size was similar in group B and C. There was no correlation between infarct size and motor function in any of the tests in rats housed in an enriched environment. (lu.se)
  • Each group (n = 30) was randomly subdivided into three subgroups that were examined at the following time points: 24 h, 48 h and 72 h post-injury. (karger.com)
  • E4 significantly prevented the reduction of the b-wave and oscillatory potential amplitudes and retinal cell loss and maintained the Bcl-2/Bax and Bcl-xL/Bax ratio balances in GK rats. (molvis.org)
  • The systemic toxicity of heavy metal mixtures in rats. (cdc.gov)
  • Their aim was to assess the potential beneficial in vivo ​ effect of the probiotic L. paraplantarum ​ BGCG11 on diabetic complications in the liver and kidneys in diabetes-induced rats. (nutraingredients-usa.com)
  • The purpose of this work was to study if enriched housing conditions and fetal neocortical transplantation could enhance the functional outcome after focal brain ischemia in adult rats. (lu.se)
  • Groups A and B were divided into subgroups of A1 and B1 (15th day), A2 and B2 (30th day), A3 and B3 (45th day) according to the date of euthanasia. (tubitak.gov.tr)
  • In this study, proteomics and metabonomics techniques were used to analyze the tissue and plasma of DOX-induced heart failure (HF) in rats and to clarify the molecular mechanism of the harmful effects of DOX on cardiac metabolism and function in rats from a new point of view. (frontiersin.org)
  • In the present study, the protective effects of EGCG with zinc were assessed on cultures of rat cardiac myoblasts exposed to hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
  • The efficacy of vascular endothelial growth factor (VEGF), COX-2, calcium and aromatase inhibitors in an ovarian hyperstimulation syndrome (OHSS) rat model was tested. (nih.gov)
  • A rat model of propofol-induced brain injury was established with or without the treatment of esketamine. (degruyter.com)
  • The rats were randomly divided into 3 groups of 10, and a modified cecal abrasion model was created. (medicaljournal-ias.org)
  • Rats were exposed to a gamma radiation dose of 8 Gy from a Cesium-137 source in order to inflict intestinal mucositis. (blogspot.com)
  • In vivo and in vitro experimental study on the effect of fluoride-induced autophagy in rat HAT-7 cell line]. (fluoridealert.org)
  • PURPOSE: To study the effect of fluoride on autophagy in rat ameloblasts both in vitro and in vivo. (fluoridealert.org)
  • The effects of high dose ascorbic acid on pregnancy rate and litter size in rats were investigated in this study. (academicjournals.org)
  • In this study, it was aimed to investigate the effects of a novel biocomposite consisting of hydroxyapatite (HA), hexagonal boron nitride (h-BN), chitosan (Cs), and type 1 collagen (Ct1) on biocompatibility and fracture healing in rats. (tubitak.gov.tr)
  • This study aimed to investigate the protective mechanism of a GLP-1R agonist E4 against early DR in Goto-Kakizaki (GK) rats. (molvis.org)
  • This study was undertaken to investigate the influence of HBO administration on the TLR4/NF-κ B signaling pathway in rats at the early stage of SAH. (karger.com)
  • The aim of the present study was to identify the effect of swimming on nerve root pain in rats with lumbar disc herniation (LDH). (iasp-pain.org)
  • The animals were randomly divided into groups of 3-5 animals. (scialert.net)
  • The body weight of rats was monitored weekly. (medscimonit.com)
  • In normal rats, no significant differences were exhibited after ECE administration in body weight, fasting blood glucose level, levels of cholesterol, triglyceride, LDL and AST in serum, organ indexes, and levels of GSH and MDA in organs. (mdpi.com)
  • The results showed abnormalities in the hematological system, decreased renal function, hepatic injury and disturbances in the electrolyte balance of the rats treated with a high dose of HMMs. (cdc.gov)
  • Similar results were found in primary rat Müller cells under high glucose culture in vitro. (molvis.org)
  • A greater portion of However, an interspecies difference in Inconsistent results have been obtained the pulmonary parenchyma (composed of air response, with rats but not mice showing an in studies using mice. (cdc.gov)
  • The speed with which rats learn these tasks suggests that they may lend themselves to a variety of behavioural investigations, including pharmacological work and studies of cerebral function. (scienceopen.com)
  • Behavioral tests including novel object recognition (NOR), open field and Morris water maze (MWM) were used to evaluate anxiety and memory in the rats. (magiran.com)
  • Adult rats were injected with LPS and GTE was administered intra-gastrically at 2, 8, 26 and 32 hours post-injection. (nature.com)
  • Histological section of the eye showed that LPS induced substantial accumulation of infiltrating cells in the vitreous humor 48 hrs after injection (n = 7) (Fig. 1b ), which was not detected in the saline-injected rats (n = 7, Fig. 1a ). (nature.com)
  • and BDL+GA 30 mg/kg+CC. The rats received GA once daily by gavage for four weeks, and dorsomorphin 6.2 µg per rat was administered on a daily basis via bilateral intraventricular injection for four weeks. (magiran.com)
  • for example, H-FABP makes up 3% of the plasmic intracellular LBPs from three different cytoplasmic protein content in rat heart. (lu.se)
  • TSN has also been confirmed to reduce podocyte damage in DN rats and high glucose-cultured podocytes [ 11 , 12 ]. (hindawi.com)
  • [ 3 ] proposed that a transport defect of glucose-6-phosphate (G6P) into the microsomal compartment may be present in some patients with GSD type I. Thus, GSD type I is divided into GSD type Ia caused by G6Pase deficiency and GSD type Ib resulting from deficiency of a specific translocase T1. (medscape.com)
  • Rats were housed in wire-floored cages under a 12 h light-dark cycle for at least 7 days prior to treatment and were fed with standard laboratory chow and tap water ad libitum. (hindawi.com)
  • RÉSUMÉ Le présent essai clinique randomisé, en double aveugle, contrôlé contre placebo, a évalué l'effet de la supplémentation en zinc sur les taux de zinc et de calcium sériques chez des femmes ostéoporotiques ménopausées. (who.int)
  • Les mesures anthropométriques, l'apport alimentaire en zinc et en calcium, les taux de zinc et de calcium sériques ont été évalués au début de l'étude puis à 60 jours. (who.int)
  • Les concentrations moyennes initiales en zinc sérique étaient nettement inférieures aux valeurs normales, mais les taux de calcium sérique moyens étaient normaux. (who.int)
  • La supplémentation en zinc peut être bénéfique aux femmes ostéoporotiques ménopausées. (who.int)
  • The rats were then put on stock diet for 7 from the local market and dried in a hot days prior to the experiment. (who.int)
  • At the end of 10 days trial, all the rats were to each diet. (who.int)
  • The rats were fed the allotted killed with an overdose of chloroform and diet ad libitum for a period of 10 days. (who.int)
  • 5 It was found that this alloplast is osteoconductive and has no toxic effect on the vital organs of rats. (allenpress.com)
  • To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)
  • [ 3 ] Thus, GSD type I is divided into GSD type Ia caused by G6Pase deficiency and GSD type Ib resulting from deficiency of a specific translocase T1. (medscape.com)