• To investigate the potential carcinogenicity of cyadox, an antimicrobial agent, four groups of Sprague-Dawley rats (50 rats/sex/group) were fed diets containing cyadox (0, 200, 600 or 2000 mg/kg) for up to two years. (ovid.com)
  • A study was conducted to observe the differences in three groups of Sprague-Dawley rats: ones that had part of the RHT pathway cut when it was an adult (AE), ones that had part of the pathway cut within 24 hours of their birth (NE), and a control group. (wikipedia.org)
  • Methods 2BP was tested through the use of repeated dose experiments among male Sprague Dawley rats. (sjweh.fi)
  • Methods: Blood was sampled, 2 d apart, from Sprague-Dawley rats (30 males and 30 females) in both fed and non-fed states at 20 wk of age (weight: 470.2 ± 23.2 g) for measurement of ionized calcium (iCa), total intact (INT) and bioactive 1-84 (BIO) PTH. (scirp.org)
  • METHODS: Forty-two male Sprague-Dawley rats were equally divided into six groups: Group I (control)--normal rat chow, Group II--fresh soy oil, Group III--soy oil heated once, Group IV--soy oil heated twice, Group V--soy oil heated five times, Group VI--soy oil heated ten times. (biomedsearch.com)
  • Methods Single atrial myocyte of SD rats was obtained by enzymatic dissociation method. (bmj.com)
  • However, both mouse and rat microdialysis studies have failed to find an increase in extracellular serotonin in the prefrontal cortex following acute or chronic atomoxetine treatment. (wikipedia.org)
  • Atomoxetine's ability to increase prefrontal cortex firing rate in anesthetized rats could not be blocked by D1 or α2-adrenergic receptor antagonists, but could be potentiated by NMDA or an α1-adrenergic receptor antagonist, suggesting a glutamatergic mechanism. (wikipedia.org)
  • Increased fructose consumption is linked to the development of metabolic syndrome (MS). Here we investigated the time course of development of MS features in high-fructose-fed Sprague Dawley rats along with circulatory testosterone and homocysteine levels. (hindawi.com)
  • High-fructose-fed rat model is a well-established animal model to elucidate mechanisms involved in fructose-induced MS development and also to study the effect of various nutrient and drug interventions on MS [ 8 ]. (hindawi.com)
  • C.-H. Ma, L.-L. Kang, H.-M. Ren, D.-M. Zhang, and L.-D. Kong, "Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF- κ B/NLRP3 inflammasome activation in high fructose-fed rats," Journal of Ethnopharmacology , vol. 172, pp. 108-117, 2015. (hindawi.com)
  • We propose that previous reports of fructose-induced hypertension reflect a heightened stress response by fructose-fed rats associated with restraint and tail cuff inflation. (biomedsearch.com)
  • Increase in hepatic triglyceride content was first observed in metabolic disturbance followed by hypertriglyceridemia and systemic insulin resistance in fructose-fed rats. (hindawi.com)
  • A few of these parameters were found to be significantly different, but were within the normal reference intervals for rats of this breed and age, and were thus not considered to be treatment-related. (plos.org)
  • After treatment with Livartho drug (206.6 mg/kg body weight) once daily for 16 days to paracetamol treated rats shows significantly lowered the afore mentioned biochemical parameter whereas protein and albumin levels were increased along with significant increased above mentioned antioxidant enzymatic parameters. (omicsonline.org)
  • Our data show that spatial memory significantly improved within 5 daily learning sessions (each 5 trials) under dim white light, which was not different between male and female rats. (hindawi.com)
  • However, dim blue and red light significantly reduced spatial learning of female rats in the 8-arm radial maze in the last training session (session 5). (hindawi.com)
  • In addition, PD168 significantly decreased (10-16%) cardiac ejection fraction (EF) and increased left ventricular area (LVA) in systole (s) and diastole (d) in PD-10 and -50 rats. (hindawi.com)
  • We also observed significantly higher HIF1α and BNIP3 (a downstream target of HIF1α) expression in the lungs of HR SD rats. (ahajournals.org)
  • Domestic rats differ from wild rats in many ways: they are calmer and significantly less likely to bite, they can tolerate greater crowding, they breed earlier and produce more offspring, and their brains, livers, kidneys, adrenal glands, and hearts are smaller. (wikipedia.org)
  • Also leptin administration to normotensive Sprague Dawley rats during pregnancy significantly increases urinary protein excretion. (wikipedia.org)
  • Rat pups treated with sodium selenite are typically used as an in vivo model to mimic age-related nuclear cataract. (molvis.org)
  • PhIP has also formed DNA adducts in vivo in both rats and monkeys. (wikipedia.org)
  • In conclusion, cyadox was not carcinogenic to rats with the liver and kidney as the target organs, and the side chain may be involved in toxicity and carcinogenicity mediated by QdNOs. (ovid.com)
  • citation needed] Despite the criticisms associated with using animals to research essentially human conditions, Sagvolden supported his Dynamic Developmental Theory of ADHD using research primarily done using Spontaneously Hypertensive Rats. (wikipedia.org)
  • Research by Terje Sagvolden suggested that rats sourced from Charles River Laboratories perform as the best model. (wikipedia.org)
  • 4. The oral bioavailability of HQ at 5 mg/kg was low in both rats (1.6%) and mice (3.9%) demonstrating significant first pass metabolism. (rti.org)
  • 2. Clearance and metabolism of EHMC in hepatocytes and disposition and metabolism of EHMC in rodents following oral (8 to 800 mg/kg) intravenous (IV) (8 mg/kg), or dermal (0.8 to 80 mg/kg representing 0.1 to 10% formulation concentration) exposure to [(14)C]EHMC were investigated in rats and mice. (rti.org)
  • Torsion of the uterus can be accompanied by haemostatic and metabolic complications, which could have caused the death of the rat. (scielo.org.za)
  • We conclude that transient decrease in circulatory testosterone and homocysteine levels and increased hepatic triglyceride content are the earliest metabolic disturbances that preceded hypertriglyceridemia and insulin resistance in fructose-fed SD rats. (hindawi.com)
  • It features competitive antagonist activity at 5-HT serotonin receptor in Sprague-Dawley rat stomachs. (wikipedia.org)
  • It was also observed that the activity of peroxisomal enzyme carnitine acetyl transferase is increased in cultures of rat liver cells. (wikipedia.org)
  • Activity anorexia (AA) is a condition where rats begin to exercise excessively while simultaneously cutting down on their food intake, similar to human anorexia nervosa or hypergymnasia. (wikipedia.org)
  • In the current study the developmental toxicity of sodium molybdate dihydrate as a representative of a broad class of soluble molybdenum(VI) compounds, was given in the diet to Sprague Dawley rats in accordance with OECD Test Guideline 414. (rti.org)
  • The rat pups in groups 2 to 6 were given a subcutaneous injection with sodium selenite (18 μmol/kg bodyweight) on postnatal (P) day 10. (molvis.org)
  • The purpose of this study was to evaluate therapeutic effect of Livartho drug in paracetamol induced hepatic damage Sprague dawley rats. (omicsonline.org)
  • The results of this study strongly indicate that Livartho drug is most effective medicine which has potent hepatoprotective action and free radical scavenger against paracetamol induced hepatic damage in Sprague dawley rats. (omicsonline.org)
  • V1AR is also known as: V1a vasopressin receptor antidiuretic hormone receptor 1A SCCL vasopressin subtype 1a receptor V1-vascular vasopressin receptor AVPR1A vascular/hepatic-type arginine vasopressin receptor Human AVPR1A cDNA is 1472 bp long and encodes a 418 amino-acid long polypeptide which shares 72%, 36%, 37%, and 45% sequence identity with rat Avpr1a, human AVPR2, rat Avpr2, and human oxytocin receptor (OXTR), respectively. (wikipedia.org)
  • Conclusion AngII and telmisartan had directly electrophysiological effects on SD rat atrial myocytes as well as telmisartan had antagonist effects on AngII at the level of angiotensin receptor. (bmj.com)
  • In all strains of rats studied, progesterone alone did not alter the ovariectomy-induced attenuation of cocaine behavior, but estrogen alone restored cocaine-induced behavioral sensitization. (aspetjournals.org)
  • Codeine did not induce analgesia in the DA rat and there was a 60% reduction in codeine analgesia in the SD rat pretreated with quinine in comparison to the untreated SD rat. (aspetjournals.org)
  • In the quinine-pretreated SD rat, there was no reduction in oxycodone analgesia but the duration of analgesia was also prolonged. (aspetjournals.org)
  • 3. With dermal application of 2, 10 or 20% [14 C]HQ, mice absorbed higher percentages of the dose than rats (37, 12, 12% versus 18.6, 4.43 and 1.79%, respectively). (rti.org)
  • 5. Following dermal application, 34-42% of an 8 mg/kg dose was absorbed in rats, and 54-62% in mice in 72 h. 6. (rti.org)
  • Experiments performed on Sprague-Dawley rats in a European patent for using Phenylpiracetam to treat sleep disorders showed an increase in extracellular dopamine levels after administration. (wikipedia.org)
  • Studies on the antidiabetic activities of Cordyceps militaris extract in diet-streptozotocin-induced diabetic Sprague-Dawley rats," BioMed Research International , vol. 2014, Article ID 160980, 11 pages, 2014. (hindawi.com)
  • The HQ mass absorbed by mice increased with dose, while in rats it was more constant over the dose range. (rti.org)
  • These results revealed that a 14-day repeated oral dose of 1,3-DCP was minimally embryotoxic but not teratogenic at a maternal toxic dose (90mg/kg/day), and was not embryotoxic at a minimally maternal toxic dose (30mg/kg/day) in rats. (sigmaaldrich.com)
  • Results The rats showed significant decreases in body weight depending on the 2BP dose. (sjweh.fi)
  • At this time ZDSD rats were severely insulin resistant with slowing of both motor and sensory nerve conduction velocities. (hindawi.com)
  • Extracts of Cordyceps militaris lower blood glucose via the stimulation of cholinergic activation and insulin secretion in normal rats," Phytotherapy Research , vol. 26, no. 8, pp. 1173-1177, 2012. (hindawi.com)
  • The no-observed-effect-level (NOEL) for carcinogenicity of cyadox fed to rats was 2000 mg/kg diet (132.18-156.28 mg/kg b.w./day). (ovid.com)