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  • congenic
  • We also developed a novel congenic rat strain harboring the Ctns ugl mutation on the F344 genetic background. (springer.com)
  • Congenitally athymic rats injected with CD45RBhigh CD4+ T cells from congenic euthymic donors developed a severe wasting disease with inflammatory infiltrates in liver, lung, stomach, thyroid, and pancreas. (ox.ac.uk)
  • This congenic strain was established by backcrossing (over 10 generations) of AR rat to F344/NSlc. (mcw.edu)
  • Liver
  • Liver marker enzyme activities in mutant rat serum are normal. (wiley.com)
  • Sakamuri VP, Ananthathmakula P, Veettil GN, Ayyalasomayajula V (2011) Vitamin A decreases pre-receptor amplification of glucocorticoids in obesity-study on the effect of Vitamin A on 11 beta-hydroxysteroid dehydrogenase type 1 activity in liver and visceral fat of WNIN/Ob obese rats. (springer.com)
  • The activities of coproporphyrinogen oxidase, protoporphyrinogen oxidase and ferrochelatase in liver homogenates of iron-overloaded and acutely or chronically ethanol-treated rats were assayed by high performance liquid chromatographic methods. (biomedsearch.com)
  • Thyroid hormone-inducible monoamine oxidase inhibitor in rat liver cytosol. (biomedsearch.com)
  • An endogenous inhibitor of monoamine oxidase (MAO) was separated by gel-filtration from 105,000 g supernate of T4-treated rat liver cytosol. (biomedsearch.com)
  • Publications] 浜田淳一: 'Differing distribution of hepatocyte growth factor-positive cells in the liver of LEC rats with acute hepatitis and hepatoma. (nii.ac.jp)
  • phenotype
  • Integrated phenotype data sets coupled with genomic resources and emerging SNP based genotypes for hundreds of strains will improve our ability to elucidate the genetic basis of disease. (mcw.edu)
  • mutation
  • Following the identification of the Tsc2 germline mutation in the Eker rat, it became the first rodent model of tuberous sclerosis and has since been exploited in many areas of tumor biology as illustrated in the content of this issue. (eurekaselect.com)
  • This strains carries the Pkdr1 mutation that causes autosomal dominant polycystic kidney disease. (mcw.edu)
  • Type
  • The Long-Evans Agouti (LEA/Tohm) rat has recently been established as a new rat model of type 2 diabetes. (springer.com)
  • We have previously reported a novel rat model of non-obese type 2 diabetes, the Long-Evans Agouti (LEA/Tohm) rat, which is characterized by a spontaneous insulin secretion-deficient diabetes model (Okamura et al. (springer.com)
  • Activation of GSH-Px promoter was found in both cell llines expressing wild-type p53 and mutant p53, indicating that GSH-Px promoter is activated by N-terminal activation domain of p53. (nii.ac.jp)
  • anion
  • Role of chloride and intracellular pH on the activity of the rat hepatocyte organic anion transporter. (jci.org)
  • Phenotypic
  • Phenotypic analysis of F344- Ctns ugl rats indicated that the incidence of urinary glucose was 100% in both males and females at around 40 weeks of age, and marked cystine accumulation was observed in the tissues, as well as remarkable renal lesions and cystine crystals in the lysosomes of the renal cortex. (springer.com)
  • In addition, we demonstrate proof of principle for the generation and cloning of human disease models in rat using ENU mutagenesis, providing good perspectives for systematic phenotypic screens in the rat. (genetics.org)
  • assays
  • As a result, extensively validated assays are available and provide a solid basis for the development of a rat screening protocol. (genetics.org)
  • pharmacology
  • However, the mouse has limitations for some fields of investigation, especially those related to physiology and pharmacology where the rat has proven to be a much better animal model. (grantome.com)
  • adult
  • In adult rats, serum bilirubin is 33 ± 8 μmoles per liter with 81.8% diconjugates and 12.1% monoconjugates vs. 0.3 ± 0.1 μmole per liter unconjugated bilirubin in normal adult rats. (wiley.com)
  • genetic
  • Considerable advances have been made in genetic manipulation of the rat. (grantome.com)
  • This program was focused on understanding the genetic basis of fundamental mechanistic pathways of the heart, lung, kidney, blood and vasculature and achieved this goal by developing two panels of consomic rat strains and ENU-induced mutant strains and physiologically characterizing these unique animal models. (mcw.edu)
  • embryos
  • This strain was produced by injecting ZFNs targeting the sequence ATCCTGGCCCTGGGTgtgtggGCTGTGGCCCAGCGG into SS/JrHsdMcwi rat embryos. (mcw.edu)
  • metabolism
  • Rats possessing disruptions in estrogen and progesterone signaling will provide new tools for biomedical scientists in a range of disciplines, including cancer biology, reproduction, women's health, environmental health, metabolism, immunology, neurosciences, and cardiovascular biology. (grantome.com)
  • dopamine
  • Based on previous findings of dysfunctions of the central dopamine system in ci2 and ci3 mutant rats, we assume that alterations in dopaminergic activity are involved in the maladaptive behavior observed in the present study. (biomedsearch.com)
  • behavior
  • Comparative analysis of anxiety-like behaviors and sensorimotor functions in two rat mutants, ci2 and ci3, with lateralized rotational behavior. (biomedsearch.com)
  • The most studied indicator of cerebral asymmetry in the rat is that of circling or rotational behavior. (biomedsearch.com)
  • The abnormal motor response to external stimuli raised the possibility that the circling rat mutants may be more likely to express anxiety-related behavior in tests of emotionality. (biomedsearch.com)
  • In contrast to our expectation, both mutants demonstrated less anxiety-related behavior than controls in tests of emotionality. (biomedsearch.com)
  • spontaneous
  • Current rat disease models are selected from existing strains and their number is thereby limited by the degree of naturally occurring variation or spontaneous mutations. (genetics.org)
  • J acob and K witek 2002 ) are primarily selected from existing laboratory strains and their number and nature is therefore limited by the degree of naturally occurring variation or the occurrence of spontaneous novel mutations. (genetics.org)
  • Publications] 浜田淳一: 'Hepatocyte growth factor and c-met expression in Long-Evans Cinnamon rats with spontaneous hepatitis and hepatoma. (nii.ac.jp)
  • embryonic
  • Haploid embryonic stem cell lines derived from androgenetic and parthenogenetic rat blastocysts. (mcw.edu)
  • METHODS
  • METHODS: In 17 normal hooded rats and 12 Royal College of Surgeons (RCS) rats, a small area of the retina was focally stimulated with electric currents through an anode placed on the fenestrated sclera and a cathode inserted into the vitreous chamber. (biomedsearch.com)
  • 2002
  • The strain was transferred from Dr. Jared Grantham, University of Kansas Medical Center to the Rat Resource and Research Center in 2002. (mcw.edu)
  • estrogen
  • Ebling FJG, Petrow V (1993) 19-Aldehydo-4-androstene-3,17-dione: an estrogen precursor that inhibits sebaceous secretion in a rat model. (springer.com)
  • biomedical
  • The rat is the most extensively studied model organism and is broadly used in biomedical research. (genetics.org)
  • THE rat is the most frequently used organism in a wide spectrum of biomedical studies, e.g. , physiological and nutritional studies, and drug development. (genetics.org)
  • tissues
  • 1. The molecular composition of acetylcholinesterase (AChE) obtained from cockroach neural, and rat brain tissues was different. (biomedsearch.com)
  • establishment
  • First, establishment of comprehensive and efficient high-throughput screening setups will be challenging, although the rat has already been used for decades as the primary model organism in, for example, behavioral neurobiology, hypertension, and diabetes research. (genetics.org)
  • markers
  • the application of the more versatile single nucleotide polymorphism (SNP) markers in the rat is still in its infancy. (genetics.org)
  • activity
  • The functional importance of impaired nigral GABAergic transmission in mutant rats was demonstrated by the fact that intranigral injection of the GABA agonist muscimol reduced the tonic extension of the hindlimbs as indicated by reduced tonic EMG activity of the gastrocnemius-soleus muscle, while intranigral injection of the GABA antagonist bicuculline increased the disturbance. (muscimol.xyz)
  • Decreased coproporphyrinogen oxidase activity was found in chronically carbonyliron-fed rats while the activities of protoporphyrinogen oxidase and ferrochelatase remained unchanged. (biomedsearch.com)